scholarly journals Gender in Endocrine Diseases: Role of Sex Gonadal Hormones

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
R. Lauretta ◽  
M. Sansone ◽  
A. Sansone ◽  
F. Romanelli ◽  
M. Appetecchia
Keyword(s):  
Human Physiology ◽  
Sex Hormones ◽  
Medical Specialty ◽  
Gonadal Hormones ◽  
Response To Therapy ◽  
Endocrine Diseases ◽  
Biological Sex ◽  
New Frontier ◽  
And Gender ◽  
The Individual

Gender- and sex- related differences represent a new frontier towards patient-tailored medicine, taking into account that theoretically every medical specialty can be influenced by both of them. Sex hormones define the differences between males and females, and the different endocrine environment promoted by estrogens, progesterone, testosterone, and their precursors might influence both human physiology and pathophysiology. With the term Gender we refer, instead, to behaviors, roles, expectations, and activities carried out by the individual in society. In other words, “gender” refers to a sociocultural sphere of the individual, whereas “sex” only defines the biological sex. In the last decade, increasing attention has been paid to understand the influence that gender can have on both the human physiology and pathogenesis of diseases. Even the clinical response to therapy may be influenced by sex hormones and gender, but further research is needed to investigate and clarify how they can affect the human pathophysiology. The path to a tailored medicine in which every patient is able to receive early diagnosis, risk assessments, and optimal treatments cannot exclude the importance of gender. In this review, we have focused our attention on the involvement of sex hormones and gender on different endocrine diseases.

scholarly journals The Human Microbiome and Gender Medicine

2018 ◽  
Vol 2 (4) ◽  
pp. 123-127 ◽  
Author(s):  
Gali Levy ◽  
Ido Solt
Keyword(s):  
Diabetes Mellitus ◽  
Immune System ◽  
Autoimmune Disease ◽  
Microbial Communities ◽  
Molecular Genetics ◽  
Sex Hormones ◽  
Human Microbiome ◽  
Gender Medicine ◽  
Biological Sex ◽  
And Gender

Discoveries in molecular genetics over the last two decades have broadened our information about the genomics of complex microbial communities. As in all other fields of medicine, there is an undeniable need to explore the microbiome and the way it is impacted by biological sex. A number, although small, of recent studies have demonstrated that women and men have striking differences in the species that constitute their microbiomes. This effects pathological physiology in fields such as hepatology, oncology, autoimmune disease (most notably diabetes mellitus), autism, and obstetrics. There is still an unfortunate lack of research being done on the “microgenderome”: the interaction between microbiota, sex hormones, and the immune system. This review will highlight some of the main areas to be affected by microgenderome physiology, with an in depth focus on obstetrics.

scholarly journals From Genes to Behavior Through Sex Hormones and Socialization: The Example of Gender Development

2018 ◽  
Vol 21 (4) ◽  
pp. 289-294 ◽  
Author(s):  
Sheri A. Berenbaum ◽  
Adriene M. Beltz
Keyword(s):  
Sex Hormones ◽  
Early Life ◽  
Gonadal Hormones ◽  
Psychological Development ◽  
Gender Development ◽  
Sex And Gender ◽  
Genes And Environment ◽  
Challenges And Opportunities ◽  
And Gender

Irving Gottesman is known primarily for his work in psychopathology, but he also had a long-standing interest in understanding psychological development generally (typical and atypical). Through his mentorship, he also influenced work in gender development. Characteristics related to sex and gender are ideally suited to study the interplay of genes and environment across development. We discuss how gender development is influenced by gonadal hormones present during early life, but not in a simple way. We describe some of the challenges and opportunities to extend our understanding of the complexity of gender development. Throughout, we consider the kinds of questions Gottesman would likely have asked and emphasize his influence on our work.

Entrepreneurship in regions: differentiated impacts of the socio cultural and gender types

2015 ◽  
Vol 28 (1) ◽  
pp. 45-76 ◽  
Author(s):  
Claudio Mancilla ◽  
José Ernesto Amorós
Keyword(s):  
Negative Impact ◽  
Positive Impact ◽  
Fear Of Failure ◽  
Content Type ◽  
Reference Models ◽  
Cultural Aspects ◽  
And Gender ◽  
The Individual ◽  
Practical Implications ◽  
Secondary City

Purpose The purpose of this paper is to study the differentiated impact of factors that influence the propensity to entrepreneur in a sample of people in Chile. A distinction is made between individuals that live in primary cities and secondary cities. The differentiating factors are socio‐cultural aspects (reference models – positive examples of entrepreneurs – and perception of social fear of failure) and the gender of the individual. Design/methodology/approach For the research data from the survey used in Chile by the Global Entrepreneurship Monitor for the years 2010 and 2011 were used. A logit model was used to determine the differentiated impact of the analysed factors and interactions were done using the method proposed by Corneliâen and Sonderhof (2009). Findings These showed that the fact that an individual lives in a secondary city decreases his entrepreneurship probability. The positive impact that the reference models have is weaker in women. Contrary to what was expected, the negative impact of the fear of failure perception is weaker in women. Practical implications These results have the implications to suggest focused public policies and differentiations that consider the socio‐cultural, territorial (focused in cities) and gender aspects. Originality/value The research contributes by giving empirical evidence of the existence of the negative impact of living in a secondary city and of differentiated effects of socio‐cultural factors from the gender perspective.

Unexplored functions of sex hormones in glioblastoma cancer stem cells

Endocrinology ◽  
2022 ◽  
Author(s):  
Juyeun Lee ◽  
Katie Troike ◽  
R’ay Fodor ◽  
Justin D Lathia
Keyword(s):  
Stem Cells ◽  
Immune Response ◽  
Sex Differences ◽  
Cancer Stem Cells ◽  
Tumor Growth ◽  
Sex Hormones ◽  
Cellular Heterogeneity ◽  
Cellular Functions ◽  
Biological Sex ◽  
Organismal Development

Abstract Biological sex impacts a wide array of molecular and cellular functions that impact organismal development and can influence disease trajectory in a variety of pathophysiological states. In non-reproductive cancers, epidemiological sex differences have been observed in a series of tumors, and recent work has identified previously unappreciated sex differences in molecular genetics and immune response. However, the extent of these sex differences in terms of drivers of tumor growth and therapeutic response is less clear. In glioblastoma, the most common primary malignant brain tumor, there is a male bias in incidence and outcome, and key genetic and epigenetic differences, as well as differences in immune response driven by immune-suppressive myeloid populations, have recently been revealed. Glioblastoma is a prototypic tumor in which cellular heterogeneity is driven by populations of therapeutically resistant cancer stem cells (CSCs) that underlie tumor growth and recurrence. There is emerging evidence that GBM CSCs may show a sex difference, with male tumor cells showing enhanced self-renewal, but how sex differences impact CSC function is not clear. In this mini-review, we focus on how sex hormones may impact CSCs in GBM and implications for other cancers with a pronounced CSC population. We also explore opportunities to leverage new models to better understand the contribution of sex hormones versus sex chromosomes to CSC function. With the rising interest in sex differences in cancer, there is an immediate need to understand the extent to which sex differences impact tumor growth, including effects on CSC function.

The impact of stereotyped perceptions of entrepreneurship and gender-role orientation on Slovak women’s entrepreneurial intentions

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Magdalena Adamus ◽  
Vladimíra Čavojová ◽  
Jakub Šrol
Keyword(s):  
Gender Role ◽  
Entrepreneurial Intentions ◽  
Role Orientation ◽  
Gender Role Orientation ◽  
Content Type ◽  
Biological Sex ◽  
Working Age ◽  
Successful Entrepreneurs ◽  
And Gender ◽  
The Impact

Purpose This study aims to investigate how congruence between the image of a successful entrepreneur and one’s own gender-role orientation affects entrepreneurial intentions (EI). Design/methodology/approach A total of 552 working-age adults (49.5% women) answered questions on gender-role orientation, perception of a successful entrepreneur, EI, antecedents of EI (perceived behavioural control (PBC), subjective norm (SN), attitude towards entrepreneurship), entrepreneurial self-efficacy and risk aversion. Findings Women reported a lower EI than men, and both male and female participants perceived successful entrepreneurs as masculine. In the final model, biological sex did not predict EIs. Rather, it was associated with the extent to which participants felt they resembled successful entrepreneurs, which, in turn, predicted greater levels of PBC, SNs and attitudes towards entrepreneurship, as well as greater EI. Originality/value The study is one of the first to study joint impacts of biological sex, gender and congruence on EIs.

“Toxic Masculinity” in the age of #MeToo: ritual, morality and gender archetypes across cultures

2018 ◽  
Vol 13 (3) ◽  
pp. 274-286 ◽  
Author(s):  
Samuel Paul Louis Veissière
Keyword(s):  
Design Methodology ◽  
Cross Cultural ◽  
Moral Panics ◽  
Content Type ◽  
Ideal Types ◽  
Biological Sex ◽  
Starting Point ◽  
And Gender ◽  
Gender Archetypes ◽  
Cultural Shifts

Purpose This paper aims to take the “toxic masculinity” (TM) trope as a starting point to examine recent cultural shifts in common assumptions about gender, morality and relations between the sexes. TM is a transculturally widespread archetype or moral trope about the kind of man one should not be. Design/methodology/approach The author revisits his earlier fieldwork on transnational sexualities against a broader analysis of the historical, ethnographic and evolutionary record. The author describes the broad cross-cultural recurrence of similar ideal types of men and women (good and bad) and the rituals through which they are culturally encouraged and avoided. Findings The author argues that the TM trope is normatively useful if and only if it is presented alongside a nuanced spectrum of other gender archetypes (positive and negative) and discussed in the context of human universality and evolved complementariness between the sexes. Social implications The author concludes by discussing stoic virtue models for the initiation of boys and argues that they are compatible with the normative commitments of inclusive societies that recognize gender fluidity along the biological sex spectrum. Originality/value The author makes a case for the importance of strong gender roles and the rites and rituals through which they are cultivated as an antidote to current moral panics about oppression and victimhood.

scholarly journals ‘'Sex Changes'? Paradigm Shifts in ‘Sex’ and ‘Gender’ following the Gender Recognition Act?’

2007 ◽  
Vol 12 (1) ◽  
pp. 75-89 ◽  
Author(s):  
Stephen Whittle ◽  
Lewis Turner
Keyword(s):  
Sex Change ◽  
Gender Recognition ◽  
Sex And Gender ◽  
Gender Variance ◽  
Paradigm Shifts ◽  
History Of ◽  
And Gender ◽  
The Individual ◽  
The Uk ◽  
Legal Understanding

Gender transformations are normatively understood as somatic, based on surgical reassignment, where the sexed body is aligned with the gender identity of the individual through genital surgery – hence the common lexicon ‘sex change surgery’. We suggest that the UK Gender Recognition Act 2004 challenges what constitutes a ‘sex change’ through the Act's definitions and also the conditions within which legal ‘recognition’ is permitted. The sex/gender distinction, (where sex normatively refers to the sexed body, and gender, to social identity) is demobilised both literally and legally. This paper discusses the history of medico-socio-legal definitions of sex have been developed through decision making processes when courts have been faced with people with gender variance and, in particular, the implications of the Gender Recognition Act for our contemporary legal understanding of sex. We ask, and attempt to answer, has ‘sex’ changed?

scholarly journals THE RELATIONSHIP BETWEEN GENDER ROLE ATTITUDES AND EPISTEMOLOGICAL BELIEFS OF UNIVERSITY STUDENTS

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Alper Çuhadaroğlu
Keyword(s):  
Gender Roles ◽  
University Students ◽  
Gender Role ◽  
Epistemological Beliefs ◽  
Qualitative Data ◽  
Gender Role Attitudes ◽  
Study Group ◽  
And Gender ◽  
The Individual ◽  
The Relationship

In this study, the relationships between university students and their perceptions of gender roles and epistemological beliefs were investigated. Gender roles are a phenomenon that are determined by culture, and begin to emerge at an early age, which may include some stereotypical behaviors along with a number of attitudes, duties and obligations that the individual is expected to perform as a woman or a man. Epistemological belief is seen as an individual feature of how knowing and learning take place. In this study, a mixed method was used. The quantitative study group consists of 517 students from both universities, while the qualitative study group consists of 85 people. Gender Role Attitudes Scale and Epistemological Beliefs Scale were used to collect quantitative data. In order to obtain qualitative data, participants were given a form consisting of open-ended questions. According to the analyses, it was determined that there was a significant relationship between the participants' epistemological beliefs and gender roles attitudes and, epistemological beliefs were a significant predictor of gender roles attitudes. The results obtained are discussed in line with the existing literature. <p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0798/a.php" alt="Hit counter" /></p>

scholarly journals Listening to Local and Foreign Sex Buyers of Men and Women in Cambodia

2016 ◽  
Vol 3 (1) ◽  
pp. 56-79
Author(s):  
Samantha Sommer Miller ◽  
Glenn Miles ◽  
James Havey
Keyword(s):  
Sex Workers ◽  
Sex Industry ◽  
Sex And Gender ◽  
Phnom Penh ◽  
Bisexual Males ◽  
And Bisexual ◽  
And Gender ◽  
Sex With Men ◽  
The Individual ◽  
Sexual Services

Research on prostitution and trafficking has largely focused on the exploitation of girls and young women. This research comes out of the “Listening to the Demand” two-part study by an independent research team on the sex industry in Phnom Penh, Cambodia. “Listening to the Demand” is a series of research exploring often over-looked populations in the anti-trafficking conversation, including men and transgender people. The first of the studies was completed in 2013 and focuses on men who purchased sex with female sex workers. Interviews of 50 Cambodian and 50 foreign heterosexual and bisexual males explored the respondents’ views and use of prostituted women in Southeast Asia’s sex industry. The second part of the research was completed in 2014 and focuses on men who purchase sex with men. In this second part of the project, 51 Cambodian and 23 foreign men who have sex with men were interviewed about their views of prostitution, the individual sex worker, and their experiences of Cambodia’s sex industry. Due to its comparative nature, the research seeks to deliver information on the differences in culture between the foreign and Cambodian men who seek to pay for sexual services. Results point to the need for proper sex and gender education as well as different approaches when planning projects to reach out to men purchasing sex. In gaining a deeper knowledge of the beliefs and behaviours among the demand population, the findings suggest more holistic approaches are needed to combat the exploitation of sexual services in Cambodia.


scholarly journals Posthumanism and the New Ethics of Medical Practice—Epidemiology as the New Deontological Paradigm

2021 ◽  
Vol 3 (1) ◽  
pp. 106-118
Author(s):  
Timea Vitan ◽  
Keyword(s):  
Medical Practice ◽  
Medical Science ◽  
Medical Specialty ◽  
Medical Doctors ◽  
Public Attention ◽  
Short Introduction ◽  
Starting Point ◽  
History Of ◽  
The Individual ◽  
Vantage Points

In the context of the COVID19 pandemic, during last year all public attention has been focused on Medicine. Epidemiology is no longer just one medical specialty among many others, but became the main paradigm and the unique background of medical science. The individual pacient has turned into the collective pacient. Medical policies are not centered on the pacient anymore, but on its social group. In this article I will try to show how the characteristics of medical practice changed since the pandemic began and which are the deontological implications of such changes. With a short introduction on the medical policies proposed by the WHO during the last decades, I wish to underline the recent history of medical practice and its obvious turning point occasioned by the pandemic. Once the new bioethical vantage points are set, I wonder to which extent posthumanist philosophy foresaw this new deontological paradigm. Having Rosi Braidotti`s “The Posthuman” as my starting point, I maintain that medical doctors no longer practice on a humanist background, but with a sort of commitment that goes beyond the individual. However, this is not an antihumansit pledge, because contemporary medical doctors still adhere to certain humanist principles. As it so often happens, we will be left with even more questions. If the pacient is no longer the individual, but the group of individuals, which is the nature of a symptom and how should we decipher its meaning? How would a new medical science look like if we are to build it not on a human but on a posthuman biology?

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