Pre-Operative Peritumoral Edema and Survival Rate in Glioblastoma Multiforme

Onkologie ◽  
2013 ◽  
Vol 36 (11) ◽  
pp. 9-9 ◽  
Author(s):  
Shui-Yuan Liu* ◽  
Wen-Zhong Mei* ◽  
Zhi-Xiong Lin
Keyword(s):  
Survival Rate ◽  
Glioblastoma Multiforme ◽  
Peritumoral Edema

Dual-isotope single-photon emission computerized tomography scanning in patients with glioblastoma multiforme: association with patient survival and histopathological characteristics of tumor after high-dose radiotherapy

1998 ◽  
Vol 89 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Richard B. Schwartz ◽  
B. Leonard Holman ◽  
Joseph F. Polak ◽  
Basem M. Garada ◽  
Marc S. Schwartz ◽  
...  
Keyword(s):  
Survival Rate ◽  
Glioblastoma Multiforme ◽  
Single Photon ◽  
Photon Emission ◽  
High Dose ◽  
Term Survival ◽  
Content Type ◽  
Dual Isotope ◽  
Fine Print

Object. The study was conducted to determine the association between dual-isotope single-photon emission computerized tomography (SPECT) scanning and histopathological findings of tumor recurrence and survival in patients treated with high-dose radiotherapy for glioblastoma multiforme. Methods. Studies in which SPECT with 201Tl and 99mTc-hexamethypropyleneamine oxime (HMPAO) were used were performed 1 day before reoperation in 47 patients with glioblastoma multiforme who had previously been treated by surgery and high-dose radiotherapy. Maximum uptake of 201Tl in the lesion was expressed as a ratio to that in the contralateral scalp, and uptake of 99mTc-HMPAO was expressed as a ratio to that in the cerebellar cortex. Patients were stratified into groups based on the maximum radioisotope uptake values in their tumor beds. The significance of differences in patient gender, histological characteristics of tissue at reoperation, and SPECT uptake group with respect to 1-year survival was elucidated by using the chi-square statistic. Comparisons of patient ages and time to tumor recurrence as functions of 1-year survival were made using the t-test. Survival data at 1 year were presented according to the Kaplan—Meier method, and the significance of potential differences was evaluated using the log-rank method. The effects of different variables (tumor type, time to recurrence, and SPECT grouping) on long-term survival were evaluated using Cox proportional models that controlled for age and gender. All patients in Group I (201Tl ratio < 2 and 99mTc-HMPAO ratio < 0.5) showed radiation changes in their biopsy specimens: they had an 83.3% 1-year survival rate. Group II patients (201T1 ratio < 2 and 99mTc-HMPAO ratio of ≥ 0.5 or 201Tl ratio between 2 and 3.5 regardless of 99mTc-HMPAO ratio) had predominantly infiltrating tumor (66.6%); they had a 29.2% 1-year survival rate. Almost all of the patients in Group III (201Tl ratio > 3.5 and 99mTc-HMPAO ratio ≥ 0.5) had solid tumor (88.2%) and they had a 6.7% 1-year survival rate. Histological data were associated with 1-year survival (p < 0.01); however, SPECT grouping was more closely associated with 1-year survival (p < 0.001) and was the only variable significantly associated with long-term survival (p < 0.005). Conclusions. Dual-isotope SPECT data correlate with histopathological findings made at reoperation and with survival in patients with malignant gliomas after surgical and high-dose radiation therapy.

MRI Radiomic Features of Peritumoral Edema May Predict the Recurrence Sites of Glioblastoma Multiforme

2021 ◽  
Author(s):  
Hao Long ◽  
Ping Zhang ◽  
Yuewei Bi ◽  
Chen Yang ◽  
Manfeng Wu ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Peritumoral Edema ◽  
Recurrence Sites

scholarly journals P.038 Investigating the role of long non-coding RNAs in glioblastoma multiforme

2018 ◽  
Vol 45 (s2) ◽  
pp. S26-S26
Author(s):  
A Lebel ◽  
V Charest ◽  
P Whitlock ◽  
D Charest ◽  
P Morin
Keyword(s):  
Survival Rate ◽  
Glioblastoma Multiforme ◽  
Brain Tumors ◽  
Malignant Gliomas ◽  
Standard Of Care ◽  
Qrt Pcr ◽  
Resistance Modulation ◽  
Non Coding Rnas ◽  
One Year

Background: Malignant gliomas are the most common and deadly brain tumors. Mean survival rate for a patient diagnosed with a glioblastoma multiforme (GBM) remains slightly over one year. Standard of care consists of treatment with temozolomide (TMZ) and radiotherapy. Recent work has highlighted functions of long non-coding RNAs (lncRNAs) in GBM progression and TMZ response even though the information regarding these newly discovered molecules is sparse. The overarching objective of this project was thus to assess the expression of select lncRNAs in GBM tumor samples and in models of TMZ resistance. Methods: A qRT-PCR-based approach was undertaken to measure six lncRNAs in 19 primary GBM samples, four GBM cell lines and in-house developed TMZ-resistant GBM cells. Results: Elevated levels of Hotair and H19 were observed in primary GBM tumors while decreased expression of MEG3 was recorded in the same samples. Interestingly, levels of PANDA increased 3.4-fold in GBM cells resistant to TMZ when compared with their sensitive counterparts. Conclusions: Overall, this work provides evidence of lncRNA deregulation in GBM tumors and reveals a previously unexplored lncRNA potentially involved in TMZ resistance. Modulation of lncRNA targets via RNAi-mediated approaches is envisioned to clarify their function and to strengthen their position as therapeutic options in GBMs.

Genome sequencing, mutational analysis, and survival rate of glioblastoma multiforme

2021 ◽  
Vol 429 ◽  
pp. 117758
Author(s):  
Urvish Patel ◽  
Hetal Gujaria ◽  
Preeti Malik ◽  
Mahika Khurana ◽  
Amrapali Patel ◽  
...  
Keyword(s):  
Survival Rate ◽  
Glioblastoma Multiforme ◽  
Genome Sequencing ◽  
Mutational Analysis

Comparison of early versus late onset of cellular immunotherapy in glioblastoma multiforme WHO IV.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e13531-e13531
Author(s):  
Jan Nesselhut ◽  
Dagmar Marx ◽  
Nicole Cillien ◽  
Raymond Y. Chang ◽  
Wulf-Peter Brockmann ◽  
...  
Keyword(s):  
Overall Survival ◽  
Survival Rate ◽  
Dendritic Cell ◽  
Glioblastoma Multiforme ◽  
Therapy Response ◽  
Newly Diagnosed ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy ◽  
Stupp Protocol

e13531 Background: Glioblastoma multiforme (GBM WHO grade IV glioma) is an aggressive disease with an unfavorable prognosis. The current first line treatment comprises radical operation and radiotherapy combined with temozolomide chemotherapy (Stupp protocol). After failure of first-line therapy there is currently no effective therapy. Here we report that dendritic cell therapy prolongs the survival for patients with newly diagnosed GBM V. Preliminary results show that adding checkpoint blockade with Nivolumab may cause a secondary therapy response. Methods: After isolating monocytes from peripheral blood of n = 11 patients with stage IV GBM, who underwent primary surgery and first-line radio-chemotherapy and from n = 34 patients, who failed first line therapy MoDC were generated using standard protocols. In 5 patients checkpoint blockade with Nivolumab was added after failure of DC therapy. Results: With a median overall survival of 41 months there is a clear improvement of the overall survival in patients, who received DC therapy after having finished the Stupp-protocol. The 3- year-survival rate after primary diagnosis is 46% (n = 5) and 1 patient is still alive after 81 months. In this patient a secondary therapy response of 16 months could be induced by adding low dose Nivolumab (1mg/kg body weight) after failure of DC therapy. The median survival after onset of DC therapy in patients who failed first line standard therapy is 10 months. The 3-year overall survival rate is 9% (n = 3). In 4 patients therapy with Nivolumab was combined causing only a limiting effect on the survival (4 to 10 months). Conclusions: Dendritic-cell based immune therapy started immediately after primary standard therapy has a clear impact on the overall survival of patients with newly diagnosed GBM IV. Whereas the therapeutic effect for patients after failure of first-line therapy is limited. Nivolumab may cause secondary therapy response in certain patients.

scholarly journals INFLUENCE OF PERITUMORAL EDEMA ON THE OUTCOME OF RADIOTHERAPY OF SUPRATENTORIAL NONCYSTIC GLIOBLASTOMA MULTIFORME

2011 ◽  
pp. 5-9
Author(s):  
Ivan Stefanović ◽  
Aleksandar Kostić ◽  
Miša Radisavljević ◽  
Slađana Filipović ◽  
Petar Bošnjaković
Keyword(s):  
Glioblastoma Multiforme ◽  
Peritumoral Edema

scholarly journals Evaluation of effect of epidermal growth factor receptor and vascular endothelial growth factor overexpression in survival of patients with glioblastoma multiforme

2021 ◽  
Vol 20 (1) ◽  
pp. 66-71
Author(s):  
Babak Alijani ◽  
◽  
Hamid Saeidi Saedi ◽  
Hadi Hajizadeh Fallah ◽  
Ehsan Kazemnejad Leili ◽  
...  
Keyword(s):  
Overall Survival ◽  
Survival Rate ◽  
Growth Factor ◽  
Glioblastoma Multiforme ◽  
Survival Rates ◽  
Growth Factor Receptor ◽  
Overall Survival Rate ◽  
Significant Difference ◽  
The Central Nervous System ◽  
The Mean

Background. In the central nervous system, glioblastoma multiforme (GBM) is one of the most important neoplasms in adults. Amplification of EGFR and VEGF genes is common in GBM. However, the role of overexpression of EGFR and VEGF in survival of patients with GBM has been a contentious issue. Therefore, we performed the present study to assess the survival rate of patients with EGFR and VEGF overexpression. Materials and methods. Resected samples of GBM patients were evaluated by immunohistochemistry for overexpression of VEGF and EGFR. The patients were followed up for a year. Results. The mean±sd of age of patients was 56.2±13.1 years. The majority of the patients were male (65.9%). Most of the patients had primary GBM (67%), notwithstanding 33% of the patients with secondary GBM. Moreover, 19.2% and 49.5% of the samples were VEGF-positive and EGFR-positive, respectively. Overall 6, 12-, and 18-month survival rates were shown to be 61.5±5.1%, 17.6±4%, and 4.4±2.1%, respectively. There was a significant difference between the mean±se survival rate in VEGF-negative patients (12±1.9 months) VEGF-positive patients (7.8±0.5 months) (P=0.045). Conclusions. We found an association between VEGF and EGFR over-expression and the survival rate of GBM patients. The VEGF overexpression was significantly associated with the overall survival rate of the GBM patients, but failed to have a prognostic value for their mortality rate. However, EGFR was a predictor of overall survival rate and mortality of GBM patients. Moreover, VEGF overexertion has a stronger association with survival rate in GBM, compared to EGFR overexpression.

Accuracy of apparent diffusion coefficient in differentiation of glioblastoma from metastasis

2021 ◽  
pp. 197140092098367
Author(s):  
Sanaz Beig Zali ◽  
Farbod Alinezhad ◽  
Mahnaz Ranjkesh ◽  
Mohammad H Daghighi ◽  
Masoud Poureisa
Keyword(s):  
Diffusion Coefficient ◽  
Standard Deviation ◽  
Glioblastoma Multiforme ◽  
Brain Metastasis ◽  
Apparent Diffusion Coefficient ◽  
Predictive Value ◽  
Magnetic Resonance Images ◽  
Peritumoral Edema ◽  
Apparent Diffusion Coefficient Values ◽  
Apparent Diffusion

Background Brain metastasis and glioblastoma multiforme are two of the most common malignant brain neoplasms. There are many difficulties in distinguishing these diseases from each other. Purpose The purpose of this study was to determine whether the mean apparent diffusion coefficient and absolute standard deviation derived from apparent diffusion coefficient measurements can be used to differentiate glioblastoma multiforme from brain metastasis based on cellularity levels. Material and methods Magnetic resonance images of 34 patients with histologically verified brain tumors were evaluated retrospectively. Apparent diffusion coefficient and standard deviation values were measured in the enhancing tumor, peritumoral region, and contralateral healthy white matter. Then, to determine whether there was a statistical difference between brain metastasis and glioblastoma multiforme, we analyzed different variables between the two groups. Results Neither mean apparent diffusion coefficient values and ratios nor standard deviation values and ratios were significantly different between glioblastoma multiforme and brain metastasis. Receiver operating characteristic curve analysis of the logistic model with backward stepwise feature selection yielded an area under the curve of 0.77, a specificity of 84%, a sensitivity of 67%, a positive predictive value of 83.33%, and a negative predictive value of 78.26% for distinguishing between glioblastoma multiforme and brain metastasis. The absolute standard deviation and standard deviation ratios were significantly higher in the peritumoral edema compared to the tumor region in each case. Conclusion Apparent diffusion coefficient values and ratios, as well as standard deviation values and ratios in peritumoral edema, cannot be used to differentiate edema with infiltration of tumor cells from vasogenic edema. However, standard deviation values could successfully characterize areas of peritumoral edema from the tumoral region in each case.

Impact of cyclooxygenase-2 expression on the survival of glioblastoma multiforme

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 12505-12505
Author(s):  
Y. Choi ◽  
D. Kim ◽  
H. Lee ◽  
W. Hur ◽  
K. Kim ◽  
...  
Keyword(s):  
Survival Rate ◽  
Glioblastoma Multiforme ◽  
Tumor Cells ◽  
Postoperative Radiotherapy ◽  
Cyclooxygenase 2 ◽  
Rank Test ◽  
Surgical Specimen ◽  
Impact On Survival ◽  
Cox 2 ◽  
Radiotherapy Dose

12505 Background: Expression of cyclooxygenase-2 (COX-2) protein in glioma patients increased proportionally to the pathologic grade. The extent of COX-2 expression is reported to have an inverse relation to survival rate in glioblastoma multiforme (GBM) patients, but the degree of COX-2 expression in the GBM specimens is variable from study to study. In order to evaluate the degree of COX-2 expression and its effect on survival in GBM patients, we conducted this study. Methods: Between 1997 and 2006, thirty consecutive patients of GBM who were treated with surgery and postoperative radiotherapy (range : 44 ∼ 65.1 Gy, median : 61.2 Gy) were included after exclusion of 3 patients who discontinued radiotherapy before 40 Gy due to mentality deterioration. Expression of COX-2 protein on surgical specimen was examined by immunohistochemistry. Survival analysis and verification were performed in respect to sex, age, resection extent, radiotherapy dose, and degree of COX-2 expression with Kaplan-Meier method and log rank test. Results: The median length of follow up was 13.25 months (6 ∼ 83 months). COX-2 was stained in all patients and COX-2 positives over 75% of tumor cells were found in 24 patients: positive in less than 25% of tumor cells, N = 3 (10.0%); 25 to 50%, 1 (3.3%); 50 to 75%, 2 (6.7%); 75 to 100%, 24 (80.0%). Median survival and 2-year survival rate were 13.5 months and 17.5%, respectively. The survival rate was influenced significantly by the degree of resection (tumor removal by 50% or more) and radiotherapy dose (60 Gy or greater) (p < 0.05). Median survivals of patients with COX- 2 positive in either more than 75% of tumor cells or at most 75% of tumor cells were 13.0 and 15.5 months, respectively (p>0.05), and the 2- year survivals of them were 13.3 and 33.3%, respectively (p>0.05). Conclusions: Eighty percent of the GBM patients were COX-2 positive in more than 75% of their tumor cells. The degree of COX-2 expression in the GBM patients had not a significant impact on survival, but the high positive rate of COX-2 in GBM could be a potential selective target for treatment. No significant financial relationships to disclose.

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