scholarly journals The Possible Therapeutic Effects of Some Medicinal Plants for Chronic Cough in Children

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
S. Gholamreza Mortazavi Moghaddam ◽  
Majid Kianmehr ◽  
Mohammad Reza Khazdair
Keyword(s):  
Smooth Muscle ◽  
Medicinal Plants ◽  
Muscle Relaxant ◽  
Chronic Cough ◽  
Respiratory Symptoms ◽  
Nigella Sativa ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Smooth Muscle Relaxant

The use of plants or their isolated bioactive components for the prevention and treatment of various disorders has been developed. Here, we aim to identify effective medicinal plants for relief of cough and respiratory symptoms in children. The data of this review article were obtained from published articles in scientific databases, including PubMed, Google Scholar, and Scopus, until December 2019. The keywords, including “Zataria multiflora Boiss.” OR “Portulaca oleracea L.” OR “Ferula assa-foetida L.” OR “Nigella sativa L.” AND “respiratory symptoms” OR “airway inflammation” OR “smooth muscle relaxant effects,” were searched individually or combined. The mentioned medicinal plants decreased total white blood cell (WBC), neutrophils, and eosinophils counts of blood and lung lavage in animal model-induced respiratory disorders. These plants also have protective effects on serum immunoglobulin, antibody titer, eosinophil count, and proinflammatory cytokines. Evidence from the studies indicated that the abovementioned medicinal plants have smooth muscle relaxant properties (bronchodilator effects) via stimulation of β-adrenoceptor or inhibition of muscarinic receptors (in vitro) and also improved the pulmonary function test in clinical settings. These medicinal plants are safe and easy to use. Based on the anti-inflammatory, anti-antispasmodic, and immunomodulatory effects, the clinical benefit may be assumed, therefore considering a place for these medicinal plants in relieve of chronic cough and symptoms of children’s allergy, asthma, and common cold.

Therapeutic effects of Nigella sativa on chronic HAART-induced hyperinsulinemia in ratsThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 2 of a 2-part Special Issue).

2009 ◽  
Vol 87 (4) ◽  
pp. 300-309 ◽  
Author(s):  
Surabhi Chandra ◽  
Subramanyam N. Murthy ◽  
Debasis Mondal ◽  
Krishna C. Agrawal
Keyword(s):  
Highly Active Antiretroviral Therapy ◽  
Nigella Sativa ◽  
Serum Insulin ◽  
Antiretroviral Drugs ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Insulin Production ◽  
Sprague Dawley ◽  
Long Term Effects

Prolonged use of highly active antiretroviral therapy (HAART) is associated with insulin resistance in HIV-1-positive patients. Small animal models that recapitulate the long-term effects of HAART may facilitate the identification of therapeutic agents to suppress these side effects. We investigated the protective effects of black seed oil (BSO) from Nigella sativa in Sprague–Dawley rats treated with a daily HAART regimen for 7 months. The antiretroviral drugs, consisting of nelfinavir (200 mg/kg), zidovudine (50 mg/kg), and efavirenz (20 mg/kg), were mixed with diet with or without BSO (400 µL/kg) supplementation. Significant increases in insulin and C-peptide levels were observed in HAART-treated groups, and concomitant BSO treatment reduced this hyperinsulinemia. Interestingly, HAART-treated rats showed reduced size of pancreatic islets that was not seen in BSO-exposed rats. In vitro studies showed that nelfinavir, alone and in combination with HAART, induced oxidative stress and decreased glucose-induced insulin production in INS-1 cells. Suppressed insulin production was restored in cells coexposed to either BSO or thymoquinone. Our findings demonstrated that chronic HAART may increase serum insulin levels by dysregulating both insulin production by β cells and insulin action at the periphery. These deleterious effects may be prevented by dietary supplementation with BSO.

scholarly journals Triterpenoids, Including One with Smooth Muscle Relaxant Activity, from Rubus idaeus (Raspberry) Leaves

2006 ◽  
Vol 1 (8) ◽  
pp. 1934578X0600100
Author(s):  
Janne Rojas Vera ◽  
Christopher G. Dacke ◽  
Asmita V. Patel ◽  
Gerald Blunden
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Column Chromatography ◽  
Muscle Relaxant ◽  
Methanol Extract ◽  
Rubus Idaeus ◽  
Guinea Pig Ileum ◽  
Muscle Relaxant Activity ◽  
Smooth Muscle Relaxant

A methanol extract of Rubus idaeus leaves was fractionated by column chromatography and the eluted samples were tested for their ability to relax transmurally stimulated Guinea pig ileum preparations in vitro. Two distinct bands of activity were detected. From band one sitosterol and eight triterpenoids were characterized, but only olean-18-ene-1β, 2α, 3α-triol demonstrated smooth muscle relaxant activity. This compound is, to the best of our knowledge, novel, as are olean-12-ene-3β, 29-diol and urs-12-ene-3β, 30-diol.

scholarly journals Smooth Muscle Relaxant Triterpenoid Glycosides from Rubus idaeus (Raspberry) Leaves

2006 ◽  
Vol 1 (9) ◽  
pp. 1934578X0600100
Author(s):  
Janne Rojas Vera ◽  
Christopher G. Dacke ◽  
Gerald Blunden ◽  
Asmita V. Patel
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxant ◽  
Methanol Extract ◽  
Rubus Idaeus ◽  
Spectrometric Data ◽  
Triterpenoid Glycosides ◽  
Muscle Relaxant Activity ◽  
Tlc Separation ◽  
Smooth Muscle Relaxant

A methanol extract of Rubus idaeus leaves had a relaxant activity on transmurally stimulated Guinea pig ileum preparations in vitro. The extract, when fractionated by column chromatography, yielded two distinct bands with pharmacological activity. After extensive column and preparative TLC separation, several compounds with smooth muscle relaxant properties were obtained. From band two, three triterpenoid glycosides were characterized, which had significant muscle relaxant activity. From spectroscopic and spectrometric data, these were identified as 3β-(O-β-D-glucopyranosyl)-olean-12-ene-1α, 2α, 3β-triol (TG1); 28-(O-β-D-glucopyranosyl)-urs-12-ene-2α, 3β, 19α-trihydroxy-28-oic acid (TG2); and 3β-(O-β-D-glucopyranosyl)-olean-12-ene-1α, 2α, 3β-trihydroxy-28-oic acid (TG3). To the best of our knowledge, TG1 and TG3 are novel compounds.

scholarly journals A Straight-Chain Alcohol Glycoside, with Smooth Muscle Relaxant Activity, from Rubus idaeus (Raspberry) Leaves

2007 ◽  
Vol 2 (9) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Asmita V. Patel ◽  
Christopher G. Dacke ◽  
Gerald Blunden ◽  
Janne Rojas Vera
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxant ◽  
Methanolic Extract ◽  
Rubus Idaeus ◽  
Straight Chain ◽  
Spectrometric Data ◽  
Muscle Relaxant Activity ◽  
Dose Dependent ◽  
Smooth Muscle Relaxant

A methanolic extract of Rubus idaeus leaves, when fractionated by column chromatography, yielded two distinct bands containing compounds that demonstrated in vitro, dose dependent, smooth muscle relaxant activity using transmurally-stimulated Guinea pig ileum preparations. From band two, following extensive chromatographic separation, several compounds with smooth muscle relaxant activity were obtained, one of which was characterized, from spectroscopic and mass spectrometric data, as 1- O-(1,2-dihydroxyethyl)-4- O-methoxy-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside.

Effects of NA0344, a new smooth muscle relaxant, on the actin-myosin-ATP interaction and myosin light chain phosphorylation in vitro

1991 ◽  
Vol 22 (3) ◽  
pp. 465-474 ◽  
Author(s):  
Kazuhiro Kohama ◽  
Toyokazu Hiramura ◽  
Hiromi Takano-Ohmuro ◽  
Hiroshi Ozaki ◽  
Hideaki Karaki ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Light Chain ◽  
Muscle Relaxant ◽  
Myosin Light Chain ◽  
Myosin Light Chain Phosphorylation ◽  
Smooth Muscle Relaxant

Smooth muscle relaxant effect of kaurenoic acid, a diterpene from Copaifera langsdorfi on rat uterus in vitro

2003 ◽  
Vol 17 (4) ◽  
pp. 320-324 ◽  
Author(s):  
K. M. de Alencar Cunha ◽  
L. A. F. Paiva ◽  
F. A. Santos ◽  
N. V. Gramosa ◽  
E. R. Silveira ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxant ◽  
Rat Uterus ◽  
Relaxant Effect ◽  
Kaurenoic Acid ◽  
Smooth Muscle Relaxant

scholarly journals Effects of Nigella sativa, Camellia sinensis, and Allium sativum as Food Additives on Metabolic Disorders, a Literature Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Akbar Anaeigoudari ◽  
Hamidreza Safari ◽  
Mohammad Reza Khazdair
Keyword(s):  
Medicinal Plants ◽  
Camellia Sinensis ◽  
Metabolic Disorders ◽  
Allium Sativum ◽  
Nigella Sativa ◽  
Food Additives ◽  
Therapeutic Effects ◽  
Alcoholic Fatty Liver ◽  
Inflammatory Reactions

Objective: Metabolic disorders (MD) can disturb intracellular metabolic processes. A metabolic disorder can be resulted from enzyme deficits or disturbances in function of various organs including the liver, kidneys, pancreas, cardiovascular system, and endocrine system. Some herbs were used traditionally for spices, food additives, dietary, and medicinal purposes. Medicinal plants possess biological active compounds that enhance human health. We aimed to provide evidence about therapeutic effects of some medicinal herbs on MD.Data Sources: PubMed, Scopus, and Google Scholar were explored for publications linked to MD until February 2021. The most literature reports that were published in the last 10 years were used. All types of studies such as animal studies, clinical trials, and in vitro studies were included. The keywords included “Metabolic disorders,” “Nigella sativa L.,” “Thymoquinone,” “White tea”OR “Camellia sinensis L.” “catechin,” and “Allium sativum L.” OR “garlic” were searched.Results: Based on the results of scientific studies, the considered medicinal plants and their active components in this review have been able to exert the beneficial therapeutic effects on obesity, diabetes mellitus and non-alcoholic fatty liver disease.Conclusions: These effects are obvious by inhibition of lipid peroxidation, suppression of inflammatory reactions, adjustment of lipid profile, reduction of adipogenesis and regulation of blood glucose level.

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