scholarly journals Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Yao Li ◽  
Ge Feng ◽  
Yuejia Deng ◽  
Jinglin Song
Keyword(s):  
Subgroup Analysis ◽  
Protective Factor ◽  
Meta Analysis ◽  
Aggressive Periodontitis ◽  
Interleukin 10 ◽  
Case Control Studies ◽  
Increased Risk ◽  
Significant Difference ◽  
Ca Model ◽  
Allele Model

Introduction. The association between interleukin-10- (IL-10-) 592 (-590, -597) C>A polymorphisms and susceptibility to chronic or aggressive periodontitis (CP or AgP) is conflicting. This meta-analysis is aimed at quantitatively estimating the association. Materials and Methods. PubMed, Embase, Web of Science, and WANFAN were searched for studies performed prior to January 31, 2018, to collect data for our research. Meta-analysis was performed using RevMan 5.3 or STATA 14.0. Results. In total, 18 studies that met our criteria were included. Overall or HWE subgroup analysis of individuals with this polymorphism revealed that in terms of CP susceptibility, there was a significant difference between case groups and control groups in the A allele versus C allele model (OR = 1.38, 95% CI = 1.17–1.64 or OR = 1.38, 95% CI = 1.12–1.70), in the AA versus CC+CA model (OR = 1.49, 95% CI =1.06–2.10 or OR = 1.42, 95% CI = 1.13–1.78), and in the CC versus CA+AA model (OR = 0.69, 95% CI = 0.51–0.92 or OR = 0.68, 95% CI = 0.49–0.93); subgroup analysis based on a nonsmoking population also displayed significance in the A allele versus C allele model (OR = 1.43, 95% CI = 1.15–1.79) and CC versus CA+AA model (OR = 0.62, 95% CI = 0.44–0.87). For this polymorphisms and AgP susceptibility, our analyses revealed a significant association in both the A allele versus C allele model (OR = 1.29, 95% CI = 1.01–1.63) and the AA versus CC+CA model (OR = 1.93, 95% CI = 1.30–2.89); subgroup analysis based on Caucasian or nonsmoking populations showed significant differences in the AA versus CC+CA model (OR = 6.29, 95% CI = 1.78–22.21 or OR = 3.24, 95% CI = 1.59–6.61). Conclusions. IL-10-592 (-590, -597) A allele and the associated AA genotype may be risk factors for the onset of CP or AgP—particularly for the AA genotype and the increased risk of AgP in Caucasian or nonsmoking populations. Conversely, the CC genotype may act as a protective factor against the onset of CP.

scholarly journals ASSOCIATION OF PROMOTER REGION POLYMORPHISMS OF INTERLEUKIN-10 GENE WITH SUSCEPTIBILITY TO COLORECTAL CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS

2018 ◽  
Vol 55 (3) ◽  
pp. 306-313 ◽  
Author(s):  
Seyed Alireza MIRJALILI ◽  
Mansour MOGHIMI ◽  
Kazem AGHILI ◽  
Mohammadali JAFARI ◽  
Seyed Mojtaba ABOLBAGHAEI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Promoter Region ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Epidemiological Studies ◽  
Recessive Model ◽  
Bibliographic Databases ◽  
Case Control Studies ◽  
Increased Risk ◽  
Allele Model

ABSTRACT BACKGROUND: Several epidemiological studies have investigated the association of promoter region polymorphisms of Interleukin-10 (IL-10) gene with colorectal cancer (CRC), while the conclusion is still conflicting and inconclusive. OBJECTIVE: We conducted this meta-analysis to evaluate the association of promoter region polymorphisms of IL-10 with CRC. METHODS: Eligible articles were identified by a search of several bibliographic databases for the period up to March 15, 2018. The strength of the association was measured by odd ratios with 95% confidence intervals. RESULTS: A total of 28 case-control studies with 5,647 CRC cases and 6,908 controls were selected, including 14 studies for IL-10 -1082A>G (rs1800896) polymorphism (2,702 cases and 3,649 controls), eleven studies for -592C>A (rs1800872) polymorphism (3,259 cases and 4,992 controls), and three studies for -819T>C (rs1800871) polymorphism (477 cases and 544 controls). By pooling all eligible studies, we found that the IL-10 -1082A>G and -592C>A polymorphisms were not associated with increased CRC risk in overall population. However, there was significant associations between the IL-10 -819T>C polymorphism and CRC susceptibility under the allele model (A vs G: OR=1.278, 95% CI 1.043-1.566, P=0.018) and the recessive model (AA vs AG+GG: OR=1.709, 95% CI 1.026-2.845, P=0.039). CONCLUSION: In this meta-analysis we found that IL-10 -819T>C polymorphism was associated with significantly increased risk of CRC; while the IL-10 -1082A>G and -592C>A polymorphisms were not associated with CRC risk. The IL-10 -819T>C polymorphism may be important as suspected predictive factor of CRC occurrence.

scholarly journals The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Kang Liu ◽  
Xiaolan Wang ◽  
Jiaxin Ye ◽  
Chao Qin ◽  
Pengfei Shao ◽  
...  
Keyword(s):  
Calcium Concentration ◽  
Protective Factor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Healthy Population ◽  
Case Control Studies ◽  
Calcium Sensing Receptor ◽  
Urine Calcium ◽  
Calcium Sensing ◽  
Increased Risk

Background. The calcium-sensing receptor gene (CaSR) is a candidate to explain urolithiasis. A number of case-control studies were conducted to investigate associations between CaSR polymorphisms with risks of hypercalciuria and urolithiasis in humans. But the results were still inconsistent.Methods. A meta-analysis was performed to address this issue. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of associations between CaSR polymorphisms and the risk of urolithiasis. The pooled standardized mean difference (SMD) with 95% CI was used for the meta-analysis of CaSR polymorphisms and urine calcium concentration.Results. For urolithiasis association, the SS genotype of A986S polymorphism was a risk factor for urolithiasis in Asians and PHPT patients, but a protective factor in Caucasians. The GG genotype of R990 polymorphism was associated with an increased risk of urolithiasis, especially in Caucasians and healthy population. Regarding urine calcium concentration association, individuals with the G allele had a higher level of urine calcium than the noncarriers.Conclusions. This meta-analysis revealed that the G allele of CaSR R990G polymorphism increases susceptibility to urolithiasis and hypercalciuria. The A986S and Q1011E polymorphisms were associated with urolithiasis and hypercalciuria in specific populations.

scholarly journals ASSOCIATION OF INTERLEUKIN-10 -1082 A/G (RS1800896) POLYMORPHISM WITH SUSCEPTIBILITY TO GASTRIC CANCER: META-ANALYSIS OF 6,101 CASES AND 8,557 CONTROLS

2018 ◽  
Vol 55 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Abolfazl NAMAZI ◽  
Mohammad FORAT-YAZDI ◽  
Mohammadali JAFARI ◽  
Soudabeh FARAHNAK ◽  
Rezvan NASIRI ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Web Of Science ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Dominant Model ◽  
Gastric Cancer Risk ◽  
Case Control Studies ◽  
Allele Model

ABSTRACT BACKGROUND: The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent. OBJECTIVE: To clarify the association, we conducted a meta-analysis to investigate the associations IL-10 -1082 A/G polymorphism with gastric cancer. METHODS: Eligible articles were identified by searching databases including PubMed, Web of Science, and Google Scholar up to August 03, 2017. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. RESULTS: A total of 30 case-control studies with 6,101 cases and 8,557 controls were included in this meta-analysis. Overall, a significant association between IL-10 -1082 A/G polymorphism and gastric cancer risk was observed under the allele model (G vs A: OR=1.305, 95% CI=1.076-1.584; P=0.007), heterozygote model and (GA vs AA: OR=1.252, 95% CI=1.252-1.054; P=0.011) and dominant model (GG+GA vs AA: OR=1.264, 95% CI=1.053-1.516; P=0.012). In the subgroup analysis by ethnicity, increased gastric cancer risk were found in Asians under the allele model (G vs A: OR=1.520, 95% CI=1.172-1.973; P=0.002), homozygote model (GG+GA vs AA: OR=1.571, 95% CI=1.023-2.414; P= 0.039), heterozygote model (GA vs AA: OR=1.465, 95% CI=1.192-1.801; P≤0.001) and dominant model (GG+GA vs AA: OR=1.448, 95% CI=1.152-1.821; P=0.002), but not among Caucasian and Latinos populations. CONCLUSION: These results suggested that the IL-10 -1082 A/G (rs1800896) polymorphism might contribute to the gastric cancer susceptibility, especially among Asians.

scholarly journals The Association Between the Gut Microbiota and Systemic Lupus Erythematosus, a Meta-Analysis

2021 ◽  
Author(s):  
Shate XIANG ◽  
Yiqian Qu ◽  
Suhai Qian ◽  
Yao Wang ◽  
Yibo Jin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gut Microbiota ◽  
Lupus Erythematosus ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Case Control ◽  
Healthy People ◽  
Case Control Studies ◽  
Systemic Lupus ◽  
Significant Difference

Abstract Introduction: Evaluate the changes of gut Microbiota in patients with Systemic Lupus Erythematosus (SLE) and healthy people by meta-analysis. Methods We searched the case-control studies of SLE and healthy controls (HCs) for detecting the diversity of gut Microbiota and the abundance level of some microbiota in the two groups. StataMP16 software was applied for this meta-analysis. The Newcastle-Ottawa quality assessment scale (NOS) was used to assess the quality of the included studies. Results Eleven case-control studies were included. There were 373 SLE patients and 1288 healthy people, involving 5 countries and 9 different cities. Compared with the HCs, the Shannon-wiener diversity index (WMD=-0.22; 95% CI=-0.32 to -0.13; P = 0.000) and Chao1 richness estimator (SMD=-0.62; 95% CI=-1.04 to -0.21; P = 0.003) of gut Microbiota in SLE decreased, and the abundance level of Ruminococcaceae decreased (SMD=--0.48; 95% CI = 0.76 to-0.21; P = 0.001). Enterobacteriaceae (SMD = 0.39,95% CI = 0.11 to 0.66;P = 0.006) and Enterococcaceae (SMD = 0.55; 95% CI = 0.19 to 0.9; P = 0.03) showed higher abundance levels in comparison with HCs. The subgroup analysis showed the abundance level of Ruminococcaceae (SMD=-0.89; 95% CI =-1.34 to -0.45; P = 0.000) was lower and Enterococcaceae was higher (SMD = 0.77; 95% CI = 0.34 to 1.21༛P = 0.001) in Chinese with SLE compared with HCs. In non-Chinese patients with SLE, there were no significant difference between the abundance level of Ruminococcaceae (SMD=-0.22; 95% CI=--0.58 to 0.13; P = 0.216) and Enterococcaceae (SMD=-0.08; 95% CI=-0.49 to 0.32; P = 0.682 ) with HCs. The subgroup analysis also found the level of Enterobacteriaceae was affected by the sample size. Conclusion Compared with the diversity of healthy people, richness and evenness of gut microbiota in patients with SLE are impaired. There is a decrease in the abundance level of beneficial bacteria and an increase in the harmful bacteria. Thus, gut microbiota in patients with SLE appear disorder, which may lead to metabolic imbalance, destruction of the integrity of the small intestine, immune system disorders and pro-inflammatory. Regulating the abundance of gut microbiota can be used as one of the key strategies for treating SLE.

scholarly journals Association Between Infections and Risk of Ankylosing Spondylitis: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiao Zhang ◽  
Zhe Sun ◽  
Aihong Zhou ◽  
Lei Tao ◽  
Yingxin Chen ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Cohort Studies ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Random Effect ◽  
Epidemiological Studies ◽  
Case Control ◽  
Total Risk ◽  
Case Control Studies ◽  
Increased Risk

BackgroundPrevious literature on the association between infections and the risk of developing ankylosing spondylitis (AS) presented controversial results. This meta-analysis aimed to quantitatively investigate the effect of infections on the risk of AS.MethodsWe searched the PubMed, Embase, and Web of Science databases until March 26, 2021 for analytical epidemiological studies on the association between infections and the risk of AS. Fixed or random effect models were used to calculate total risk estimates based on study heterogeneity. Subgroup analysis, and sensitivity analysis were also performed. Publication bias was estimated using funnel plots and Begg’s test.ResultsSix case-control articles (n=1,296,239) and seven cohort articles (n=7,618,524) were incorporated into our meta-analysis. The pooled odds ratio (OR) from these case-control studies showed that infections were associated with an increased risk of AS (OR=1.46, 95% confidence interval [CI], 1.23–1.73), and the pooled relative risk (RR) from the cohort studies showed the same findings (RR=1.35, 95% CI, 1.12–1.63). Subgroup analysis showed that infections in participants with unadjusted comorbidities (OR=1.66, 95% CI, 1.35–2.03), other types of infection (OR=1.40, 95% CI, 1.15–1.70), and infection of the immune system (OR=1.46, 95% CI, 1.42–1.49) were associated with the risk of AS in case-control studies. In cohort studies, infections with adjusted comorbidities (RR=1.39, 95% CI, 1.15–1.68), viral infection (RR=1.43, 95% CI, 1.22–1.66), other types of infection (RR=1.44, 95% CI, 1.12–1.86), and other sites of infection (RR=1.36, 95% CI, 1.11–1.67) were associated with an increased risk of AS.ConclusionsThe findings of this meta-analysis confirm that infections significantly increase the risks of AS. This is helpful in providing an essential basis for the prevention of AS via the avoidance of infections.

scholarly journals Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis

2020 ◽  
Vol 48 (4) ◽  
pp. 030006052090486 ◽  
Author(s):  
ZiYin Zhu ◽  
Ji-Bin Liu ◽  
Xi Liu ◽  
LinXue Qian
Keyword(s):  
Breast Cancer ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Population Based ◽  
Case Control ◽  
Recessive Model ◽  
Breast Cancers ◽  
Case Control Studies ◽  
Asian Populations ◽  
Increased Risk

Objective To evaluate the correlation between interleukin 10 (IL-10) −1082A/G polymorphism (rs1800896) and breast cancers by performing a meta-analysis. Methods The Embase and Medline databases were searched through 1 September 2018 to identify qualified articles. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were applied to evaluate associations. Results In total, 14 case-control studies, including 5320 cases and 5727 controls, were analyzed. We detected significant associations between the IL10 −1082 G/G genotype and risk of breast cancer (AA + AG vs. GG: OR = 0.88, 95% CI = 0.80–0.97). Subgroup analyses confirmed a significant association in Caucasian populations (OR = 0.89, 95% CI = 0.80–0.99), in population-based case-control studies (OR = 0.87, 95% CI = 0.78–0.96), and in studies with ≥500 subjects (OR = 0.88, 95% CI = 0.79–0.99) under the recessive model (AA + AG vs. GG). No associations were found in Asian populations. Conclusions The IL10 −1082A/G polymorphism is associated with an increased risk of breast cancer. The association between IL10 −1082 G/G genotype and increased risk of breast cancer is more significant in Caucasians, in population-based studies, and in larger studies.

scholarly journals Serum level of IL-10 and IL-10-1082G/A polymorphism are associated with the risk of ischemic stroke: A meta-analysis

2020 ◽  
Author(s):  
Xiaodong Rui ◽  
Yeqin Sha ◽  
Shuang Wen ◽  
Qingyang Sun ◽  
Jingming Hu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Serum Level ◽  
Ethnic Groups ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Case Control Studies ◽  
Chinese Han ◽  
Increased Risk ◽  
Newcastle Ottawa Scale ◽  
The Relationship

Abstract BACKGROUND Stroke is one of the leading causes of disability and mortality among adults worldwide. The aim of the study was to confirm the relationship of serum interleukin-10 (IL-10) and its gene polymorphism with the risk of ischemic stroke (IS). METHODS PubMed and China Wanfang database were systematically searched up to September 2, 2019. Studies illustrating on the association between serum IL-10 or IL-10-1082G/A, IL-10-819C/T, IL-10- 592C/A polymorphisms and IS susceptibility were included in this study. Newcastle–Ottawa scale was used to assess the study quality. RevMan 5.3 was used for statistical analysis. RESULTS: Seventeen case-control studies were included in this meta-analysis which provides 3754 patients with IS and 5064 controls. Combined analysis indicated that patients with IS had lower serum level of IL-10 (Mean difference [MD]: -4.25; 95% confidence interval [CI]: -6.14 to -2.36, p<0.0001). An association was identified between IL-10-1082G/A polymorphism and the risk of IS, but no association was found between polymorphism of IL-10-819C/T or IL-10- 592C/A and the risk of IS when all ethnic groups were considered together. For IL-10-1082G/A polymorphism, individuals with AA-genotype might have an increased risk of IS among Chinese Han population while no such correlation was observed in other ethnic group. CONCLUSION This meta-analysis suggested that low serum level of IL-10 and IL-10-1082G/A polymorphism may be associated with the risk of IS. More clinical studies should be conducted to confirm the relationship between serum IL-10 level and the risk of IS in all ethnic groups.

scholarly journals A meta-analysis of serum osteocalcin level in postmenopausal osteoporotic women compared to controls

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhongyu Liu ◽  
Ruiqiang Chen ◽  
Yutong Jiang ◽  
Yang Yang ◽  
Lei He ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Significant Difference ◽  
High Bone ◽  
Study Population

Abstract Background Circulatory osteocalcin (OC) has been widely used as a biomarker to indicate bone turnover status in postmenopausal osteoporosis (PMO). However, the change of serum OC (sOC) level in PMO cases compared to postmenopausal controls remains controversial. Methods We searched the online database of PubMed and Cochrane Library. A meta-analysis of case-control studies was performed to compare the pooled sOC level between PMO patients and postmenopausal controls. Subgroup analysis according to potential confounding factors (different OC molecules and regions of the study population) was also performed. Results Ten case-control studies with 1577 postmenopausal women were included in this meta analysis. We found no significant difference in the pooled sOC level [mean difference (MD) = 1.84, 95% confidence interval (CI): (− 1.49, 5.16), p = 0.28] between PMO patients and controls. Subgroup analysis also revealed no significant difference in intact OC [MD = 1.76, 95%CI: (− 1.71, 5.23), p = 0.32] or N-terminal mid-fragment of the OC molecule [MD = 0.67, 95%(− 5.83, 7.18), p = 0.84] between groups. For different regions, no significant difference in sOC was found in Asian population between cases and controls [MD = -0.06, 95%(− 6.02, 5.89), p = 0.98], while the pooled sOC level was significantly higher in European PMO cases than controls [MD = 3.15, 95%(0.90, 5.39), p = 0.006]. Conclusions Our analysis revealed no significant difference in sOC level between PMO cases and controls according to all the current eligible studies. OC molecules are quite heterogeneous in the circulation and can be influenced by glucose metabolism. Therefore, sOC is currently not a good indicator for the high bone turnover status in PMO. More trials with standardized methodologies for the evaluation of circulatory OC are awaited to update our current findings.

scholarly journals Meta-Analysis of the Association between Vitiligo and Human Leukocyte Antigen-A

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Zhangjun Li ◽  
Jianwen Ren ◽  
Xinwu Niu ◽  
Qingqiang Xu ◽  
Xiaopeng Wang ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Case Control Studies ◽  
Leukocyte Antigen ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
Typing Methods ◽  
Chinese National Knowledge Infrastructure

Objective. The objective of this study was to systematically evaluate the association between vitiligo and human leukocyte antigen- (HLA-) A.Methods. PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, and reference lists were searched for relevant original articles.Results. Nineteen case-control studies comprising 3042 patients and 5614 controls were included, in which 33 HLA-A alleles were reported. Overall, three alleles (HLA-A⁎02,A⁎33, and Aw⁎31) were significantly associated with increased risk of vitiligo, two (HLA-A⁎09 and Aw⁎19) were associated with decreased risk, and the remaining 28 were unassociated. Twelve alleles, seven alleles, and 19 alleles were common to three ethnicities, both types of vitiligo, and both typing methods, respectively. In the subgroup analysis by ethnicity and typing methods, the association of six alleles and five alleles was inconsistent in three populations and both typing methods, respectively. In the subgroup analysis by clinical type, the association of all seven alleles was consistent in both types of vitiligo.Conclusion. The meta-analysis suggests that HLA-A⁎02,A⁎33, and Aw⁎31 are associated with increased risk of vitiligo, while HLA-A⁎09 and Aw⁎19 are associated with decreased risk of vitiligo. The association of some alleles varies in terms of ethnicity and typing methods.

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