scholarly journals Factors Requiring Adjustment in the Interpretation of Serum Carcinoembryonic Antigen: A Cross-Sectional Study of 18,131 Healthy Nonsmokers

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Hae Yeon Kang ◽  
Eun Kyung Choe ◽  
Kyu Joo Park ◽  
Young Lee
Keyword(s):  
Carcinoembryonic Antigen ◽  
Glycosylated Hemoglobin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cancer Prediction ◽  
Serum Carcinoembryonic Antigen ◽  
Age Regression ◽  
Serum Cea ◽  
Wbc Count

Serum carcinoembryonic antigen (CEA) is a well-known tumor marker for colorectal adenocarcinoma. However, CEA levels can be influenced by various nonmalignant conditions. A retrospective, cross-sectional study was performed including 18,131 healthy nonsmokers who underwent health check-ups with evaluation of the serum CEA level. In the training set, multivariate analysis revealed that the log-transformed CEA level had positive relationships with age (regression coefficient (r) = 0.005, P<0.001), white blood cell (WBC) count (r=0.007, P=0.016), hemoglobin (HB, r=0.016, P<0.001), aspartate aminotransferase (AST, r=0.002, P=0.005), creatinine (r=0.076, P=0.038), and glycosylated hemoglobin (HbA1c, r=0.052, P<0.001); body mass index (BMI, r=−0.007, P<0.001) showed a negative correlation. The results for age, BMI, WBC count, HB, AST, and HbA1c were validated in the test set. We were able to construct the following model to predict the log-transformed CEA level: log (CEA + 0.51) = −0.204 − 0.051 (gender) + 0.005 (age) − 0.006 (BMI) + 0.008 (WBC count) + 0.016 (HB) + 0.002 (AST) + 0.062 (creatinine) + 0.054 (HbA1c). For colorectal cancer prediction, the model with the observed CEA and adjusted CEA levels had significantly high predictive power (AUC 0.756, P<0.001) than the model only including the observed CEA level (AUC 0.693, P<0.001). Factors influencing serum CEA levels should be adjusted before clinical interpretation to increase the predictive value of CEA.

scholarly journals Cross-Sectional Study of Periodontal Care and Glycosylated Hemoglobin in an Insured Population

Diabetes Care ◽  
2010 ◽  
Vol 33 (8) ◽  
pp. 1753-1758 ◽  
Author(s):  
L. Spangler ◽  
R. J. Reid ◽  
R. Inge ◽  
K. M. Newton ◽  
P. Hujoel ◽  
...  
Keyword(s):  
Glycosylated Hemoglobin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

To Study the Electroencephalogram Changes in Children with Acute Encephalitis

2021 ◽  
Vol 15 (12) ◽  
pp. 3325-3327
Author(s):  
Nasreen Ali ◽  
Hina Hussain
Keyword(s):  
Cerebral Palsy ◽  
Normal Cell ◽  
Cross Sectional Study ◽  
Spinal Fluid ◽  
Sectional Study ◽  
Cross Sectional ◽  
Acute Encephalitis ◽  
The Mean ◽  
Wbc Count ◽  
Written Informed Consent

Aim: To study the electroencephalogram changes in children with acute encephalitis. Study design: Cross-sectional study. Place and duration of study: The cases were admitted from OPD and emergency over duration of 10 months from May2009 to March 2010 in Children Hospital PIMS, Islamabad. Method: Patients with Cerebral Palsy, Degenerative Brain disease, Cerebral Malaria and Meningitis were excluded. Written informed consent was taken from parents /guardians. All patients, from both genders, age varying from 4 months to 12 years, fitting the criteria of Acute Encephalitis according to ICD 9 & 10 were included in the study, which were 56 in total. All cases had Lumbar puncture and Cerebro Spinal Fluid examination. The findings of pleocytosis (WBC count more than5 u/l), protein and sugar were recorded. EEG (Electroencecephlogram) was done in 52 patients, frequencies and percentages were calculated of the findings. Results: The mean age was 4. 6 years, (varying from 4 months to 12 years) with a standard deviation of 3. 2. From a total of fifty six patients, 38(68%) were males and 18(32%) females. All cases presented with fever (100%). Cerebro Spinal Fluid examination, showed Pleocytosis in 30(54%) while 46(46%) had normal cell count. Cerebro Spinal Fluid protein content was normal in 45(80%) and increased in 11(20%). Cerebro Spinal Fluid sugar was normal in 50(89%) and 6(11%) had low. Electroencephalogram was done in fifty-two patients out of which 30(58%) were normal, 22(42%) were abnormal. Intermittent slowing was found in 17(77%) and 5(23%) cases had focal discharges along with intermittent slowing, out of which three were unilateral temporo-frontal discharges, two cases had other focal discharges on EEG. Conclusion: In patients with Acute Encephalitis, slowing of the rhythm was the most frequent abnormal Electroencephalogram finding, followed by focal discharges in children admitted in Children’s Hospital PIMS, Islamabad. Keywords: Acute Encephalitis, Electroencephalogram (electro encephalogram), Cerebro Spinal Fluid Pleocytosis, Fever

scholarly journals Metabolic control in patients with type 2 diabetes mellitus in a public hospital in Peru: a cross-sectional study in a low-middle income country

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2577 ◽  
Author(s):  
Irma Elizabeth Huayanay-Espinoza ◽  
Felix Guerra-Castañon ◽  
María Lazo-Porras ◽  
Ana Castaneda-Guarderas ◽  
Nimmy Josephine Thomas ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Public Hospital ◽  
Glycosylated Hemoglobin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Middle Income

ObjectiveThe objective of this study was to assess patients’ achievement of ADA (American Diabetes Association) guideline recommendations for glycosylated hemoglobin, lipid profile, and blood pressure in a type 2 diabetes mellitus (T2DM) outpatient clinic in a low-middle income country (LMIC) setting.MethodsThis is a descriptive cross-sectional study with 123 ambulatory T2DM patients who are being treated at a public hospital in Lima, Peru. Data was gathered via standardized interviews, clinical surveys, and anthropomorphic measurements for each patient. Blood samples were drawn in fasting state for measures of glucose, glycosylated hemoglobin (HbA1c), and lipid profile. Laboratory parameters and blood pressure were evaluated according to ADA recommendations.ResultsOf the 123 patients, 81 were women and the mean age was 61.8 years. Glycemic control was abnormal in 82 (68.33%) participants, and 45 (37.50%) were unable to control their blood pressure. Lipid profile was abnormal in 73 (60.83%) participants. Only nine (7.50%) participants fulfilled ADA recommendations for glycemic, blood pressure, and lipid control.ConclusionsAmongst individuals with type 2 diabetes, there was poor attainment of the ADA recommendations (HbA1c, blood pressure and LDL-cholesterol) for ambulatory T2DM patients. Interventions are urgently needed in order to prevent long-term diabetic complications.

Glycemic control and its associated factors among patients with diabetes mellitus: a cross-sectional study in Bangladesh

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Hasan Mahmud Reza ◽  
Towhid Hasan ◽  
Marjia Sultana ◽  
Md. Omar Faruque
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Glycosylated Hemoglobin ◽  
Cross Sectional Study ◽  
Poor Glycemic Control ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Content Type

Purpose Diabetes mellitus is becoming a growing concern worldwide. Hence, the purpose of this study is to assess the magnitude of poor glycemic control and to identify the determinants of poor glycemic control among diabetic patients attending a tertiary care hospital in Bangladesh. Design/methodology/approach This cross-sectional study was conducted among 732 diabetes patients seeking care at the outpatient department of Bangladesh Institute of Health Sciences Hospital, Dhaka, Bangladesh. Information, including glycemic status, was collected from patients’ medical records using a structured questionnaire. Findings About 87.6% of the patients were found to have poor glycemic control (glycosylated hemoglobin = 7%). Variables that were significant in bivariate analysis were put into a multivariate model where the factors associated with poor glycemic control were patients aged 41–60 years (odds ratio (OR)=2.26; 95% confidence interval (CI): 1.19–4.32, p = 0.013), suffering from diabetes for > 7 years (OR = 1.84; 95% CI: 1.12–2.99, p = 0.015), using insulin (OR = 2.34; 95% CI: 1.23–4.47; p = 0.010) or diet alone (OR = 0.20; 95% CI: 0.05–0.80, p = 0.023) as a type of diabetes treatment and proper use of medicine (OR = 0.37; 95% CI: 0.17–0.82, p = 0.015). Originality/value The high prevalence of poor glycemic control among diabetic patients is evident; therefore, strategic management and proper attention focusing on the predictors of poor glycemic control are necessary to reduce the long-term complications of diabetes.

scholarly journals Evaluating Association between Glycosylated Hemoglobin and the Spectrum and Antibiotic Resistance of Uropathogens: A Cross Sectional Study

2020 ◽  
Author(s):  
Mehrdad Haghighi ◽  
Hamid Kariman ◽  
Mohammad Sistanizad
Keyword(s):  
Antibiotic Resistance ◽  
Urine Culture ◽  
Glycosylated Hemoglobin ◽  
Cross Sectional Study ◽  
Resistance Pattern ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tract Infections ◽  
Study Participants ◽  
Possible Cause

Background: Antimicrobial resistance among uropathogens causing community-acquired urinary tract infections (UTIs) is a worldwide concern. It has been suggested that diabetes could be a possible cause of antibiotic resistance. This study was undertaken to identify the responsible microbial culprits for UTI in patients with different range of glycosylated hemoglobin (HbA1C) and evaluate their corresponding resistance pattern. Methods: In a cross-sectional study between 2013 to 2018, data related to the urine culture and sensitivity of patients who had bacteriuria were gathered. For patients with positive urine culture, HbA1C was requested and correlations between HbA1C level with microorganism and its susceptibility were evaluated. Results: In total, 121 patients were recruited. All study participants were female. The mean age of the patients was 50.2 ± 22.5 (range 19-96). All study participants were of the same race. Fifteen (12.4%) out of 121 patients were diabetics. There were no difference between bacteriology of UTIs in diabetic and nondiabetic patients with the preponderance being caused by E. coli and other gram-negative organisms but, there were positive association between HbA1C and resistance to Nalidixic acid and Gentamicin. Conclusion: Our study supports the findings that diabetes in itself could be a possible cause of antibiotic resistance to some antimicrobial agents.   J Pharm Care 2019; 7(3): 70-74.

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