scholarly journals INFLUENCE OF SUNSHINE ON THE SERUM LEVELS OF VITAMIN D

2019 ◽  
Vol 31 (4) ◽  
pp. 1081-1085
Author(s):  
Ivelina Dobreva ◽  
Pavlina Teneva ◽  
Valya Trencheva
Keyword(s):  
Vitamin D ◽  
Mental Illness ◽  
Sunshine Duration ◽  
Geographic Location ◽  
Serum Levels ◽  
Phosphate Metabolism ◽  
Direct Sunlight ◽  
Direct Exposure ◽  
Study Participants ◽  
Calcium And Phosphate Metabolism

Vitamin D - anti-rheumatic vitamin - directly related to calcium and phosphate metabolism and bone formation. In recent years, it has been proven to be much more important because it also has an impact on cells of the immune system, heart, endocrine and muscle cells. Vitamin deficiency also involves mental illness such as depression and schizophrenia. For the synthesis of enough vitamin D it is necessary to have a daily, all year round direct exposure to direct sunlight for at least 20-30 minutes a day. The geographic location of Republic of Bulgaria provides the average annual sunshine duration around 2150 hours and it is about 49% of the maximum possible sunshine. However, the majority (58.33%) of the study participants had a "deficiency" in serum levels of vitamin D, snd there is also a large percentage of those who are less often outdoors.

scholarly journals ABNORMALITY IN SERUM CALCIUM, PHOSPHATE AND VITAMIN-D LEVELS IN CHRONIC RENAL FAILURE PATIENTS: A CASE CONTROL STUDY IN THE EASTERN INDIAN POPULATION

2021 ◽  
pp. 5-7
Author(s):  
Chinmoy Ghosh ◽  
Sandip Chakraborty ◽  
Arnab Ghosh ◽  
Sayantan Dasgupta
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Calcium Phosphate ◽  
Serum Levels ◽  
Vitamin D Levels ◽  
Important Health ◽  
Calcium Phosphorus ◽  
Healthy Control ◽  
Study Participants

Chronic renal failure (CRF) is one of the most important health problems in our population. From the early stages of the disease progression, the activation of Vitamin D in kidney is affected, resulting in abnormality in the regulation of calcium and phosphate homeostasis in the blood. In the present study, 30 Chronic Renal Failure patients visiting Nephrology OPD and 30 age and sex matched volunteers were studied. Serum levels of Urea, Creatinine, Calcium, Phosphate and Vitamin D were measured in the study participants. The data after statistical analysis showed signicantly higher levels of Phophate and signicantly lower levels of Calcium and Vitamin D in the CRF patients in comparison to healthy control subjects. Phosphate and Vitamin D also shows signicant correlation with serum creatinine levels in the CRF patients. The present study conrms the abnormality in Calcium-Phosphorus metabolism as a complication of CRF in our population, and highlights the importance of regularly measuring these parameters in CRF patients and possible need of taking corrective measures in this regard.

scholarly journals Vitamin D Review: The Low Hanging Fruit for Human Health

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Lucy N. W. Mungai ◽  
Zanuba Mohammed ◽  
Michuki Maina ◽  
Omar Anjumanara
Keyword(s):  
Vitamin D ◽  
Cell Death ◽  
Immune Regulation ◽  
The Body ◽  
The Sun ◽  
Biological Processes ◽  
Phosphate Metabolism ◽  
Vitamin D Levels ◽  
Bone Mineralisation ◽  
Calcium And Phosphate Metabolism

Vitamin D is an important hormone that is known for the regulation of calcium and phosphate metabolism. Vitamin D deficiency leads to rickets in children and osteoporosis in adults leading to poor bone mineralisation and can also lead to serious dental complications in the same population. Recent studies have shown vitamin D to work as a hormone needed not only in bone and teeth but also in other body organs from intrauterine life up to old age. It has been demonstrated that Vitamin D has various effects on biological processes that deal with cell growth, differentiation, cell death, immune regulation, DNA stability, and neuronal growth. Despite being readily formed in the body through the intervention of the sun, patients are still found to have low vitamin D levels. We review studies done to show how vitamin D works.

scholarly journals Non-Skeletal Activities of Vitamin D: From Physiology to Brain Pathology

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 341 ◽  
Author(s):  
Giulia Bivona ◽  
Luisa Agnello ◽  
Chiara Bellia ◽  
Giorgia Iacolino ◽  
Concetta Scazzone ◽  
...  
Keyword(s):  
Vitamin D ◽  
Brain Function ◽  
Clinical Care ◽  
Phosphate Metabolism ◽  
Brain Pathology ◽  
Reference Measurement ◽  
The Past ◽  
Vitamin D Levels ◽  
Calcium And Phosphate Metabolism

Vitamin D is a secosteroid hormone regulating the expression of almost 900 genes, and it is involved in the regulation of calcium and phosphate metabolism, immune response, and brain development. Low blood vitamin D levels have been reported in patients affected by various diseases. Despite a large amount of literature data, there is uncertainty surrounding the role of vitamin D as a serum biomarker in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Indeed, the lack of internationally recognized 25(OH)D3 reference measurement procedures and standard materials in the past led to unstandardized serum total 25(OH)D3 results among research and clinical care laboratories. Thus, most of the literature studies reported unstandardized data, which are of little use and make it difficult to draw conclusions of the role of vitamin D in AD and PD. This review summarizes the extra-skeletal actions of vitamin D, focusing its role in immunomodulation and brain function, and reports the issue of lacking standardized literature data concerning the usefulness of vitamin D as a biomarker in AD and PD.

scholarly journals Vitamin D Intoxication and Nephrocalcinosis in a Young Breastfed Infant

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Abdullah Al-Kandari ◽  
Hussain Sadeq ◽  
Rita Alfattal ◽  
Maryam AlRashid ◽  
Mayra Alsaeid
Keyword(s):  
Vitamin D ◽  
Side Effects ◽  
Calcium Level ◽  
Bone Development ◽  
Phosphate Metabolism ◽  
Vitamin D Intoxication ◽  
History Of ◽  
Potential Risks ◽  
Vitamin D Supplements ◽  
Calcium And Phosphate Metabolism

Numerous studies were performed assessing the benefits and side effects of vitamin D. Vitamin D helps in regulating the calcium and phosphate metabolism leading to a healthy mineral and bone development. Vitamin D intoxication is an uncommon event that leads to hypercalcemia which can be associated with both immediate and late morbidities that can cause severe renal complications. Here, we present a case of a 4-month-old girl with a history of decreased feed and activity due hypercalcemia and high vitamin D level, which led to nephrocalcinosis. The patient received IV fluids, IV diuretics, methylprednisolone, and bisphosphonate in order to normalize the calcium level in blood. With clear verbal and written instructions for the dosage and administration of vitamin D supplements, as well as clear warnings of the potential risks of overdose, vitamin D intoxication could be an easily avoidable condition.

scholarly journals Oral intermittent Vitamin D substitution: Influence of pharmaceutical form and dosage frequency on medication adherence: A randomized clinical trial

2020 ◽  
Author(s):  
Jean-Pierre Rothen ◽  
Jonas Rutishauser ◽  
Philipp N Walter ◽  
Kurt E Hersberger ◽  
Isabelle Arnet
Keyword(s):  
Vitamin D ◽  
Focus Group ◽  
Serum Levels ◽  
Vitamin D Levels ◽  
Pharmaceutical Form ◽  
Secondary Endpoints ◽  
Monthly Administration ◽  
Solid Form ◽  
Study Participants ◽  
Dosage Frequency

Abstract Background: To assess adherence to and preference for vitamin D substitution with different pharmaceutical forms and frequencies of administration.Methods: A focus group of stakeholders aimed at preparing the design of an interventional, randomized, cross-over study with 2 x 2 groups obtaining monthly or weekly vitamin D products in liquid or solid form for 3 months each. Dosage corresponds to cumulated amount of recommended 800 IU daily (5.600 IU weekly / 24.000 IU monthly). Main inclusion criteria were a vitamin D serum value <50 nmol/l and age ≥18 years. Primary endpoint was adherence, secondary endpoints were preferences and vitamin D serum levels. Results: The focus group reached consensus for preference of a monthly administration of solid forms to adults. Full datasets were obtained from 97 participants. Adherence was significantly higher with monthly (79.5 – 100.0%) than weekly (66.4 – 98.1 %) administration. Vitamin D levels increased significantly (p<0.001) in all participants. An optimal value of >75 nmol/l was achieved by 32% after 3 months and by 50% after 6 months. Preferred formulation was solid form (tablets, capsules) for 71% of participants, and preferred dosage frequency was monthly for 39% of participants.Conclusions: Monthly oral vitamin D in solid form lead to the highest adherence, and is preferred by the participants. However, only one third of study participants achieved values in the optimal range of >75 nmol/l cholecalciferol using weekly or monthly administration providing an average daily cholecalciferol dose of 800 IU.

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