scholarly journals Relations of Mood with Body Mass Index Changes in Severely Obese Women Enrolled in a Supported Physical Activity Treatment

Obesity Facts ◽  
2008 ◽  
Vol 1 (2) ◽  
pp. 88-92 ◽  
Author(s):  
James J. Annesi
2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Ana Paula dos Santos Rodrigues ◽  
Lorena Pereira Souza Rosa ◽  
Hugo Delleon da Silva ◽  
Elisângela de Paula Silveira-Lacerda ◽  
Erika Aparecida Silveira

Background. ThePPARG2Pro12Ala (rs1801282) andIL6-174G >C (rs1800795) have important function in body weight regulation and a potential role in obesity risk. We aimed to investigate the association betweenPPARG2Pro12Ala andIL6-174G >C variants and the genotypes interaction with body composition, metabolic markers, food consumption, and physical activity in severely obese patients.Methods. 150 severely obese patients (body mass index (BMI) ≥ 35 kg/m2) from Central Brazil were recruited. Body composition, metabolic parameters, physical activity, and dietary intake were measured. The genotype was determined by the qPCR TaqMan Assays System. Multiple linear regression and multiple logistic regression models were fitted adjusting for confounders.Results. Ala carriers of the Pro12Ala polymorphism had higher adiposity measures (BMI:p=0.031, and fat mass:p=0.049) and systolic blood pressure (p=0.026) compared to Pro homozygotes. We found no important associations between the -174G >C polymorphism and obesity phenotypes. When genotypes were combined, individuals with genotypes ProAla + AlaAla and GC + CC presented higher BMI (p=0.029) and higher polyunsaturated fatty acids (PUFAs) consumption (p=0.045) compared to the ones with genotypes ProPro and GG, and individuals carriers of thePPARG2Ala allele only (genotype ProAla + AlaAla and GG) had higher fat mass and systolic and diastolic blood pressure compared to the ones with genotypes ProPro and GG.Conclusions. Severely obese individuals carrying the Ala allele of thePPARG2Pro12Ala polymorphism had higher measures of adiposity and blood pressure, while no important associations were found for theIL6-174G >C polymorphism.


2020 ◽  
Vol 35 (3) ◽  
pp. 676-683 ◽  
Author(s):  
Gabriela P Mena ◽  
Gregore I Mielke ◽  
Wendy J Brown

Abstract STUDY QUESTION Do physical activity (PA), sitting time (ST) and body mass index (BMI) affect fertility over a 15-year period in Australian women? SUMMARY ANSWER Moderate and high levels of PA confer advantages for fertility in women with normal BMI, but increased risk of infertility was observed in obese women. WHAT IS KNOWN ALREADY Higher BMI is positively associated with higher rates of problems with fertility, but the effects of physical activity and sitting time on fertility are less well understood. STUDY DESIGN, SIZE, DURATION Participants in The Australian Longitudinal Study of Women’s Health (ALSWH) completed mailed surveys in 2000, with follow-ups in 2003, 2006, 2009, 2012 and 2015 (N = 6130). PARTICIPANTS/MATERIALS, SETTING, METHODS Participants were aged 22 to 27 in 2000. They were asked to report their physical activity levels, sitting time and fertility problems in each survey from 2000 to 2015. BMI was calculated from self-reported weight and height. Cumulative incidence of fertility problems was calculated from 2000 to 2015 and hazard ratios (HR) and 95% CIs were calculated using survival analysis. MAIN RESULTS AND THE ROLE OF CHANCE From 2000 to 2015, the cumulative incidence of fertility problems was 15.4% (95% CI: 14.5–16.4). High levels of PA were associated with reduced risk of problems with fertility [HR 0.82 (95% CI: 0.69–0.98)], and higher BMI was positively associated with fertility problems [overweight: HR 1.18, (95% CI 0.99–1.39); obese: HR 1.36, (95% CI 1.14–1.63)]. In survival analyses, incidence rates were highest in every survey interval in women who reported low PA levels and in women who were obese. Overall, ST was not associated with fertility problems. In stratified models, high levels of PA attenuated the risk of problems with fertility in women who were in the normal BMI category [HR 0.64, (95% CI 0.49–0.82)]. LIMITATIONS, REASONS FOR CAUTION The ALSWH relies on self-reported data, which may be subject to recall bias. WIDER IMPLICATIONS OF THE FINDINGS The study provides estimates of problems with fertility in a cohort of young adult Australian women, and the results indicate that these are inversely associated with physical activity levels and positively associated with BMI. However, the high infertility risk in obese women was not attenuated by high levels of PA. The protective effects of PA were only observed in women with normal BMI. As rates of developing problems with fertility were highest in every survey interval among women who reported low levels of physical activity and in women who were obese, these findings suggest that improving physical activity levels could be an affordable strategy to reduce problems with fertility in women who are trying to conceive. These findings should be considered by clinical and public health practitioners. STUDY FUNDING/COMPETING INTEREST(S) The ALSWH is funded by the Australian Government. Funding for these analyses was provided by a University of Queensland (UQ) International Postgraduate Research Scholarship and a UQ International Development Fellowship. The authors declare no conflicts of interest.


2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Randi Jepsen ◽  
Eivind Aadland ◽  
Lesley Robertson ◽  
Ronette L. Kolotkin ◽  
John Roger Andersen ◽  
...  

It is unknown how changes in physical activity may affect changes in quality of life (QoL) outcomes during lifestyle interventions for severely obese adults. The purpose of this study was to examine associations in the patterns of change between objectively assessed physical activity as the independent variable and physical, mental, and obesity-specific QoL and life satisfaction as the dependent variables during a two-year lifestyle intervention. Forty-nine severely obese adults (37 women;43.6±9.4years; body mass index42.1±6.0 kg/m2) participated in the study. Assessments were conducted four times using Medical Outcomes Study Short-Form 36 Health Survey (SF-36), Obesity-Related Problems (OP) scale, a single item on life satisfaction, and accelerometers. The physical component summary (PCS) score and the mental component summary (MCS) score were used as SF-36 outcomes. Associations were determined using linear regression analyses and reported as standardized coefficients (stand. coeff.). Change in physical activity was independently associated with change in PCS (stand. coeff. = 0.35,P=.033), MCS (stand. coeff. = 0.51,P=.001), OP (stand. coeff. = −0.31,  P=.018), and life satisfaction (stand. coeff. = 0.39,P=.004) after adjustment for gender, age, and change in body mass index.


2016 ◽  
Vol 4 (3) ◽  
pp. 353-358 ◽  
Author(s):  
Nayera E. Hassan ◽  
Saneya Wahba ◽  
Inas R. El-Alameey ◽  
Sahar A. El-Masry ◽  
Mones M. AbuShady ◽  
...  

BACKGROUND: Obesity and related morbidity increase in Egyptian women and their children. A better understanding of dietary and activity patterns is needed to reduce obesity prevalence.AIM: The present study aimed to assess dietary patterns and physical activity in Egyptian overweight and obese mothers and to explore its relationships with their children's body mass index (BMI).SUBJECTS AND METHODS: This descriptive case-control study was conducted at the National Research Center. The study included a sample of 64 overweight and obese mothers and 75 children, compared with apparently healthy non-obese mothers and their children of matched age and social class. Tested questionnaires were used to collect information of the studied subjects.RESULTS: A statistically significantly higher incidence of unemployment, large family size was observed in overweight & obese women compared to controls (P < 0.05). Those women who consumed vegetables more than 3 times a week were less likely to be overweight or obese (P < 0.05). No significant association were detected between mothers' physical activity, dietary behaviour variables and children’s BMI except for consuming beverages with added sugar (95%CI = 0.074-0.985, P<0.05).CONCLUSION: Improper dietary patterns, nonworking mothers and big family size are associated with obesity among Egyptian women. Emphasis should be given to increasing physical activity and encourage healthier diets among Egyptian mothers and their children.


Endocrinology ◽  
2007 ◽  
Vol 148 (6) ◽  
pp. 2955-2962 ◽  
Author(s):  
Nava Bashan ◽  
Karina Dorfman ◽  
Tanya Tarnovscki ◽  
Ilana Harman-Boehm ◽  
Idit F. Liberty ◽  
...  

MAPKs and inhibitory-κB kinase (IKK) were suggested to link various conditions thought to develop in adipose tissue in obesity (oxidative, endoplasmic reticulum stress, inflammation) with insulin resistance. Yet whether in obesity these kinases are affected in a fat-depot-differential manner is unknown. We assessed the expression and phosphorylation of these kinases in paired omental and abdominal-sc fat biopsies from 48 severely obese women (body mass index &gt; 32 kg/m2). Protein and mRNAs of p38MAPK, ERK, c-Jun kinase-1, and IKKβ were increased 1.5–2.5-fold in omental vs. sc fat. The phosphorylated (activated) forms of these kinases were also increased to similar magnitudes as the total expression. However, phosphorylation of insulin receptor substrate-1 on Ser312 (equivalent of murine Ser307) was not increased in omental, compared with sc, fat. Consistently, fat tissue fragments stimulated with insulin demonstrated that tyrosine phosphorylation and signal transduction to Akt/protein kinase B in omental fat was not inferior to that observable in sc fat. Comparison with lean women (body mass index 23.2 ± 2.9 kg/m2) revealed similar ERK2 and IKKβ expression and phosphorylation in both fat depots. However, as compared with lean controls, obese women exhibited 480 and 270% higher amount of the phosphorylated forms of p38MAPK and c-Jun kinase, respectively, in omental, but not sc, fat, and this expression level correlated with clinical parameters of glycemia and insulin sensitivity. Increased expression of stress-activated kinases and IKK and their phosphorylated forms in omental fat occurs in obesity, potentially contributing to differential roles of omental and sc fat in the pathophysiology of obesity.


CNS Spectrums ◽  
2009 ◽  
Vol 14 (7) ◽  
pp. 372-383 ◽  
Author(s):  
Rani A. Desai ◽  
Melinda Manley ◽  
Mayur M. Desai ◽  
Marc N. Potenza

ABSTRACTIntroduction: The objective of the study was to examine gender differences in the relationship between weight group (under-weight to severely obese), and Axis I and Axis II psychopathology.Methods: Data from the National Epidemiologic Survey of Alcohol and Related Conditions (NESARC) were analyzed. Logistic regression models examined the past-year likelihood for meeting diagnostic criteria for psychiatric disorders. Interactions between weight group and gender were utilized to determine whether associations were significantly different in men and women after adjusting for demographic characteristics.Results: First, consistent with previous NESARC analyses, the prevalence estimates of psychiatric disorders were higher among people of higher body mass index groups, regardless of gender. However, these patterns differed across genders. Both severely obese women and men, in comparison to normal weight respondents, were much more likely to meet criteria for affective and anxiety disorders, but these associations were significantly (1.5–2 times) stronger among women. For Axis II disorders, while there were very few associations between personality disorders and weight in men, among women increases in weight group were associated with increases in the likelihood of meeting criteria for a personality disorder.Conclusion: Weight and psychopathology appear more strongly associated in women than in men. While these data do not allow for identification of underlying mechanisms, they highlight the importance of assessing for psychopathology in overweight and obese patients, and suggest that weight management may be an important consideration in the treatment of psychiatric disorders.


2015 ◽  
Vol 105 (7) ◽  
pp. 1468-1474 ◽  
Author(s):  
Barbara B. Brown ◽  
Carol M. Werner ◽  
Calvin P. Tribby ◽  
Harvey J. Miller ◽  
Ken R. Smith

Author(s):  
Jessica Currie ◽  
David Collier ◽  
Thomas D. Raedeke ◽  
Lesley D. Lutes ◽  
C. David Kemble ◽  
...  

Abstract Background While severe obesity in childhood poses the greatest long-term health risks, access to treatment is a common barrier. The present pilot study examined the effect of a 7-week low-dose physical activity (PA) intervention on PA and body mass index (BMI) in severe obese adolescents delivered via telephone and mail. Methods Adolescents (n = 64) receiving care from a pediatric obesity medical clinic were randomized to a control (n = 30) or intervention (n = 34) group. Height and weight were measured and BMI z-scores were calculated. PA was assessed by a pedometer. All measurements were completed pre- and post-intervention. The intervention group received weekly newsletters and telephone calls discussing various PA topics based on motivational interviewing for 7 weeks. The control group received no contact. A series of 2 × 2 (group by time) repeated measures analysis of covariances (ANCOVAs) adjusting for length of time between visits were performed to examine the effect of the intervention on PA and BMI z-scores. Results The majority of adolescents were severely obese (77%, BMI: > 99th percentile). Intention-to-treat analysis revealed intervention effects were not observed for either pedometer steps or BMI z-score (p > 0.05). Among those with complete data, adolescents who successfully changed their BMI z-score had larger BMI z-score changes than those who did not change their BMI z-score (p = 0.0001). This improvement was due to something other than PA as the change in BMI z-score was similar among those who did and did not successfully increase PA levels (p > 0.05). Conclusions More intensive, comprehensive, and longer-term treatment is needed in this high risk population.


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