The Vitamin D Analog 1α,25-Dihydroxy-2β-(3-Hydroxypropyloxy) Vitamin D3 (Eldecalcitol) is a Potent Regulator of Calcium and Phosphate Metabolism

2011 ◽  
Vol 89 (5) ◽  
pp. 372-378 ◽  
Author(s):  
Alex J. Brown ◽  
Cynthia S. Ritter
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Phosphate Metabolism ◽  
Vitamin D Analog ◽  
Calcium And Phosphate Metabolism

scholarly journals INFLUENCE OF SUNSHINE ON THE SERUM LEVELS OF VITAMIN D

2019 ◽  
Vol 31 (4) ◽  
pp. 1081-1085
Author(s):  
Ivelina Dobreva ◽  
Pavlina Teneva ◽  
Valya Trencheva
Keyword(s):  
Vitamin D ◽  
Mental Illness ◽  
Sunshine Duration ◽  
Geographic Location ◽  
Serum Levels ◽  
Phosphate Metabolism ◽  
Direct Sunlight ◽  
Direct Exposure ◽  
Study Participants ◽  
Calcium And Phosphate Metabolism

Vitamin D - anti-rheumatic vitamin - directly related to calcium and phosphate metabolism and bone formation. In recent years, it has been proven to be much more important because it also has an impact on cells of the immune system, heart, endocrine and muscle cells. Vitamin deficiency also involves mental illness such as depression and schizophrenia. For the synthesis of enough vitamin D it is necessary to have a daily, all year round direct exposure to direct sunlight for at least 20-30 minutes a day. The geographic location of Republic of Bulgaria provides the average annual sunshine duration around 2150 hours and it is about 49% of the maximum possible sunshine. However, the majority (58.33%) of the study participants had a "deficiency" in serum levels of vitamin D, snd there is also a large percentage of those who are less often outdoors.

scholarly journals Simultaneous Synthesis of Vitamins D2, D4, D5, D6, and D7 from Commercially Available Phytosterol, β-Sitosterol, and Identification of Each Vitamin D by HSQC NMR

Metabolites ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 107
Author(s):  
Shiro Komba ◽  
Eiichi Kotake-Nara ◽  
Wakako Tsuzuki
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Chemical Industry ◽  
Chemical Shifts ◽  
Vitamin D Analogs ◽  
Vitamin D Analog ◽  
Simultaneous Synthesis ◽  
The Difference ◽  
Pure Cholesterol ◽  
Tokyo Chemical Industry

We succeeded in simultaneously synthesizing the vitamin D family, vitamins D2, D4, D5, D6, and D7, from β-sitosterol, which is sold as a commercially available reagent from Tokyo Chemical Industry Co., Ltd. It is officially sold as a mixture of four phytosterols {β-sitosterol (40–45%), campesterol (20–30%), stigmasterol, and brassicasterol}. Owing to this, we anticipated that, using this reagent, various vitamin D analogs could be synthesized simultaneously. We also synthesized vitamin D3 from pure cholesterol and analyzed and compared all vitamin D analogs (D2, D3, D4, D5, D6, and D7) by HSQC NMR. We succeeded in clearly demonstrating the difference in the NMR chemical shifts for each vitamin D analog.

scholarly journals Vitamin D Review: The Low Hanging Fruit for Human Health

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Lucy N. W. Mungai ◽  
Zanuba Mohammed ◽  
Michuki Maina ◽  
Omar Anjumanara
Keyword(s):  
Vitamin D ◽  
Cell Death ◽  
Immune Regulation ◽  
The Body ◽  
The Sun ◽  
Biological Processes ◽  
Phosphate Metabolism ◽  
Vitamin D Levels ◽  
Bone Mineralisation ◽  
Calcium And Phosphate Metabolism

Vitamin D is an important hormone that is known for the regulation of calcium and phosphate metabolism. Vitamin D deficiency leads to rickets in children and osteoporosis in adults leading to poor bone mineralisation and can also lead to serious dental complications in the same population. Recent studies have shown vitamin D to work as a hormone needed not only in bone and teeth but also in other body organs from intrauterine life up to old age. It has been demonstrated that Vitamin D has various effects on biological processes that deal with cell growth, differentiation, cell death, immune regulation, DNA stability, and neuronal growth. Despite being readily formed in the body through the intervention of the sun, patients are still found to have low vitamin D levels. We review studies done to show how vitamin D works.

scholarly journals Non-Skeletal Activities of Vitamin D: From Physiology to Brain Pathology

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 341 ◽  
Author(s):  
Giulia Bivona ◽  
Luisa Agnello ◽  
Chiara Bellia ◽  
Giorgia Iacolino ◽  
Concetta Scazzone ◽  
...  
Keyword(s):  
Vitamin D ◽  
Brain Function ◽  
Clinical Care ◽  
Phosphate Metabolism ◽  
Brain Pathology ◽  
Reference Measurement ◽  
The Past ◽  
Vitamin D Levels ◽  
Calcium And Phosphate Metabolism

Vitamin D is a secosteroid hormone regulating the expression of almost 900 genes, and it is involved in the regulation of calcium and phosphate metabolism, immune response, and brain development. Low blood vitamin D levels have been reported in patients affected by various diseases. Despite a large amount of literature data, there is uncertainty surrounding the role of vitamin D as a serum biomarker in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Indeed, the lack of internationally recognized 25(OH)D3 reference measurement procedures and standard materials in the past led to unstandardized serum total 25(OH)D3 results among research and clinical care laboratories. Thus, most of the literature studies reported unstandardized data, which are of little use and make it difficult to draw conclusions of the role of vitamin D in AD and PD. This review summarizes the extra-skeletal actions of vitamin D, focusing its role in immunomodulation and brain function, and reports the issue of lacking standardized literature data concerning the usefulness of vitamin D as a biomarker in AD and PD.

Selective inhibition of cyclooxygenase-2 (COX-2) by 1α,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog

2008 ◽  
Vol 104 (5) ◽  
pp. 1832-1842 ◽  
Author(s):  
Rachamallu Aparna ◽  
Jagu Subhashini ◽  
Karnati R. Roy ◽  
G. Satyanarayana Reddy ◽  
Matthew Robinson ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Selective Inhibition ◽  
Cyclooxygenase 2 ◽  
Vitamin D Analog ◽  
Cox 2

scholarly journals Vitamin D Intoxication and Nephrocalcinosis in a Young Breastfed Infant

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Abdullah Al-Kandari ◽  
Hussain Sadeq ◽  
Rita Alfattal ◽  
Maryam AlRashid ◽  
Mayra Alsaeid
Keyword(s):  
Vitamin D ◽  
Side Effects ◽  
Calcium Level ◽  
Bone Development ◽  
Phosphate Metabolism ◽  
Vitamin D Intoxication ◽  
History Of ◽  
Potential Risks ◽  
Vitamin D Supplements ◽  
Calcium And Phosphate Metabolism

Numerous studies were performed assessing the benefits and side effects of vitamin D. Vitamin D helps in regulating the calcium and phosphate metabolism leading to a healthy mineral and bone development. Vitamin D intoxication is an uncommon event that leads to hypercalcemia which can be associated with both immediate and late morbidities that can cause severe renal complications. Here, we present a case of a 4-month-old girl with a history of decreased feed and activity due hypercalcemia and high vitamin D level, which led to nephrocalcinosis. The patient received IV fluids, IV diuretics, methylprednisolone, and bisphosphonate in order to normalize the calcium level in blood. With clear verbal and written instructions for the dosage and administration of vitamin D supplements, as well as clear warnings of the potential risks of overdose, vitamin D intoxication could be an easily avoidable condition.

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