scholarly journals X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis

2020 ◽  
Vol 26 (21) ◽  
pp. 5567-5578
Author(s):  
Rossella Tricarico ◽  
Emmanuelle Nicolas ◽  
Michael J. Hall ◽  
Erica A. Golemis
Author(s):  
K. . Togawa

Agricultural workers can be exposed to a wide variety of agents (e.g. pesticides), some of which may have adverse health effects, such as cancer. To study the health effects of agricultural exposures, an international consortium of agricultural cohort studies, AGRICOH, was established. The present analysis compared cancer incidence between the AGRICOH cohorts and the general population and found lower overall cancer incidence in the AGRICOH cohorts, with some variation across cohorts for specific cancer types. The observed lower cancer incidence may be due to healthy worker bias or lower prevalence of risk factors in the agricultural populations. Further analysis is underway.


Author(s):  
Romy F. Willemsen ◽  
Jessica McNeil ◽  
Emily Heer ◽  
Steven T. Johnson ◽  
Christine M. Friedenreich ◽  
...  

2020 ◽  
Vol 189 (9) ◽  
pp. 942-950
Author(s):  
Yejin Mok ◽  
Shoshana H Ballew ◽  
Yingying Sang ◽  
Josef Coresh ◽  
Corinne E Joshu ◽  
...  

Abstract Few studies have comprehensively investigated the association of 2 key kidney disease measures, estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR), with cancer incidence. In 8,935 participants at the baseline (1996–1998) from the Atherosclerosis Risk in Communities study, we quantified the associations of eGFR (based on creatinine and cystatin C) and ACR with cancer risk using Cox regression models adjusted for potential confounders. Due to changing guidelines for prostate cancer screening during the follow-up period, we investigated overall cancer, overall nonprostate cancer, and site-specific cancer. During a median follow-up of 14.7 years, 2,030 incident cancer cases occurred. In demographically adjusted models, low eGFR and high ACR were associated with cancer incidence (both overall and overall nonprostate cancer). These associations were attenuated after adjusting for other shared risk factors, with a significant association remaining only for ACR (≥103 compared with 5 mg/g) and overall nonprostate cancer. For site-specific cancer, only high ACR showed a significant association with lung and urinary tract cancers. Of these, the association between ACR and lung cancer appeared most robust in several sensitivity analyses. Kidney disease measures, particularly high ACR, were independently associated with cancer risk. The association between ACR and lung cancer was uniquely robust, warranting future studies to explore potential mechanisms.


2018 ◽  
Vol 27 (4) ◽  
pp. 391-398 ◽  
Author(s):  
Joséphine Bryere ◽  
Olivier Dejardin ◽  
Ludivine Launay ◽  
Marc Colonna ◽  
Pascale Grosclaude ◽  
...  

2003 ◽  
Vol 160 (6) ◽  
pp. 691-706 ◽  
Author(s):  
Lois B. Travis ◽  
Michael Hauptmann ◽  
Linda Knudson Gaul ◽  
Hans H. Storm ◽  
Marlene B. Goldman ◽  
...  

Author(s):  
Tomas Tanskanen ◽  
Karri J M Seppä ◽  
Anni Virtanen ◽  
Nea K Malila ◽  
Janne M Pitkäniemi

Abstract The world’s population is aging rapidly. This study reports the burden of cancer in the oldest old (≥85 years) in Finland in 1953-2017 and estimates age-specific cancer rates in the old population (65-99 years) in 1988-2017. The Finnish Cancer Registry provided data on all cancer diagnoses, cancer deaths and other deaths in cancer patients in Finland in 1953-2017. Between 1953-1957 and 2013-2017, the proportion of incident cancers in those aged ≥85 years increased from 1.5% to 9.6% (597 to 15,360 new cases), and in 2013-2017, more new cancers were diagnosed at age ≥85 years than age <50 years. Cancer incidence and excess mortality attributable to cancer peaked at age 85-94 years and declined subsequently, whereas cancer-specific mortality continued to increase or plateaued. Due to demographic changes, the number of new cancers in the oldest old has increased substantially in Finland, and currently, nearly one in 10 cancers are diagnosed in this age group. The increasing cancer burden in the oldest old poses a major challenge for healthcare and needs to be addressed in designing clinical research and reporting of cancer registries. In old populations with competing risks of death, we propose excess cancer mortality as a measure of cancer-related mortality.


he term cancer does not stand for a single disease, but represents a collection of diseases characterized by uncontrolled cell proliferation. Now a days cancer is one of the main disease to affect the human beings. Due to this is causes death. It is a challenging one to the society for their health problem. The main objective is to explore the design and trends of the cancer incidence in location of the nine regional cancer centers and cancer treatment facilities in the area. (ie., Coimbatore, Kanniyakumari, Salem, Thanjavur, Tirunelveli, Madurai, Trichy, Chennai, Kanchipuram).The cancer cases were separated district wise regional cancer centers for specific cancer sites and age-standardized incident rates were calculated for females. By using Mathematical Technique we found to the cancer incidence and age adjusted of cancer. ie) which district wise regional cancer centers higher in the cancer incidence and age adjusted and which district wise regional cancer centers least in the cancer incidence and age adjusted ?vvvv


2009 ◽  
Vol 11 (2) ◽  
Author(s):  
Bjørn Møller ◽  
Aage Andersen

<strong><span style="font-family: TimesNewRomanPS-BoldMT;"><font face="TimesNewRomanPS-BoldMT"><p align="left"> </p></font></span><p align="left"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">ENGLISH SUMMARY</span></span></p></strong><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><font face="TimesNewRomanPSMT" size="2"><font face="TimesNewRomanPSMT" size="2"><p align="left">Møller B, Andersen Aa.</p></font></font></span><font face="TimesNewRomanPSMT" size="2"><p align="left"> </p></font></span><p align="left"><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">Cancer and mortality among Norwegian chimney sweeps.</span></span></strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-ItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-ItalicMT;"><em><font face="TimesNewRomanPS-ItalicMT" size="2"><font face="TimesNewRomanPS-ItalicMT" size="2"><p align="left">Nor J Epidemiol</p></font></font></em></span><em><font face="TimesNewRomanPS-ItalicMT" size="2"><p align="left"> </p></font></em></span><p align="left"> </p></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">2001; </span></span><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">11 </span></span></strong><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">(2): 193-196.<p align="left">The aim of the study was to investigate cancer incidence and mortality among Norwegian chimney</p><p align="left">sweeps. A cohort of 1483 persons was established by collecting information about current and former</p><p align="left">chimney sweeps from all the local authorities. Information from housing censuses (HS) in 1960, 1970</p><p align="left">and 1980 were used to study the quality of the data. This revealed that the mortality among those chimney</p><p align="left">sweeps in HS that are included in our cohort is lower than the mortality among those not reported</p><p align="left">to us from the local authorities. Because of this, only a sub-cohort of 287 chimney sweeps from the</p><p align="left">largest cities were considered reliable. The uncertainty concerning risks for the different cancer sites in</p><p align="left">this group is large, since calculations are based on very few cases. The standardized incidence rate</p><p align="left">(SIR) for total cancer is 1.3 (95% CI: 1.0–1.8), and the standardized mortality rate (SMR) for all deaths</p><p align="left">is 1.2 (95% CI: 1.0–1.4). We also analyzed the 1292 persons who stated chimney sweep as occupation</p><p align="left">in the housing censuses in 1960, 1970 or 1980. SIR and SMR analyses in this group show no increased</p><p>risk for any specific cancer sites, nor for any cause specific death.</p></span></span></p>


Biometrics ◽  
2002 ◽  
Vol 58 (3) ◽  
pp. 492-501 ◽  
Author(s):  
Leonhard Knorr-Held ◽  
Günter Raßer ◽  
Nikolaus Becker

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