scholarly journals A Case of Renal Pelvic Cancer with a Complete Duplication of the Renal Pelvis and Ureter

2021 ◽  
pp. 202-206
Author(s):  
Takuma Nirei ◽  
Tadashi Tabei ◽  
Hiroki Ito ◽  
Kazuki Kobayashi
Keyword(s):  
Renal Pelvis ◽  
Histopathological Examination ◽  
Upper Urinary Tract ◽  
Magnetic Resonance Imaging Scan ◽  
Ectopic Ureter ◽  
Gross Hematuria ◽  
Pelvic Cancer ◽  
Renal Pelvic Cancer ◽  
Enhanced Computed Tomography ◽  
Complete Duplication

This paper describes a case of renal pelvic cancer with a complete duplication of the renal pelvis and ureter, which is substantially rare. A 76-year-old man was referred to the hospital because of gross hematuria for 2 years. A tumor was detected in the upper right kidney using enhanced computed tomography and magnetic resonance imaging scan, and the downstream ureter was suspected to open into the prostate. Retrograde ureteroscopy via the ectopic ureter orifice showed a hemorrhagic papillary tumor consistent with imaging findings. Laparoscopic radical nephroureterectomy was performed and the prostate was preserved because the tumor was only in the renal pelvis. Histopathological examination showed the tumor as a high-grade urothelial carcinoma. There was no sign of recurrence at one and a half years after operation. Ureteroscopy was effective in detecting an upper urinary tract tumor, even via ectopic ureter orifice, and preserving the prostate was possible.

Chinese Herb Resveratrol Inhibits Renal Pelvic Cancer Cell Proliferation via Regulating miR-30a-5p

2021 ◽  
Vol 15 (2) ◽  
pp. 253-259
Author(s):  
Zunwei Zhu ◽  
Jinggong Wu ◽  
Lieyu Xu ◽  
Yong Wan ◽  
Haichao Chao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Survival ◽  
Renal Pelvis ◽  
Cell Apoptosis ◽  
Target Gene ◽  
Chinese Herb ◽  
Cancer Cell Proliferation ◽  
Pelvic Cancer ◽  
Renal Pelvic Cancer

Renal pelvis cancer (RPC) is rare with unclear pathogenesis. Resveratrol (RSV) also plays a beneficial role in preventing chronic diseases related to inflammation. But its effect on RPC cells has not been reported. RPC cells were cultured and treated with resveratrol for 48 hours followed by analysis of cell proliferation, apoptosis and cell cycle, and miR-30a-5p expression. The expression of miR-30a-5p effects proliferation, apoptosis and cell cycle was also assessed. After treatment, RPC cells showed upregulated miR-30a-5p, decreased cell survival and enhanced cell apoptosis rate compared with abnormal cell cycle (P < 0.05), and the effect was more significant with the increase in concentration (P < 0.05). The miR-30a-5p target gene is AVEN. miR-30a-5p downregulation can reverse its effect on RPC cells (P < 0.05). Resveratrol treatment on RPC cells can upregulate miR-30a-5p, inhibite cell proliferation, promotes apoptosis, and changes cell cycle.

Accuracy of an urine-based liquid biopsy genetic test in detecting renal pelvic cancer.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16500-e16500
Author(s):  
Yansheng Xu ◽  
Min Shi ◽  
Yiming Liang ◽  
Hongzhao Li ◽  
Xin Ma ◽  
...  
Keyword(s):  
High Risk ◽  
Renal Pelvis ◽  
Liquid Biopsy ◽  
Genetic Test ◽  
Methylation Status ◽  
Pathology Report ◽  
Low Grade ◽  
Tumor Implantation ◽  
Pelvic Cancer ◽  
Renal Pelvic Cancer

e16500 Background: Renal pelvis cancer is accounting for about two-thirds of upper tract urinary carcinoma. Lesions in renal pelvis often lead to a differential diagnosis that requires ureteroscopic biopsy. Besides causing discomfort and pain, ureteroscopy prior to surgery increases risk of tumor implantation and recurrence. Although urine cytology and FISH were applied, more effective non-invasive diagnostic method is imperative for diagnosis of renal pelvic cancer. Methods: A total of 141 patients with one or more lesions in renal pelvis detected by ultrasound were enrolled. 50-ml first-void urine sample was collection before ureteroscopic biopsy and was analysis by Genetron uro-18 genes panel, by which mutations in 17 genes and methylation status of ONECUT2 were analysis using high-throughput sequencing. If mutations and/or ONECUT2 methylation were detected in urine sediment DNA, the patients were considered as high risk of renal pelvis cancer. The results of the urine-based liquid biopsy genetic test were compared with pathology report and urine FISH results of urinary cells. Results: According to pathological analysis with ureteroscopic biopsy, 42 out of 141 patients (29.7%) were diagnosis with renal pelvic cancer: 13 low-grade, 24 high-grade, 5 equivocal. For 33 renal pelvic cancer patients with FISH testing result of urinary cells, only 54.5% (18/33) samples were positive. By Genetron uro-18 genes test, 95 patients (67.4%) were classified as high risk and 46 (32.6%) patients were low risk. The overall specificity was 88.0% (88/95) and overall sensitivity was 92.9% (39/42), which is significant higher than FISH test of urinary cells. Conclusions: With high specificity and sensitivity, Genetron uro-18 genes test could be incorporated in renal pelvic cancer diagnosis, especially for patients with a ultrasound detectable lesions. Ureteroscopy prior to surgery could be reduced, which may lead to decrease risk of tumor implantation and recurrence.

scholarly journals Methotrexate-Associated Lymphoproliferative Disorder: Dermoscopic Features

2018 ◽  
Vol 10 (2) ◽  
pp. 149-153 ◽  
Author(s):  
Takeshi Namiki ◽  
Yumiko Sone ◽  
Keiko Miura ◽  
Masaru Tanaka ◽  
Hiroo Yokozeki
Keyword(s):  
Lymphoproliferative Disorder ◽  
Histopathological Examination ◽  
Subcutaneous Tissue ◽  
Lymphoid Cells ◽  
Erythematous Plaque ◽  
Rheumatic Arthritis ◽  
Barr Virus ◽  
Perivascular Infiltrate ◽  
Epstein Barr ◽  
Enhanced Computed Tomography

Methotrexate-related lymphoproliferative disorder (MTX-LPD) is a rare disorder caused by long-term MTX therapy for autoimmune diseases. There has been no report of the dermoscopic features of MTX-LPD to date. A 64-year-old female presented with a slightly elevated indurated erythematous plaque with scales on her right thigh. The patient had been treated for rheumatic arthritis with MTX and prednisolone for more than 15 years, and 18 mg/week MTX without prednisolone had been administered in the last year. Dermoscopy revealed dotted vessels and glomerular vessels on pink homogeneous areas and multiple surface scales. Enhanced computed tomography showed multiple nodules and lymphadenopathies at the mediastinum and axillae. Histopathological examination revealed telangiectasia in the superficial dermis. Atypical lymphoid cells were scattered in the whole dermis and subcutaneous tissue. A perivascular infiltrate of atypical lymphocytes and histiocytoid cells partially destroyed the vessel walls. Epstein-Barr virus in situ hybridization showed a positive result. The cessation of MTX reduced the erythematous plaque, and lymphadenopathies at the neck, mediastinum, and axillae were not palpable. We discuss the relevance of these dermoscopic and histopathological features. The accumulation of such cases will reveal the dermoscopic features of MTX-LPD and the utility of dermoscopy for the diagnosis of MTX-LPD.

Renal pelvic cancer: A review of 611 patients treated in Illinois 1975–1985

Urology ◽  
1992 ◽  
Vol 40 (5) ◽  
pp. 393-399 ◽  
Author(s):  
Patrick Guinan ◽  
Nicholas J. Vogelzang ◽  
Randal Randazzo ◽  
Stephen Sener ◽  
Joan Chmiel ◽  
...  
Keyword(s):  
Pelvic Cancer ◽  
Renal Pelvic Cancer

Factitious Hematuria With Underlying Renal Abnormalities

PEDIATRICS ◽  
1988 ◽  
Vol 82 (3) ◽  
pp. 377-379
Author(s):  
RICHARD F. SALMON ◽  
BILLY S. ARANT ◽  
MICHEL G. BAUM ◽  
RONALD J. HOGG
Keyword(s):  
Vesicoureteric Reflux ◽  
Term Pregnancy ◽  
Gross Hematuria ◽  
Persistent Symptoms ◽  
History Of ◽  
Appropriate Therapy ◽  
Complete Duplication ◽  
Renal Abnormalities ◽  
Recurrent Hematuria ◽  
Collecting System

Factitious hematuria is a well-described cause of hematuria in adult patients but is rarely seen or considered in children.1-6 In this article, a 5-year-old girl with a history of gross hematuria with more than one pathologic explanation for recurrent hematuria is described. Because of persistent symptoms despite appropriate therapy, a factitious cause was considered. CASE REPORT The patient was the healthy product of the uncomplicated full-term pregnancy of an unmarried woman who reared the child in the home of her mother and sister. The diagnosis of urinary tract infection was made first at 2 years of age. In subsequent radiographic studies, two normal kidneys were identified, with complete duplication of the left collecting system and bilateral grade 2 vesicoureteric reflux.

scholarly journals Acute Abdomen due to Mutual Tangle of Two Small Paratubal Cysts

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Hiroharu Kobayashi ◽  
Shinichi Shibuya ◽  
Kentaro Iga ◽  
Keiichiro Kato ◽  
Airi Kato ◽  
...  
Keyword(s):  
Acute Abdomen ◽  
Histopathological Examination ◽  
Lower Abdominal Pain ◽  
Cystic Teratoma ◽  
Cystic Mass ◽  
Mature Cystic Teratoma ◽  
Contrast Enhanced ◽  
The Right ◽  
Enhanced Computed Tomography ◽  
Paratubal Cyst

A 30-year-old woman (gravida 0) visited our hospital with a complaint of right lower abdominal pain. Transvaginal ultrasonography revealed a 5-cm swollen right ovary, which was suspected to be a mature cystic teratoma. Pelvic examination revealed moderate pain. Contrast-enhanced computed tomography showed a 44-mm cystic mass containing fat and calcified material in the right pelvis. Since torsion was suspected, emergent laparoscopic surgery was performed. Intraoperative findings were a swollen right ovary without torsion or congestion. Two small pedunculated 1- and 2-cm diameter paratubal cysts that grew from almost the same place of the ampulla of the right fallopian tube were observed. The thin stalk of the 1-cm paratubal cyst was entangled around the stalk of the 2-cm paratubal cyst, with its head congested. Through a small abdominal laparoscopic incision, the tumor of the right ovary and the two paratubal cysts were excised. Histopathological examination revealed that the right ovarian tumor was a mature cystic teratoma, and the two paratubal cysts had no malignancy. This case showed that only a 2-cm tumor with congestion caused the acute abdomen.

Renal Pelvic Cancer with Tumor Thrombus in the Vena Cava Inferior

1997 ◽  
Vol 59 (4) ◽  
pp. 263-265 ◽  
Author(s):  
Masaya Fujimoto ◽  
Yuichi Tsujimoto ◽  
Norio Nonomura ◽  
Yasuyuki Kojima ◽  
Tsuneharu Miki ◽  
...  
Keyword(s):  
Tumor Thrombus ◽  
Vena Cava ◽  
Vena Cava Inferior ◽  
Pelvic Cancer ◽  
Renal Pelvic Cancer

scholarly journals A Child with Right Complete Ureteral Duplication Revealed by Sepsis in Northern Benin: A Case Report

2020 ◽  
Vol 3 (1) ◽  
pp. 71-74
Author(s):  
Agbeille Mohamed F ◽  
Agossou J ◽  
Gandaho I ◽  
Kpanidja MG ◽  
Noudamadjo A ◽  
...  
Keyword(s):  
Case Report ◽  
Urinary Tract ◽  
Lumbar Spine ◽  
Early Diagnosis ◽  
Upper Urinary Tract ◽  
Urinary Tract Abnormalities ◽  
Ureteral Duplication ◽  
The Right ◽  
Upper Urinary Tract Abnormalities ◽  
Complete Duplication

Upper urinary tract abnormalities are relatively common and may be diagnosed before or at birth. Some cases will be seen during complications that most often are obstructive. We herein report one case of complete right ureter duplication revealed by sepsis. The case involved one little girl aged 3 years, referred from a peripheral health center for prolonged fever. Physical examination found out a right flank mass connecting with the lumbar spine, renal ballottement, and pain due to a blow to the right flank. Further explorations helped establish the diagnosis of complete duplication of the right ureter with the destruction of the upper renal pelvis. Little girl benefitted from a dual antibiotic therapy combined with partial nephrectomy of the right kidney upper pole. Infectious are serious complications in upper urinary tract obstructions resulting in kidney destruction; therefore, early diagnosis is required.

scholarly journals Inflammatory myofibroblastic tumor of the bladder: case report and review of the literature

2013 ◽  
Vol 7 (3-4) ◽  
pp. e237-40 ◽  
Author(s):  
Li Wei ◽  
Liang Jianbo ◽  
Wei Qiang ◽  
Yu Hai ◽  
Lan Zhixiang
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Bladder Tumor ◽  
Malignant Potential ◽  
Rare Tumor ◽  
Review Of The Literature ◽  
Gross Hematuria ◽  
Contrast Enhanced ◽  
Enhanced Computed Tomography ◽  
Contrast Enhanced Computed Tomography

Inflammatory myofibroblastic tumor (IMT) is a rare tumor with malignant potential, and it has been described in many major organs. However, bladder location is very uncommon. We report the case of a 23-year-old women presented with painless gross hematuria last for 2 weeks. Contrast-enhanced computed tomography (CT) revealed a bladder tumor. The patient underwent a open partial cystectomy and the final pathologic diagnosis was inflammatory myofibroblastic tumor of bladder. Typical IMTs can be locally aggressive, thus close follow-up is necessary.

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