Gelatin-Containing Vaccines for Varicella, Zoster, Measles, Mumps, and Rubella Induce Basophil Activation in Patients with Alpha-Gal Syndrome

2021 ◽  
pp. 1-7
Author(s):  
Paul Schmidle ◽  
Jana Mehlich ◽  
Knut Brockow ◽  
Ulf Darsow ◽  
Tilo Biedermann ◽  
...  
Keyword(s):  
Case Reports ◽  
Meat Products ◽  
Live Vaccine ◽  
Basophil Activation ◽  
Type I ◽  
Mmr Vaccine ◽  
Varicella Zoster ◽  
Additional Tool ◽  
Severe Anaphylaxis ◽  
New Type

Background: The alpha-gal syndrome (AGS) describes a new type I allergy entity to the carbohydrate epitope galactose-α-1,3-galactose (alpha-gal), which is mainly found in mammalian food products (e.g., beef, pork, and venison). Apart from meat products, alpha-gal can also be found in products containing gelatin of bovine or porcine origin. Recent case reports pointed to severe anaphylaxis in patients suffering from AGS after vaccination with vaccines containing hydrolyzed gelatin. It was the objective of this study to evaluate if basophil activation tests (BATs) performed with such vaccines were positive in patients with AGS. Methods: BAT was performed with different dilutions of a gelatin-containing measles, mumps, and rubella (MMR) live vaccine; an attenuated varicella (V) vaccine; an attenuated V-zoster (VZ) vaccine; a MMR live vaccine not containing gelatin (non-gelatin MMR vaccine) in 2 patients with confirmed AGS, 2 patients highly suspicious for AGS, and 2 healthy individuals without any previous medical history for allergies. Results: All patients showed strongly positive results for all gelatin-containing vaccines (MMR vaccine, V vaccine, and VZ vaccine). Non-gelatin MMR vaccine was negative. The 2 healthy controls did not show any basophil activation. Conclusions: Gelatin-containing vaccines should be administered with caution or avoided in patients with AGS because of their high potential to activate basophils indicating a risk for anaphylaxis. Also, BAT is a useful additional tool when it comes to screening for potentially high-risk alpha-gal-containing drugs.

scholarly journals Management of Amelogenesis Imperfecta in Childhood: Two Case Reports

2021 ◽  
Vol 18 (13) ◽  
pp. 7204
Author(s):  
Mirja Möhn ◽  
Julia Camilla Bulski ◽  
Norbert Krämer ◽  
Alexander Rahman ◽  
Nelly Schulz-Weidner
Keyword(s):  
Case Reports ◽  
Treatment Options ◽  
Permanent Dentition ◽  
Amelogenesis Imperfecta ◽  
Structural Defects ◽  
Type I ◽  
Oral Rehabilitation ◽  
Self Confidence ◽  
Health Quality ◽  
Masticatory System

Amelogenesis imperfecta (AI) is defined as an interruption of enamel formation due to genetic inheritance. To prevent malfunction of the masticatory system and an unaesthetic appearance, various treatment options are described. While restoration with a compomer in the anterior region and stainless steel crowns in the posterior region is recommended for deciduous dentition, the challenges when treating such structural defects in mixed or permanent dentition are changing teeth and growing jaw, allowing only temporary restoration. The purpose of this case report is to demonstrate oral rehabilitation from mixed to permanent dentition. The dentition of a 7-year-old patient with AI type I and a 12-year-old patient with AI type II was restored under general anesthesia to improve their poor aesthetics and increase vertical dimension, which are related to problems with self-confidence and reduced oral health quality of life. These two cases show the complexity of dental care for structural anomalies of genetic origin and the challenges in rehabilitating the different phases of dentition.

scholarly journals Treatment of Syringomyelia Associated with Chiari malformation (Type I), FMD was effective-2 Case Reports-

2004 ◽  
Vol 53 (1) ◽  
pp. 80-84
Author(s):  
Takashi Inokuchi ◽  
Hironobu Akune ◽  
Toshio Tokuhisa ◽  
Masakazu Kouzuma ◽  
Hideki Ota
Keyword(s):  
Chiari Malformation ◽  
Case Reports ◽  
Type I ◽  
Chiari Malformation Type I

scholarly journals TolC-Dependent Modulation of Host Cell Death by the Francisella tularensis Live Vaccine Strain

2014 ◽  
Vol 82 (5) ◽  
pp. 2068-2078 ◽  
Author(s):  
Christopher R. Doyle ◽  
Ji-An Pan ◽  
Patricio Mena ◽  
Wei-Xing Zong ◽  
David G. Thanassi
Keyword(s):  
Cell Death ◽  
Immune Responses ◽  
Host Cell ◽  
Francisella Tularensis ◽  
Vaccine Strain ◽  
Live Vaccine ◽  
Live Vaccine Strain ◽  
Type I ◽  
Content Type ◽  
Host Cell Death

ABSTRACTFrancisella tularensisis a facultative intracellular, Gram-negative pathogen and the causative agent of tularemia. We previously identified TolC as a virulence factor of theF. tularensislive vaccine strain (LVS) and demonstrated that a ΔtolCmutant exhibits increased cytotoxicity toward host cells and elicits increased proinflammatory responses compared to those of the wild-type (WT) strain. TolC is the outer membrane channel component used by the type I secretion pathway to export toxins and other bacterial virulence factors. Here, we show that the LVS delays activation of the intrinsic apoptotic pathway in a TolC-dependent manner, both during infection of primary macrophages and during organ colonization in mice. The TolC-dependent delay in host cell death is required forF. tularensisto preserve its intracellular replicative niche. We demonstrate that TolC-mediated inhibition of apoptosis is an active process and not due to defects in the structural integrity of the ΔtolCmutant. These findings support a model wherein the immunomodulatory capacity ofF. tularensisrelies, at least in part, on TolC-secreted effectors. Finally, mice vaccinated with the ΔtolCLVS are protected from lethal challenge and clear challenge doses faster than WT-vaccinated mice, demonstrating that the altered host responses to primary infection with the ΔtolCmutant led to altered adaptive immune responses. Taken together, our data demonstrate that TolC is required for temporal modulation of host cell death during infection byF. tularensisand highlight how shifts in the magnitude and timing of host innate immune responses may lead to dramatic changes in the outcome of infection.

scholarly journals Physics and Modeling of Various Hazardous Landslides

Geosciences ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 108
Author(s):  
Jόnas Elíasson ◽  
Þorsteinn Sæmundsson
Keyword(s):  
Turbulent Flows ◽  
High Velocity ◽  
Wave Theory ◽  
Type I ◽  
Flow Paths ◽  
Stable Slope ◽  
Slope Factor ◽  
New Type ◽  
Flowing Material ◽  
Type Studies

In 2014, the Varnes classification system for landslides was updated. Complex landslides can still be a problem to classify as the classification does not include the flow type in the hydrodynamical sense. Three examples of Icelandic landslides are presented and later used as case studies in order to demonstrate the methods suggested to analyze the flow. The methods are based on the different physical properties of the flow types of the slides. Three different flow types are presented, named type (i), (ii), and (iii). Types (i) and (ii) do not include turbulent flows and their flow paths are sometimes independent of the velocity. Type (iii) include high velocity flows; they are treated with the translator wave theory, where a new type of a slope factor is used. It allows the slide to stop when the slope has flattened out to the value that corresponds to the stable slope property of the flowing material. The type studies are for a fast slide of this type, also a large slip circle slide that turns into a fast-flowing slide farther down the path and finally a large slide running so fast that it can run for a kilometer on flat land where it stops with a steep front.

More to Be Learned From Crigler-Najjar Patients

PEDIATRICS ◽  
1993 ◽  
Vol 92 (1) ◽  
pp. 184-184
Author(s):  
THOR WILLY RUUD HANSEN
Keyword(s):  
Case Reports ◽  
Type I ◽  
Total Body

To the Editor.— In a recent study by Galbraith et al,1 the use of tin-mesoporphyrin in two patients with the Crigler-Najjar type I syndrome is described. The feasibility of this kind of treatment is documented, and the authors' comments on the size of the total-body bilirubin pool as well as their calculations on bilirubin production and clearance in these patients are illuminating. Personally, I am intrigued as much by aspects of the case reports, about which the authors do not comment, probably because these aspects are outside the focus of their paper.

scholarly journals Complete Genome Sequence of Brevibacterium linens SMQ-1335

2016 ◽  
Vol 4 (6) ◽  
Author(s):  
Alessandra G. de Melo ◽  
Simon J. Labrie ◽  
Jeannot Dumaresq ◽  
Richard J. Roberts ◽  
Denise M. Tremblay ◽  
...  
Keyword(s):  
Complete Genome Sequence ◽  
Open Reading Frames ◽  
Type I ◽  
Industrial Strain ◽  
Modification System ◽  
Brevibacterium Linens ◽  
Restriction Modification System ◽  
New Type ◽  
Restriction Modification ◽  
Reading Frames

Brevibacterium linens is one of the main bacteria found in the smear of surface-ripened cheeses. The genome of the industrial strain SMQ-1335 was sequenced using PacBio. It has 4,209,935 bp, a 62.6% G+C content, 3,848 open reading frames, and 61 structural RNAs. A new type I restriction-modification system was identified.

scholarly journals A Study on A New Type 1 Half-Logistic Family of Distributions and Its Applications

2020 ◽  
Vol 8 (4) ◽  
pp. 934-949
Author(s):  
Morad Alizadeh ◽  
Alireza Nematollahi ◽  
Emrah Altun ◽  
Mahdi Rasekhi
Keyword(s):  
Residual Life ◽  
Moment Generating Function ◽  
Likelihood Method ◽  
Mean Deviation ◽  
Model Parameters ◽  
Type I ◽  
Monte Carlo Simulation Study ◽  
New Type ◽  
Application Fields ◽  
Family Of Distributions

In this paper, we propose a new class of continuous distributions with two extra shape parameters called the a new type I half logistic-G family of distributions. Some of important properties including ordinary moments, quantiles, moment generating function, mean deviation, moment of residual life, moment of reversed residual life, order statistics and extreme value are obtained. To estimate the model parameters, the maximum likelihood method is also applied by means of Monte Carlo simulation study. A new location-scale regression model based on the new type I half logistic-Weibull distribution is then introduced. Applications of the proposed family is demonstrated in many fields such as survival analysis and univariate data fitting. Empirical results show that the proposed models provide better fits than other well-known classes of distributions in many application fields.

scholarly journals The Importance of Interferon-Tau in the Diagnosis of Pregnancy

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Alicja Kowalczyk ◽  
Ewa Czerniawska-Piątkowska ◽  
Marcjanna Wrzecińska
Keyword(s):  
Dairy Cattle ◽  
Specific Protein ◽  
Type I ◽  
Reproductive Disorders ◽  
Interferon Tau ◽  
Interferon Stimulated Genes ◽  
Genes Encoding ◽  
Pregnancy Status ◽  
New Type ◽  
Pregnancy Recognition

Several decades of improving dairy cattle towards unilateral utilization of dairy cattle led to enormous progress in the field of milk yield; however, it resulted in a number of unfavorable features, such as reproductive disorders, increased calf mortality, and reduced health. Most cases of embryo loss and/or lost pregnancies occur during the first four to five weeks of gestation; accurate detection for pregnancy during this period is likely to contribute to an improvement in gestation rates. A specific protein, interferon-tau (IFNT), stimulates interferon-stimulated genes (ISGs), and their expression increases during gestation within 21 days after insemination. In bovines, the early conceptus undergoes a phase of rapid growth and elongation before implantation, the latter occurring 2–3 weeks after fertilization. IFNT acts mainly in the endometrium of the luminal epithelium. It is a new type I interferon that regulates several genes encoding uterine-derived factors. They are crucial in the processes of preparing the uterus for placenta attachment, modifying the uterine immune system, and regulating early fetal development. Because IFNT is expressed and induces ISGs in the endometrium during pregnancy recognition, it was reasoned that surrogate markers for pregnancy or IFNT might be present in the blood and provide an indicator of pregnancy status in cattle.

Close Reduction Percutaneous Pinning (CRPP) versus Open Reduction Internal Fixation (ORIF) for Pediatric Supracondylar Humerus Fractures Gartland Type II and III: A Systematic Review and Meta-analysis

2021 ◽  
Vol 71 (4) ◽  
pp. 187-193
Author(s):  
Putu Astawa ◽  
Made Agus Maharjana ◽  
Surya Adisthanaya ◽  
Made Winatra Satya Putra ◽  
Agus Suarjaya Putra ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Reports ◽  
Meta Analysis ◽  
Fixed Effect Model ◽  
Cosmetic Outcome ◽  
Type I ◽  
Type Ii ◽  
Supracondylar Humerus Fractures ◽  
Significant Difference ◽  
Humerus Fractures

Introduction: Displaced supracondylar fracture in children is a challenging injury that may result in impaired functional and cosmetic outcome if not well-treated. Utilization of Closed Reduction and Percutaneus Pinning (CRPP) increased for this pathology, some authors believe ORIF results better anatomical reduction and lower rate of loss of reduction. Study aims to compare CRPP and ORIF for pediatric supracondylar humerus fracture. Method: Systematic review was conducted based on PRISMA guideline. Inclusion criteria were age <18 years old, comparing CRPP and ORIF for Supracondylar Humerus Fractures Gartland Type II, II.Studies of one surgical technique, Gartland type I, case reports were excluded. For meta-analysis, 6 studies were included and fixed effect model used to pool the result. In each study, mean difference (MD) with 95% confidence interval (CI) was calculated for dichotomous outcomes using Review Manager. Result: Total of 252 patients aged 0-15 years old were included. CRPP more often performed than ORIF. Satisfactory outcomes measured by Flynn’s criteria were achieved in 87.74% in CRPP and 86.73% in ORIF patient group, indicating significant difference (Heterogeneity, I2 = 23%; WMD, 1.26; 0.58 to 2.73; P =0.56). Conclusion: Current systematic review and meta-analysis suggest that for displaced supracondylar humerus fractures, ORIF offers a comparable functional and cosmetic outcome compared to CRPP.

Youssef syndrome with a summary of management options

2021 ◽  
Vol 14 (8) ◽  
pp. e244247
Author(s):  
Anupama Bahadur ◽  
Anoosha K Ravi ◽  
Megha Ajmani ◽  
Rajlaxmi Mundhra
Keyword(s):  
Case Reports ◽  
Therapeutic Options ◽  
Urinary Continence ◽  
Type I ◽  
Ct Urography ◽  
Lower Segment ◽  
Management Options ◽  
Urogenital Fistula ◽  
Diagnostic Modalities ◽  
Youssef Syndrome

Vesicouterine fistula is one of the rare varieties of urogenital fistula. Type I urogenital fistula or Youssef syndrome is characterised by menouria, amenorrhoea and urinary continence and it mostly follows lower segment caesarean delivery. There are only scattered case reports to help guide diagnostic and therapeutic options for this condition. These patients mostly need a combination of diagnostic modalities to confirm the diagnosis. Here, we present one such case of para 4 live 4 with classical symptoms of Youssef syndrome following a laparotomy for uterine rupture repair. CT urography confirmed the diagnosis and cystoscopy helped localise the exact location. Transabdominal fistula excision and repair was done. The paper also presents a summary of diagnostic and therapeutic options for this condition as reported in previous case reports for easy reference for practising gynaecologists and urologists.

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