scholarly journals Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Yunfeng Han ◽  
Yunan Xiang ◽  
Yi Shi ◽  
Xi Tang ◽  
Lin Pan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Drug Candidate ◽  
Therapeutic Effects ◽  
Diabetes Treatment ◽  
Pharmacological Activities ◽  
Good Therapeutic Effect ◽  
Study Results ◽  
Main Component ◽  
Diabetes Mellitus Treatment ◽  
Application Prospects

Traditional Chinese medicine (TCM) has good clinical application prospects in diabetes treatment. In addition, TCM is less toxic and/or has fewer side effects and provides various therapeutic effects. Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Berberidis Cortex). Furthermore, BBR can reduce blood sugar and blood fat, alleviate inflammation, and improve the state of patients. Based on the recent study results of BBR in diabetes treatment, the BBR pharmacokinetics and mechanism on diabetes are mainly studied, and the specific molecular mechanism of related experimental BBR is systematically summarized and analyzed. Clinical studies have proved that BBR has a good therapeutic effect on diabetes, suggesting that BBR may be a promising drug candidate for diabetes. More detailed BBR mechanisms and pathways of BBR need to be studied further in depth, which will help understand the BBR pharmacology in diabetes treatment.

scholarly journals Peer Support for Dietary Compliance Patients with Diabetes Mellitus

2020 ◽  
Vol 7 (3) ◽  
pp. 432-438
Author(s):  
Caturia Sasti Sulistyana
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Peer Support ◽  
Sampling Technique ◽  
Dietary Compliance ◽  
Study Results ◽  
Patients With Diabetes ◽  
Post Test ◽  
Sugar Levels ◽  
Diabetes Mellitus Treatment

Diabetes mellitus is one of chronic disease whose incidence increases. The success of diabetes mellitus treatment is strongly influenced by patient compliance to carry out treatment. The purpose of this study was to determine the effect of peer support on dietary compliance of diabetes mellitus sufferers at Randu Agung RW X. This study used pre-experiment one-group pre-post test design on sample of 28 diabetes mellitus sufferers in Randu Agung RW X, used purposive sampling technique. The instrument used Satuan Acara Kegiatan (SAK), attendance list, and compliance questionnaire of diabetes mellitus with 3J program. The analysis of the data used the Mc Nemar test. The statistical test results obtained P <0.05 (0.000), it meant H1 was accepted; there was an effect between peer support and dietary compliance in diabetes mellitus sufferers. Peer support is a new technique to control the blood sugar levels of people with diabetes by involving peers who have similar diseases to share experiences, provide support, and motivation so that enthusiasm in running their dietary increases. If someone sees other people successfully controlling their blood sugar levels through good dietary compliance, it will foster that person's enthusiasm to be able to comply with the diabetes mellitus dietary program. The implication of the study results is that providing education with peer support can help other people in similar situations to increase dietary compliance in diabetes mellitus sufferers.

Patient Perspectives on the Burden of Type 2 Diabetes Mellitus Treatment

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 726-P
Author(s):  
KRISTINA YU-ISENBERG ◽  
GEOF D. GRAY ◽  
CATHERINE FOLEY ◽  
JONATHAN T. STOKES ◽  
ALAN SHIELDS ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Patient Perspectives ◽  
Diabetes Mellitus Treatment

90-LB: Treatments and Trends in Glycemic Control for Patients with Type 2 Diabetes Mellitus Treatment following Metformin

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 90-LB
Author(s):  
SANJAY K. BAJPAI ◽  
RADHIKA NAIR ◽  
TICH CHANGAMIRE ◽  
RICHARD SHEER ◽  
QIANQIAN WANG ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Diabetes Mellitus Treatment

SGLT2 Inhibitors in Diabetes Mellitus Treatment

2017 ◽  
Vol 12 (1) ◽  
pp. 8-18 ◽  
Author(s):  
Juan Rosas-Guzman ◽  
Juan Rosas-Saucedo ◽  
Alma Romero-Garcia
Keyword(s):  
Diabetes Mellitus ◽  
Sglt2 Inhibitors ◽  
Diabetes Mellitus Treatment

Novel Swellable/Expandable Gastroretentive Floating Films of Gliclazide Folded in Capsule Shell for the Effective Management of Diabetes Mellitus: Formulation Development, Optimization and In vitro Evaluation

2020 ◽  
Vol 15 ◽  
Author(s):  
Diksha Sharma ◽  
Deepak Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Drug Absorption ◽  
Gastric Fluid ◽  
Stability Study ◽  
Gastric Retention ◽  
Effective Management ◽  
In Vitro Evaluation ◽  
Capsule Shell ◽  
Study Results

Background: Gliclazide (GLZ) belongs to the second-generation of sulphonylureas, is a drug of choice for the management of type II DM. It belongs to BCS Class II. The major site of drug absorption for GLZ is the stomach; it displayed variation in the drug absorption rate and bioavailability due to the shorter gastric retention time. Floating mechanism performance gets affected when the gastric fluid level not sufficiently higher, which ultimately obstructs the floating behavior, which is the major limitation of reported formulations. This limitation can get over by folded the film into the capsule shell that dissolved in gastric fluid and film swell/expands to dimensions higher than pylorus sphincter (12mm), thus prevents its evacuation. Objective: To explore the floating mechanism in the designing of films along with a tendency to expand by swelling and unfolding by utilizing a mixture of hydrophilic and hydrophobic polymer to achieve the controlled drug delivery and prolonged gastric retention of drug. Methods: The gastroretentive floating films were formulated by the solvent casting technique using 32 full factorial design and subjected to in vitro evaluation parameters, drug-excipient compatibility, X-ray diffraction and accelerated stability study. Results: The pre-formulation study established the purity and identification of drug. FTIR study confirmed no drug excipient interaction. F3, F6, and F9 were optimized based on in vitro floating characteristics, swelling/expanding ability, and unfolding time study. All developed formulations were unfolded within 14-22 min after capsule disintegration. The F3 was selected as final formulation as its ability to control the release of drug for 24 hrs followed by Zero-order kinetics having super case 2 transport. XRD confirmed the amorphousness of drug within formulation. The stability study results revealed that formulation was quite stable at extreme storage condition. Conclusion: The developed novel formulation has a good potential for the effective management and treatment of Diabetes Mellitus.

scholarly journals A Novel Approach to Pharmacy Practice Law Instruction

Pharmacy ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 75
Author(s):  
Matthew Deneff ◽  
Lisa M. Holle ◽  
Jill M. Fitzgerald ◽  
Kathryn Wheeler
Keyword(s):  
Student Perceptions ◽  
Pharmacy Practice ◽  
Pharmacy Education ◽  
Survey Study ◽  
State Laws ◽  
Institutional Review ◽  
Novel Approach ◽  
Study Results ◽  
Course Changes ◽  
Main Component

Pharmacy law instruction is often taught as a didactic course; however practical application of pharmacy law is a main component of pharmacy practice. Technology-based simulations are becoming more frequently used to enhance didactic pharmacy education. The goal of this study was to evaluate the utility of and student perceptions on the usefulness of MyDispense community pharmacy simulation for additional law instruction that if successful might prompt curricular revamping. This Institutional Review Board–approved, two-year, qualitative, prospective, survey study was conducted in a case study class where students completed MyDispense exercises focused on common legal issues that arise in practice, both individually before and within groups during class. Participating students completed a qualitative survey directed at use of MyDispense for pharmacy law review, which included a series of close-ended questions graded on a Likert scale and open-ended questions thematically grouped. Thirty-eight (41%) and twenty-eight (31%) students completed surveys in 2017 and 2018, respectively. The majority of respondents felt exercises improved their understanding of pharmacy laws, focused on challenging areas, and were more interesting than additional lectures. However, certain topics were reported as irrelevant based on practice experiences or not ideal for simulation, and students desired exercises on state laws versus pharmacy policies. Students reported the MyDispense simulation exercises helped them to recall pharmacy laws and focus on topics that were challenging. These study results prompted curricular revamping to incorporate MyDispense throughout the curriculum for practice in recognizing and solving legal scenarios, along with didactic course changes.

scholarly journals Ayurveda Body–Mind Constitutional Types and Role of Yoga Intervention Among Type 2 Diabetes Mellitus Population of Chandigarh and Panchkula Regions

2021 ◽  
pp. 097275312110000
Author(s):  
Madhava Sai Sivapuram ◽  
Vinod Srivastava ◽  
Navneet Kaur ◽  
Akshay Anand ◽  
Raghuram Nagarathna ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Profiles ◽  
Control Groups ◽  
Yoga Intervention ◽  
Positive Effects ◽  
Study Results ◽  
Significant Difference ◽  
And Control

Background: Type 2 diabetes needs a better understanding of etiological factors and management strategies based on lifestyle and constitutional factors, given its high association rate with many cardiovascular, neurological disorders, and COVID-19 infection. Purpose: The present study was undertaken to investigate the effect of Diabetes-specific integrated Yoga lifestyle Protocol (DYP) on glycemic control and lipid profiles of diabetic adults. Along with the DYP intervention, the individuals residing in Chandigarh and Panchkula union territories in the northern part of India were assessed for Ayurveda-based body–mind constitutional type. Ayurveda describes body–mind constitution as “ prakriti,” which has been discussed from two angles, namely physiological and psychological as body and mind are correlated. Methods: Cluster sampling of waitlist control study subjects was used as the sampling method for the study. A total of 1,215 registered subjects (81 diabetic) responded in randomly selected clusters in Chandigarh and Panchkula. Ayurveda physicians did Ayurveda body–mind constitutional assessment called prakriti assessment (physiological body–mind constitution assessment) in 35 participants (23 diabetic, 12 prediabetic) as a part of the study. Results: A group of 50 subjects was randomly selected for yoga intervention out of 81 diabetes mellitus adults, and 31 subjects were enrolled as waitlist controls. A significant decrease in the glycosylated hemoglobin levels from 8.49 ± 1.94% to 7.97 ± 2.20% in the intervention group was noticed. The lipid profiles of the DYP intervention and control groups were monitored. Three-month follow-up results of lipid profile diagnostic tests in intervention and control groups showed a significant difference between the two groups ( P < 0.05). Most diabetic and prediabetic individuals were found to have pitta dosha ( pitta controls all heat, metabolism, and transformation in the mind and body) as dominant constitution type. Conclusion: The study results demonstrated significant positive effects of yoga in diabetic individuals. This study has indicated the evidence for the safety and efficacy of the validated DYP for community-level interventions to prevent maladies like brain damage and stroke.

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