scholarly journals Primary Cranial Vault Lymphoma Extending between Subcutaneous Tissue and Brain Parenchyma without Skull Destruction after Mild Head Trauma: A Case Report and Literature Review

2021 ◽  
pp. 1118-1123
Author(s):  
Kengo Setta ◽  
Takaaki Beppu ◽  
Yuichi Sato ◽  
Hiroaki Saura ◽  
Junichi Nomura ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Head Trauma ◽  
Dura Mater ◽  
Subcutaneous Tissue ◽  
Bone Destruction ◽  
B Cell Lymphoma ◽  
Brain Parenchyma ◽  
Skin Tumor ◽  
Cranial Vault ◽  
The Brain

Malignant lymphoma of the head rarely arises outside of the brain parenchyma as primary cranial vault lymphoma (PCVL). A case of PCVL that invaded from subcutaneous tissue into the brain, passing through the skull, and occurred after mild head trauma is reported along with a review of the literature. The patient was a 75-year-old man with decreased activity. One month before his visit to our hospital, he bruised the left frontal area of his head. Magnetic resonance imaging showed homogeneously enhanced tumors with contrast media in the subcutaneous tissue corresponding to the head impact area and the cerebral parenchyma, but no obvious abnormal findings in the skull. A biopsy with craniotomy was performed under general anesthesia. The pathological diagnosis was diffuse large B-cell lymphoma. On histological examination, tumor cells grew aggressively under the skin. Tumor cells invaded along the emissary vein into the external table without remarkable bone destruction and extended across the skull through the Haversian canals in the diploe. Tumor cells were found only at the perivascular areas in the dura mater and extended into the brain parenchyma. Considering the history of head trauma and the neuroimaging and histological findings, the PCVL in the present case arose primarily under the skin, passed though the skull and dura mater, and invaded along vessels and reached the brain.

scholarly journals Multifocal Primary Central Nervous System (CNS) Diffuse Large B-Cell Lymphoma (DLBCL) in a Patient with Aquired Immunodeficiency Syndrome (AIDS)

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S90-S90
Author(s):  
H Khokhar ◽  
K Wang ◽  
D Luis
Keyword(s):  
Basal Ganglia ◽  
B Cell ◽  
Tumor Cells ◽  
B Cell Lymphoma ◽  
Brain Parenchyma ◽  
Lymphoid Cells ◽  
Cerebellar Hemisphere ◽  
Temporal Region ◽  
Barr Virus ◽  
The Brain

Abstract Introduction/Objective Primary CNS DLBCL is a rare entity, with an incidence of less than 0.47 per 100,000, however, in immunocompromised patients, especially those with Human Immunodeficiency Virus (HIV-1) infection, the incidence increases dramatically to 2-6 percent. Here we present a case of multifocal DLBCL in a young 28-year-old homeless male with untreated AIDS and polysubstance abuse. Methods/Case Report He presented to the hospital with altered state of consciousness; a Computerized Tomography (CT) scan showed three ring-enhancing masses; one in the left fronto-temporal region, the largest in the left basal ganglia and the third in the cerebellum. The main lesion was biopsied and diagnosed as DLBCL. The patient developed aspiration pneumonia and demised from respiratory failure Results (if a Case Study enter NA) NA Conclusion Coronal sections of the brain revealed a large grey-tan, soft lesion of poorly defined, irregular borders located in the left basal ganglia that measured 5 x 4 x 4 cm, extended dorsally and laterally. A similar lesion was observed in the deep left cerebral hemisphere, affecting the temporal lobe and extending rostrally into the frontal lobe, but completely separate from the tumor in the basal ganglia. A third, much smaller lesion was found in the right cerebellar hemisphere. Histologically, the tumor was composed of sheets of atypical lymphoid cells with increased nuclear to cytoplasmic ratio, increased mitotic activity, and showed scattered areas of necrosis. In the peripheral areas, tumor cells were located in the Virchow Robin space, and in more central areas they have broken into the brain parenchyma. Tumor cells were positive for CD20 and CD79a, indicating their B-cell origin. Other markers positive by immunohistochemistry were PAX5, MUM1 and BCL6 and the Epstein-Barr Virus (EBV) latent membrane protein (LMP). Fluorescence In situ hybridization (FISH) corroborated the presence of Eptein-Barr encoded RNAs.

scholarly journals Macrophages and microglia: the cerberus of glioblastoma

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Alice Buonfiglioli ◽  
Dolores Hambardzumyan
Keyword(s):  
Tumor Cells ◽  
Innate Immune System ◽  
Tumor Heterogeneity ◽  
Expression Profiles ◽  
Brain Parenchyma ◽  
Innate Immune ◽  
Malignant Growth ◽  
Neoplastic Cells ◽  
Functional Roles ◽  
The Brain

AbstractGlioblastoma (GBM) is the most aggressive and deadliest of the primary brain tumors, characterized by malignant growth, invasion into the brain parenchyma, and resistance to therapy. GBM is a heterogeneous disease characterized by high degrees of both inter- and intra-tumor heterogeneity. Another layer of complexity arises from the unique brain microenvironment in which GBM develops and grows. The GBM microenvironment consists of neoplastic and non-neoplastic cells. The most abundant non-neoplastic cells are those of the innate immune system, called tumor-associated macrophages (TAMs). TAMs constitute up to 40% of the tumor mass and consist of both brain-resident microglia and bone marrow-derived myeloid cells from the periphery. Although genetically stable, TAMs can change their expression profiles based upon the signals that they receive from tumor cells; therefore, heterogeneity in GBM creates heterogeneity in TAMs. By interacting with tumor cells and with the other non-neoplastic cells in the tumor microenvironment, TAMs promote tumor progression. Here, we review the origin, heterogeneity, and functional roles of TAMs. In addition, we discuss the prospects of therapeutically targeting TAMs alone or in combination with standard or newly-emerging GBM targeting therapies.

Otorhinolaryngological Complications of Progressive Facial Hemiatrophy (Romberg's Disease)

1995 ◽  
Vol 104 (11) ◽  
pp. 853-857 ◽  
Author(s):  
Christoph Matthias ◽  
Klaus Terstegge ◽  
Hartmut Siemes
Keyword(s):  
Hearing Loss ◽  
Subcutaneous Tissue ◽  
Bone Destruction ◽  
Anterior Wall ◽  
Interdisciplinary Cooperation ◽  
Unilateral Hearing Loss ◽  
Romberg's Disease ◽  
The Brain ◽  
Facial Hemiatrophy ◽  
Romberg’S Disease

Progressive facial hemiatrophy (PFH) is characterized by slowly progressive atrophy of subcutaneous tissue. Bone, muscles, nerves, the eye, and the brain may be affected by atrophy. Four patients suffering from various otorhinolaryngological complications of PFH or Romberg's disease are reported. Unilateral hearing loss could be located in the inner ear of one patient by audiologic examination. Localized bone destruction and disintegration of a portion of the anterior wall of the frontal sinus were observed in a patient after more than three decades. Marked shrinking of the homolateral parotid gland and homolateral masticatory spasm are reported as further otorhinolaryngological manifestations. The various complications of PFH call for close interdisciplinary cooperation.

Primary cutaneous diffuse large B-cell lymphoma with cranial vault and dura mater involvement

2014 ◽  
Vol 30 (1) ◽  
pp. 186-187 ◽  
Author(s):  
M. Mascolo ◽  
V. Piccolo ◽  
G. Iannuzzo ◽  
P. Di Lorenzo ◽  
G. De Rosa ◽  
...  
Keyword(s):  
B Cell ◽  
Dura Mater ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Cranial Vault ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals The Presence and Potential Role of ALDH1A2 in the Glioblastoma Microenvironment

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2485
Author(s):  
Stephanie Sanders ◽  
Denise M. Herpai ◽  
Analiz Rodriguez ◽  
Yue Huang ◽  
Jeff Chou ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Potential Role ◽  
Therapeutic Agents ◽  
Brain Parenchyma ◽  
Low Grade ◽  
Effective Management ◽  
Diffuse Infiltration ◽  
Protein Levels ◽  
The Brain

Glioblastoma (GBM) is the most aggressive malignant glioma. Therapeutic targeting of GBM is made more difficult due to its heterogeneity, resistance to treatment, and diffuse infiltration into the brain parenchyma. Better understanding of the tumor microenvironment should aid in finding more effective management of GBM. GBM-associated macrophages (GAM) comprise up to 30% of the GBM microenvironment. Therefore, exploration of GAM activity/function and their specific markers are important for developing new therapeutic agents. In this study, we identified and evaluated the expression of ALDH1A2 in the GBM microenvironment, and especially in M2 GAM, though it is also expressed in reactive astrocytes and multinucleated tumor cells. We demonstrated that M2 GAM highly express ALDH1A2 when compared to other ALDH1 family proteins. Additionally, GBM samples showed higher expression of ALDH1A2 when compared to low-grade gliomas (LGG), and this expression was increased upon tumor recurrence both at the gene and protein levels. We demonstrated that the enzymatic product of ALDH1A2, retinoic acid (RA), modulated the expression and activity of MMP-2 and MMP-9 in macrophages, but not in GBM tumor cells. Thus, the expression of ALDH1A2 may promote the progressive phenotype of GBM.

Experimental study of high-resolution ultrasound imaging of hemorrhage, bone fragments, and foreign bodies in head trauma

1981 ◽  
Vol 54 (3) ◽  
pp. 304-309 ◽  
Author(s):  
Dieter R. Enzmann ◽  
Richard H. Britt ◽  
Bernie Lyons ◽  
T. L. Buxton ◽  
D. A. Wilson
Keyword(s):  
High Resolution ◽  
Intracerebral Hemorrhage ◽  
Head Trauma ◽  
Foreign Bodies ◽  
Intraoperative Imaging ◽  
Ultrasound Image ◽  
Brain Parenchyma ◽  
Content Type ◽  
High Resolution Ultrasonography ◽  
The Brain

✓ The accuracy of high-resolution ultrasound scans in detecting foreign bodies and hemorrhage within the brain was evaluated by comparison with computerized tomography (CT) scans and gross pathology. The test lesions were blood and foreign bodies consisting of bone, wood, and metal placed in the brain of an experimental animal. High-resolution ultrasound scans (10 MHz) performed in coronal and sagittal planes accurately delineated the position and spatial orientation of these foreign bodies and hemorrhage. Both hemorrhage and foreign bodies were echogenic compared to normal, hypoechoic brain parenchyma. Metal fragments had a highly characteristic echo pattern caused by sound reverberation within the object. Acute intracerebral hemorrhage produced an ultrasound image consisting of sharply circumscribed homogeneous echoes. The sonographic shape of intracerebral hemorrhage correlated closely with the area of increased density seen on the CT scan. High-resolution ultrasonography accurately delineated experimentally produced components of head trauma and may prove useful as an intraoperative imaging technique to facilitate surgery in head-injured patients.

scholarly journals Rare pathological variants and presentations of primary central nervous system lymphomas

2006 ◽  
Vol 21 (5) ◽  
pp. 1-6 ◽  
Author(s):  
Arnaldo Neves Da Silva ◽  
Maria Beatriz Lopes ◽  
David Schiff
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Lymphoma ◽  
Central Nervous System Lymphoma ◽  
B Cell Lymphoma ◽  
Brain Parenchyma ◽  
Low Grade ◽  
Rare Form ◽  
Large B Cell Lymphoma ◽  
The Brain

✓ Primary central nervous system lymphoma (PCNSL) is a rare form of primary brain neoplasm, accounting for less than 3% of all primary brain tumors. Ninety percent of cases involve a large B-cell lymphoma that presents as a homogeneously enhancing lesion or lesions, typically deep-seated in the brain parenchyma. The authors describe unusual pathological forms of PCNSLs, including low-grade, T-cell, and Burkitt types, and also rare presentations such as neurolymphomatosis and pituitary lymphomas.

scholarly journals A microfabricated, 3D-sharpened silicon shuttle for insertion of flexible electrode arrays through dura mater into brain

2019 ◽  
Author(s):  
Hannah R. Joo ◽  
Jiang Lan Fan ◽  
Supin Chen ◽  
Jeanine A. Pebbles ◽  
Hexin Liang ◽  
...  
Keyword(s):  
Dura Mater ◽  
Single Unit ◽  
Field Potential ◽  
Brain Parenchyma ◽  
Vascular Damage ◽  
Electrode Arrays ◽  
Surgical Time ◽  
Flexible Polymer ◽  
The Brain ◽  
Tissue Compression

AbstractElectrode arrays for chronic implantation in the brain are a critical technology in both neuroscience and medicine. Recently, flexible, thin-film polymer electrode arrays have shown promise in facilitating stable, single-unit recordings spanning months in rats. While array flexibility enhances integration with neural tissue, it also requires removal of the dura mater, the tough membrane surrounding the brain, and temporary bracing to penetrate the brain parenchyma. Durotomy increases brain swelling, vascular damage, and surgical time. Insertion using a bracing shuttle results in additional vascular damage and brain compression, which increase with device diameter; while a higher-diameter shuttle will have a higher critical load and more likely penetrate dura, it will damage more brain parenchyma and vasculature. One way to penetrate the intact dura and limit tissue compression without increasing shuttle diameter is to reduce the force required for insertion by sharpening the shuttle tip. We describe a novel design and fabrication process to create silicon insertion shuttles that are sharp in three dimensions and can penetrate rat dura, for faster, easier, and less damaging implantation of polymer arrays. Sharpened profiles are obtained by reflowing patterned photoresist, then transferring its sloped profile to silicon with dry etches. We demonstrate that sharpened shuttles can reliably implant polymer probes through dura to yield high quality single unit and local field potential recordings for at least 95 days. On insertion directly through dura, tissue compression is minimal. This is the first demonstration of a rat dural-penetrating array for chronic recording. This device obviates the need for a durotomy, reducing surgical time and risk of damage to the blood-brain barrier. This is an improvement to state-of-the-art flexible polymer electrode arrays that facilitates their implantation, particularly in multi-site recording experiments. This sharpening process can also be integrated into silicon electrode array fabrication.

scholarly journals A rare case of hemorrhagic mineralising angiopathy after trivial head trauma

2019 ◽  
Author(s):  
Yareeda Sireesha ◽  
Niloufer Ali ◽  
Mathukumalli Neeharika ◽  
Meena Angamattu Kanikannan
Keyword(s):  
Basal Ganglia ◽  
Head Injury ◽  
Head Trauma ◽  
Rare Case ◽  
Hemorrhagic Stroke ◽  
Brain Parenchyma ◽  
Imaging Findings ◽  
Acute Trauma ◽  
The Brain ◽  
Current Report

:Infarction of the basal ganglia after minor head injury �is a� well described entity .�Mineralising angiopathy� is a term to describe mineralisation along� the lenticulostriate vessels that predisposes infants to stroke,even after trivial head injury.(1)The prognosis in these children is excellent.The supratentorial compartment is relatively mobile in comparision to the fixed infratentorial compartment �offering greater shearing forces between the perforating vessels and the brain parenchyma following �an acute trauma.(2)The acute angulation of the lenticulostriate perforators is further responsible for its propensity of the basal ganglia for the insult.(3) The current report is unique as it presents a young boy with hemorrhagic stroke in the�� basal ganglia after a trivial trauma and �imaging findings suggestive of mineralising angiopathy

scholarly journals Predetermined Interplay of the Projected Malignant Transformation Step as Injury Non- Resolution

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Lawrence M Agius
Keyword(s):  
Tumor Cells ◽  
Malignant Transformation ◽  
System Biology ◽  
Glioma Cell ◽  
Glioma Cells ◽  
Brain Parenchyma ◽  
Cell Component ◽  
The Brain

Non-resolution of carcinogenesis is a paramount consideration in the systems of non-immunogenicity of tumor cells in general and as further projected by the infiltrating glioma cell within the brain parenchyma. In such terms, the performance dynamics for further progression are change attributes that bespeak of the systems of overlap and of interactivity of multiple pathways of pro-apoptosis and of anti-apoptosis as projected by mirrored system biology of cell component injury. It is within the single transformation phenomenon step in malignancy emergence that the pro-apoptosis projects the predetermination for non-resolution of cell component injury and as further determined by non-immunogenicity of the infiltrating glioma cells..

Sign in / Sign up

Export Citation Format

Share Document