scholarly journals Rare Development of Primary Parotid Gland Epithelial-Myoepithelial Carcinoma in a Child

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Daniyah Saleh ◽  
Doaa Al Ghamdi
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Parotid Gland ◽  
English Literature ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
High Rate ◽  
Low Grade ◽  
Concomitant Treatment ◽  
Neck Lymph Node

Salivary gland tumors are uncommon in children. They consist of variable histopathological subtypes of benign and malignant tumors. EMC is a discrete entity among the WHO classification of salivary gland tumors since 1991. EMC is considered a low-grade malignant salivary gland tumor arising from intercalated ducts. Typically, it affects an adult female individual. Surgical resection with a negative margin is the mainstay treatment option. EMC has a potential for metastasis with a high rate of recurrence. Based on the available English literature, two cases of EMC diagnosed in a pediatric age group have been reported. Therefore, we describe the third EMC that developed in the left parotid gland of a young child. The diagnosis of EMC was established through histopathological examination of the total parotidectomy specimen and neck lymph node dissection, together with ancillary studies. Later, the patient suffered from cervical lymph node enlargement due to metastasis in which FNAB was taken. Metastasis from the known EMC was suspected with cytomorphological features in smears and cell block. Immunohistochemistry markers for the biphasic components were supportive of EMC. Due to advanced disease, the patient necessitated a concomitant treatment of radiochemotherapy. Besides, there was radiological evidence of bilateral multiple lung metastatic nodules. However, a biopsy was not sent for pathological confirmation.

scholarly journals Pattern of distribution of different salivary gland tumors; a retrospective study in NICRH, Dhaka

2016 ◽  
Vol 15 (1) ◽  
pp. 95-98
Author(s):  
Afroza Khanam ◽  
Gulshan Akhter ◽  
Md. Abdur Rahman
Keyword(s):  
Salivary Gland ◽  
Retrospective Study ◽  
Parotid Gland ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Major Salivary Gland ◽  
Gland Tumor ◽  
Minor Salivary Gland Tumors ◽  
Malignant Salivary Gland Tumors

Background: Salivary gland tumors are rare, generally benign and affect both major and minor salivary glands.Objective: To find out the pattern of distribution of different benign and malignant salivary gland epithelial tumors and their relation to age and sex in a tertiary care center in Bangladesh.Methodology: This is a retrospective study. Details of epithelial salivary gland tumors were obtained from department of ENT, National institute of cancer & research hospital (NICRH), Dhaka, Bangladesh from the period January 2009 to December 2012 (3 years).Result: A total number of 261 cases presenting with both benign and malignant salivary gland tumors were analyzed according to gender, age and histopathological findings. There were 130 (49.84%) males and 131 (50.19%) females with the male female ration of 1: 0.99. Age of study population ranged from 10 to 70 years with the mean age 40.78. Percentage of benign salivary gland tumors was 73.94% and malignant salivary gland tumor 26.05%. Among major salivary gland tumors, no sublingual tumors were found and parotid gland tumors were the commonest. Whereas, among minor salivary gland tumors palatal minor salivary tumors were common.Conclusion: Parotid gland was the most common site of origin of both benign and malignant salivary gland tumors. Histopathologically, pleomorphic adenoma was the most common benign salivary gland tumor and mucoepidermoid carcinoma was the most frequent malignant neoplasm. Adenoid cystic carcinoma was common minor salivary gland tumor.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.90-94

scholarly journals Mucoepidermoid Carcinoma: A Demographic and Histopathological Profile

2020 ◽  
Vol 9 (4) ◽  
pp. 298-302
Author(s):  
Zainab Niazi
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumors ◽  
Anatomical Site ◽  
Low Grade ◽  
High Grade ◽  
Male Patients ◽  
Histopathological Grading ◽  
Malignant Salivary Gland Tumors

Background: To find the frequency and clinico-pathological presentation of mucoepidermoid carcinoma (MEC).Materials and Methods:In this study, we included all the malignant salivary gland tumors. Among these the frequency of mucoepidermoid carcinoma was considered. Age, gender, histopathological grading and anatomical site of tumor were included in data analysis.Results:Out of 60 malignant salivary gland tumors reported to the histopathology department, 30 tumors were diagnosed as mucoepidermoid carcinomas. The patient’s age having mucoepidermoid carcinoma ranged from 6 to 88 years, mean age of 44.9±19.2SD. The male patients were 23 in number while female were 7. Out of 30 cases, 73.3% patients had tumor in parotid gland, while13.3% patients in submandibular gland . Other tumors were in palate, retromolar area, and in posterior 1/3rdof tongue (13.3%). According to histopathological grading 26.6% cases of MEC were of high grade, 26.6 % were intermediate grade and 36.6% were low grade.Conclusions:According to this study, the frequency of MEC was 50% among all salivary gland tumors. MEC was mostly found in parotid gland and histopathologically low grade type was the most common.

scholarly journals Low Grade Central Mucoepidermoid Carcinoma

2015 ◽  
Vol 5 (1) ◽  
pp. 31-34
Author(s):  
Kartik Poonja ◽  
Janaki Subramanian Iyer ◽  
Leela Poonja
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Male Patient ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumor ◽  
Malignant Neoplasm ◽  
Low Grade ◽  
Gland Tumor ◽  
Malignant Salivary Gland Tumor ◽  
Central Mucoepidermoid Carcinoma

ABSTRACT Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, comprising about 15% of all salivary gland tumors and 30% of all salivary malignancies. Most of the MEC arise in the parotid gland. Rarely, it originates in the mandible and maxilla as an intraosseous variant, referred to as ‘central mucoepidermoid carcinoma’ or ‘intraosseous mucoepidermoid carcinoma’. Central mucoepidermoid carcinomas (CMECs) are extremely rare, but well-known entity, comprising 2 to 3% of all MECs reported. Histopathologically, this malignant neoplasm is characterized by mucous, intermediate and epidermoid cells. In this report, we present a case of a male patient diagnosed as low grade CMEC. How to cite this article Iyer JS, Poonja K, Pathak J, Patel S, Poonja L. Low Grade Central Mucoepidermoid Carcinoma. J Contemp Dent 2015;5(1):31-34.

scholarly journals Case Report: Complete Response of Recurrent and Metastatic Cystadenocarcinoma of the Parotid Gland With a Single Course of Combined Nivolumab and Ipilimumab Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Yoshiyuki Nakamura ◽  
Masahiro Nakayama ◽  
Bungo Nishimura ◽  
Naoko Okiyama ◽  
Ryota Tanaka ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Parotid Gland ◽  
Lymph Node Metastases ◽  
Checkpoint Inhibitors ◽  
Complete Response ◽  
Lung Nodules ◽  
Low Grade ◽  
Node Metastases ◽  
Multiple Lung Nodules

Although cystadenocarcinoma is classified as a low-grade histological subtype of salivary gland carcinoma (SGC), recurrence and metastases sometimes develop. However, standard treatments for advanced cases have not yet been established. Here, we present a case of unresectable local recurrence and cervical lymph node metastases of cystadenocarcinoma of the parotid gland with multiple lung nodules, all of which showed complete response with only a single course of combined nivolumab and ipilimumab therapy. The patient's medical history of metastatic melanoma roused our suspicions that the multiple lung nodules were cystadenocarcinoma metastases or malignant melanoma. Combination therapy was used based on our suspected diagnosis of lung metastases of melanoma although histological examination of the lung nodules could not be performed. While various chemotherapies are used for advanced SGCs including cystadenocarcinoma, overall, the results are unsatisfactory. In contrast, there have not yet been any reports of advanced cystadenocarcinoma of the salivary gland treated with immune checkpoint inhibitors (ICIs). Given that, in our case, a single course of combined ICI therapy induced a complete response in the unresectable and lymph node metastases from the cystadenocarcinoma and the multiple lung nodules, ICIs, including combined therapy, could be a promising treatment for advanced cystadenocarcinoma.

scholarly journals Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma

2021 ◽  
Author(s):  
Costantino Ricci ◽  
Federico Chiarucci ◽  
Francesca Ambrosi ◽  
Tiziana Balbi ◽  
Barbara Corti ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Tumors ◽  
Melanin Pigment ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Pertinent Literature

AbstractThe presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. In addition, a review of the pertinent literature is also proposed, discussing the pathologic mechanisms potentially involved in this phenomenon.

scholarly journals Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors

2007 ◽  
Vol 18 (3) ◽  
pp. 192-197 ◽  
Author(s):  
Roberta Barroso Cavalcante ◽  
Fernanda Ferreira Lopes ◽  
Andréa Soares Ferreira ◽  
Roseana de Almeida Freitas ◽  
Lélia Batista de Souza
Keyword(s):  
Salivary Gland ◽  
Myoepithelial Cells ◽  
Salivary Gland Tumors ◽  
Low Grade ◽  
Tubular Structures ◽  
Immunohistochemical Markers ◽  
Adenoid Cystic ◽  
Peripheral Cells ◽  
Diffuse Distribution ◽  
Labeling Pattern

Myoepithelial cells present a complex immunophenotype, with the expression of proteins varying according to the stage of normal or neoplastic differentiation of the cell. In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calponin and HHF-35 was applied to 28 salivary gland tumors. The results demonstrated a higher percent sensitivity of vimentin and calponin compared to HHF-35. However, calponin and HHF-35 presented a focal labeling pattern in contrast with the diffuse distribution of vimentin. The cells predominantly stained by all tested antibodies included nonluminal cells in duct-like and tubular structures, such as those seen in pleomorphic adenomas and adenoid cystic carcinomas, as well as cells in the cords and nests of polymorphous low-grade adenocarcinomas and peripheral cells of sheets and nests of myoepitheliomas. In conclusion, the combination of calponin and vimentin is suggested for the identification of myoepithelial cells in salivary gland tumors.

Terminal duct adenocarcinomas of the parotid gland

1995 ◽  
Vol 109 (5) ◽  
pp. 466-468 ◽  
Author(s):  
Bonnie L. Kemp ◽  
John G. Batsakis ◽  
Adel K. El-Naggar ◽  
Sophia N. Kotliar ◽  
Mario A. Luna
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Minor Salivary Gland ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Biological Behaviour ◽  
Parotid Neoplasms ◽  
Clinicopathological Study

AbstractThe major salivary glands are considered to rarely be the sites of primary terminal duct adenocarcinomas, a neoplasm with a considerable predilection for origin from intraoral minor salivary glands. We present a clinicopathological study of 22 terminal duct adenocarcinomas of the parotid gland, the largest single series to date. A comparison between the parotid neoplasms and over 200 minor salivary gland terminal duct adenocarcinomas indicates there is little difference in biological behaviour and confirms the low-grade quality of the carcinomas, regardless of site of origin.

scholarly journals Dedifferentiated Acinic Cell Carcinoma of the Parotid Gland With Myoepithelial Features

2002 ◽  
Vol 126 (9) ◽  
pp. 1104-1105 ◽  
Author(s):  
Simonetta Piana ◽  
Alberto Cavazza ◽  
Corrado Pedroni ◽  
Rosa Scotti ◽  
Luigi Serra ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Clinical Course ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Epithelial Proliferation ◽  
Acinic Cell

Abstract Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course. We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.

scholarly journals Mammary analogue secretory carcinoma: a rare salivary gland tumor

2020 ◽  
Vol 6 (5) ◽  
pp. 998
Author(s):  
Shashikant Anil Pol ◽  
Surinder K. Singhal ◽  
Nitin Gupta ◽  
Himanshu Bayad
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
Good Prognosis ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
Grade Malignancy ◽  
Enhanced Computed Tomography ◽  
Slow Growing

<p>Mammary analogue secretary carcinoma are salivary gland tumors similar to secretary carcinoma of breast histologically. It usually affects adults with mean age group of 45 years. Clinically it is usually slow growing, low grade malignancy with favorable prognosis. We are reporting a case of 47 years old female presented with complaints of swelling behind left ear for last 7 years. It was slow growing, painless and persistent. On examination, 4 x 3 cm swelling was present just below left ear lobule. It was nontender, firm, irregular in shape with smooth surface with slight mobility and overlying skin pinchable. Fine needle aspiration cytology suggested benign tumor with cystic change. On contrast enhanced computed tomography scan, there was a lobulated hypodense lesion measuring 24×35×32 mm with internal septations and enhancement of wall in expected location of superficial as well as deep lobe of left parotid gland. Patient underwent left total conservative parotidectomy and histopathology came out to be secretory analogue mammary carcinoma. Subsequently she received post-operative radiotherapy. Patient is on regular follow up and disease free till date. Usually mammary analogue secretory carcinoma is a low-grade malignancy with good prognosis. Immunohistochemistry is confirmatory which shows positivity for S-100 protein and mammaglobin.</p>

Parotid Gland and Other Salivary Gland Tumors

2011 ◽  
pp. 237-259
Author(s):  
Frédérique Dubrulle ◽  
Raphaëlle Souillard-Scemama
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Gland Tumors
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