Near-Infrared Photoimmunotherapy for Cancers of the Gastrointestinal Tract

Background: Cancers of the gastrointestinal (GI) tract are the common leading cause of cancer-related death in the world. Recent advances in cancer therapies such as intensive multidrug chemotherapy and molecular targeted treatment have improved therapeutic efficacy; however, the outcomes are not satisfied. Moreover, these therapies also cause severe side effects. New type of cancer therapies is urgently needed to improve the outcomes and to reduce side effects of GI tract cancers. Summary: This account is a comprehensive review article on the newly developed, photochemistry-based cancer therapy named as near-infrared photoimmunotherapy (NIR-PIT). NIR-PIT is a highly selective tumor treatment that employs an antibody-photoabsorber conjugate, which is activated by near-infrared light. A world-wide phase 3 clinical trial of NIR-PIT against recurrent head and neck cancer patients is currently underway. NIR-PIT differs from conventional cancer therapies such as surgery, chemotherapy, and radiation in its selectivity for killing cancer cells and cells treated with NIR-PIT leading to immunogenic cell death. Preclinical research in animals with combining cancer-targeting NIR-PIT and other cancer immunotherapies could lead to responses not only in local tumor but also in distant metastases. NIR-PIT also leads to an immediate and dramatic increase in vascular permeability after therapy. From these aspects, NIR-PIT appears to be a promising new form of cancer therapy. NIR-PIT could be readily translated into clinical use for virtually any cancers in the near future provided suitable humanized antibodies are available. Here, we describe the specific advantages and applications of NIR-PIT in the GI tract. Key Messages: We believe that NIR-PIT with NIR excitation light, which can be delivered via a fiber optic diffuser through endoscopes, is a promising method for a new treatment of GI cancers.

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Comparison of Four Common Gold Nanoparticles for Photothermal Cancer Therapy: A Review

International Journal of Engineering Materials and Manufacture ◽

10.26776/ijemm.05.04.2020.02 ◽

2020 ◽

Vol 5 (4) ◽

pp. 116-129

Author(s):

Sabrina N. Saiphoo ◽

Cassidy M. Rose ◽

Alexander T. Dunn ◽

Dwij J. Padia ◽

Muhammad Hasibul Hasan

Keyword(s):

Gold Nanoparticles ◽

Side Effects ◽

Cancer Therapy ◽

Photothermal Therapy ◽

Near Infrared ◽

Treatment Options ◽

Infrared Light ◽

Gold Nanospheres ◽

Cancerous Tissue ◽

Patient Prognosis

Current cancer treatment options, including surgery, chemotherapy and radiation therapy, often cause damage to healthy tissue and reduce a patient's quality of life with well-known side effects, such as pain, infection and nerve damage. Recent research has shown that gold nanoparticles used as photothermal agents in photothermal therapy may pose as an alternative to traditional treatments. This great potential is due to their ability to selectively accumulate in cancerous tissue, efficiently absorb near-infrared light, and kill cancerous tissue without harming surrounding cells. Gold nanoparticles show promise in increasing treatment efficacy and reducing the side effects associated with cancer therapy. While recent studies show the potential of gold nanoparticles, the existing literature is limited in drawing comparisons between studies and practical use for photothermal therapy. This paper reviews notable studies on four common gold nanoparticles used in the therapeutic treatment of cancer: gold nanocages, gold nanospheres, gold nanorods, and gold nanoshells. By comparing key characteristics of the particles’, including their synthesis, toxicity, absorption spectrum, and selective photothermal lethality, gold nanospheres can be recommended for use in photothermal therapy. Although forms of each gold nanoparticle were found to have a low toxicity, gold nanospheres can be rapidly synthesized and appear to exceed in selective photothermal lethality and immature tumour accumulation. Due to these advantages in using gold nanospheres for photothermal therapy, cancer could be treated more effectively and improve patient prognosis.

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Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

Current Drug Targets ◽

10.2174/1389450121666200514222900 ◽

2020 ◽

Vol 21 (11) ◽

pp. 1084-1098

Author(s):

Fengqian Chen ◽

Yunzhen Shi ◽

Jinming Zhang ◽

Qi Liu

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Therapeutic Index ◽

Delivery Systems ◽

Epigenetic Therapy ◽

Cancer Therapies ◽

Therapeutic Benefits ◽

High Therapeutic Index

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.

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Recent Near-Infrared Light-Activated Nanomedicine toward Precision Cancer Therapy

Journal of Materials Chemistry B ◽

10.1039/d1tb00671a ◽

2021 ◽

Author(s):

Xiaowei Luan ◽

Yongchun Pan ◽

Yanfeng Gao ◽

Yujun Song

Keyword(s):

Cancer Therapy ◽

Near Infrared ◽

Infrared Light ◽

Human Society ◽

Near Infrared Light ◽

History Of ◽

The Universe

Light has witnessed the history of mankind and even the universe. It is of great significances to the life of human society, contributing to energy, agriculture, communication, and much more....

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Near-infrared Light Triggered Activation of Pro-drug Combination Cancer Therapy and Induction of Immunogenic Cell Death

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2021.120972 ◽

2021 ◽

pp. 120972

Author(s):

Xuejia Kang ◽

Yuxin Cai ◽

Qi Wang ◽

Chuanyu Wang ◽

Wu Chen ◽

...

Keyword(s):

Cell Death ◽

Cancer Therapy ◽

Drug Combination ◽

Near Infrared ◽

Infrared Light ◽

Immunogenic Cell Death ◽

Near Infrared Light ◽

Combination Cancer Therapy

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Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

Nano-Micro Letters ◽

10.1007/s40820-020-00516-z ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

Songtao Zhang ◽

Longhai Jin ◽

Jianhua Liu ◽

Yang Liu ◽

Tianqi Zhang ◽

...

Keyword(s):

Cancer Therapy ◽

Bovine Serum Albumin ◽

Synergistic Effect ◽

Bovine Serum ◽

Photothermal Therapy ◽

Near Infrared ◽

Infrared Light ◽

Photothermal Effect ◽

Reaction Efficiency

AbstractIn spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

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Biocompatible PEGylated Fe3O4 Nanoparticles as Photothermal Agents for Near-Infrared Light Modulated Cancer Therapy

International Journal of Molecular Sciences ◽

10.3390/ijms151018776 ◽

2014 ◽

Vol 15 (10) ◽

pp. 18776-18788 ◽

Cited By ~ 30

Author(s):

Gang Yuan ◽

Yongjie Yuan ◽

Kan Xu ◽

Qi Luo

Keyword(s):

Cancer Therapy ◽

Fe3o4 Nanoparticles ◽

Near Infrared ◽

Infrared Light ◽

Near Infrared Light

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Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

International Journal of Molecular Sciences ◽

10.3390/ijms20020341 ◽

2019 ◽

Vol 20 (2) ◽

pp. 341 ◽

Cited By ~ 8

Author(s):

Dik-Lung Ma ◽

Chun Wu ◽

Sha-Sha Cheng ◽

Fu-Wa Lee ◽

Quan-Bin Han ◽

...

Keyword(s):

Side Effects ◽

Cancer Therapy ◽

Adverse Effects ◽

Metal Complexes ◽

Natural Product ◽

Cancer Care ◽

Cancer Therapies ◽

The Future ◽

Therapy Development ◽

Enhanced Selectivity

Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.

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Near-infrared light-controlled circularly polarized luminescence of self-organized emissive helical superstructures assisted by upconversion nanoparticles

Chemical Communications ◽

10.1039/d0cc05910b ◽

2020 ◽

Vol 56 (88) ◽

pp. 13649-13652 ◽

Cited By ~ 1

Author(s):

Ao Juan ◽

Hao Sun ◽

Jinghui Qiao ◽

Jinbao Guo

Keyword(s):

Near Infrared ◽

Infrared Light ◽

Upconversion Nanoparticles ◽

Near Infrared Light ◽

Excitation Light ◽

Circularly Polarized ◽

Self Organized ◽

Circularly Polarized Luminescence ◽

Polarized Luminescence ◽

First Time

The reversible switching of circularly polarized luminescence in a self-organized emissive helical superstructure using 980 nm NIR excitation light with different power intensities is reported for the first time.

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