scholarly journals Role of Diet and Nutritional Supplements in Parkinson’s Disease Progression

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Laurie K. Mischley ◽  
Richard C. Lau ◽  
Rachel D. Bennett

Objectives. The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson’s disease (PD) progression.Methods. The patient-reported outcomes in PD (PRO-PD) were used as the primary outcome measure, and a food frequency questionnaire (FFQ) was used to assess dietary intake. In this cross-sectional analysis, regression analysis was performed on baseline data to identify the nutritional and pharmacological interventions associated with the rate of PD progression. All analyses were adjusted for age, gender, and years since diagnosis.Results. 1053 individuals with self-reported idiopathic PD were available for analysis. Foods associated with the reduced rate of PD progression included fresh vegetables, fresh fruit, nuts and seeds, nonfried fish, olive oil, wine, coconut oil, fresh herbs, and spices (P<0.05). Foods associated with more rapid PD progression include canned fruits and vegetables, diet and nondiet soda, fried foods, beef, ice cream, yogurt, and cheese (P<0.05). Nutritional supplements coenzyme Q10 and fish oil were associated with reduced PD progression (P=0.026andP=0.019, resp.), and iron supplementation was associated with faster progression (P=0.022).Discussion. These are the first data to provide evidence that targeted nutrition is associated with the rate of PD progression.

Author(s):  
Daniela Salgado Amaral ◽  
Danielle Sanguinetti ◽  
Juliana Cassiano Amancio Da Silva ◽  
Priscila Romão Caldas ◽  
José Ângelo Peixoto Da Costa ◽  
...  

A Doença de Parkinson (DP) é uma síndrome neurodegenerativa que se caracteriza essencialmente por déficts motores, incluindo prejuízos nas habilidades manuais, o que interferem no desempenho das atividades cotidianas. Os terapeutas ocupacionais utilizam recursos de Tecnologia Assistiva (TA) para favorecer a autonomia e independência. O uso de TA impressa em 3D é um recurso inovador e possibilita a personalização com baixo custo. O objetivo desta pesquisa é descrever o processo de avaliação e desenvolvimento de produtos de TA em 3D para pessoas com déficit de função manual por Doença de Parkinson. Trata-se de um estudo observacional, descritivo, de corte transversal, do tipo relato de caso. A paciente estudada tinha 61 anos, diagnosticada há 3 anos e era auxiliar administrativa. Apresentava déficit nas habilidades manuais de leve à moderado e as atividades com maior prejuízos funcionais foram: usar colher, varrer casa, usar escova de dentes e manusear a agulha de crochê. A pontuação média de desempenho foi 6,0 e de satisfação 4,5, de acordo com a Medida Canadense de Desempenho Ocupacional, para as atividades citadas. Após escaneamento do membro superior foi impressa em 3D uma adaptação universal para favorecer as atividades do uso da colher, da escova de dente e da agulha de crochê. O recurso proporcionou um melhor desempenho nas atividades e a paciente destacou satisfação com o uso do recurso e serviço utilizados. Dessa forma, A TA impressa em 3D pode ser um recurso eficaz e se faz necessário ampliar os estudos na área. AbstractParkinson's disease (PD) is a neurodegenerative syndrome that is essentially characterized by motor deficit, including impairments in manual skills, which may interfere with the performance of daily activities. Occupational therapists use Assistive Technology (AT) resources to promote autonomy and independence. The use of AT printed in 3D is a resourse innovative and possibility of customization and low cost. The objective of the research is to describe the process of evaluating and developing 3D AT products for people with Parkinson's disease manual function deficit. This is an observational, descriptive, cross-sectional study of the case report type. The patient studied was 61 years old, diagnosed 3 years ago and was an administrative assistant. There were deficits in the manual skills of mild to moderate and the activities with the greatest functional losses were: to use spoon, to sweep house, to use toothbrush, and to handle the crochet needle. The average performance score was 6.0 and satisfaction 4.5, According to the Canadia Measure of Occupational Performance, for the above activities. After scanning the upper limb was printed in 3D universal adaptation with main focus on favoring the activities of using the spoon, toothbrush and crochet needle. The resource favored a better performance in the activities and the patient reported satisfaction with the use of the resource and service used. Assistive technology printed in 3D can be an effective resource, it is necessary to expand the studies in the area.Keywords: Parkinson's disease; Self-Help Devices; Occupational Therapy. Resumen La enfermedad de Parkinson (DP) es un síndrome neurodegenerativo que se caracteriza esencialmente por déficits motores, incluyendo perjuicios en las habilidades manuales, lo que puede interferir en el desempeño de las actividades cotidianas. Los terapeutas ocupacionales utilizan recursos de Tecnología Asistiva (TA) para favorecer la autonomía e independencia. El uso de TA impresa en 3D es un recurso innovador por la posibilidad de la personalización y bajo costo. El objetivo de la investigación es describir el proceso de evaluación y desarrollo de productos de TA en 3D para personas con déficit de función manual por enfermedad de Parkinson. Se trata de un estudio observacional, descriptivo, de corte transversal, del tipo relato de caso. La paciente estudiada tenía 61 años, diagnosticada hace 3 años y era auxiliar administrativo. Presentaba déficit en las habilidades manuales de leve a moderado y las actividades con mayor perjuicios funcionales fueron: usar cuchara, barrer casa, usar cepillo de dientes, y manipular la aguja de crochet. La puntuación media de rendimiento fue de 6,0 y de satisfacción 4,5, de acuerdo con la Medida Canadiense de Desempeño Ocupacional, para las actividades citadas. Después del escaneado del miembro superior se imprimió en 3D adaptación universal con principal foco en favorecer las actividades del uso de la cuchara, del cepillo de dientes y de la aguja de crochet. El recurso favoreció un mejor desempeño en las actividades y la paciente relató satisfacción con el uso del recurso y servicio utilizados. La tecnología asistiva impresa en 3D puede ser un recurso eficaz, se hace necesario ampliar los estudios en el área.Palavras clave: Enfermedad de Parkinson; Dispositivos de Autoayuda; Terapia Ocupacional.


2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Laurie K. Mischley ◽  
Leanna J. Standish ◽  
Noel S. Weiss ◽  
Jeannie M. Padowski ◽  
Terrance J. Kavanagh ◽  
...  

Objectives. Oxidative stress contributes to Parkinson’s disease (PD) pathophysiology and progression. The objective was to describe central and peripheral metabolites of redox metabolism and to describe correlations between glutathione (Glu) status, age, and disease severity.Methods. 58 otherwise healthy individuals with PD were examined during a single study visit. Descriptive statistics and scatterplots were used to evaluate normality and distribution of this cross-sectional sample. Blood tests and magnetic resonance spectroscopy (MRS) were used to collect biologic data. Spearman’s rank-order correlation coefficients were used to evaluate the strength and direction of the association. The Unified PD Rating Scale (UPDRS) and the Patient-Reported Outcomes in PD (PRO-PD) were used to rate disease severity using regression analysis.Results. Blood measures of Glu decreased with age, although there was no age-related decline in MRS Glu. The lower the blood Glu concentration, the more severe the UPDRS (P=0.02, 95% CI: −13.96, −1.14) and the PRO-PD (P=0.01, 95% CI: −0.83, −0.11) scores.Discussion. These data suggest whole blood Glu may have utility as a biomarker in PD. Future studies should evaluate whether it is a modifiable risk factor for PD progression and whether Glu fortification improves PD outcomes.


2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
He-Yang You ◽  
Lei Wu ◽  
Hai-Ting Yang ◽  
Chen Yang ◽  
Xiao-Ling Ding

Background. Pain is frequent in Parkinson’s disease (PD) and Parkinson-plus syndrome. This study aimed to assess the prevalence, characteristics, therapy (especially the effect of dopaminergic therapy), and associated symptoms of pain in Parkinson's disease and multiple system atrophy (MSA) patients. Methods. Seventy-one PD patients, sixty-five MSA patients, and forty age-matched healthy controls were enrolled and evaluated by using the German pain questionnaire and visual analogue scale (VAS). In addition, the influence of pain in PD patients on anxiety, depression, and the quality of life was assessed with the Hospital Anxiety and Depression Scale (HADS) and Parkinson’s Disease Questionnaire (PDQ-39). Results. Compared to that of the healthy controls, the PD and MSA patients had a significantly higher presence of pain (P<0.01, P<0.01). PD patients had a higher presence of pain than MSA patients (P=0.007). No difference in VAS scores was observed between the PD and MSA patients (P=0.148). A total of 21 PD patients (42.85%) with pain and 13 MSA patients (43.33%) with pain received treatment. A total of 13 PD patients with pain and 6 MSA patients with pain had an improved pain intensity after using dopaminergic medication. The differences in the disease duration, Hoehn and Yahr stages, and scores on the Unified Parkinson’s Disease Rating Scale motor score, HAD-D, HAD-A, and PDQ-39 were significant between the PD patients with and without pain. Conclusion. PD and MSA patients are prone to pain with insufficient treatment. Pain interventions should be provided as soon as possible to improve the patient’s life.


BMJ Open ◽  
2014 ◽  
Vol 4 (1) ◽  
pp. e003976 ◽  
Author(s):  
Eirik Auning ◽  
Veslemøy Krohn Kjærvik ◽  
Per Selnes ◽  
Dag Aarsland ◽  
Astrid Haram ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Taylor Andrew Finseth ◽  
Jessica Louise Hedeman ◽  
Robert Preston Brown ◽  
Kristina I. Johnson ◽  
Matthew Sean Binder ◽  
...  

Introduction. Complementary and alternative medicine (CAM) is frequently used by Parkinson’s disease (PD) patients. We sought to provide information on CAM use and efficacy in PD patients in the Denver metro area with particular attention to cannabis use given its recent change in legal status.Methods. Self-administered surveys on CAM use and efficacy were completed by PD patients identified in clinics and support groups across the Denver metro area between 2012 and 2013.Results. 207 patients (age69±11; 60% male) completed the survey. Responses to individual CAM therapy items showed that 85% of respondents used at least one form of CAM. The most frequently reported CAMs were vitamins (66%), prayer (59%), massage (45%), and relaxation (32%). Self-reported improvement related to the use of CAM was highest for massage, art therapy, music therapy, and cannabis. While only 4.3% of our survey responders reported use of cannabis, it ranked among the most effective CAM therapies.Conclusions. Overall, our cross-sectional study was notable for a high rate of CAM utilization amongst PD patients and high rates of self-reported efficacy across most CAM modalities. Cannabis was rarely used in our population but users reported high efficacy, mainly for nonmotor symptoms.


2021 ◽  
pp. 1-15
Author(s):  
Cristina Simonet ◽  
Miquel A. Galmes ◽  
Christian Lambert ◽  
Richard N. Rees ◽  
Tahrina Haque ◽  
...  

Background: Bradykinesia is the defining motor feature of Parkinson’s disease (PD). There are limitations to its assessment using standard clinical rating scales, especially in the early stages of PD when a floor effect may be observed. Objective: To develop a quantitative method to track repetitive tapping movements and to compare people in the early stages of PD, healthy controls, and individuals with idiopathic anosmia. Methods: This was a cross-sectional study of 99 participants (early-stage PD = 26, controls = 64, idiopathic anosmia = 9). For each participant, repetitive finger tapping was recorded over 20 seconds using a smartphone at 240 frames per second. From each video, amplitude between fingers, frequency (number of taps per second), and velocity (distance travelled per second) was extracted. Clinical assessment was based on the motor section of the MDS-UPDRS. Results: People in the early stage of PD performed the task with slower velocity (p <  0.001) and with greater frequency slope than controls (p = 0.003). The combination of reduced velocity and greater frequency slope obtained the best accuracy to separate early-stage PD from controls based on metric thresholds alone (AUC = 0.88). Individuals with anosmia exhibited slower velocity (p = 0.001) and smaller amplitude (p <  0.001) compared with controls. Conclusion: We present a simple, proof-of-concept method to detect early motor dysfunction in PD. Mean tap velocity appeared to be the best parameter to differentiate patients with PD from controls. Patients with anosmia also showed detectable differences in motor performance compared with controls which may suggest that some are in the prodromal phase of PD.


2018 ◽  
Vol 8 (11) ◽  
pp. 194 ◽  
Author(s):  
Edward Botsford ◽  
Jayan George ◽  
Ellen Buckley

Metal storage disorders (MSDs) are a set of rare inherited conditions with variable clinical pictures including neurological dysfunction. The objective of this study was, through a systematic review, to identify the prevalence of Parkinsonism in patients with MSDs in order to uncover novel pathways implemented in Parkinson’s disease. Human studies describing patients of any age with an MSD diagnosis were analysed. Foreign language publications as well as animal and cellular studies were excluded. Searches were conducted through PubMed and Ovid between April and September 2018. A total of 53 publications were identified including 43 case reports, nine cross-sectional studies, and one cohort study. The publication year ranged from 1981 to 2018. The most frequently identified MSDs were Pantothenate kinase-associated neurodegeneration (PKAN) with 11 papers describing Parkinsonism, Hereditary hemochromatosis (HH) (7 papers), and Wilson’s disease (6 papers). The mean ages of onset of Parkinsonism for these MSDs were 33, 53, and 48 years old, respectively. The Parkinsonian features described in the PKAN and HH patients were invariably atypical while the majority (4/6) of the Wilson’s disease papers had a typical picture. This paper has highlighted a relationship between MSDs and Parkinsonism. However, due to the low-level evidence identified, further research is required to better define what the relationship is.


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