scholarly journals Tiotropium Bromide Attenuates Mucus Hypersecretion in Patients with Stable Chronic Obstructive Pulmonary Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Suyun Yu ◽  
Caili Zhang ◽  
Zhijun Yan ◽  
Qingqing Fang ◽  
Xiwen Gao
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Treatment Group ◽  
Lung Function ◽  
Pulmonary Function ◽  
Tiotropium Bromide ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Mucus Hypersecretion ◽  
Acid Glycoprotein

Background. Patients with stable chronic obstructive pulmonary disease (COPD) have been observed to benefit from tiotropium bromide. However, there are few studies of tiotropium bromide on sputum and sputum viscosity. To evaluate the effect of tiotropium bromide on mucus hypersecretion, a randomized, double-blind controlled trial was performed. Methods. 120 cases of patients with pulmonary function grade II were divided into two groups, which include the treatment group given tiotropium bromide powder inhalation (18 μg, inhalation, QD) and the control group given formoterol fumarate powder inhalation (12 μg, inhalation, BID) plus ambroxol hydrochloride tablets (60 mg, oral, TID). After 3 months of treatment, the pulmonary function and α1-acid glycoprotein (α1-AGP) in sputum were detected, and the changes of glycoprotein and Ca2+ content were evaluated by Miller classification. Results. Three patients (2 cases in the treatment group and 1 case in the control group) were dropped due to loss of follow-up, and 117 cases of patients were enrolled in this study. After 3 months of treatment, the sputum character score, α1-acid glycoprotein, Ca2+ content, and lung function of the two groups were significantly improved; group comparison analyses revealed that there was no significant difference in the content of α1-AGP, Ca2+ in sputum, and lung function between the two groups ( P > 0.05 ), but the improvement of sputum properties was significant ( P < 0.05 ), and the treatment group was better than the control group ( t = − 2.77 ; P = 0.007 ). Conclusions. Inhaled tiotropium bromide can effectively inhibit the mucus hypersecretion in stable COPD patients, improve the sputum properties and lung function of patients, and improve the quality of life of patients.

Application of Dejian Psychosomatic Therapy to Smokers with Stable Chronic Obstructive Pulmonary Disease

2021 ◽  
Vol 7 (6) ◽  
pp. 5103-5107
Author(s):  
Liu Xin
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Treatment Group ◽  
Lung Function ◽  
Pulmonary Disease ◽  
Statistical Significance ◽  
Good Effect ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Group Control Group

To explore the intervention effect of Dejian psychosomatic therapy on chronic obstructive pulmonary disease (COPD) in elderly smokers, in as to improve clinical impact of COPD in smokers who are the aged. Forty elderly smokers with COPD were comprise of treatment group, control group, which are trained for 45 days to test the following indicators. Vital mass Index (VMI), forced Vital capacity (FVC), Maximum Chase air volume (MVV) and so on showed significant improvement in lung function indicators in both the treatment group and the control group (P < 0.05). Improvement impact of control group was not better than that of the treatment group, with statistical significance (P < 0.01). Dejian psychosomatic therapy has a systematic good effect on copd smokers, promoting the improvement and promotion of lung function, and strengthening the physical function of copd smokers in stable stage.

scholarly journals Therapeutic Effect Observation of Tiotropium Bromide in the Treatment of Overlap Syndrome

2020 ◽  
Vol 3 (1) ◽  
pp. 15
Author(s):  
Yunchao Huang ◽  
Ting Wang
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Sleep Apnea ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Overlap Syndrome ◽  
Tiotropium Bromide ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Obstructive Sleep

Objective: To study the M receptor blocker on inhalation in patients with overlap syndrome (chronic obstructive pulmonary disease and Obstructive sleep apnea syndrome) curative effect analysis. Methods: 25 patients with overlap syndrome as the experimental group, chronic obstructive pulmonary disease patients (30) as control group, patients with overlap syndrome use inhaled tiotropium powder treat 30 days, to observe the changes of pulmonary function, polysomnography, and other indicators after treatment. Results: Overlap syndrome were treated by tiotropium bromide inhalation powder, has improved the pulmonary function, the sleep apnea index and lowest nocturnal oxygen saturation after treatment. Conclusion: tiotropium bromide has a preferable effective in treatment of overlap syndrome, COPD and OSAHS are interacting with each other.

scholarly journals The Effects of Quercetinon Interleuikin (IL-8) Serum, %Forced Expiratory Volume in One Second (FEV1), and COPD Assessment Test (CAT) Scores in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients

2019 ◽  
Vol 39 (2) ◽  
pp. 103-112
Author(s):  
Maratus Sholihah ◽  
Suradi Suradi ◽  
Jatu Aphridasari
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Treatment Group ◽  
Serum Level ◽  
Pulmonary Disease ◽  
Standard Therapy ◽  
Flavonoid Compound ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Introduction: Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide. Cigarette smoke and noxious agent result in oxidative stress and activate release of inflammatory mediators such as Interleukin-8 (IL-8). Quercetin is a flavonoid compound containing anti-inflammatory effects which can be used as an adjuvant therapy in stable COPD. Objective: To analyze the effect of quercetin on serum IL-8 levels, % VEP1, and CAT score of stable COPD patients. Methods: Experimental clinical trial with pre-test and pasca-test design was performed in 30 patients with stable COPD in Dr. Moewardi Surakarta between December 2017 and January 2018. The samples taken by using purposive sampling were divided into two groups treatment groups received standard therapy and quercetin 500mg/day for 28 days and control groups only received standard therapy. The decrease in inflammation was measured by serum IL-8 examination, improvement of obstruction measured by %FEV1 and clinical improvement measured by CAT score. Results: IL-8 serum level was significantly lower in treatment group than of in control group (p=0,001). The percentage of FEV1 was insignificant different between the two group (p=0,236). However CAT score was significantly lower in treatment group compared to that of in control group (p=0,001) Conclusions: Quercetin can decrease IL-8 serum level and decrease CAT score when given in combination with standard therapy for COPD patients. (J Respir Indo 2019; 39(2))

scholarly journals Computed tomography-derived area and density of pectoralis muscle associated disease severity and longitudinal changes in chronic obstructive pulmonary disease: a case control study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
So Hyeon Bak ◽  
Sung Ok Kwon ◽  
Seon-Sook Han ◽  
Woo Jin Kim
Keyword(s):  
Computed Tomography ◽  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Disease Severity ◽  
Chronic Obstructive ◽  
Pectoralis Muscle ◽  
Obstructive Pulmonary Disease ◽  
Longitudinal Changes

Abstract Background Muscle wasting is associated with prognosis in patients with chronic obstructive pulmonary disease (COPD). The cross-sectional area of skeletal muscles on computed tomography (CT) could serve as a method to evaluate body composition. The present study aimed to determine the ability of CT-derived pectoralis muscle area (PMA) and pectoralis muscle density (PMD) to determine the severity of COPD and change in longitudinal pulmonary function in patients with COPD. Methods A total of 293 participants were enrolled in this study, a whom 222 had undergone at least two spirometry measurements within 3 years after baseline data acquisition. PMA and PMD were measured from a single axial slice of chest CT above the aortic arch at baseline. The emphysema index and bronchial wall thickness were quantitatively assessed in all scans. The generalized linear model was used to determine the correlation between PMA and PMD measurements and pulmonary function. Results PMA and PMD were significantly associated with baseline lung function and the severity of emphysema (P < 0.05). Patients with the lowest PMA and PMD exhibited significantly more severe airflow obstruction (β = − 0.06; 95% confidence interval: − 0.09 to − 0.03]. PMA was statistically associated with COPD assessment test (CAT) score (P = 0.033). However, PMD did not exhibit statistically significant correlation with either CAT scores or modified Medical Research Council scores (P > 0.05). Furthermore, neither PMA nor PMD were associated with changes in forced expiratory volume in 1 s over a 3-year periods. Conclusions CT-derived features of the pectoralis muscle may be helpful in predicting disease severity in patients with COPD, but are not necessarily associated with longitudinal changes in lung function.

Electroacupuncture Reduces Hypothalamic and Medullary Expression of Orexins and their Receptors in a Rat Model of Chronic Obstructive Pulmonary Disease

2018 ◽  
Vol 36 (5) ◽  
pp. 312-318 ◽  
Author(s):  
Xin-Fang Zhang ◽  
Qin Qin ◽  
Wen-Ye Geng ◽  
Chuan-Wei Jiang ◽  
Yong Liu ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Protein Expression ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Rat Model ◽  
Normal Group ◽  
Cigarette Smoke Exposure ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Objectives Decreased lung function in chronic obstructive pulmonary disease (COPD) is correlated with abnormal excitability of the respiratory centre where orexin neuropeptides from the hypothalamus are responsible for regulating respiration. We hypothesised that improvements in pulmonary function with electroacupuncture (EA) may be related to orexins in a rat model of COPD. Methods The COPD model was established by cigarette smoke exposure and lipopolysaccharide injection. Modelled rats received EA at BL13 and ST36 for two weeks, after which lung function was tested. Orexin levels in the hypothalamus and medulla were detected by ELISA, while mRNA/protein expression and localisation of orexins and their receptors were investigated using real time PCR, Western blotting and immunohistochemistry, respectively. Results The decrease in lung function observed in COPD rats was improved after EA treatment. Orexin levels in the hypothalamus and medulla were significantly higher in COPD rats than in normal rats, but were significantly reduced in the EA-treated group. There was a negative correlation between orexin content and lung function. In the hypothalamus, mRNA and protein expression and immunoreactivity of orexins were significantly higher in the COPD group than in the normal group, but a significant decrease was observed after EA. In the medulla, the expression and immunoreactivity of orexin receptors were significantly higher in the COPD group than in the normal group, but a significant decrease was observed after EA. Conclusions The positive effect of EA on pulmonary function in COPD rats may be related to downregulation of orexins and their receptors in the medulla.

scholarly journals Ability of γ-tocotrienol to Mitigate Inflammation and Preserve Lung Function in a Model of E-Cigarette Induced Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 437-437
Author(s):  
Maureen Meister ◽  
Will Conrad ◽  
Albert Adhya ◽  
Shiying Zhang ◽  
Chi In Vong ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Pulmonary Function Tests ◽  
Periodic Acid ◽  
Metabolic Reprogramming ◽  
Chronic Obstructive ◽  
Collagen Deposition ◽  
Obstructive Pulmonary Disease

Abstract Objectives Chronic obstructive pulmonary disease (COPD) remains a leading cause of death and treatment options for this condition remain scant. This study aims to examine the ability of γ-tocotrienol to mitigate disease progression in an animal model of COPD induced by e-cigarettes. We hypothesize that γ-tocotrienol will attenuate inflammation and subsequently slow the progression of e-cigarette induced COPD. Methods Scnn1b-Tg + mice (n = 10/group), were exposed to e-cigarette vapor twice daily for 10 days in an acute model and daily for eight weeks in a chronic model with or without γ-tocotrienol at a dose of 100 mg/kg/day. Following the treatment, animals underwent pulmonary function testing. Upon sacrifice, bronchoalveolar lavage (BAL) fluid and serum were collected for analysis of cytokine expression through cytokine array. Markers of oxidative stress, inflammation, and fibrosis in the lung were assessed via western blot. Mucus accumulation and structural changes (i.e., emphysema) were measured through Periodic Acid-Schiff and Hematoxylin and Eosin staining, respectively. Collagen deposition were evaluated by Sirius Red staining and Sircol Collagen assay. Cell morphology in BAL fluid was analyzed by Diff staining. Results In the acute model, γ-tocotrienol was evidenced to decrease collagen deposition and mucus accumulation in the bronchioles. Additionally, γ-tocotrienol reduced expression of cytokines C-X3-C motif chemokine ligand (CX3CL) 1 (P = 0.017), interleukin (IL) 4 (P = 0.0038) and T-cell immunoglobulin and mucin domain (TIM) 1 (P = 0.0215). Evidenced by large effect size, pulmonary function tests evidenced the ability of γ-tocotrienol to preserve lung function following 8 weeks of e-cigarette exposure. In addition, macrophage presence in BAL fluid was decreased following in mice supplemented with γ-tocotrienol following e-cigarette exposure. Conclusions Our results show the ability of γ-tocotrienol to attenuate the inflammatory response, and preserve lung function in models of e-cigarette induced COPD. These results indicate potential beneficial effects of γ-tocotrienol as an ancillary treatment in COPD. Funding Sources This work was supported by FAMRI foundation “METABOLIC REPROGRAMMING IN PATIENTS WITH COPD”, YCSA 2015.

scholarly journals A study to assess the effectiveness of breathing exercises on selected pulmonary parameters on patients with chronic obstructive pulmonary disease at selected hospitals Chennai

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1939-1944
Author(s):  
Ambiga K
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Hold Time ◽  
Sampling Technique ◽  
Control Group ◽  
Chronic Obstructive ◽  
Breathing Exercise ◽  
Obstructive Pulmonary Disease ◽  
Breathing Exercises

The most frequent chronic lung disease characterized by increased resistivity to airflow as a result of airway obstruction. A study to assess the effectiveness of breathing exercises on selected pulmonary parameters on patients with chronic obstructive pulmonary disease. To assess the pulmonary function before administering breathing exercises, to assess the pulmonary function after administering breathing exercises. The research design used in this study was quasi-experimental, two groups before and after design. Non-probability convenient sampling technique was followed to allow the samples to an experimental and control group. The tool contains 3 parts part A-demographic variables, part B-measurement of pulmonary parameters and part C-self-instructional module on breathing exercises. The practicing of breathing exercise was found to be effective in improving the pulmonary parameters. Younger age patients gained more breathing hold time after practicing breathing exercise. Non-smokers gained more chest expansion and PEFR after practicing breathing exercise. The results of the study were concluded that selected breathing exercises (Pursed lip and Diaphragmatic Breathing Exercise) given to the COPD patients was effective to improve in their pulmonary parameters.

scholarly journals WeChat as a Platform for Baduanjin Intervention in Patients With Stable Chronic Obstructive Pulmonary Disease in China: Retrospective Randomized Controlled Trial (Preprint)

2020 ◽  
Author(s):  
Junjie Bi ◽  
Wei Yang ◽  
Ping Hao ◽  
Yongmei Zhao ◽  
Dan Wei ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Rehabilitation ◽  
Life Quality ◽  
Satisfaction Survey ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Significant Difference ◽  
Before And After

BACKGROUND Pulmonary rehabilitation is a crucial part of the nonpharmacological treatment of stable chronic obstructive pulmonary disease (COPD), but management remains problematic. WeChat could serve as a useful tool in patient management. Baduanjin is a popular exercise in China that is usually applied in pulmonary rehabilitation, which has been confirmed to be effective in improving lung function and life quality. OBJECTIVE This study aimed to explore the efficiency of WeChat in the management of Baduanjin exercise in COPD patients. METHODS A total of 200 patients from the respiratory department of Putuo Hospital participated in the Baduanjin rehabilitation project from September 2018 to October 2019, and were randomly assigned to the WeChat and control groups and followed up using the WeChat platform or telephone for 12 weeks. The frequency of Baduanjin exercise, lung function (percentage of forced expiratory volume in 1 second predicted, FEV1% predicted), and COPD assessment test (CAT) scores were collected and compared between the two groups. The number of message exchanges and a satisfaction survey on the WeChat platform were used to assess the feasibility of WeChat management outside the hospital. RESULTS The Baduanjin exercise frequency significantly differed between the control group and WeChat group (<i>F</i>=33.82, <i>P&lt;</i>.001) and across various time points (<i>F</i>=214.87, <i>P&lt;</i>.001). After the follow-up on WeChat, there were fewer patients not performing Baduanjin exercise. The FEV1% predicted value significantly differed before and after Baduanjin exercise in the control group (<i>Z</i>=−3.686, <i>P</i>&lt;.001) and the WeChat group (<i>Z</i>=−6.985, <i>P&lt;</i>.001). A significant difference in the FEV1% predicted value was observed after Baduanjin exercise between the two groups (<i>Z</i>=−3.679, <i>P</i>&lt;.001). The CAT score significantly differed before and after Baduanjin exercise in the control group (<i>Z</i>=−4.937, <i>P&lt;</i>.001) and the WeChat group (<i>Z</i>=−5.246, <i>P</i>&lt;.001). A significant difference in the CAT score was observed after Baduanjin exercise between the two groups (<i>Z</i>=−5.246, <i>P&lt;</i>.001). The number of completed Baduanjin exercises, lung function, and CAT scores in active patients were higher than those in nonactive patients. All satisfaction survey items were scored with more than 4 points. Among the items, the highest score (mean 4.54, SD 0.77) was for continued WeChat management, followed by the effective management of Baduanjin exercise (mean 4.46, SD 0.87). The patients in the WeChat group showed much higher enthusiasm for and compliance with Baduanjin exercise, resulting in better life quality and lung function. The patients were very satisfied with the WeChat management because of the obvious curative effect and home feeling. CONCLUSIONS The WeChat platform provided a feasible, effective, and sustainable management plan for Baduanjin rehabilitation. CLINICALTRIAL Chinese Clinical Trial Registry ChiCTR1900028248; http://www.chictr.org.cn/showprojen.aspx?proj=46995

scholarly journals The effect of administration of lycopene on interleukin 8 levels and hospitalization time of patients with chronic obstructive pulmonary disease exacerbations

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yusup Subagio Sutanto ◽  
Diana Kurniasari Sagita ◽  
Suradi Suradi ◽  
Hendra Kurniawan
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Treatment Group ◽  
Pulmonary Disease ◽  
Standard Therapy ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Chronic Inflammatory Response ◽  
Consecutive Sampling ◽  
Hospitalization Time

Abstrak. Latar Belakang: Eksaserbasi pada penyakit paru obstruktif kronik  merupakan kondisi akut yang ditandai dengan hambatan aliran udara yang persisten dari respon inflamasi kronik yang berlebihan pada saluran napas dan parenkim paru yang disebabkan oleh paparan gas atau partikel berbahaya. Peningkatan peradangan saluran napas selama eksaserbasi menyebabkan peningkatan kadar IL-8 dan risiko rawat inap. Likopen merupakan karotenoid yang memiliki efek positif pada sistem pernapasan. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian likopen terhadap kadar IL-8 dan lama rawat inap pasien PPOK eksaserbasi akut.Metode: Uji eksperimental dengan desain pretest dan posttest pada 30 pasien PPOK eksaserbasi di RSUD Dr. Moewardi, Surakarta dan RSUD Dr. Soehadi Prijonegoro, Sragen dilakukan pada bulan Februari-Maret 2018. Pengambilan sampel secara consecutive sampling dibagi menjadi dua kelompok yaitu kelompok perlakuan yang mendapat terapi standar dan likopen 1x10 mg/hari selama pengobatan dan kelompok kontrol hanya mendapat terapi standar. Dilakukan pengukuran kadar IL-8 dan waktu rawat inap pasien dengan PPOK eksaserbasi.Hasil: Terdapat perbedaan yang bermakna antara kelompok perlakuan dibandingkan dengan kelompok kontrol untuk penurunan IL-8 (p = 0,029) dan penurunan waktu rawat inap (p = 0,000).Kesimpulan: Pemberian likopen 1x10 mg / hari secara signifikan menurunkan kadar IL-8 dan lama rawat inap pasien eksaserbasi PPOK.Kata kunci: eksaserbasi akut, kadar IL-8, lama rawat inap, likopen, PPOK.Abstract. Background: Exacerbated chronic obstructive pulmonary disease is an acute condition, characterized by persistent air flow limitations, related to the excessive chronic inflammatory response in the airways and lung parenchyma caused by exposure to harmful gases or particles. Increased airway inflammation during exacerbations leads to increased levels of IL-8 and the risk of hospitalization. Lycopene is a carotenoid which has a positive effect on the respiratory system. The purpose of this study was to determine the effect of administration  lycopene to IL-8 levels and hospitalization time of patients with COPD disease exacerbations.Methods: The  experimental test with pretest and posttest  design for 30 patients with COPD exacerbations in Dr. Moewardi Surakarta Hospital and Dr. Soehadi Prijonegoro Sragen Hospital was conducted from February to March 2018. Samples were taken by consecutive sampling divided into two groups including the treatment group receiving standard therapy and lycopene 1x10 mg / day during treatment and the control group only receiving standard therapy. IL-8 levels  and hospitalization time of patients with COPD disease exacerbations  were measured.Results: There were significant differences between the treatment group compared to the control group for a decrease in IL-8 (p = 0.029) and a decrease in hospitalization time (p = 0,000).Conclusion: The administration of lycopene 1x10 mg / day significantly reduce IL-8 levels and hospitalization time of patient with COPD exacerbations.Keywords: lycopene, COPD, acute exacerbation, IL-8 level, hospitalization time 

scholarly journals Regression analysis to estimate the response of the respiratory organs to exposure of air microtoxicants in chronic obstructive pulmonary disease

2021 ◽  
pp. 45-52
Author(s):  
T. I. Vitkina ◽  
L. V. Veremchuk ◽  
T. A. Gvozdenko ◽  
E. E. Mineeva
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Respiratory Failure ◽  
Lung Function ◽  
Respiratory System ◽  
Toxic Metals ◽  
Regression Models ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
The City

Inroduction. The assessment of the respiratory system is of particular importance in the context of increasing impact of anthropogenic factors on human health. Aim. Evaluation the response of the lung function indices to the effects of micro-suspensions and toxic metals in patients with chronic obstructive pulmonary disease (COPD), using regression models. Materials and methods. The study involved 60 patients with stable mild-to-moderate COPD and 30 healthy people (the control group). The analysis of lung function was carried out by spirometry and body plethysmography. Arterial oxygen saturation (SaO2 ) was measured by pulse oximetry. Exhaled CO2 concentration and blood carboxyhemoglobin (COHb%) concentration were assessed using a portable analyzer MicroCO Meter. The pollution of the city atmosphere was assessed by aerosol suspensions of solid particles in the areas of residence of the examined patients. Fractional composition of suspended particles (0-1, 1-10, 10-50, 50-100, 100-400, 400-700,> 700 μm; %) were analyzed in the areas of residence of the examined patients. Toxic metal (Pb, Cr, Mn, Fe, Co, Ni, Cu, Zn; μg/L) levels in the air samples were determined. The statistical module "Multiple regression" was used for assessing the response of functional parameters of the respiratory system. Results. The analysis of one-factor and multi-factor regression models made it possible to identify both trigger factors of dust and technogenic air pollution and the synergistic effect of the influence of dominant factors. It has been shown that multifactorial reactions to technogenic impact manifest as altered blood oxygen saturation and carboxyhemoglobin level and thereby contribute to the development of respiratory failure. Conclusion. Patients with COPD exhibited increased bronchial resistance to the effect of the trigger factor (Pb – 1 hazard class) associated with high motorization of the city. The response of pulmonary gas exchange (SaO2 ) to Pb in the control group indicates prolonged exposure to toxic metals can cause developing respiratory failure even in the healthy population of the city.

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