scholarly journals Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Masaya Iwamuro ◽  
Toshi Murakami ◽  
Takehiro Tanaka ◽  
Shohei Oka ◽  
Seiji Kawano ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Diseases ◽  
Gastric Ulcers ◽  
Blood Eosinophil ◽  
Gastric Lesions ◽  
Blood Eosinophil Count ◽  
Steroid Administration ◽  
Eosinophilic Gastritis ◽  
Old Japanese ◽  
Previously Treated

A 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient’s request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dupilumab treatment revealed gastric ulcers; subsequently, eosinophilic gastritis was diagnosed from biopsy examinations. The gastric lesions were resolved by steroid administration. This case report underscores that eosinophil-associated gastrointestinal diseases should be considered in the differential diagnosis of gastric lesions occurring in patients who were treated with dupilumab.

Cytoprotective and antisecretory properties of methanolic extract of Distemonanthus benthamianus (Caesalpiniaceae) stem bark on acute gastric ulcer in rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Vanessa Mba Matah Marthe ◽  
Gilbert Ateufack ◽  
Marius Mbiantcha ◽  
William Yousseu Nana ◽  
Albert Donatien Atsamo ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Gastric Lesion ◽  
Stem Bark ◽  
Male Rats ◽  
Gastric Ulcers ◽  
Gastric Lesions ◽  
Mucus Production ◽  
Antisecretory Activity ◽  
Antisecretory Effect ◽  
Pylorus Ligation

AbstractObjectivesIn African traditional medicine, Distemonanthus benthamianus (Caesalpiniaceae) is used to treat many diseases including gastric ulcers. We evaluated in this study, the cytoprotective and antisecretory properties of the methanolic extract of the stem bark of this plant using different technics of gastric lesion induction.MethodsCytoprotective and antisecretory activity of the methanolic extract of D. benthamianus stem bark was evolved through six methods of gastric lesion induction in experimental Wistar male rats (150–200 g): (1) gastric lesions induced by HCl/ethanol, (2) gastric lesions induced by Indomethacin- HCl/ethanol, (3) gastric lesion induced by Indomethacin, (4) gastric lesions induced by Pylorus ligation, (5) gastric lesions induced by histamine-Pylorus ligation, (6) gastric lesions induced by carbachol-Pylorus ligation. Mucus and gastric mucosal ulceration were evaluated. pH, gastric volume, and acidity were quantified in all pylorus ligation induction technics. Nitric oxide (NO) level was determined in indomethacin induced gastric ulcers.ResultsAt different doses (125, 250 and 500 mg/kg), extract reduced significantly the ulcer index. In all models used, that is 100.00% with HCl/ethanol; 100.00% with HCl/ethanol/indomethacin; 95.70% with Indomethacin; 74.79% with pylorus ligation, 95.94% histamine-Pylorus ligation, 99.54% carbachol-Pylorus ligation at the highest dose of 500 mg/kg. The lesion formation reduces in all the methods used followed by a significant increase of mucus production. The pylorus ligation technic revealed that the extract has an antisecretory activity.ConclusionsThe methanolic extract of D. benthamianus stem bark has both cytoprotective and antisecretory effects. This extract exerts its antisecretory effect trough cholinergic and histaminergic pathways.

Point-of-care blood eosinophil count in a severe asthma clinic setting

2017 ◽  
Vol 119 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Enrico Heffler ◽  
Giovanni Terranova ◽  
Carlo Chessari ◽  
Valentina Frazzetto ◽  
Claudia Crimi ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Eosinophil Count ◽  
Point Of Care ◽  
Blood Eosinophil ◽  
Blood Eosinophil Count ◽  
Clinic Setting

scholarly journals Blood eosinophil count to predict bronchial eosinophilic inflammation in COPD

2016 ◽  
Vol 47 (5) ◽  
pp. 1562-1564 ◽  
Author(s):  
Florence Schleich ◽  
Jean-Louis Corhay ◽  
Renaud Louis
Keyword(s):  
Eosinophil Count ◽  
Blood Eosinophil ◽  
Eosinophilic Inflammation ◽  
Blood Eosinophil Count

Clinical variables and protein biomarkers associated with blood eosinophil count and asthma in young adults

2021 ◽  
Author(s):  
Maura Kere ◽  
Sophia Björkander ◽  
Susanna Klevebro ◽  
Maria Ödling ◽  
Sandra Ekström ◽  
...  
Keyword(s):  
Young Adults ◽  
Eosinophil Count ◽  
Blood Eosinophil ◽  
Protein Biomarkers ◽  
Blood Eosinophil Count ◽  
Clinical Variables

scholarly journals Prevalence, distribution and pattern of gastric lesions in slaughtered pigs in south-western Nigeria

2016 ◽  
Vol 83 (1) ◽  
Author(s):  
Oladipo O. Omotosho ◽  
Benjamin O. Emikpe ◽  
Olalekan T. Lasisi ◽  
Theophilus A. Jarikre
Keyword(s):  
Standard Technique ◽  
Gastric Ulcers ◽  
Economic Losses ◽  
Gastric Lesions ◽  
Swine Industry ◽  
Chi Square ◽  
Slaughter House ◽  
Gross Lesions ◽  
Frequency Counts ◽  
Slaughtered Pigs

Gastric lesions, especially ulceration, cause significant economic losses in the swine industry worldwide. The study was designed to assess its prevalence, distribution and pattern in pigs in south-western Nigeria. Slaughter house surveys were conducted on three government-established abattoirs in Lagos, Ogun and Oyo states. Stomachs from 480 pigs were assessed for gross lesions, which were graded using a modification of a standard technique. Tissues from different regions of the stomach were routinely stained to assess histopathologic changes. Data were presented as frequency counts and analysed using analysis of variance and chi-square technique. Significance was determined at p ≤ 0.05. Gastric lesions were encountered across the four regions of the stomach with a point prevalence of 57.29%. The prevalence of lesions in the non-glandular region was 32.9%, with severe hyperkeratosis (13.13%) being most frequently observed (p < 0.05). Erosions were significantly higher in the cardia (8.54%) (p < 0.05), followed by fundus (8.33%). Gastric ulcers were significantly higher in the fundus (19.58%) (p < 0.05). Scars of healed ulcers and lacerations were also observed in the fundus (5.42%) (p < 0.05). The gastric lesion distribution across the four regions of the stomach and the occurrence of ulceration in the fundus showed an unusual pattern, which is rarely reported in other parts of the world. The reason for these findings in pigs in Nigeria is not fully understood; therefore, further studies are required to identify and manage these factors for increased productivity, improved animal welfare and enhanced food security.Keywords: prevalence; gastric; lesions; fundic ulcers; pigs

scholarly journals Longitudinal stability of blood eosinophil count strata in the COPD COSYCONET cohort

2018 ◽  
Vol Volume 13 ◽  
pp. 2999-3002 ◽  
Author(s):  
Timm Greulich ◽  
Sina Mager ◽  
Tanja Lucke ◽  
Andreas Rembert Koczulla ◽  
Robert Bals ◽  
...  
Keyword(s):  
Eosinophil Count ◽  
Blood Eosinophil ◽  
Longitudinal Stability ◽  
Blood Eosinophil Count

scholarly journals Gastric Lesions in Culled Sows: An Underestimated Welfare Issue in Modern Swine Production

Agriculture ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 927
Author(s):  
Piotr Cybulski ◽  
Aleksandra Woźniak ◽  
Joachim Urban ◽  
Tomasz Stadejek
Keyword(s):  
Clinical Symptoms ◽  
Gastric Ulceration ◽  
Gastric Ulcers ◽  
Gastric Lesions ◽  
Swine Production ◽  
Veterinary Practitioner ◽  
Welfare Issue ◽  
Commercial Farms ◽  
Production Losses ◽  
Management Issues

Specific anatomy of the porcine stomach results in a high risk of ulceration in the pars oesophagea. A fully developed ulcer leads to intermittent gastrointestinal bleeding followed by clinical symptoms of chronic pain; thus, gastric ulceration in pigs causes significant production losses and serious welfare problems. Nowadays, gastric ulceration is common in domestic pigs throughout the world, but a great deal of attention has been directed at finishers. This paper was intended to provide new data on the prevalence of the disease in commercially reared highly prolific sows. The study was carried out on 329 culled sows from four commercial farms located in Northern Poland. The severity of gross pathological lesions of pars oesophagea was assigned to grade 0 (no lesions), 1 (parakeratosis), 2 (erosion), or 3 (gastric ulceration with or without stenosis) by a veterinary practitioner. Abattoir analysis revealed 66.6% of sows’ stomachs with some degree of alterations. Gastric ulceration was detected in 45.5% of examined organs. Parakeratosis and erosion were found in 1.2 and 15.8% of stomachs, respectively. The investigation did not find any oesphageal strictures. Our investigation of the problem in high health status hyper-prolific sows showed the lowest prevalence of gastric lesions (i.e., ulcerative and preulcerative alterations collectively) compared to earlier studies but the highest percentage of gastric ulcers. The results indicate that gastric ulcers may be a highly prevalent and underestimated welfare issue in sows in modern pig production, worth further studies focusing on particular risk factors related to feeding, genetics, management issues, and sows longevity.

scholarly journals Agarwood Alcohol Extract Protects against Gastric Ulcer by Inhibiting Oxidation and Inflammation

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Canhong Wang ◽  
Deqian Peng ◽  
Yangyang Liu ◽  
Yulan Wu ◽  
Peng Guo ◽  
...  
Keyword(s):  
Nuclear Factor Kappa B ◽  
Gastrointestinal Diseases ◽  
Interleukin 10 ◽  
Gastric Ulcers ◽  
Mucosal Protection ◽  
Ulcer Index ◽  
Alcohol Extract ◽  
Ameliorative Effect ◽  
Inflammatory Proteins ◽  
Better Than

Background. Agarwood has been used for centuries, especially for treatment of gastrointestinal diseases. Earlier studies of our laboratory suggested that agarwood alcohol extracts (AAEs) provided gastric mucosal protection. This study aims to investigate the ameliorative effect of AAEs on ethanol-induced gastric ulcers and its mechanism. Methods. Mice were given agarwood induced by the whole-tree agarwood-inducing technique alcohol extract (WTAAE, 0.71, 1.42, and 2.84 g/kg), wild agarwood induced by axe wounds alcohol extract (WAAE, 2.84 g/kg), and burning-chisel-drilling agarwood alcohol extract (FBAAE, 2.84 g/kg) orally, respectively. After 7 days’ pretreatment with AAEs, the gastric ulcers were induced by absolute ethanol. The ulcer index, gastric histopathology, biochemical parameters, and inflammatory proteins were evaluated. Results. Pharmacological results showed AAEs (1.42 and 2.84 g/kg) reduced the gastric occurrence and ulcer inhibition rates up to more than 60%. AAEs decreased the level of nitric oxide (NO) and increased glutathione (GSH) and superoxide dismutase (SOD) levels. Besides, AAEs decreased the levels of interleukin-1β (IL-1β) and interleukin-6 (IL-6), but the interleukin-10 (IL-10) was upregulated. The expressions of nuclear factor kappa B (NF-κB) and phosphorylated protein 38 (p-P38) were inhibited. The effect of WTAAE was better than that of FBAAE and similar to that of WAAE at the dose of 2.84 g/kg. Conclusions. These results demonstrate that agarwood alleviates the occurrence and development of gastric ulcers via inhibiting oxidation and inflammation.

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