scholarly journals Spindle Cell Hemangioma in the Mucosa of the Upper Lip: A Case Report and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Kazuhiro Murakami ◽  
Kazuhiko Yamamoto ◽  
Tsutomu Sugiura ◽  
Tadaaki Kirita
Keyword(s):  
Factor Viii ◽  
Spindle Cell ◽  
Wilms Tumor ◽  
Smooth Muscle Actin ◽  
Neck Region ◽  
Surgical Excision ◽  
Vascular Lesion ◽  
Upper Lip ◽  
Mixed Cell ◽  
Spindle Cell Hemangioma

Spindle cell hemangioma (SCH) is a unique benign vascular lesion. We present a case of SCH in the upper lip of a 41-year-old woman. A submucosal nodular mass 30 × 20 mm in size was observed in the left upper lip. The mass developed 5 years earlier and enlarged after repeated ethanol injections. The mass was elastic firm, mobile, bluish in color, and well demarcated in magnetic resonance imaging. Under the clinical diagnosis of hemangioma, surgical excision was performed under local anesthesia. Microscopically, the lesion was composed of irregular cavernous spaces and multiple solid cellular areas. Cavernous spaces were filled with a mix of erythrocytes and organizing thrombi. The solid areas showed proliferation of spindle-shaped cells arranged haphazardly or in short interlacing fascicles. Immunohistochemically, most cells strongly reacted with vimentin. CD31, CD34, factor VIII, smooth muscle actin, and Wilms tumor-1 reacted with endothelial cells lining the cavernous spaces. The cells within solid areas consisted of mixed cell population with variable reaction for the markers except for factor VIII. From these findings, the diagnosis of SCH was made. Two years after surgery, no recurrence was noted. A review of SCH in the head and neck region is made.

scholarly journals Description of a Rare Case of Nodular Fasciitis of the Apical Aspect of the Upper Buccal Sulcus

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Ana Amélia Souza ◽  
Eldon Guttenberg Cariri Neto ◽  
Vera Cavalcanti de Araújo ◽  
Fabricio Passador-Santos ◽  
Maria Teresa de Seixas Alves ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Rare Case ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
Surgical Excision ◽  
Nodular Fasciitis ◽  
Muscle Actin ◽  
Complete Surgical Excision ◽  
Histopathologic Diagnosis ◽  
Spindle Cell Proliferation

This report describes a rare case of nodular fasciitis (NF) of the oral cavity, discussing the clinical, histological, and immunohistochemical characteristics. Histopathologic diagnosis of this type of lesion can be challenging due to its differential diagnosis, which principally includes sarcoma. The patient presented with a painless, well-defined nodule, reported as increasing in size, located at the apical aspect of the upper left buccal sulcus. Histologically, the lesion revealed spindle cell proliferation arranged in fascicles, while immunohistochemistry demonstrated positivity for smooth muscle actin. Eight months after complete surgical excision, no signs of local recurrence have been observed.

scholarly journals Infantile Myofibroma Eroding into the Frontal Bone: A Case Report and Review of Its Histopathologic Differential Diagnosis

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Aatish Thennavan ◽  
Venkadasalapathi Narayanaswamy ◽  
Thanvir Mohammed Niazi ◽  
Lakshmi Rao ◽  
Raghu Radhakrishnan
Keyword(s):  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
Neck Region ◽  
Final Diagnosis ◽  
Muscle Actin ◽  
Radiological Findings ◽  
Head And Neck Region ◽  
Spindle Cell Tumours ◽  
Myofibroblastic Differentiation ◽  
Infantile Myofibroma

Infantile myofibroma is a rare and benign tumour of children presenting in the head and neck region. Rendering a final diagnosis of infantile myofibroma can be challenging in the light of nonspecific clinical, radiological findings and its histopathological similarities with a number of neoplasms especially spindle cell tumours. In this paper we discuss a case of infantile myofibroma in a 2-month-old infant, enumerating the various differential entities that have to be eliminated in reaching its specific diagnosis and highlighting the importance of immunopositivity to vimentin and smooth muscle actin (SMA) in establishing its myofibroblastic differentiation.

Malignant transformation of leiomyoma of the mandible into leiomyosarcoma: A case report

2020 ◽  
Author(s):  
Masoud Fallahi Motlagh ◽  
Yousef Janbaz ◽  
Zahra Mirzaei
Keyword(s):  
Case Report ◽  
Spindle Cell ◽  
Neck Region ◽  
Surgical Excision ◽  
Metastatic Tumor ◽  
Cell Tumor ◽  
Spindle Cell Tumor ◽  
Head And Neck Region ◽  
Clinical Appearance

Lelomyosarcoma(LMS) is an uncommon malignant spindle cell tumor of the head and neck region. It is extremely rare in the oral cavity that arises from smooth muscle differentiation. It may arise as primary, radiation-associated, or metastatic tumor. The clinical appearance of these tumors can be deceptively benign and can be mistaken for non-malignant conditions. Here We present a case with atypical leiomyoma of the mandible in a 40-year- old man who referred with complaint of pain and swelling in his jaw. He underwent surgery and histology and immonohistochemestery studies confirmed the diagnosis. After 6 months recurrence occurred. Histologic examination confirmed leiomyosarcoma so he was managed with surgical excision followed by radiotherapy and chemotherapy without any recurrence or metastasis after 2 years of follow-up.

scholarly journals Atypical presentation and management of an epithelioid hemangioma: a case report and review of the literature

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Claire J. Wiggins ◽  
Rami P. Dibbs ◽  
Erica L. Bartlett ◽  
Daniel J. Ashton ◽  
Renata S. Maricevich
Keyword(s):  
Subcutaneous Tissue ◽  
Pediatric Population ◽  
Neck Region ◽  
Surgical Excision ◽  
Vascular Lesion ◽  
Vascular Anomalies ◽  
Preoperative Embolization ◽  
Epithelioid Hemangioma ◽  
Recommended Treatment ◽  
Complete Surgical Excision

Abstract Background Epithelioid hemangioma is a rare, benign vascular lesion classically presenting with painless nodules in the head and neck region. Hemangioma lesions are typically small, located within the dermis and subcutaneous tissue, and rarely exceed 10 cm in size. Complete surgical excision, with negative margins, is the recommended treatment as local recurrence is common. We describe an unusual presentation of epithelioid hemangioma that, to our knowledge, has not been previously described in the literature, epithelioid. Case presentation We report an atypical case of a large epithelioid hemangioma lesion with deep intramuscular involvement in a 16-year-old male. Ultrasound and MRI showed a hypervascular mass on the patient’s left upper back, and biopsy confirmed the diagnosis. Treatment consisted of preoperative embolization followed by excision and local tissue rearrangement. Conclusions Epithelioid hemangiomas are considered uncommon in the pediatric population. Moreover, it is challenging to diagnose these lesions due to their similarities to other vascular anomalies. We aim to increase awareness of this condition and obtain more precision in diagnosis, thus standardizing the approach for those treating individuals with vascular anomalies.

scholarly journals Intraosseous Myofibroma of the Mandible in a 7-Year-Old Patient: A Case Report

2021 ◽  
Vol 27 (1) ◽  
pp. 1-7
Author(s):  
Meshala Bala Sundram ◽  
Navasheilla Retna Retnasingam ◽  
Bahruddin Saripudin ◽  
Zuraiza Mohamad Zaini
Keyword(s):  
Differential Diagnosis ◽  
Oral Cavity ◽  
Histopathological Examination ◽  
Smooth Muscle Actin ◽  
Neck Region ◽  
Immunohistochemical Analysis ◽  
Surgical Excision ◽  
Permanent Molar ◽  
Complete Surgical Excision ◽  
Left Posterior

Myofibroma is a benign fibrous tumour that occurs predominantly in the head and neck region followed by the trunk and extremities. However, cases occurring in the oral cavity are rare, presenting with a variable clinical appearances and wide differential diagnosis.  We reported a case of a 7-year-old girl who was referred to the Department of Paediatric Dentistry, Tengku Ampuan Rahimah Hospital with a progressively enlarging painless swelling on the left posterior region of the mandible over the past 3 months.  The swelling was associated with ulceration and displaced lower left first permanent molar.  Radiographic investigations reported well-defined radiolucency at molar area, alveolar expansion and bone resorption of the left posterior alveolar ridge of the mandible. Complete surgical excision of the lesion was performed under general anaesthesia.  Histopathological examination revealed proliferation of spindle shaped cells with biphasic growth pattern. Immunohistochemical staining showed strong positivity with vimentin and smooth muscle actin whilst negative for desmin, S100 and CD34 establishing the diagnosis of myofibroma. Although rare, myofibroma should be considered as a differential diagnosis for solitary firm swelling in the oral cavity. Histopathological examination together with immunohistochemical analysis is essential for an accurate diagnosis.

scholarly journals Successful Outcome After Intralesional Curettage for Spindle Cell Hemangioma of Fibula in an Infant: A Case Report

2021 ◽  
Vol 9 ◽  
Author(s):  
Tao Han ◽  
Rufa Wang ◽  
Xiaoguang Zhou
Keyword(s):  
Spindle Cell ◽  
Bone Structure ◽  
Early Stage ◽  
Bone Destruction ◽  
Vascular Lesion ◽  
Successful Outcome ◽  
Intralesional Curettage ◽  
Proximal Fibula ◽  
Digital Radiograph ◽  
Spindle Cell Hemangioma

Spindle cell hemangioma (SCH), a non-neoplastic reactive vascular lesion, rarely locates in bones. We herein report a successful case of intralesional curettage for an infant with SCH of fibula. An 11-month-old boy was admitted to our center with a painless mass in the right proximal calf. Preoperative digital radiograph demonstrated a massive vascular lesion with an irregular bone destruction of proximal fibula. The lesion was removed via the intralesional curettage approach and pathologically diagnosed as SCH. The patient gained bone structure recovery of right proximal fibula. Two years after the surgery, he experienced no local recurrence. For the management of SCH of fibula with partial bone destruction, we suggest early-stage intralesional curettage as its safety and effectiveness.

Oncocytic Lipoadenoma: Report of 3 Rare Cases Involving the Parotid Gland, Including a Synchronous Presentation With Paraganglioma of the Right Carotid Bifurcation and Literature Review

2021 ◽  
pp. 106689692110219
Author(s):  
John L.S. Cunha ◽  
Marco A. Peñalonzo ◽  
Ciro D. Soares ◽  
Bruno A.B. de Andrade ◽  
Mário J. Romañach ◽  
...  
Keyword(s):  
English Language ◽  
Smooth Muscle Actin ◽  
Salivary Gland Tumor ◽  
Surgical Excision ◽  
Carotid Bifurcation ◽  
Alpha Smooth Muscle Actin ◽  
S 100 ◽  
The Right ◽  
Adequate Management ◽  
Adipose Cells

Oncocytic lipoadenoma (OL) is a rare salivary gland tumor characterized by the presence of oncocytic cells and mature adipose tissue. To date, only 30 cases of OL have been reported in the English-language literature. We present 3 additional OL cases involving the parotid, including a synchronous presentation with paraganglioma of the right carotid bifurcation. Microscopically, both the OLs were composed of a mixed population of oncocytes and adipocytes in varying proportions surrounded by a thin, connective tissue fibrous capsule. Oncocytes were positive for pan-cytokeratins (CKs) AE1/AE3, epithelial membrane antigen, CK5, CK7, CK14, CK18, and CK19. Calponin, p63, alpha-smooth muscle actin, and carcinoembryonic antigen were negative. Vimentin and S-100 protein were positive only in adipose cells. Despite distinctive morphologic features, OL is often misdiagnosed, given its rarity. We hope to contribute to surgeons’ and pathologists’ awareness and knowledge regarding the existence of this tumor and provide adequate management through conservative surgical excision.

scholarly journals Cutaneous leiomyosarcoma with visceral metastases in a White Carneau pigeon and literature review

2021 ◽  
pp. 104063872199206
Author(s):  
Niora J. Fabian ◽  
Michael Y. Esmail ◽  
Lauren Richey ◽  
Sureshkumar Muthupalani ◽  
Jennifer L. Haupt ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Surgical Excision ◽  
Columba Livia ◽  
Avian Species ◽  
Doppler Imaging ◽  
Mesenchymal Tumors ◽  
Tissue Mass ◽  
Color Flow ◽  
Visceral Metastases

Cutaneous leiomyosarcomas are malignant mesenchymal tumors of smooth muscle origin and are reported occasionally in avian species. A 14-y-old male laboratory White Carneau pigeon ( Columba livia) was presented for surgical excision of a cervical soft tissue mass. Ultrasonography with color flow Doppler imaging revealed multiple cavitations of mixed echogenicity within the mass and vascularization. Histologically, the dermis and subcutis were expanded by a densely cellular multinodular mass comprised of fusiform cells forming haphazardly arranged broad streams and short interwoven bundles, often surrounding blood vessels and variably sized cavitations. Neoplastic cells were strongly immunopositive for desmin and α–smooth muscle actin, and negative for pancytokeratin, S100, and von Willebrand factor. Based on histopathology and IHC findings, the cutaneous mass was diagnosed as leiomyosarcoma (LMS). The pigeon died 312 d post-operatively. Postmortem examination revealed masses infiltrating the left and right pulmonary airways and one hepatic nodule, but no regrowth at the surgical site. Histologic and IHC evaluation of the pulmonary and hepatic masses were consistent with LMS, representing metastatic foci from the primary cutaneous LMS. Our case highlights the malignant behavior and histomorphologic features of cutaneous LMS in an avian species.

scholarly journals Do GISTs Occur in Rats and Mice? Immunohistochemical Characterization of Gastrointestinal Tumors Diagnosed as Smooth Muscle Tumors in The National Toxicology Program

2019 ◽  
Vol 47 (5) ◽  
pp. 577-584
Author(s):  
Kyathanahalli S. Janardhan ◽  
Priyanka Venkannagari ◽  
Heather Jensen ◽  
Mark J. Hoenerhoff ◽  
Ronald A. Herbert ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cell Morphology ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
Gi Tract ◽  
Toxicological Studies ◽  
Smooth Muscle Tumors ◽  
Hematoxylin And Eosin ◽  
Cells Of Cajal ◽  
Rats And Mice

The majority of the tumors in the gastrointestinal (GI) tract of rats and mice, with spindle cell morphology, are diagnosed as smooth muscle tumors (SMTs). Similarly, several decades ago human GI tumors with spindle cell morphology were also diagnosed as SMTs. However, later investigations identified most of these tumors in humans as gastrointestinal stromal tumors (GISTs). The GISTs are considered to arise from the interstitial cells of Cajal located throughout the GI tract. Positive immunohistochemical staining with CKIT antibody is a well-accepted diagnostic marker for GISTs in humans. Since there is a considerable overlap between the histomorphology of SMTs and GISTs, it is not possible to distinguish them on hematoxylin and eosin stained sections. As a result, GISTs are not routinely diagnosed in toxicological studies. The current study was designed to evaluate the tumors diagnosed as leiomyoma or leiomyosarcoma in the National Toxicology Program’s 2-year bioassays using CKIT, smooth muscle actin, and desmin immunohistochemistry. The results demonstrate that most of the mouse SMTs diagnosed as leiomyoma or leiomyosarcoma are likely GISTs, whereas in rats the tumors are likely SMTs and not GISTs.

scholarly journals Basal Cell Carcinoma of the Head and Neck Region in Ethnic Chinese

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Velda Ling Yu Chow ◽  
Jimmy Yu Wai Chan ◽  
Richie Chiu Lung Chan ◽  
Joseph Hon Ping Chung ◽  
William Ignace Wei
Keyword(s):  
Neck Region ◽  
Surgical Excision ◽  
Chinese Patients ◽  
Skin Closure ◽  
Recurrence Rates ◽  
Tumour Control ◽  
Female Patients ◽  
Ethnic Chinese ◽  
Elderly Female ◽  
Tertiary Centre

Objectives.This study aims to report our experience in the management of HNBCC in ethnic Chinese over a 10-year period.Methods.A retrospective review of all ethnic Chinese patients with HNBCC treated in a tertiary centre from 1999 to 2009.Results.From 1999 to 2009, 225 patients underwent surgical excision for HNBCC. Majority were elderly female patients. Commonest presentation was a pigmented (76.2%) ulcer (64.8%) over the nose (31.6%). Median skin margin taken on tumour excision was 2.0 mm; primary skin closure was achieved in 51.8%. Postresection skin margin was clear in 75.4%. Of those with inadequate skin margins, 56.7% opted for further treatment, 43.4% for observation. Recurrence rates were 2.6% and 13.8%, respectively (). Overall recurrence rate was 5.5%.Conclusions.HNBCC commonly presented as pigmented ulcers over the nose of elderly female patients in our locality. Adequate tumour excision ± reconstruction offered the best chance of cure. Reexcision of those with inadequate skin margins improved local tumour control.

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