The Natural Compound Ascorbigen Modulates NADPH-Quinone Oxidoreductase (NQO1) mRNA and Enzyme Activity Levels in Cultured Liver Cells and in Laboratory Rats

2008 ◽  
Vol 53 (2) ◽  
pp. 122-128 ◽  
Author(s):  
Anika E. Wagner ◽  
Hubert Hug ◽  
Richard Gössl ◽  
Georges Riss ◽  
Bernd Mussler ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Natural Compound ◽  
Liver Cells ◽  
Activity Levels ◽  
Quinone Oxidoreductase ◽  
Laboratory Rats ◽  
Cultured Liver Cells

scholarly journals The Induction of δ-Aminolevulinic Acid Synthetase in Cultured Liver Cells

1972 ◽  
Vol 247 (9) ◽  
pp. 2820-2827 ◽  
Author(s):  
L. James Strand ◽  
Joan Manning ◽  
Harvey S. Marver
Keyword(s):  
Aminolevulinic Acid ◽  
Liver Cells ◽  
Cultured Liver Cells

scholarly journals Low Psychosine in Krabbe Disease with Onset in Late Infancy: A Case Report

2021 ◽  
Vol 7 (2) ◽  
pp. 28
Author(s):  
Camille S. Corre ◽  
Dietrich Matern ◽  
Joan E. Pellegrino ◽  
Carlos A. Saavedra-Matiz ◽  
Joseph J. Orsini ◽  
...  
Keyword(s):  
New York ◽  
Enzyme Activity ◽  
Clinical Presentation ◽  
Neurodegenerative Disorder ◽  
New York State ◽  
Disease Onset ◽  
Early Infancy ◽  
Krabbe Disease ◽  
Activity Levels ◽  
Hematopoietic Stem

Krabbe disease (KD) is a rare inherited neurodegenerative disorder caused by a deficiency in galactocerebrosidase enzyme activity, which can present in early infancy, requiring an urgent referral for hematopoietic stem cell transplantation, or later in life. Newborn screening (NBS) for KD requires identification and risk-stratification of patients based on laboratory values to predict disease onset in early infancy or later in life. The biomarker psychosine plays a key role in NBS algorithms to ascertain probability of early-onset disease. This report describes a patient who was screened positive for KD in New York State, had a likely pathogenic genotype, and showed markedly reduced enzyme activity but surprisingly low psychosine levels. The patient ultimately developed KD in late infancy, an outcome not clearly predicted by existing NBS algorithms. It remains critical that psychosine levels be evaluated alongside genotype, enzyme activity levels, and the patient’s evolving clinical presentation, ideally in consultation with experts in KD, in order to guide diagnosis and plans for monitoring.

scholarly journals Metabolism of glycerol monoethers in cultured liver cells and implications for monoglyceride pathways

1976 ◽  
Vol 17 (6) ◽  
pp. 629-636
Author(s):  
C G Mackenzie ◽  
O K Reiss ◽  
E Moritz ◽  
J B Mackenzie
Keyword(s):  
Liver Cells ◽  
Cultured Liver Cells

scholarly journals The Molecular Basis of Quantitative Genetic Variation in Central and Secondary Metabolism in Arabidopsis

Genetics ◽  
1998 ◽  
Vol 149 (2) ◽  
pp. 739-747 ◽  
Author(s):  
Thomas Mitchell-Olds ◽  
Deana Pedersen
Keyword(s):  
Enzyme Activity ◽  
Genetic Variation ◽  
Secondary Metabolism ◽  
Genetic Correlations ◽  
Theoretical Models ◽  
Model Systems ◽  
Activity Levels ◽  
Significant Qtls ◽  
Cis Acting ◽  
Quantitative Genetic

Abstract To find the genes controlling quantitative variation, we need model systems where functional information on physiology, development, and gene regulation can guide evolutionary inferences. We mapped quantitative trait loci (QTLs) influencing quantitative levels of enzyme activity in primary and secondary metabolism in Arabidopsis. All 10 enzymes showed highly significant quantitative genetic variation. Strong positive genetic correlations were found among activity levels of 5 glycolytic enzymes, PGI, PGM, GPD, FBP, and G6P, suggesting that enzymes with closely related metabolic functions are coregulated. Significant QTLs were found influencing activity of most enzymes. Some enzyme activity QTLs mapped very close to known enzyme-encoding loci (e.g., hexokinase, PGI, and PGM). A hexokinase QTL is attributable to cis-acting regulatory variation at the AtHXK1 locus or a closely linked regulatory locus, rather than polypeptide sequence differences. We also found a QTL on chromosome IV that may be a joint regulator of GPD, PGI, and G6P activity. In addition, a QTL affecting PGM activity maps within 700 kb of the PGM-encoding locus. This QTL is predicted to alter starch biosynthesis by 3.4%, corresponding with theoretical models, suggesting that QTLs reflect pleiotropic effects of mutant alleles.

scholarly journals The effect of paracetamol on human Chang liver cells infected by different dengue serotypes based on liver enzyme activity

2012 ◽  
Vol 16 ◽  
pp. e107
Author(s):  
H. Roslee ◽  
C. Hui Yee ◽  
S. Fakurazi ◽  
F. Azizi Jalilian ◽  
F. Othman ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Liver Enzyme ◽  
Liver Cells ◽  
Liver Enzyme Activity ◽  
Chang Liver

scholarly journals Protective Effects of 3-benzoyl-7-hydroxy Coumarin on Liver of Adult Rat Exposed to Aluminium Chloride

2021 ◽  
Vol 68 (1) ◽  
pp. 222-228
Author(s):  
Ahmet Özkaya ◽  
Kenan Türkan
Keyword(s):  
Oxidative Stress ◽  
Enzyme Activity ◽  
Aluminium Chloride ◽  
Control Group ◽  
Albino Rats ◽  
Activity Levels ◽  
Protective Effects ◽  
Adult Rat ◽  
Antioxidant Enzyme System ◽  
Hydroxy Coumarin

In this study, the effects of 3-benzoyl-7-hydroxy coumarin molecule on mineral and antioxidant enzymes were investigated in rat liver exposed to oxidative stress with aluminium chloride (AlCl3). Adult male Wistar albino rats were divided into four groups as Control, Coumarin, AlCl3, and Coumarin + AlCl3. Coumarin at the dose of 10 mg/kg and AlCl3 at the dose of 8.3 mg/kg were administered for 30 days every other day. In AlCl3 group, malondialdehyde (MDA), iron (Fe), aluminium (Al) and copper (Cu) levels increased compared to the control group, while glutathione (GSH) level, glutathione S-transferase (GST), and carboxylesterase (Ces) enzyme activity levels decreased. In Coumarin + AlCl3 group, MDA, Fe, Al and Cu levels decreased with the effect of coumarin compared to AlCl3 group, while GSH level, and GST enzyme activity levels increased. According to our results, AlCl3 generates oxidative stress in rat livers, and we believe that 3-benzoyl-7-hydroxy coumarin has an ameliorative effect on antioxidant enzyme system, Al, Fe and Cu levels.

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