scholarly journals Whitening Activity of Constituents Isolated from the Trichosanthes Pulp

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Rongchao Zhang ◽  
Xiuqin Hu ◽  
Bo Zhang ◽  
Zhen Wang ◽  
Chunxiang Hao ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Salicylic Acid ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cinnamic Acid ◽  
Coumaric Acid ◽  
Development And Utilization ◽  
First Time ◽  
Further Development ◽  
Whitening Activity

Whitening cosmetics market has a bright future, and pure natural whitening products of traditional Chinese medicine have always been a research hotspot. In this research, the whitening active ingredient of Chinese medicine Trichosanthes pulp was isolated and purified for the first time, and its whitening mechanism was clarified. Chromatographic methods such as silica gel, ODS, and HPLC were used to isolate and purify them. B16 cells were used to measure the antioxidant activity, tyrosinase activity, and melanin removal activity. A total of 20 compounds were isolated, including p-hydroxybenzaldehyde (1), salicylic acid (2), vanillic acid (3), isovanillic acid (4), protocatechuate (5), trans-cinnamic acid (6), 4-coumaric acid (7), trans-ferulic acid (8), drechslerol-B (9), cyclotucanol 3-palmitate (10), 5-acetoxymethyl-2-furaldehyde (11), 5-hydroxymethylfurfural (12), diosmetin (13), apigenin (14), chrysoeriol (15), luteolin (16), 4′-hydroxyscutellarin (17), quercetin (18), 3′,5-dihydroxy-7-(β-D-glucopyranosyloxy)-4′-methoxyflavone (19), and cofloxacin-7-O-β-D-glucoside (20). Among them, compounds 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, and 20 have good antioxidant repairing effects; compounds 3, 4, 5, 6, and 7 have high black inhibition; compounds 1, 2, 3, 4, 5, 6, 7, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, and 20 have obvious tyrosine acidase inhibitory activity. The results laid foundation for the further development and utilization of Trichosanthes pulp resources and also provide a basis for the development of natural whitening cosmetics.

scholarly journals Advances in Modern Pharmacology Research of Tabanus

2021 ◽  
Vol 5 (5) ◽  
pp. 117-119
Author(s):  
Yue Qu ◽  
Zhenyuan Hu ◽  
Yue Zhao
Keyword(s):  
Salivary Gland ◽  
Platelet Aggregation ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Special Focus ◽  
Pharmacological Effects ◽  
Active Components ◽  
Development And Utilization ◽  
The Rich ◽  
Further Development

Tabanus is a traditional Chinese medicine. In recent years, various protein active components derived from the Tabanus salivary gland have been explored, and many promising components were found to have therapeutic effect. The rich active components in its salivary gland have pharmacological effects, such as anti-platelet aggregation, anti-inflammatory, anti-infection, immunosuppression, anti-angiogenic, and anti-tumor effects. This paper summarizes findings from the related articles about Tabanus in recent years with a special focus on its pharmacological effects so as to provide reference for its further development and utilization.

scholarly journals Stability of Active Ingredients of Traditional Chinese Medicine (TCM)

2009 ◽  
Vol 4 (12) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Wang Meng ◽  
Ren Xiaoliang ◽  
Gao Xiumei ◽  
Franco Francesco Vincieri ◽  
Anna Rita Bilia
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Animal Origin ◽  
Active Ingredients ◽  
Rational Development ◽  
Plant Constituents ◽  
Crude Drugs ◽  
The Stability ◽  
First Time

Studies on stability of active ingredients are fundamental and critical for the rational development of Traditional Chinese Medicine (TCM) in view of its modernization and worldwide use. The stability of both active and marker constituents of plants used in TCM is reviewed for the first time. More than 100 papers, mostly written in Chinese, have been reviewed. Studies concerning plant constituents were analyzed according to their chemical classification of active ingredients. In addition, several crude drugs of animal origin are also reported. Stability of active ingredients is summarized during extraction and/or storage of the herbal drug preparations, and under stress conditions (pH, temperature, solvents, light, and humidity) and in the presence of preservatives, antioxidants, and metals.

scholarly journals The Applications and Obstacles of Metabonomics in Traditional Chinese Medicine

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Ping Liu ◽  
Songlin Liu ◽  
Daizhi Tian ◽  
Ping Wang
Keyword(s):  
Mass Spectrometry ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Gas Chromatography Mass Spectrometry ◽  
Liquid Chromatography Mass Spectrometry ◽  
Analytical Technique ◽  
Chromatography Mass Spectrometry ◽  
Wide Range ◽  
Further Development ◽  
Analytical Technology

In the recent years, a wide range of metabonomic technologies are widely used in the modern research of traditional chinese medicine (TCM). At present, the most prevailing methods for TCM research are mainly nuclear magnetic resonance (NMR), gas chromatography-mass spectrometry (GC-MS), and liquid chromatography-mass spectrometry (LC-MS). With these techniques, metabonomics will help to understand syndromes, efficacy and toxicity of TCM. However, every analytical technique has its advantages and drawbacks, and there exist some obstacles of its applications on TCM. So, we discuss metabonomics in TCM and analyze some problems of its applications to study TCM in recent years. We believe that with the further development of metabonomic analytical technology, especially multianalysed techniques, metabonomics will greatly promote TCM research and be beneficial to the modernization of TCM.

scholarly journals Holistic and dynamic metabolic alterations of traditional Chinese medicine syndrome in a toxic heat and blood stasis syndrome rat model

RSC Advances ◽  
2017 ◽  
Vol 7 (89) ◽  
pp. 56471-56483
Author(s):  
Jing-Jing Xu ◽  
Feng Xu ◽  
Shu-Jie Shen ◽  
Teng Li ◽  
Yi-Fan Zhang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Rat Model ◽  
Blood Stasis ◽  
Blood Stasis Syndrome ◽  
Chinese Medicine Syndrome ◽  
Dynamic Changes ◽  
Metabolic Alterations ◽  
Traditional Chinese Medicine Syndrome ◽  
First Time

Dynamic changes of the metabolic network during the evolution of a syndrome based on the toxic heat and blood stasis syndrome (THBSS) rat model have been elucidated for the first time.

scholarly journals Role of Salicylic Acid and Components of the Phenylpropanoid Pathway in Basal and Cultivar-Related Resistance of Oilseed Rape (Brassica napus) to Verticillium longisporum

Plants ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 491 ◽  
Author(s):  
Xiaorong Zheng ◽  
Birger Koopmann ◽  
Andreas von Tiedemann
Keyword(s):  
Salicylic Acid ◽  
Brassica Napus ◽  
Ferulic Acid ◽  
Cinnamic Acid ◽  
Sinapic Acid ◽  
Coumaric Acid ◽  
Basal Resistance ◽  
Remarkable Increase ◽  
Verticillium Longisporum

Enhanced resistance is a key strategy of controlling ‘Verticillium stem striping’ in Brassica napus caused by the soil-borne vascular pathogen Verticillium longisporum. The present study analyses the role of a broad range of components in the phenylpropanoid and salicylic acid (SA) pathways in basal and cultivar-related resistance of B. napus towards V. longisporum. A remarkable increase of susceptibility to V. longisporum in SA-deficient transgenic NahG plants indicated an essential role of SA in basal resistance of B. napus to V. longisporum. Accordingly, elevated SA levels were also found in a resistant and not in a susceptible cultivar during early asymptomatic stages of infection (7 dpi), which was associated with increased expression of PR1 and PR2. In later symptomatic stages (14 or 21 dpi), SA responses did not differ anymore between cultivars varying in resistance. In parallel, starting at 7 dpi, an overall increase in phenylpropanoid syntheses developed in the resistant cultivar, including the activity of some key enzymes, phenylalanine ammonium lyase (PAL), cinnamyl alcohol dehydrogenase (CAD) and peroxidase (POX) and the expression of key genes, PAL4, CCoAMT, CCR, POX. As a consequence, a remarkable increase in the levels of phenolic acids (t-cinnamic acid, p-coumaric acid, caffeic acid, ferulic acid, sinapic acid) occurred associated with cultivar resistance. A principal component analysis including all 27 traits studied indicated that component 1 related to SA synthesis (PR1, PR2, POX, level of free SA) and component 2 related to lignin synthesis (level of free ferulic acid, free p-coumaric acid, conjugated t-cinnamic acid) were the strongest factors to determine cultivar-related resistance. This study provides evidence that both SA and phenolic acid synthesis are important in cultivar-related resistance, however, with differential roles during asymptomatic and symptomatic stages of infection.

scholarly journals Antioxidant Activity of the Fungus Cordyceps sinensis Grown on Two Different Media

2018 ◽  
Vol 62 (3) ◽  
pp. 68-73
Author(s):  
A. Uhrinová ◽  
N. Poľančíková
Keyword(s):  
Antioxidant Activity ◽  
Oryza Sativa ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Chemical Constituents ◽  
Cordyceps Sinensis ◽  
Dpph Assay ◽  
Extraction Procedures ◽  
Natural Remedy ◽  
Antitumour Effects

Abstract Cordyceps sinensis, a species of the genus Ascomycetes, is recognised as the most famous tonic herb and natural remedy in traditional Chinese medicine for centuries. Various pharmacological actions of the chemical constituents of C. sinensis have been reported, including: antitumour effects, hepatoprotective and anti-inflammatory effects, and antioxidant, nephroprotective and anti-apoptotic properties. In this study we tested the antioxidant activity of extracts of the fungus C. sinensis grown on two subspecies of rice, Oryza sativa var. Indica and Oryza sativa var. Japonica. The extracts were prepared with methanol by two different extraction procedures (reflux and ultrasound). The antioxidant activity of the extracts was determined by the DPPH assay. Our investigations showed that the sample 1 (grown on Oryza sativa var. Japonica) exhibited higher antioxidant activity than the sample 2 (grown on Oryza sativa var. Indica). The higher antioxidant activity of the sample 1 was observed with both extraction procedures.

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