Abstract 4257: Dietary nutrient intake, ethnicity, and epigenetic silencing of lung cancer genes detected in sputum in New Mexican smokers

Background Assuming that the entire airway is affected by the same inhaled carcinogen, similar molecular alterations may occur in the lung and oral cavity. Thus, we hypothesized that DNA methylation profiles in the oral epithelium may be a promising biomarker for lung cancer risk stratification. Methods A methylation-specific polymerase chain reaction was performed on oral epithelium from 16 patients with lung cancer and 32 controls without lung cancer. Genes showing aberrant methylation profiles in the oral epithelium were compared between patients and controls. Results The analysis revealed that HOXD11 and PCDHGB6 were methylated more frequently in patients than in controls ( p = 0.0055 and p = 0.0247, respectively). Combined analyses indicated that 8 of 16 (50%) patients and 3 of 32 (9.4%) controls showed DNA methylation in both genes ( p = 0.0016). Among the population limited to current and former smokers, 6 of 11 (54.5%) patients showed methylation in both genes, compared to 1 of 17 (5.9%) controls ( p = 0.0037). In a subgroup analysis limited to the population above 50-years old, 8 of 16 (50%) patients and 2 of 16 (12.5%) controls showed methylation in both genes ( p = 0.0221). Conclusions The results of this study indicate that specific gene methylation in the oral epithelium might be a promising biomarker for lung cancer risk assessment, especially among smokers. Risk stratification through the analysis of DNA methylation profiles in the oral epithelium may be a useful and less invasive first-step approach in an efficient two-step lung cancer screening strategy.

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The Association between Daily Total Dietary Nutrient Intake and Recent Glycemic Control States of Non-Pregnant Adults 20+ Years Old from NHANES 1999–2018 (Except for 2003–2004)

Nutrients ◽

10.3390/nu13114168 ◽

2021 ◽

Vol 13 (11) ◽

pp. 4168

Author(s):

Yin Bai ◽

Hao Zhang ◽

Jie Yang ◽

Lei Peng

Keyword(s):

Glycemic Control ◽

Vitamin B6 ◽

Nutrient Intake ◽

Roc Analysis ◽

Glycosylated Hemoglobin ◽

Dietary Vitamin ◽

P Value ◽

Dependent Variables ◽

Dietary Nutrient ◽

Daily Total

(1) Background: Although daily total dietary nutrient intakes were potentially important factors in maintaining glycemic balance, their overall effect on glycemic control was still unclear among American adults. Objectives: We aimed to examine the association between daily total dietary nutrient intake and recent glycemic control status (RGCS). Methods: This cohort was composed of 41,302 individuals from the National Health and Nutrition Examination Survey (NHANES). The daily total intake of dietary nutrients and RGCS were independent and dependent variables, respectively. To evaluate their association, we carried out binary logistic regression, model fitting, linear discriminant analysis, and the receiver operator characteristic (ROC) analysis. Results: The result of robust check model showed that only the daily total dietary vitamin B6 intake (adjusted OR = 0.848; 95% CI: 0.738, 0.973; p-value = 0.019) was significantly negatively correlated with RGCS. When daily total dietary vitamin B6 intake and glycosylated hemoglobin (HbA1c) were used as independent variables and dependent variables, respectively, to fit the curves and lines, the established robust check model could distinguish American adults with different RGCS well. Moreover, the robust check model results of ROC analysis indicated that daily total dietary vitamin B6 intake might be a potential predictor for RGCS (AUC = 0.977; 95% CI: 0.974, 0.980; p-value < 0.001). (2) Conclusions: This study showed that only daily total dietary vitamin B6 intake was a beneficial factor in RGCS, but it might need further multicenter or prospective studies to verify whether vitamin B6 had biological implications and public health meaning for glycemic control among American adults (specifically referred to non-pregnant participants over 20 years old).

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Maternal Dietary Nutrient Intake During Pregnancy and Offspring Linear Growth and Bone: The Vitamin D in Pregnancy Cohort Study

Calcified Tissue International ◽

10.1007/s00223-016-0199-2 ◽

2016 ◽

Vol 100 (1) ◽

pp. 47-54 ◽

Cited By ~ 6

Author(s):

Natalie K. Hyde ◽

Sharon L. Brennan-Olsen ◽

John D. Wark ◽

Sarah M. Hosking ◽

Julie A. Pasco

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Nutrient Intake ◽

Linear Growth ◽

Pregnancy Cohort ◽

Dietary Nutrient ◽

In Pregnancy

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Abstract P078: Contribution of Nutrients from Consumption of Low/Non-Fat/Light Ice Cream and Frozen Yogurt versus Regular Ice Cream to Total Daily Nutrient Intake

Circulation ◽

10.1161/circ.125.suppl_10.ap078 ◽

2012 ◽

Vol 125 (suppl_10) ◽

Author(s):

Jessica Smerling ◽

Douglas Balentine ◽

Mary Kearney ◽

Carolyn Scrafford ◽

Leila Barraj ◽

...

Keyword(s):

Nutrient Intake ◽

Saturated Fat ◽

Ice Cream ◽

The United States ◽

United States Department ◽

Nutrient Intakes ◽

Frozen Yogurt ◽

Dietary Nutrient ◽

Nationally Representative ◽

The Impact

Objective: The impact on nutrient intake of replacing regular ice cream with low/non-fat/light ice cream and frozen yogurt (lower fat ice cream) is heretofore unknown. The objective of this study was to evaluate the contribution of daily nutrient intake from ice cream consumption to total daily dietary nutrient intake. Methods: Food intake and frequency of consumption data were based on the National Health and Nutrition Examination Survey (NHANES) (2003–2004 and 2005–2006) and nutrient composition data from the United States Department of Agriculture (USDA) Food and Nutrient Database for Dietary Studies (FNDDS). The NHANES datasets provide nationally representative nutrition and health data of the civilian U.S. population. A total of 16,783 individuals in the 2003–2006 survey periods provided 2 complete days of dietary recalls and nutrient intake estimates were derived using 2-day average intake analysis. Results: Mean consumption of regular and lower fat ice cream products in the US population was 68.5 and 77.1 grams/day, respectively and frequency of consumption was 0.2 and 0.22 eating occasion/day, respectively among consumers of ice cream. Figure 1 reveals that lower fat ice cream contributed equal or greater amounts of calcium, phosphorus, potassium, riboflavin, and niacin to daily nutrient intakes for the U.S. population when compared with regular ice cream, with the exception of vitamin D. Alternatively, lower fat ice cream contributed lesser amounts of energy, saturated fat, and added sugar to daily nutrient intakes when compared to regular ice cream; lower fat ice cream contributed 56% less saturated fat to daily nutrient intake compared to regular ice cream. Conclusion: Consumers of low/non-fat/light ice cream and frozen yogurt had lower percent contribution of saturated fat to total daily nutrient intake compared to users of regular ice cream. Figure 1

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Epigenetic silencing of chemokine CCL2 represses macrophage infiltration to potentiate tumor development in small cell lung cancer

Cancer Letters ◽

10.1016/j.canlet.2020.11.034 ◽

2021 ◽

Vol 499 ◽

pp. 148-163

Author(s):

Yang Zheng ◽

Zhihong Wang ◽

Simeng Wei ◽

Ziling Liu ◽

Guojiang Chen

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Tumor Development ◽

Small Cell ◽

Epigenetic Silencing ◽

Macrophage Infiltration ◽

Small Cell Lung

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The Infant Gut Microbiota and Risk of Asthma: The Effect of Maternal Nutrition during Pregnancy and Lactation

Microorganisms ◽

10.3390/microorganisms8081119 ◽

2020 ◽

Vol 8 (8) ◽

pp. 1119 ◽

Cited By ~ 1

Author(s):

Naser A. Alsharairi

Keyword(s):

Gut Microbiota ◽

Early Life ◽

Nutrient Intake ◽

Maternal Nutrition ◽

Current Knowledge ◽

Increased Risk ◽

Dietary Nutrient ◽

Pregnancy And Lactation ◽

Gut Microbiota Composition

Research has amply demonstrated that early life dysbiosis of the gut microbiota influences the propensity to develop asthma. The influence of maternal nutrition on infant gut microbiota is therefore of growing interest. However, a handful of prospective studies have examined the role of maternal dietary patterns during pregnancy in influencing the infant gut microbiota but did not assess whether this resulted in an increased risk of asthma later in life. The mechanisms involved in the process are also, thus far, poorly documented. There have also been few studies examining the effect of maternal dietary nutrient intake during lactation on the milk microbiota, the effect on the infant gut microbiota and, furthermore, the consequences for asthma development remain largely unknown. Therefore, the specific aim of this mini review is summarizing the current knowledge regarding the effect of maternal nutrition during pregnancy and lactation on the infant gut microbiota composition, and whether it has implications for asthma development.

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Dietary nutrient profiles of wild wolves: insights for optimal dog nutrition?

British Journal Of Nutrition ◽

10.1017/s0007114514002311 ◽

2014 ◽

Vol 113 (S1) ◽

pp. S40-S54 ◽

Cited By ~ 34

Author(s):

Guido Bosch ◽

Esther A. Hagen-Plantinga ◽

Wouter H. Hendriks

Keyword(s):

Food Waste ◽

Nutrient Intake ◽

Foraging Ecology ◽

Prey Availability ◽

Domestic Dogs ◽

Free Living ◽

Nutrient Profile ◽

Dietary Nutrient ◽

Nutrient Profiles

Domestic dogs diverged from grey wolves between 13 000 and 17 000 years ago when food waste from human settlements provided a new niche. Compared to the carnivorous cat, modern-day dogs differ in several digestive and metabolic traits that appear to be more associated with omnivorous such as man, pigs and rats. This has led to the classification of dogs as omnivores, but the origin of these ‘omnivorous’ traits has, hitherto, been left unexplained. We discuss the foraging ecology of wild wolves and calculate the nutrient profiles of fifty diets reported in the literature. Data on the feeding ecology of wolves indicate that wolves are true carnivores consuming a negligible amount of vegetal matter. Wolves can experience prolonged times of famine during low prey availability while, after a successful hunt, the intake of foods and nutrients can be excessive. As a result of a ‘feast and famine’ lifestyle, wolves need to cope with a highly variable nutrient intake requiring an adaptable metabolism, which is still functional in our modern-day dogs. The nutritive characteristics of commercial foods differ in several aspects from the dog's closest free-living ancestor in terms of dietary nutrient profile and this may pose physiological and metabolic challenges. The present study provides new insights into dog nutrition and contributes to the ongoing optimisation of foods for pet dogs.

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