scholarly journals Development of a Mixing Process Using an HB-Type Impeller to Easily Achieve Scale-Up by Maintaining Geometrical Similarity

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Yoshihito Kato ◽  
Haruki Furukawa ◽  
Yasuyuki Ikeda ◽  
Toshikazu Nakanishi ◽  
Tadashi Sano ◽  
...  
Keyword(s):  
Scale Up ◽  
Scaling Up ◽  
Laboratory Scale ◽  
Industrial Scale ◽  
Geometrical Shape ◽  
Line Pattern ◽  
Mixing Process ◽  
Home Base ◽  
Mixing Performance ◽  
Better Than

In recent years, a novel home base-type (HB-type) impeller was developed to be based on observation of the streak line pattern. An HB impeller must be simple, speedy, and stable (3S). When an HB impeller is used on the laboratory beaker scale, the mixing performance of the HB impeller is better than that of a normal cylindrical stirring bar. In addition, an industrial-scale HB impeller has been constructed based on the observation of the streak line and isolated mixing regions in the vessel. The present authors believe that scale-up of the mixing process is very easy because the geometrical shape of the impeller can be kept consistent when scaling up from the laboratory scale to the industrial scale.

Scaling up of Equal Channel Angular Pressing (ECAP) for the Production of Forging Stock

2006 ◽  
Vol 503-504 ◽  
pp. 371-378 ◽  
Author(s):  
R. Srinivasan ◽  
B. Cherukuri ◽  
Prabir K. Chaudhury
Keyword(s):  
Energy Savings ◽  
Scale Up ◽  
Hot Forging ◽  
Rate Sensitivity ◽  
Scaling Up ◽  
Industrial Applications ◽  
Laboratory Scale ◽  
Industrial Scale ◽  
Ultrafine Grain ◽  
Hot Workability

Over the past two decades equal channel angular processing (ECAP) and other severe plastic deformation (SPD) processes have been shown, in the laboratory scale, to produce material with promising properties for industrial applications. In particular, ultrafine grain (UFG) metals produced by ECAP process, for example, have been shown to exhibit higher strain rate sensitivity at lower temperatures and higher strain rates. These factors translate to improved hot formability. However, scale up of these processes to manufacture industrial size components has not been widely undertaken. In this study, billets of annealed AA6061 with 12.5 mm (0.5-in), 50 mm (2-in) and 100 mm (4-in) square cross section were ECAP processed. For the first time, these larger SPD billets were used as starting stock for subsequent hot forging. Several parts were forged on an industrial scale press with the UFG material, as well as conventional stock materials. These parts varied in complexity, as well as size in order to cover the variability in industrial components. This paper will present the effect of scaling up on the mechanical properties, microstructure, and the hot workability of the alloy from the laboratory scale (12.5 mm) to industrial scale (100 mm). Results show that both the forging temperature of the billets and the starting billet size can be substantially decreased compared to conventional forging practice. Therefore, the use of SPD materials, as forging stock, results in decreased energy usage and increased material yield. Results presented will include examples of forged parts, estimated energy savings associated with the use of SPDUFG stock, and properties after forging and subsequent heat treatment.

Scale-up and scale-down techniques for fermentations of polyene antibiotics

1990 ◽  
Vol 55 (7) ◽  
pp. 1730-1740 ◽  
Author(s):  
Petr Ettler
Keyword(s):  
Dehydrogenase Activity ◽  
Scale Up ◽  
Scaling Up ◽  
Industrial Scale ◽  
Laboratory Findings ◽  
Polyene Antibiotics ◽  
Activity Determination ◽  
Simultaneous Control ◽  
Streptomyces Noursei ◽  
Scale Down

Our philosophy of successful biotechnology transfer to industrial scale covers the comparison of complex sets of microbiological, analytical and bioengineering data from cultivations in various scales and different geometries of mixing with laboratory findings. In particular, the availability of nutrients to producing microorganism should be understood, therefore for quick scaling-up procedure of polyene antibiotics produced by Streptomyces noursei we recommend to use physiological marker as total dehydrogenase activity determination. The utility of scale-down tests for identification of process fluctuation, validation of new substrate batches and simultaneous control of inoculum quality was proved.

Effects of Different Structure Rotors on Mixing Process and Quality of Short Fiber-Rubber Composite Material

2009 ◽  
Vol 87-88 ◽  
pp. 277-281
Author(s):  
Chuan Sheng Wang ◽  
De Wei Zhang ◽  
Hui Guang Bian
Keyword(s):  
Composite Material ◽  
Composite Materials ◽  
Short Fiber ◽  
Experimental Results ◽  
Mixing Process ◽  
Mixing Performance ◽  
Rubber Composite ◽  
New Type ◽  
Better Than

The structure of rotors is an important factor, which impacts the quality of the mixed rubber. For the short fiber-rubber composite material, the structure of the rotors is most important. Through the experiments study, the mixing performances of four-wing synchronous rotor, six-wing synchronous rotor and new type of six-wing synchronous varying clearance rotor have been studied. The experimental results indicated that the mixing performance of the new type rotor is much better than the four-wing and six-wing synchronous rotor for the mixing of short fiber-rubber composite materials.

Scaling up Process Output of Monomer Reactor

2013 ◽  
Vol 748 ◽  
pp. 299-303 ◽  
Author(s):  
Anika Zafiah M. Rus ◽  
Muhamad Soqhimi Mohamad Isa ◽  
Nurul Saidatul Syida Sulong
Keyword(s):  
Scale Up ◽  
Scaling Up ◽  
Pilot Scale ◽  
Industrial Scale ◽  
Important Process ◽  
Laboratory Equipment ◽  
Cooking Oil ◽  
Used Cooking Oil ◽  
Process Output

A monomer processing reactor is a device to process used cooking oil into new substance that can be used for other applications. In this study, used cooking oil was converted to monomer via simple reactor comprised of stirrer started with laboratory scale of 2L to 5L of monomer production. A scale up process is an important process for approaching industrial scale productions. The scale up process was increased to pilot scale before it reaches to industrial scale. The reactor is designed based on lab scale process for producing monomer from used cooking oil. The most important point of the device design is to produce larger amount of monomer compared to lab scale equipment. The device can produce 15liters of monomer per production. The monomer has the same properties and quality of monomer that were produced using laboratory equipment.

Turbulent Mixing and Scale-Up of Ejectors at High Schmidt Number

2011 ◽  
Vol 233-235 ◽  
pp. 1340-1344
Author(s):  
Lian Xiang Ma ◽  
Rong Shan Bi ◽  
Xin Shun Tan ◽  
Zhen Dong Liu ◽  
Wen Wu Chen ◽  
...  
Keyword(s):  
Turbulent Mixing ◽  
Schmidt Number ◽  
Mixture Fraction ◽  
Scale Up ◽  
Least Square Method ◽  
Least Square ◽  
Mixing Process ◽  
Cfd Simulations ◽  
Mixing Performance ◽  
Cfd Models

Micro- and Macro-mixing models were built and numerical investigation of turbulent mixing in ejectors was carried out. Mixture fraction and its variance presented by Fox were remodeled to demonstrate micro- and macro-mixing performance. The length needed to reach 98% micro- and macro-mixing were founded is functions of uj/umand D/d. The mathematical scale-up models were presented based on the simulation results using least square method for micro- and macro-mixing and five different cases were used to validate the models. The results showed that macro-mixing scale-up model agreed well with CFD simulations but the micro-mixing scale-up model had a less precision compared with that of macro-mixing model. This because that the mechanism of micro-mixing process is very complexity but the CFD models we used in this work are fairy simple.

scholarly journals Strategies for involving patients and the public in scaling-up initiatives in health and social services: protocol for a scoping review and Delphi survey

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Ali Ben Charif ◽  
◽  
Karine V. Plourde ◽  
Sabrina Guay-Bélanger ◽  
Hervé Tchala Vignon Zomahoun ◽  
...  
Keyword(s):  
Social Services ◽  
Scoping Review ◽  
Delphi Study ◽  
Public Involvement ◽  
Scale Up ◽  
Scaling Up ◽  
Delphi Survey ◽  
The Public ◽  
Health And Social Services ◽  
Scoping Reviews

Abstract Background The scale-up of evidence-based innovations is required to reduce waste and inequities in health and social services (HSS). However, it often tends to be a top-down process initiated by policy makers, and the values of the intended beneficiaries are forgotten. Involving multiple stakeholders including patients and the public in the scaling-up process is thus essential but highly complex. We propose to identify relevant strategies for meaningfully and equitably involving patients and the public in the science and practice of scaling up in HSS. Methods We will adapt our overall method from the RAND/UCLA Appropriateness Method. Following this, we will perform a two-prong study design (knowledge synthesis and Delphi study) grounded in an integrated knowledge translation approach. This approach involves extensive participation of a network of stakeholders interested in patient and public involvement (PPI) in scaling up and a multidisciplinary steering committee. We will conduct a systematic scoping review following the methodology recommended in the Joanna Briggs Institute Reviewers Manual. We will use the following eligibility criteria: (1) participants—any stakeholder involved in creating or testing a strategy for PPI; (2) intervention—any PPI strategy proposed for scaling-up initiatives; (3) comparator—no restriction; (4) outcomes: any process or outcome metrics related to PPI; and (5) setting—HSS. We will search electronic databases (e.g., Medline, Web of Science, Sociological Abstract) from inception onwards, hand search relevant websites, screen the reference lists of included records, and consult experts in the field. Two reviewers will independently select and extract eligible studies. We will summarize data quantitatively and qualitatively and report results using the PRISMA extension for Scoping Reviews (PRISMA-ScR) checklist. We will conduct an online Delphi survey to achieve consensus on the relevant strategies for PPI in scaling-up initiatives in HSS. Participants will include stakeholders from low-, middle-, and high-income countries. We anticipate that three rounds will allow an acceptable degree of agreement on research priorities. Discussion Our findings will advance understanding of how to meaningfully and equitably involve patients and the public in scaling-up initiatives for sustainable HSS. Systematic review registration We registered this protocol with the Open Science Framework on August 19, 2020 (https://osf.io/zqpx7/).

scholarly journals Effect of Aspect Ratio on the Mixing Performance in the Kenics Static Mixer

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 464
Author(s):  
Xingren Jiang ◽  
Ning Yang ◽  
Rijie Wang
Keyword(s):  
Pharmaceutical Industry ◽  
Aspect Ratio ◽  
Flow Reactor ◽  
Mixing Time ◽  
Continuous Process ◽  
Scale Up ◽  
Influence Factors ◽  
Continuous Manufacturing ◽  
Static Mixer ◽  
Mixing Performance

Continuous manufacturing has received increasing interest because of the advantages of intrinsic safety and enhanced mass transfer in the pharmaceutical industry. However, the difficulty for scale-up has limited the application of continuous manufacturing for a long time. Recently, the tubular flow reactor equipped with the Kenics static mixer appears to be a solution for the continuous process scale-up. Although many influence factors on the mixing performance in the Kenics static mixer have been investigated, little research has been carried out on the aspect ratio. In this study, we used the coefficient of variation as the mixing evaluation index to investigate the effect of the aspect ratio (0.2–2) on the Kenics static mixer’s mixing performance. The results indicate that a low aspect ratio helps obtain a shorter mixing time and mixer length. This study suggests that adjusting the aspect ratio of the Kenics static mixer can be a new strategy for the scale-up of a continuous process in the pharmaceutical industry.

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