scholarly journals Vitamin D Intoxication and Nephrocalcinosis in a Young Breastfed Infant

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Abdullah Al-Kandari ◽  
Hussain Sadeq ◽  
Rita Alfattal ◽  
Maryam AlRashid ◽  
Mayra Alsaeid
Keyword(s):  
Vitamin D ◽  
Side Effects ◽  
Calcium Level ◽  
Bone Development ◽  
Phosphate Metabolism ◽  
Vitamin D Intoxication ◽  
History Of ◽  
Potential Risks ◽  
Vitamin D Supplements ◽  
Calcium And Phosphate Metabolism

Numerous studies were performed assessing the benefits and side effects of vitamin D. Vitamin D helps in regulating the calcium and phosphate metabolism leading to a healthy mineral and bone development. Vitamin D intoxication is an uncommon event that leads to hypercalcemia which can be associated with both immediate and late morbidities that can cause severe renal complications. Here, we present a case of a 4-month-old girl with a history of decreased feed and activity due hypercalcemia and high vitamin D level, which led to nephrocalcinosis. The patient received IV fluids, IV diuretics, methylprednisolone, and bisphosphonate in order to normalize the calcium level in blood. With clear verbal and written instructions for the dosage and administration of vitamin D supplements, as well as clear warnings of the potential risks of overdose, vitamin D intoxication could be an easily avoidable condition.

scholarly journals VITAMIN D INTOXICATION IN INFANTS WITH VITAMIN D SUPPLEMENTS

2020 ◽  
Vol 10 (1) ◽  
pp. 67-71
Author(s):  
Awat J. Mustafa ◽  
◽  
Aso F. Salih ◽  
Keyword(s):  
Vitamin D ◽  
Vitamin D Intoxication ◽  
Vitamin D Supplements

scholarly journals Vitamin D Intoxication in An Elderly: A Case Report

2019 ◽  
Vol 3 (4) ◽  
pp. 147-149
Author(s):  
Sahil Singh ◽  
Prernika Mittal ◽  
Ajay Sharma
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
High Serum ◽  
Intravenous Fluids ◽  
Serum Vitamin D ◽  
Replacement Surgery ◽  
Vitamin D Intoxication ◽  
History Of ◽  
Very High

Vitamin D is a very common prescribed drug for numerous indications. Due to scarce knowledge and poor awareness of the various formulations, preparations and dosages of Vitamin D, there are many chances of prescription errors, medication errors, product use issue and undesirable adverse drug reactions. We hereby detail case of 70-year-old ex-army gentleman reported to us with a history of lethargy, confusion, reduced appetite and gait imbalance since few days with a history of knee replacement surgery 2 years back. Medical history was not of much relevance before it was revealed that he was getting cholecalciferol injection with a strength of 600000 IU once a week for few months. He was detected to have very high serum vitamin D level and hypercalcemia. He was started on intravenous fluids, diuretics and glucocorticoids. In a few days, after effective treatment, the patient was discharged in a recovering stage and advised to stop intake calcium and vitamin D in any form. At his last follow up, after a few months of discharge, he had totally recovered.

scholarly journals INFLUENCE OF SUNSHINE ON THE SERUM LEVELS OF VITAMIN D

2019 ◽  
Vol 31 (4) ◽  
pp. 1081-1085
Author(s):  
Ivelina Dobreva ◽  
Pavlina Teneva ◽  
Valya Trencheva
Keyword(s):  
Vitamin D ◽  
Mental Illness ◽  
Sunshine Duration ◽  
Geographic Location ◽  
Serum Levels ◽  
Phosphate Metabolism ◽  
Direct Sunlight ◽  
Direct Exposure ◽  
Study Participants ◽  
Calcium And Phosphate Metabolism

Vitamin D - anti-rheumatic vitamin - directly related to calcium and phosphate metabolism and bone formation. In recent years, it has been proven to be much more important because it also has an impact on cells of the immune system, heart, endocrine and muscle cells. Vitamin deficiency also involves mental illness such as depression and schizophrenia. For the synthesis of enough vitamin D it is necessary to have a daily, all year round direct exposure to direct sunlight for at least 20-30 minutes a day. The geographic location of Republic of Bulgaria provides the average annual sunshine duration around 2150 hours and it is about 49% of the maximum possible sunshine. However, the majority (58.33%) of the study participants had a "deficiency" in serum levels of vitamin D, snd there is also a large percentage of those who are less often outdoors.

scholarly journals Vitamin D Review: The Low Hanging Fruit for Human Health

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Lucy N. W. Mungai ◽  
Zanuba Mohammed ◽  
Michuki Maina ◽  
Omar Anjumanara
Keyword(s):  
Vitamin D ◽  
Cell Death ◽  
Immune Regulation ◽  
The Body ◽  
The Sun ◽  
Biological Processes ◽  
Phosphate Metabolism ◽  
Vitamin D Levels ◽  
Bone Mineralisation ◽  
Calcium And Phosphate Metabolism

Vitamin D is an important hormone that is known for the regulation of calcium and phosphate metabolism. Vitamin D deficiency leads to rickets in children and osteoporosis in adults leading to poor bone mineralisation and can also lead to serious dental complications in the same population. Recent studies have shown vitamin D to work as a hormone needed not only in bone and teeth but also in other body organs from intrauterine life up to old age. It has been demonstrated that Vitamin D has various effects on biological processes that deal with cell growth, differentiation, cell death, immune regulation, DNA stability, and neuronal growth. Despite being readily formed in the body through the intervention of the sun, patients are still found to have low vitamin D levels. We review studies done to show how vitamin D works.

Artefactual 25-OH vitamin D concentration in multiple myeloma

2017 ◽  
Vol 54 (6) ◽  
pp. 716-720 ◽  
Author(s):  
Michal WS Ong ◽  
Rashim Salota ◽  
Tracy Reeman ◽  
Marta Lapsley ◽  
Lydia Jones
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Rheumatoid Factor ◽  
Reference Method ◽  
Sun Exposure ◽  
High Concentration ◽  
History Of ◽  
High Concentrations ◽  
Vitamin D Supplements ◽  
25 Oh Vitamin D

The most commonly used techniques to measure vitamin D are automated immunoassays which are known to be affected by interferences, especially from immunoglobulins present in the patient’s serum. We present a case of a patient with myeloma in whom interference with the vitamin D assay was identified. An 83-year-old female, known to have IgG myeloma, was found to have a high concentration of 25-OH vitamin D on a routine test without any signs of vitamin D toxicity. She was not taking vitamin D supplements or any other multivitamin preparation and had minimal sun exposure. The initial and subsequent samples run by the ARCHITECT 25-OH vitamin D assay (chemiluminescent microparticle immunoassay technology, Abbott Laboratories, Abbott Park, IL) showed a high concentration of 25-OH vitamin D of 281 nmol/L and 327 nmol/L, respectively. Further fresh samples taken for 25-OH vitamin D and analysed by liquid chromatography-mass spectrometry (LC-MS/MS) and ARCHITECT analysis showed results of 49 nmol/L and 289 nmol/L, respectively. Our patient had high concentrations of circulating IgG paraproteins and had a long history of rheumatoid arthritis; paraproteins and rheumatoid factor may interfere in the assay. In conclusion, we report a case of a patient with IgG myeloma and rheumatoid arthritis with high concentrations of 25-OH vitamin D detected by the Abbott ARCHITECT, but not by a reference method (LC-MS/MS). The most likely cause of the discordant results is interference in the immunoassay by the paraprotein but interference from rheumatoid factor remains a possibility.

scholarly journals Non-Skeletal Activities of Vitamin D: From Physiology to Brain Pathology

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 341 ◽  
Author(s):  
Giulia Bivona ◽  
Luisa Agnello ◽  
Chiara Bellia ◽  
Giorgia Iacolino ◽  
Concetta Scazzone ◽  
...  
Keyword(s):  
Vitamin D ◽  
Brain Function ◽  
Clinical Care ◽  
Phosphate Metabolism ◽  
Brain Pathology ◽  
Reference Measurement ◽  
The Past ◽  
Vitamin D Levels ◽  
Calcium And Phosphate Metabolism

Vitamin D is a secosteroid hormone regulating the expression of almost 900 genes, and it is involved in the regulation of calcium and phosphate metabolism, immune response, and brain development. Low blood vitamin D levels have been reported in patients affected by various diseases. Despite a large amount of literature data, there is uncertainty surrounding the role of vitamin D as a serum biomarker in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Indeed, the lack of internationally recognized 25(OH)D3 reference measurement procedures and standard materials in the past led to unstandardized serum total 25(OH)D3 results among research and clinical care laboratories. Thus, most of the literature studies reported unstandardized data, which are of little use and make it difficult to draw conclusions of the role of vitamin D in AD and PD. This review summarizes the extra-skeletal actions of vitamin D, focusing its role in immunomodulation and brain function, and reports the issue of lacking standardized literature data concerning the usefulness of vitamin D as a biomarker in AD and PD.

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