scholarly journals A Longitudinal Study of the Metabolic Syndrome and Risk of Postmenopausal Breast Cancer

2009 ◽  
Vol 18 (7) ◽  
pp. 2046-2053 ◽  
Author(s):  
Geoffrey C. Kabat ◽  
Mimi Kim ◽  
Rowan T. Chlebowski ◽  
Janu Khandekar ◽  
Marcia G. Ko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Longitudinal Study ◽  
Postmenopausal Breast Cancer ◽  
The Metabolic Syndrome

scholarly journals Minireview: Obesity and Breast Cancer: A Tale of Inflammation and Dysregulated Metabolism

2013 ◽  
Vol 27 (5) ◽  
pp. 715-725 ◽  
Author(s):  
Evan R. Simpson ◽  
Kristy A. Brown
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Postmenopausal Breast Cancer ◽  
Breast Tumors ◽  
The Other ◽  
Cellular Mechanisms ◽  
Related Factors ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
The One

Abstract In addition to the spectrum of conditions known collectively as the Metabolic Syndrome, obesity is now recognized to be associated with increased risk of several cancers including colon, endometrial, and breast cancer. Obesity and carcinogenesis share 2 characteristics in common. On the one hand, they involve inflammatory pathways, and on the other hand, they involve dysregulated metabolism. In this review we focus on postmenopausal breast cancer and discuss the metabolic and cellular mechanisms whereby obesity and breast cancer are related. Because a majority of postmenopausal breast tumors are estrogen responsive, we include a discussion of the action of obesity-related factors on estrogen formation within the breast.

scholarly journals A longitudinal study over 40 years to study the metabolic syndrome as a risk factor for cardiovascular diseases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lars Lind ◽  
Johan Sundström ◽  
Johan Ärnlöv ◽  
Ulf Risérus ◽  
Erik Lampa
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Longitudinal Study ◽  
Clinical Intervention ◽  
The Elderly ◽  
Adult Men ◽  
The Metabolic Syndrome ◽  
The Impact ◽  
Over 40 Years

AbstractThe impact of most, but not all, cardiovascular risk factors decline by age. We investigated how the metabolic syndrome (MetS) was related to cardiovascular disease (CVD) during 40 years follow-up in the Uppsala Longitudinal Study of Adult Men (ULSAM, 2,123 men all aged 50 at baseline with reinvestigations at age 60, 70, 77 and 82). The strength of MetS as a risk factor of incident combined end-point of three outcomes (CVD) declined with ageing, as well as for myocardial infarction, ischemic stroke and heart failure when analysed separately. For CVD, the risk ratio declined from 2.77 (95% CI 1.90–4.05) at age 50 to 1.30 (95% CI 1.05–1.60) at age 82. In conclusion, the strength of MetS as a risk factor of incident CVD declined with age. Since MetS was significantly related to incident CVD also at old age, our findings suggest that the occurrence of MetS in the elderly should not be regarded as innocent. However, since our data were derived in an observational study, any impact of MetS in the elderly needs to be verified in a randomized clinical intervention trial.

Dexamethasone decreases the autotaxin‐lysophosphatidate‐inflammatory axis in adipose tissue: implications for the metabolic syndrome and breast cancer

2018 ◽  
Vol 33 (2) ◽  
pp. 1899-1910 ◽  
Author(s):  
Guanmin Meng ◽  
Xiaoyun Tang ◽  
Zelei Yang ◽  
Yuan Yuan Zhao ◽  
Jonathan M. Curtis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
The Metabolic Syndrome

scholarly journals Prevalence of Metabolic Syndrome among Breast Cancer Survivors in East Coast of Peninsular Malaysia

2021 ◽  
Author(s):  
Mohd Razif Shahril ◽  
Syed Amirfaiz ◽  
Pei Lin Lua ◽  
Ali Nurnazahiah ◽  
Nor Syamimi Zakarai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
East Coast ◽  
Fasting Blood Glucose ◽  
Peninsular Malaysia ◽  
The Metabolic Syndrome ◽  
Metabolic Syndrome Components

Abstract Background: To date, limited data are available on metabolic syndrome prevalence among breast cancer survivors in Malaysia. Therefore, this study was conducted to determine the prevalence of metabolic syndrome and abnormal metabolic syndrome components among breast cancer survivors in East Coast of Peninsular Malaysia. Methods: This cross-sectional study included 95 breast cancer survivors (age 53.7±7.6 years) who have completed main cancer treatments for ≥6 months. Cancer survivors were recruited from two main government hospitals in Kelantan and Terengganu using a purposive sampling method. Results: According to the Harmonized criteria, the metabolic syndrome prevalence was 50.5%. Among those with metabolic syndrome, the most prevalent abnormal metabolic components were triglycerides (91.2%), fasting blood glucose (79.6%) and HDL-c level (78.4%). Except for total cholesterol and LDL-c, all other metabolic syndrome components were significantly different (p<0.05) between those with and without metabolic syndrome. Significant differences between metabolic syndrome and non-metabolic syndrome groups were found for weight, BMI, waist circumference, body fat percentage and cancer stages (p<0.05). However, no significant relationship was reported between sociodemographic, clinical parameters and metabolic syndrome among breast cancer survivors in this study. Conclusions: Metabolic syndrome was highly prevalent among breast cancer survivors. It is recommended for health care professionals to closely monitor and improve the triglycerides, blood glucose and HDL-c level of the breast cancer survivors under their care to control the detrimental effect of metabolic syndrome.

scholarly journals A longitudinal study of the metabolic syndrome and risk of colorectal cancer in postmenopausal women

2012 ◽  
Vol 21 (4) ◽  
pp. 326-332 ◽  
Author(s):  
Geoffrey C. Kabat ◽  
Mimi Y. Kim ◽  
Ulrike Peters ◽  
Marcia Stefanick ◽  
Lifang Hou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metabolic Syndrome ◽  
Longitudinal Study ◽  
Postmenopausal Women ◽  
The Metabolic Syndrome

Cardiorespiratory Fitness, Macronutrient Intake, and the Metabolic Syndrome: The Aerobics Center Longitudinal Study

2006 ◽  
Vol 106 (5) ◽  
pp. 673-679 ◽  
Author(s):  
Carrie E. Finley ◽  
Michael J. LaMonte ◽  
Carol I. Waslien ◽  
Carolyn E. Barlow ◽  
Steven N. Blair ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Longitudinal Study ◽  
Cardiorespiratory Fitness ◽  
Macronutrient Intake ◽  
The Metabolic Syndrome ◽  
Aerobics Center Longitudinal Study

scholarly journals Is metabolic syndrome the link between obesity and postmenopausal breast cancer?

2010 ◽  
Vol 69 (OCE2) ◽  
Author(s):  
L. A. Healy ◽  
A. M. Ryan ◽  
P. Carroll ◽  
D. Ennis ◽  
T. Boyle ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Postmenopausal Breast Cancer

scholarly journals Comorbid pathology and prognosis of breast cancer in women in menopause.

2018 ◽  
Vol 96 (1) ◽  
pp. 55-59
Author(s):  
Nailya S. Asfandiyarova ◽  
E. P. Kulikov ◽  
A. S. Skopin ◽  
A. N. Demko ◽  
A. A. Nikiforov
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Arterial Hypertension ◽  
Visceral Obesity ◽  
Suppressor Cells ◽  
Cancer Prognosis ◽  
Lymph Node Status ◽  
Regional Lymph Nodes ◽  
The Metabolic Syndrome ◽  
Menopausal Women

Comorbid pathology is important in the survival of patients with breast cancer. The main aim of the present study was to investigate prognostic criteria of the 5-year survival menopausal women with breast cancer, including both the classic criteria (age, tumor size, lymph node status, hormonal status) and the presence of comorbid pathology (arterial hypertension, visceral obesity, diabetes mellitus, metabolic syndrome, immunodeficiency). A prospective cohort study included 98 patients with breast cancer (aged 63 ± 9 years, BMI 31.6 ± 4.8 kg/m2). Criteria favorable short-term (5 years) of the cancer prognosis of breast cancer in menopausal women are the size of the tumor less than 5 cm, the absence of metastases in regional lymph nodes, and the absence of the metabolic syndrome, dyslipidemia, high activity of suppressor cells. Age, anthropometric indices (BMI, waist circumference etc.), presence of arterial hypertension do not give information about the 5-year survival rate in breast cancer.

scholarly journals Role of physical activity and metabolic syndrome in determining the risk of postmenopausal breast cancer: a systematic review

2021 ◽  
Vol 8 (7) ◽  
pp. 3561
Author(s):  
Shuwaathi Thamil Manni ◽  
Amuthaganesh Mathialagan ◽  
Kanakeswary Karisnan ◽  
Calvin P. Noris
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Metabolic Syndrome ◽  
Postmenopausal Breast Cancer ◽  
Case Control Studies ◽  
Lifestyle Modifications ◽  
Eligibility Criteria ◽  
Increased Risk ◽  
Dose Response Effect

Physical activity (PA) and metabolic syndrome (MetS) have emerged as crucial factors in facilitating the incidence of postmenopausal (PM) breast cancer (BC). The association of PA, MetS and its components with PM BC was explored in this study. PRISMA guideline was followed and online databases were searched comprehensively to find relevant cohort and case-control studies until 18 February 2021 using keywords such as “physical activity”, “metabolic syndrome” and “breast cancer”. Eligible studies evaluating BC in postmenopausal women with a clear definition and measure of PA, MetS and its individual components were selected. A total of twenty-three articles related to PA and fifteen articles for MetS met the eligibility criteria and were assessed thoroughly. PA and MetS were significantly associated with PM BC. There was evidence of dose-response effect of PA and Mets on PM BC. Obesity, diabetes and dyslipidaemia were independently associated with PM BC and posed an increased risk on PM BC whereas the association of HPTN with PM BC was not prominent. Consistent and sustained long term PA throughout one’s lifetime was observed to decrease PM BC risk whereas increasing number of MetS components increased the risk of PM BC. Routine screening for PM women with ≥2 MetS components and obese or overweight women with any of the MetS components may be beneficial in early BC detection. Lifestyle modifications with emphasis on long term PA would be beneficial to public health in preventing and improving MetS outcomes as well as a primary prevention of sporadic PM BC.

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