Clinical effects of triple therapy combined with traditional Chinese medicine in treatment ofHelicobacter pylori-associated chronic gastritis

2015 ◽  
Vol 23 (12) ◽  
pp. 1963
Author(s):  
Han-Zhou Wu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Triple Therapy ◽  
Chronic Gastritis ◽  
Clinical Effects

scholarly journals Study on the Mechanism of Lianpu Drink for the Treatment of Chronic Gastritis Based on Network Pharmacology

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Shuhan Zhou ◽  
Yanjun Duan ◽  
Yu Deng ◽  
Miao Wang ◽  
Chaoqun Huang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Signaling Pathway ◽  
Chronic Gastritis ◽  
Mechanisms Of Action ◽  
Network Pharmacology ◽  
Biological Pathway ◽  
Disease Network ◽  
Target Disease ◽  
Compound Target

Chronic gastritis (CG) places a considerable burden on the healthcare system worldwide. Traditional Chinese Medicine (TCM) formulas characterized by multicompounds and multitargets have been acknowledged with striking effects in the treatment of CG in China’s history. Nevertheless, their accurate mechanisms of action are still ambiguous. In this study, we analyzed the effective compounds, potential targets, and related biological pathway of Lianpu Drink (LPD), a TCM formula which has been reported to have a therapeutic effect on CG, by contrasting a “compound-target-disease” network. According to the results, 92 compounds and 5762 putative targets of LPD were screened; among them, 8 compounds derived from different herbs in LPD and 30 common targets related to LPD and CG were selected as candidate compounds and precision targets, respectively. Meanwhile, the predicted common targets were verified by Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway analysis and pharmacological experiments. The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and β-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins. The study provides evidence for the mechanism of understanding of LPD for the treatment of CG.

scholarly journals Chinese star anise and anise, magic herbs in traditional Chinese medicine and modern pharmaceutical science

2019 ◽  
Vol 5 (3) ◽  
pp. 162-179 ◽  
Author(s):  
Mohamad Hesam Shahrajabian ◽  
Wenli Sun ◽  
Qi Cheng
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Antioxidant Activities ◽  
Antimicrobial Properties ◽  
Sweet Taste ◽  
Clinical Effects ◽  
Plant Oil ◽  
Pharmaceutical Science ◽  
Star Anise ◽  
Asian Medicine

Star anise (Illicium verum Hook. f.) is an important herb in traditional Chinese medicine as well as traditional Asian medicine. The fruit is aromatic and has a strong, pungent and mildly sweet taste. Star anise is one of the many species that contain bioactive compounds as well as a number of phenolic and flavonoid compounds, having antioxidant, preservative and antimicrobial properties. All relevant papers in the English language from researchers of different countries were collected. The keywords of Chinese star anise, anise, traditional Chinese medicine and modern pharmaceutical science were searched in Google Scholar, Scopus, Research Gate and PubMed. Its seeds are good source of minerals like calcium, iron, copper, potassium, manganese, zinc, and magnesium. The essential oil of Chinese star anise contains anethole which has shown several functional properties including antimicrobial, antioxidant, hypoglycemic, hypolipidemic and oestrogenic properties. Due to all positive characteristics, such as antidiabetic, hypolipidemic, antioxidant activities, anticancer and antimicrobial properties, both seeds and essential oils of anise is promising for safe use as super food supplements and raw constituents in the both pharmaceutical and food industries. Anise seed oil contains anethol, estragole, eugenol, pseudisoeugenol, methyl chavicol and anisaldehyde, coumarins, scopoleting, umbelliferon, estrols, terpene hydrocarbons, and polyacetylenes as the major compounds. The plant oil has both pharmacological and clinical effects. The pharmacological effects consist of antimicrobial, hepatopreotective, anticonvulsant, anti-inflammatory, antispasmodic, bronchodilator, estrogenic, expectorant and insecticidal effects, and clinical effects such as nausea, constipation, menopausal period, virus, diabetes, obesity and sedative action. Combined with a nutritious diet, other traditional Chinese and Asian medicine, Chinese star anise and ansie seed may improve various aspects of health. More clinical studies are necessary to uncover the numerous substances and their effects in ginseng that contribute to public health. Asian J. Med. Biol. Res. June 2019, 5(3): 162-179

The Current Application of LC-MS/MS in Pharmacokinetics of Traditional Chinese Medicines (Recent Three Years): A Systematic Review

2020 ◽  
Vol 21 (12) ◽  
pp. 969-978
Author(s):  
Yang Wang ◽  
Lu Zhang ◽  
Shuang Gu ◽  
Zhaorui Yin ◽  
Zhe Shi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
High Sensitivity ◽  
High Specificity ◽  
Chemical Components ◽  
Clinical Effects ◽  
High Throughput Analysis ◽  
Current Application

Background: With significant clinical effects, traditional Chinese medicine (TCM) has been attracting increasing interest of the world’s scientific community. However, TCM contains immense amounts of chemical components. It is a great challenge to objectively evaluate the correlation between the in vivo process and the therapeutic effect of TCM. The purpose of this systematic review was to summarize the recent investigation (from 2017 to 2019) on preclinical pharmacokinetics (PK) of TCM via liquid chromatography coupled with mass spectrometry (LC-MS/MS). Method: We reviewed the published articles regarding the PK of TCM by LC-MS/MS. In addition, we summarized information on PK parameter of bioactive components, single herb and traditional Chinese medicine prescriptions. Results: The vast majority of literature on preclinical PK of TCM uses single oral administration, the biological matrix is mostly rat plasma, and the main PK parameters include AUC, Cmax, Tmax and T1/2, etc. Conclusion: Although LC-MS/MS can be used for high-throughput analysis, the characterization of in vivo processes of TCM still has a long way. With the advantages of high sensitivity, high specificity and simple operation, the increasingly mature LC-MS/MS technology will play an important role in the PK study of TCM.

Revealing the potential pharmacological mechanism of traditional Chinese medicine by integrating metabolite profiling of Q-marker and network pharmacology, prim-O-glucosylcimifugin as an example

2021 ◽  
Author(s):  
Fengxiang Zhang ◽  
Yu-Lin-Lan Yuan ◽  
Shuang-shuang Cui ◽  
Guanhua Wang ◽  
Rui-man Li
Keyword(s):  
Quality Control ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Metabolite Profiling ◽  
Network Pharmacology ◽  
Clinical Effects ◽  
Pharmacological Mechanism

Along with the definite clinical effects, traditional Chinese medicine (TCM) increasingly gains worldwide attention. Quality control marker (Q-marker) is always used to confirm the primary effects of herbs or TCM....

Fuzzy model based on local injection of MTX combined with traditional Chinese medicine guided by ultrasound intervention to treat CSP

2021 ◽  
pp. 1-11
Author(s):  
Hong Zhao ◽  
Meiyan Li ◽  
Fen Tian ◽  
Li Zhang ◽  
Junnan Lv ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Conservative Treatment ◽  
Cesarean Section ◽  
Machine Vision ◽  
Fuzzy Model ◽  
The Body ◽  
Clinical Effects ◽  
Bp Network ◽  
Control Plan

In view of pregnancy at the uterine scar after cesarean section, there is an urgent need to find a conservative treatment mode with drugs that can improve the success rate of treatment, shorten the conservative treatment time, and cause little harm to the body. This research combines ultrasound intervention technology to construct a fuzzy model to comprehensively evaluate the clinical effects of traditional Chinese medicine combined with western medicine in the treatment of CSP. Moreover, this research combines the current application algorithms of machine vision to explain the relevant principles of ultrasound interventional vision. In addition, this research uses the background subtraction method to extract the target, and uses the machine vision algorithm to extract the ultrasonic detection target object. Finally, this research adjusts the control parameters according to the fuzzy control, and outputs the optimal control plan with BP network training. The results of this study show that the combination of Chinese and Western medicines in the treatment of uterine scars after cesarean section has the advantages of small gestational sacs, short pregnancy, and low blood β-HCG, and it has the advantages of less pain, economy, fewer side effects, and successfully preserves the uterus. Therefore, it is worthy of clinical application.

scholarly journals Utilization of traditional Chinese medicine in the intensive care unit

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Xia Zhang ◽  
Mingqi Wang ◽  
Wen Wang ◽  
Ling Li ◽  
Xin Sun
Keyword(s):  
Intensive Care ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Herbal Medicines ◽  
Patient Characteristics ◽  
Cross Sectional Study ◽  
Critical Conditions ◽  
Clinical Effects ◽  
Cross Sectional ◽  
Icu Patients

AbstractPrevious studies showed that traditional Chinese medicine (TCM) may be effective for patients with critical conditions. However, the extent to which TCM is used in intensive care units (ICUs) remains less investigated. This study aimed to investigate the utilization of TCM among ICU patients. Using a cross-sectional study design, we examined the use of TCMs among ICU patients. The data were from a well-established ICU registry from a large teaching hospital in west China. Our study found that TCM was widely used among ICU, in particular TCM injections and oral liquids. The use of TCM often differed by ICUs, and TCM injections and oral liquids were mostly used in neurological ICU, while Chinese herbal medicines (CHMs) were often used in general ICU. The use of TCM was also highly associated with patient characteristics. Patients with pancreatitis were administered with most TCM, patients with cerebrovascular disease with most TCM injections and those with chronic renal failure with most oral liquids. Future efforts should include generation of high-quality evidence guidelines about clinical effects of TCM interventions among ICU patients.

scholarly journals Traditional Chinese medicine in treating IgA nephropathy: from basic science to clinical research

2021 ◽  
Vol 9 (3) ◽  
pp. 161-167
Author(s):  
Xin-hui Wang ◽  
Rui Lang ◽  
Ying Liang ◽  
Qin Zeng ◽  
Nan Chen ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Iga Nephropathy ◽  
Basic Science ◽  
Mesangial Cells ◽  
Herbal Medicines ◽  
Clinical Effects ◽  
Glomerular Mesangial Cells ◽  
High Quality Research ◽  
Pharmacological Mechanism

Abstract IgA nephropathy (IgAN) is a major cause of chronic kidney disease (CKD) and end-stage renal disease worldwide. Currently, clinical interventions for IgAN are limited, and many patients seek out alternative therapies such as traditional Chinese medicine (TCM). In the last several years, TCM has accumulated ample application experiences and achieved favorable clinical effects. This article summarizes high-quality research from basic science to clinical applications aimed to provide more evidence-based medicine proof for the clinical treatment of IgAN. In summary, qi and yin deficiency accounted for the largest proportion in IgAN patients, and the treatment of IgAN should be based on supplementing qi and nourishing yin. Further, for patients with severe IgAN, the treatment combination of Chinese and Western medicines is better than pure Chinese medicine or hormone therapy. In addition, the pharmacological mechanism of Chinese herbal medicines is mostly based on restoring the immune function, relieving the inflammation damage, and inhibiting proliferation of the glomerular mesangial cells.

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