Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease

Purpose. Various studies have shown an association between miRNA polymorphisms and susceptibility to autoimmune disease (AD); however, the results are inconclusive. To evaluate whether miRNA polymorphisms account for a significant risk of AD, a total of 87 articles, including 39431 patients and 56708 controls, were identified to estimate their association with 12 AD subtypes. Methods. Several electronic databases were searched to analyze population-based studies on the relationship between miRNA variants and AD risk. Fixed effects or random effect models were used in the meta-analysis for the risk assessment. Results. In our meta-analysis, miR-146a rs2910164/rs57095329 conferred a marginally elevated risk for AD (allele model, OR = 1.08 , 95% CI: 1.01-1.15, P = 0.019 ; allele model, OR = 1.09 , 95 CI: 1.05-1.15, P < 0.001 , respectively). Furthermore, miR-196a2 rs11614913 was also associated with AD risk (allele model, OR = 0.92 , 95% CI: 0.88-0.97, P = 0.001 ) as well as miR-499 rs3746444 (allele model, OR = 1.16 , 95% CI: 1.03-1.29, P = 0.011 ). In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15 , 95% CI: 1.06-1.24, P < 0.001 ; allele model, OR = 1.11 , 95% CI:1.01-1.22, P = 0.043 , respectively). Conclusions. Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD.

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Correlation between Methylenetetrahydrofolate Reductase Polymorphisms and Hepatocellular Carcinoma: A Meta-Analysis

Annals of Nutrition and Metabolism ◽

10.1159/000496428 ◽

2019 ◽

Vol 74 (3) ◽

pp. 251-256 ◽

Cited By ~ 1

Author(s):

Hailong Su ◽

Guo Zhang

Keyword(s):

Hepatocellular Carcinoma ◽

Gene Polymorphisms ◽

Methylenetetrahydrofolate Reductase ◽

Meta Analysis ◽

Random Effect ◽

Recessive Model ◽

Mthfr Gene ◽

Systematic Research ◽

The Relationship ◽

Random Effect Models

Background: The correlation between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and hepatocellular carcinoma (HCC) remains controversial. Objectives: We performed this study to better assess the relationship between MTHFR gene polymorphisms and the likelihood of HCC. Methods: A systematic research of PubMed, Medline, and Embase was performed to retrieve relevant articles. ORs and 95% CIs were calculated. Results: A total of 15 studies with 8,378 participants were analyzed. In overall analyses, a significant association with the likelihood of HCC was detected for the rs1801131 polymorphism with fixed-effect models (FEMs) in recessive comparison (p = 0.002, OR 0.62, 95% CI 0.43–0.82). However, no positive results were detected for the rs1801133 polymorphism in any comparison. Further subgroup analyses revealed that the rs1801131 polymorphism was significantly associated with the likelihood of HCC in Asians with both FEMs (recessive model: p < 0.0001, OR 0.42, 95% CI 0.29–0.62; allele model: p = 0.004, OR 1.20, 95% CI 1.06–1.35) and random-effect models (recessive model: p = 0.002, OR 0.47, 95% CI 0.29–0.75). Nevertheless, we failed to detect any significant correlation between the rs1801133 polymorphism and HCC. Conclusions: Our findings indicated that the rs1801131 polymorphism may serve as a genetic biomarker of HCC in Asians.

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Cyp2C19*2 Polymorphism Related to Clopidogrel Resistance in Patients With Coronary Heart Disease, Especially in the Asian Population: A Systematic Review and Meta-Analysis

Frontiers in Genetics ◽

10.3389/fgene.2020.576046 ◽

2020 ◽

Vol 11 ◽

Author(s):

Ying Sun ◽

Qing Lu ◽

Xuefei Tao ◽

Biao Cheng ◽

Guoxing Yang

Keyword(s):

Gene Polymorphism ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Asian Population ◽

Fixed Effect Model ◽

Clopidogrel Resistance ◽

Effect Model ◽

The Relationship ◽

Allele Model

In recent years, the relationship between Cyp2C19*2 gene polymorphism and clopidogrel resistance reflected by platelet function assay has been studied extensively, but there is no clear conclusion yet. In order to evaluate the relationship between Cyp2C19*2 gene polymorphism and clopidogrel resistance more accurately, meta-analysis was conducted in this study. The I2 value taking 50% as the limit, the heterogeneity is judged as high or low, and then a random effect model or a fixed effect model is selected for statistical analysis. PubMed, EMBASE, Web of Science, CNKI, and China Wanfang database were searched, and the related literatures from the establishment of the database to May 2020 were collected and analyzed by STATA 15.0 software. A total of 3,073 patients were involved in 12 studies, including 1,174 patients with clopidogrel resistance and 1,899 patients with non-clopidogrel resistance. The results of this study showed that allele model (A vs. G): OR = 2.42 (95%CI: 1.97–2.98); dominant model (AA+GA vs. GG): OR = 2.74 (95%CI: 2.09–3.59); recessive model (AA vs. GA+GG): OR = 4.07 (95%CI: 3.06–5.41); homozygous model (AA vs. GG): OR = 5.70 (95%CI: 4.22–7.71); heterozygote model (GA vs. GG): OR = 2.32 (95%CI: 1.76–3.07), the differences were statistically significant. Also, the analysis of the Ethnicity subgroup indicated that the Asian allele model and the other four gene models were statistically significant. In conclusion, Cyp2C19*2 gene polymorphism is strongly associated with clopidogrel resistance. Allele A, genotype GA, AA, and GG + GA can increase clopidogrel resistance, especially in the Asian population.

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Abstract 718: The Association of Erectile Dysfunction with Carotid Intima Media Thickness and Endothelial Dysfunction: A Meta-Analysis

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.35.suppl_1.718 ◽

2015 ◽

Vol 35 (suppl_1) ◽

Author(s):

Bryan D Vo ◽

Ehimen Aneni ◽

Ebenezer Oni ◽

Wazim Maziak ◽

Theodore Feldman ◽

...

Keyword(s):

Erectile Dysfunction ◽

Meta Analysis ◽

Random Effect ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Individual Participant Data ◽

Media Thickness ◽

Individual Participant ◽

The Relationship ◽

Random Effect Models

Introduction: A recent meta-analysis showed that erectile dysfunction (ED) was associated with elevated cardiovascular disease (CVD) mortality. However, findings from studies examining the relationship between ED and sub-clinical CVD have been conflicting. This study summarizes the current evidence related to the association of ED and vascular disease as measured by flow mediated dilation (FMD) of the endothelium and carotid intima media thickness (CIMT). Methods: We searched multiple internet databases for published literature on studies assessing the association of ED and FMD, and CIMT between 1964 and 2014. A total of 11 studies met the inclusion criteria for examining the association between ED and FMD, while 7 studies met criteria for assessing the association with CIMT. Fixed-effect and random-effect models were used to assess and compare the standardized mean difference (SMD) of FMD and CIMT between persons with and without ED. Results: From a total of 795 individual participant data (590 with and 205 without ED), persons with ED had a 0.66mm (0.49, 0.83) increase in CIMT by fixed effects model or 0.67mm (0.44, 0.90) by random effects model compared to those without ED. Similarly, from 1055 individual participant data (536 with and 419 without ED), ED was associated with a significant reduction in FMD by both fixed effect (-1.10% (95% CI: -2.10, -0.95)) and random effect models (-1.53% (95% CI: -2.10, -0.95)). There was significant heterogeneity among studies assessing the relationship between ED and FMD (I2 = 93.2%, p<0.001) but not among those comparing CIMT among persons with ED (I2 = 43.5% p=0.09). Conclusion: This study confirms that ED is associated with both worsening endothelial function and increased CIMT. Thus, worsening vascular function may be a pathogenic mechanism for increased CVD morbidity and mortality in persons with ED. A diagnosis of ED should prompt a thorough CV work-up and aggressive preventive management.

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Serum Uric Acid and the Risk of Dementia: A Systematic Review and Meta-Analysis

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.625690 ◽

2021 ◽

Vol 13 ◽

Author(s):

Zhike Zhou ◽

Shanshan Zhong ◽

Yifan Liang ◽

Xiaoqian Zhang ◽

Rongwei Zhang ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Web Of Science ◽

Meta Analysis ◽

Random Effect ◽

Standard Mean Difference ◽

Low Concentrations ◽

Meta Regression Analysis ◽

The Relationship ◽

Random Effect Models

Background: This meta-analysis aimed to evaluate the relationship between serum uric acid (UA) and the risk of dementia and its subtypes.Methods: Embase, PubMed, and Web of Science were searched from inception to July 2020. Random-effect models were employed to analyze the standard mean difference (SMD) with the corresponding 95% confidence intervals (CI).Results: Twenty-three eligible studies involving 5,575 participants were identified. The overall results showed lower levels of UA in dementia relative to non-dementia controls [SMD = −0.32 (−0.64; −0.01) p = 0.04]. The subgroup analysis of the type of dementia demonstrated a significant association of UA with Alzheimer's disease (AD) [SMD = −0.58 (−1.02; −0.15) p = 0.009] and Parkinson's disease with dementia (PDD) [SMD = −0.33 (−0.52; −0.14) p = 0.001] but not with vascular dementia (VaD). The stratification analysis of the concentrations of UA revealed that the UA quartile 1–2 was negatively correlated with dementia and neurodegenerative subtypes (p < 0.05), whereas a positive correlation of UA quartile 4 with dementia was noted (p = 0.028). Additionally, the meta-regression analysis on confounders showed that not age, body mass index, diabetes mellitus, hypertension, or smoking but education (p = 0.003) exerted an influence of the UA in the risk estimate of dementia.Conclusions: Low concentrations of UA (< 292 μmol/L or 4.91 mg/dL) is a potential risk factor for AD and PDD but not for VaD. The mechanism of different concentrations of the UA in dementia needs to be confirmed through further investigation.

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Sense of Purpose in Life Is Associated with Lower Risk of Incident Dementia: A Meta-Analysis

Journal of Alzheimer s Disease ◽

10.3233/jad-210364 ◽

2021 ◽

pp. 1-10

Author(s):

Angelina R. Sutin ◽

Damaris Aschwanden ◽

Martina Luchetti ◽

Yannick Stephan ◽

Antonio Terracciano

Keyword(s):

Lower Risk ◽

Meta Analysis ◽

Random Effect ◽

Purpose In Life ◽

Population Based ◽

Primary Data ◽

Or Education ◽

Total N ◽

Sense Of Purpose ◽

Incident Dementia

Background: A sense of purpose in life has been associated with healthier cognitive outcomes across adulthood, including risk of dementia. The robustness and replicability of this association, however, has yet to be evaluated systematically. Objective: To test whether a greater sense of purpose in life is associated with lower risk of dementia in four population-based cohorts and combined with the published literature. Methods: Random-effect meta-analysis of prospective studies (individual participant data and from the published literature identified through a systematic review) that examined sense of purpose and risk of incident dementia. Results: In six samples followed up to 17 years (four primary data and two published; total N = 53,499; n = 5,862 incident dementia), greater sense of purpose in life was associated with lower dementia risk (HR = 0.77, 95%CI = 0.73–0.81, p < 0.001). The association was generally consistent across cohorts (I2 = 47%), remained significant controlling for clinical (e.g., depression) and behavioral (e.g., physical inactivity) risk factors, and was not moderated by age, gender, or education. Conclusion: Sense of purpose is a replicable and robust predictor of lower risk of incident dementia and is a promising target of intervention for cognitive health outcomes.

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Association of bisphenol A with puberty timing: a meta-analysis

Reviews on Environmental Health ◽

10.1515/reveh-2020-0091 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Hui Meng ◽

Yunping Zhou ◽

Yunxia Jiang

Keyword(s):

Bisphenol A ◽

Confidence Intervals ◽

Random Effects ◽

Strong Correlation ◽

Fixed Effects ◽

Meta Analysis ◽

Random Effects Models ◽

Study Heterogeneity ◽

The Relationship ◽

Prevalence Ratios

AbstractObjectivesThe results of existing studies on bisphenol A (BPA) and puberty timing did not reach a consensus. Thereby we performed this meta-analytic study to explore the association between BPA exposure in urine and puberty timing.MethodsMeta-analysis of the pooled odds ratios (OR), prevalence ratios (PR) or hazards ratios (HR) with 95% confidence intervals (CI) were calculated and estimated using fixed-effects or random-effects models based on between-study heterogeneity.ResultsA total of 10 studies involving 5621 subjects were finally included. The meta-analysis showed that BPA exposure was weakly associated with thelarche (PR: 0.96, 95% CI: 0.93–0.99), while no association was found between BPA exposure and menarche (HR: 0.99, 95% CI: 0.89–1.12; OR: 1.02, 95% CI: 0.73–1.43), and pubarche (OR: 1.00, 95% CI: 0.79–1.26; PR: 1.00, 95% CI: 0.95–1.05).ConclusionsThere was no strong correlation between BPA exposure and puberty timing. Further studies with large sample sizes are needed to verify the relationship between BPA and puberty timing.

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LO84: The incidence of fall-related intracranial bleeding in older adults taking anticoagulants, antiplatelets and neither medication: a meta-analysis

CJEM ◽

10.1017/cem.2020.138 ◽

2020 ◽

Vol 22 (S1) ◽

pp. S38-S38

Author(s):

K. de Wit ◽

D. Nishijima ◽

S. Mason ◽

R. Jeanmonod ◽

S. Parpia ◽

...

Keyword(s):

Older Adults ◽

Meta Analysis ◽

Grey Literature ◽

Random Effect ◽

Intracranial Bleeding ◽

Inclusion Criteria ◽

Antiplatelet Medication ◽

Cochrane Database ◽

Random Effect Models ◽

Anticoagulant Medication

Introduction: It is unclear whether anticoagulant or antiplatelet medications increase the risk for intracranial bleeding in older adults after a fall. Our aim was to report the incidence of intracranial bleeding among older adults presenting to the emergency department (ED) with a fall, among patients taking anticoagulants, antiplatelet medications, both medications and neither medication. Methods: This was a systematic review and meta-analysis, PROSPERO reference CRD42019122626. Medline, EMBASE (via OVID 1946 - July 2019), Cochrane, Database of Abstracts of Reviews of Effects databases and the grey literature were searched for studies reporting on older adults who were evaluated after a fall. We included prospective studies conducted in the ED where more than 80% of the cohort were 65 years or older and had fallen. We contacted study authors for aggregate data on intracranial bleeding in patients prescribed anticoagulant medication, antiplatelet medication and neither medication. Incidences of intracranial bleeding were pooled using random effect models, and I2 index was used to assess heterogeneity. Results: From 7,240 publication titles, 10 studies met inclusion criteria. The authors of 8 of these 10 studies provided data (on 9,489 patients). All studies scored low or moderate risk of bias. The pooled incidence of intracranial bleeding among patients taking an anticoagulant medication was 5.1% (n = 5,016, 95% Confidence Interval (CI): 4.1 to 6.3%) I2 = 42%, a single antiplatelet 6.4% (n = 2,148, 95% CI: 5.4 to 7.6%) I2 = 75%, both anticoagulant and antiplatelet medications 5.9% (n = 212, 95% CI: 1.3 to 13.5%) I2 = 72%, and neither of these medications 4.8% (n = 1,927, 95% CI: 3.5 to 6.2%) I2 = 50%. A sensitivity analysis restricted to patients who had a head CT in the ED reported incidences of 6.1% (n = 3,561, 95% CI: 3 to 8.3%), 8.4% (n = 1,781, 95% CI: 5.5 to 11.8%), 6.7% (n = 206, 95% CI 1.5 to 15.2%) and 6.6% (n = 1,310, 95% CI: 5.0 to 8.4%) respectively. Conclusion: The incidence of fall-related intracranial bleeding in older ED patients was similar among patients who take anticoagulant medication, antiplatelet medication, both and neither medication, although there was heterogeneity between study findings.

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Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies

npj Schizophrenia ◽

10.1038/s41537-021-00161-4 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Emanuele F. Osimo ◽

Luke Baxter ◽

Jan Stochl ◽

Benjamin I. Perry ◽

Stephen A. Metcalf ◽

...

Keyword(s):

Cohort Studies ◽

Meta Analysis ◽

Random Effect ◽

Population Based ◽

Continuous Variable ◽

Cross Sectional ◽

Standard Deviation Increase ◽

Suspected Infection ◽

Longitudinal Association ◽

Incident Cases

AbstractMeta-analyses of cross-sectional studies suggest that patients with psychosis have higher circulating levels of C-reactive protein (CRP) compared with healthy controls; however, cause and effect is unclear. We examined the prospective association between CRP levels and subsequent risk of developing a psychotic disorder by conducting a systematic review and meta-analysis of population-based cohort studies. Databases were searched for prospective studies of CRP and psychosis. We obtained unpublished results, including adjustment for age, sex, body mass index, smoking, alcohol use, and socioeconomic status and suspected infection (CRP > 10 mg/L). Based on random effect meta-analysis of 89,792 participants (494 incident cases of psychosis at follow-up), the pooled odds ratio (OR) for psychosis for participants with high (>3 mg/L), as compared to low (≤3 mg/L) CRP levels at baseline was 1.50 (95% confidence interval [CI], 1.09–2.07). Evidence for this association remained after adjusting for potential confounders (adjusted OR [aOR] = 1.31; 95% CI, 1.03–1.66). After excluding participants with suspected infection, the OR for psychosis was 1.36 (95% CI, 1.06–1.74), but the association attenuated after controlling for confounders (aOR = 1.23; 95% CI, 0.95–1.60). Using CRP as a continuous variable, the pooled OR for psychosis per standard deviation increase in log(CRP) was 1.11 (95% CI, 0.93–1.34), and this association further attenuated after controlling for confounders (aOR = 1.07; 95% CI, 0.90–1.27) and excluding participants with suspected infection (aOR = 1.07; 95% CI, 0.92–1.24). There was no association using CRP as a categorical variable (low, medium or high). While we provide some evidence of a longitudinal association between high CRP (>3 mg/L) and psychosis, larger studies are required to enable definitive conclusions.

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PSII-17 Program Chair Poster Pick: Effect of ruminal protozoa on methane emissions in ruminants – a meta-analysis

Journal of Animal Science ◽

10.1093/jas/skaa278.698 ◽

2020 ◽

Vol 98 (Supplement_4) ◽

pp. 397-398

Author(s):

Xiaoxia Dai ◽

Kenneth Kalscheur ◽

Pekka Huhtanen ◽

Antonio Faciola

Keyword(s):

Dairy Cows ◽

Meta Analysis ◽

Random Effect ◽

Negative Relationship ◽

Small Ruminants ◽

Methane Emissions ◽

Mitigation Strategies ◽

Positive Relationships ◽

Ruminal Fermentation ◽

The Relationship

Abstract The effects of ruminal protozoa (RP) concentration on methane emissions from ruminants were evaluated in a meta-analysis using 67 publications reporting data from 85 in vivo experiments. Experiments included in the database reported methane emissions (g/kg DMI) and RP (log10 cells/mL) from the same group of animals. Quantitative data including diet chemical composition, ruminal fermentation, total tract digestibility, and milk production; and qualitative information including methane mitigation strategies, animal type, and methane measurement methods were also collected. The studies were conducted in dairy cows (51%), beef steers (32%) and small ruminants (32%). 70% of the studies reported a reduction in methane emissions. Supplemental lipids reduced methane emissions 95% of the time. The relationship between methane emissions and RP concentration was evaluated as a random coefficient model with the experiment as a random effect and weighted by the inverse pooled SEM squared, including the possibility of covariance between the slope and the intercept. A quadratic effect of RP concentration on methane emissions was detected: CH4= -28.8 + 12.2 × RP-0.64 × RP2. To detect potential interfering factors in the relationship, the influence of several qualitative and quantitative factors were separately tested. Acetate, butyrate, and isobutyrate molar proportions had positive relationships with methane emissions and influenced the relationship between RP concentration and methane emissions, where the presence of ruminal fermentation variables reduced the effects of RP concentration in methane emissions. Total tract digestibility of DM, OM, and CP had negative relationships while NDF digestibility had a positive relationship with methane emissions; however, they only changed the magnitude of intercept and slope of RP and RP2 for the relationship. For dairy cows, milk fat and protein concentrations had positive relationships and milk yield had a negative relationship with methane emissions and changed the magnitude of intercept and slope of RP and RP2 for the relationship.

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Low birth weight, preterm birth and small for gestational age association with adult depression: systematic review and meta-analysis

The British Journal of Psychiatry ◽

10.1192/bjp.bp.113.139014 ◽

2014 ◽

Vol 205 (5) ◽

pp. 340-347 ◽

Cited By ~ 31

Author(s):

Christian Loret De Mola ◽

Giovanny Vinícius Araújo De França ◽

Luciana de Avila Quevedo ◽

Bernardo Lessa Horta

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Premature Birth ◽

Fixed Effects ◽

Meta Analysis ◽

Adult Depression ◽

Meta Analyses ◽

Relationship Of ◽

The Relationship

BackgroundThere is no consensus on the effects that low birth weight, premature birth and intrauterine growth have on later depression.AimsTo review systematically the evidence on the relationship of low birth weight, smallness for gestational age (SGA) and premature birth with adult depression.MethodWe searched the literature for original studies assessing the effect of low birth weight, premature birth and SGA on adult depression. Separate meta-analyses were carried out for each exposure using random and fixed effects models. We evaluated the contribution of methodological covariates to heterogeneity using meta-regression.ResultsWe identified 14 studies evaluating low birth weight, 9 premature birth and 4 SGA. Low birth weight increased the odds of depression (OR = 1.39, 95% CI 1.21–1.60). Premature birth and SGA were not associated with depression, but publication bias might have underestimated the effect of the former and only four studies evaluated SGA.ConclusionsLow birth weight was associated with depression. Future studies evaluating premature birth and SGA are needed.

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