Erythrocyte Aggregation in Relation to Thrombotic Disorders of the Retina

2015 ◽  
pp. 40-45 ◽  
Author(s):  
N. J. van Haeringen ◽  
E. Glasius
Keyword(s):  
Erythrocyte Aggregation

The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Drinda ◽  
Neumann ◽  
Pöhlmann ◽  
Vogelsang ◽  
Stein ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Plasma Viscosity ◽  
Laser Doppler ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Long Term Effects ◽  
Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

Bovine hypodermatosis in Stavropol region: distribution, pathogenesis, veterinary and sanitary assessment of slaughter products

2020 ◽  
pp. 7-10
Author(s):  
Vasiliy P. Petropavlovsky ◽  
◽  
Vyacheslav V. Marchenko ◽  
Lyudmila S. Vikulova ◽  
Olga D. Chepeleva ◽  
...  
Keyword(s):  
Preventive Measures ◽  
Climatic Conditions ◽  
The Body ◽  
Erythrocyte Aggregation ◽  
Economic Damage ◽  
Hydropic Degeneration ◽  
Hypoderma Lineatum ◽  
Hypoderma Bovis ◽  
Stavropol Region ◽  
Histomorphological Changes

Summary. Data on distribution of hypodermatosis among large horned cattle in Stavropol region are presented in the article. It was proved that this pathology is widespread in this region. From 12% to 38% of animals from the total number of examined livestock are affected. Ordinary subcutaneous botfly (stroma) Hypoderma bovis de Geer and south subcutaneous botfly (pischevodnik) Hypoderma lineatum de Villers parasites on large horned cattle. The species ratio of gadflies is: Hypoderma bovis (de Gee - 61.1%, Hypoderma lineatum de Villers - 38.9%). The disease is widespread in all climatic zones of Stavropol region. Animals of all age and sex groups are infected, but young animals are more often affected. Linear relationship between the indicators of the transformation of climatic conditions in Stavropol region, the spread of hypodermatosis and the timing of treatment and preventive measures were determined. Authors proved that the complete death of H. bovis and H. lineatum imago (regardless of the time of their hatching) was noted when the temperature drops to -3°C for two days. Thus, this temperature determines the start of treatment and preventive measures against hypodermatosis in the area of animal welfare. When analyzing the histomorphological changes caused by H. bovis and H. lineatum in the body of large horned cattle, perforation of the skin, swelling of adjacent tissues, disorganization of the stroma and structural elements, erythrocyte aggregation, hemorrhages, hydropic degeneration of cellular elements, tissue necrosis, polymorphonuclear leukocyte infiltration of affected organs and tissues were observed. The data on pathogenesis were presented, the analysis of economic damage and the veterinary and sanitary assessment of the products of slaughter of cattle with hypodermatosis were carried out.

Alcohol Intake and Erythrocyte Aggregation

1955 ◽  
Vol 16 (4) ◽  
pp. 614-618 ◽  
Author(s):  
O. Forsander ◽  
Heikki Suomalainen
Keyword(s):  
Alcohol Intake ◽  
Erythrocyte Aggregation

Methodological Aspects of Erythrocyte Aggregation

2007 ◽  
Vol 2 (3) ◽  
pp. 240-245 ◽  
Author(s):  
Alexander Pribush ◽  
Naomi Meyerstein
Keyword(s):  
Erythrocyte Aggregation ◽  
Methodological Aspects

Influence of acute-phase proteins on erythrocyte aggregation

Biorheology ◽  
1995 ◽  
Vol 32 (2-3) ◽  
pp. 218-218 ◽  
Author(s):  
X WENG ◽  
G CLOUTIER ◽  
R BEAULIEU
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Erythrocyte Aggregation

scholarly journals Behaviour of Human Erythrocyte Aggregation in Presence of Autologous Lipoproteins

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
C. Saldanha ◽  
J. Loureiro ◽  
C. Moreira ◽  
J. Martins e Silva
Keyword(s):  
Particle Number ◽  
Plasma Osmolality ◽  
Erythrocyte Aggregation ◽  
Lipoprotein Subfractions ◽  
Autologous Plasma ◽  
Aggregation Index ◽  
Number Range ◽  
Human Blood Samples ◽  
Range Of Values

The aim of this work was to evaluatein vitrothe effect of autologous plasma lipoprotein subfractions on erythrocyte tendency to aggregate. Aliquots of human blood samples were enriched or not (control) with their own HDL-C, LDL-C, or VLDL-C fractions obtained from the same batch by density gradient ultracentrifugation. Plasma osmolality and erythrocyte aggregation index (EAI) were determined. Blood aliquots enriched with LDL-C and HDL-C showed significant higher EAI than untreated aliquots, whereas enrichment with VLDL-C does not induce significant EAI changes. For the same range of lipoprotein concentrations expressed as percentage of osmolality variation, the EAI variation was positive and higher in presence of HDL-C than upon enrichment with LDL-C (P<0.01). Particle size, up to LDL diameter values, seems to reinforce erythrocyte tendency to aggregate at the same plasma osmolality (particle number) range of values.

Effects on Erythrocyte Aggregation and Blood Coagulation from Iohexol Solutions with and without Sodium Chloride

1995 ◽  
Vol 36 (2) ◽  
pp. 204-209
Author(s):  
C.-M. Chai ◽  
T. Almén ◽  
P. Aspelin ◽  
L. Bååth
Keyword(s):  
Sodium Chloride ◽  
Blood Coagulation ◽  
Glucose Solution ◽  
Cell Aggregation ◽  
Test Solution ◽  
Erythrocyte Aggregation ◽  
Cell Aggregates ◽  
Red Cell ◽  
Red Blood Cell Aggregation ◽  
Osmotic Effects

Solutions of the nonionic monomeric contrast medium iohexol (300 mg I/ml) with and without added NaCl were investigated for effects on red blood cell aggregation and blood coagulation. Three volumes of a test solution were mixed in test tubes with one volume of human blood. During 30 min samples of the mixture were taken for investigation. Six test solutions were used: 1) iohexol, 2) iohexol+glucose 280 mM, 3) iohexol+NaCl 150 mM, 4) glucose 280 mM, 5) glucose 140 mM+NaCl 75 mM, 6) NaCl 150 mM. Test solutions with NaCl caused no aggregation. Test solutions without NaCl always caused macroscopic red cell aggregates. These aggregates always disappeared when saline was added to the sample. The macroscopic red cell aggregates could be dispersed to microscopic aggregates by shaking the test tubes. During the next 30 min macroscopic aggregates returned in the glucose solution but not in the iohexol solutions. In 30 min, blood mixed with iohexol solutions never coagulated while blood layered on top of the same iohexol solutions always coagulated. Blood mixed with solutions 5 and 6, both without iohexol, always coagulated. It is concluded that adding 150 mM NaCl to iohexol did not eliminate its ability to antico-agulate whole blood, but inhibited its ability to aggregate red cells. This inhibition was not caused by the osmotic effects of the added NaCl.

CHARACTERISTIC OF AGGREGATHOSCOPY METHOD FOR REGISTERING OF ERYTHROCYTES MICRORHEOLOGY

2017 ◽  
Author(s):  
А. Муравьев ◽  
И. Тихомирова ◽  
А. Замышляев ◽  
П. Михайлов ◽  
Е. Петроченко ◽  
...  
Keyword(s):  
Image Processing ◽  
Prostaglandin F2α ◽  
Accurate Method ◽  
Erythrocyte Aggregation ◽  
Suspension Stability ◽  
Ionophore A23187 ◽  
Test Results ◽  
Rate Test ◽  
Positive Correlations ◽  
Special Computer Program

Введение. Две микрореологические характеристики определяют кровоток в системе сосудов микроциркуляции — агрегация и деформируемость эритроцитов. В подавляющем большинстве приборов для регистрации агрегации эритроцитов (АЭ) отсутствует визуализация процесса, и интерпретация данных основывается на его косвенных характеристиках. Материалы и методы. Проведено исследование АЭ на созданной установке — агрегатоскопе, получены данные регистрации картины АЭ с последующей обработкой изображения с помощью специальной программы для ЭВМ. Информативность полученных данных была проверена в сравнительных исследованиях с использованием агрегометра эритроцитов Myrenne M1 и теста СОЭ. Результаты. Получены значительные положительные корреляции (r=0,90 и r=0,86, соответственно). Показано, что агрегатоскоп дает четкую картину изменения АЭ (ее снижение) при инкубации эритроцитов с хелатором Са2+ (ЭДТА, верапамил, изобутилметилксантин, монафрам). В ответ на инкубацию с препаратами другой группы, известными как стимуляторы АЭ (CaCl2, ионофор А23187, фенилэфрин, простагландин F2α), был получен достоверный прирост агрегации. Заключение. Метод агрегатоскопии в сочетании с программной обработкой изображений является удобным и надежным инструментом оценки суспензионной стабильности крови и точным методом измерения важной микрореологической характеристики эритроцитов — их агрегации. Introduction. Aggregation and deformability of erythrocytes are two microrheological characteristics that determine the blood fl ow in microcirculation vessels. In large majority of devices for registration of erythrocyte aggregation (EA) there is no visualization of the process, and the interpretation of the data is based on its indirect characteristics. Materials and methods. EA investigation was carried out on the created unit — aggregatoscop. Data were obtained for registration of EA followed by image processing using a special computer program. Data informativeness was verified in comparative studies using erythrocyte aggregometer Myrenne M1 and erythrocyte sedimentation rate test. Results. Significant positive correlations were obtained (r=0,90 and r=0,86, respectively). It was shown that aggregatoscop gave a clear picture of EA changes (its reduction) during erythrocytes incubation with Са2+ chelator (EDTA, verapamil, isobutylmethylxanthine, monaphram). Reliable increasing of aggregation was obtained in response to incubation with other agents — EA stimulants (CaCl2, ionophore A23187, phenylephrine, prostaglandin F2α). Conclusion. Aggregoscopy method in combination with software image processing is a convenient and reliable tool for assessing of blood suspension stability and an accurate method for measuring of important microrheological characteristics of erythrocytes — their aggregation.

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