Systematic Desensitization as a Component for Treatment of Alopecia Areata: A Case Study

1980 ◽  
Vol 46 (3) ◽  
pp. 875-881 ◽  
Author(s):  
Judith E. Stowe ◽  
Edward Goldenberg
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Physiological Changes ◽  
Autonomic Activity ◽  
Systematic Desensitization ◽  
Hair Regrowth ◽  
History Of

Systematic desensitization and relaxation were employed to examine their effects on hair growth in a 20-yr.-old male with a 4-yr. history of alopecia areata. Six bald scalp patches were photographed over 6 mo.; 2 ordered hierarchies involving interpersonal and compulsive themes were presented in 8 treatment sessions. Results indicated nearly complete hair regrowth over the 6 mo., with no new appearances of bald patches. Both rate and duration of growth exceeded that reported in dermatological literature, suggesting that autonomic activity associated with anxiety and nervousness are correlated with physiological changes precipitating hair loss.

A Case Study: Massage, Relaxation, and Reward for Treatment of Alopecia Areata

1994 ◽  
Vol 74 (3_suppl) ◽  
pp. 1315-1318 ◽  
Author(s):  
Sharon C. Putt ◽  
Lawrence Weinstein ◽  
Mary T. Dzindolet
Keyword(s):  
Alopecia Areata ◽  
Behavior Modification ◽  
Psychological Factors ◽  
Hair Growth ◽  
Autoimmune Process ◽  
Common Cause ◽  
Treatment Techniques ◽  
History Of ◽  
Treatment Designs

Alopecia areata, a common cause of hair loss, is generally considered the consequence of an autoimmune process. Both physiological and psychological factors have been implicated. Previous studies have not incorporated behavior modification in their treatment designs. In this study, three treatment techniques (hair massage, relaxation procedures, and monetary reward) were applied to a 16-year-old male with a five-year history of alopecia areata. Comparison for seven months without treatment versus seven months with treatment showed that loss of hair was markedly reduced after three months of treatment. During the last four months of the study, new hair growth was evidenced.

Hair Growth in a Patient with Alopecia Areata on Tocilizumab

2021 ◽  
pp. 1-5
Author(s):  
Chloe J. Walker ◽  
Kelly E. Flanagan ◽  
James T. Pathoulas ◽  
Isabel Pupo Wiss ◽  
Maryanne M. Senna
Keyword(s):  
Monoclonal Antibody ◽  
Autoimmune Disease ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Interleukin 6 ◽  
Hair Growth ◽  
Posterior Uveitis ◽  
Case Presentation ◽  
Antibody Targeting ◽  
Growth Changes

<b><i>Introduction:</i></b> Tocilizumab (TCZ), a recombinant humanized antihuman monoclonal antibody targeting interleukin-6 (IL-6) signaling, is often utilized in the management of autoimmune disease. Few reports have demonstrated hair growth changes in patients on TCZ. <b><i>Case Presentation:</i></b> Herein, we review the literature and report a 21-year-old woman with progressive alopecia areata (AA) presenting with AA improvement while on TCZ for concomitant posterior uveitis. <b><i>Discussion:</i></b> Our case demonstrates the potential ability of TCZ to disrupt IL-6 signaling involved in AA, leading to hair loss and regrowth.

Disorders of Hair

2013 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Basic Knowledge ◽  
Androgenetic Alopecia ◽  
Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

scholarly journals Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 466 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Growth ◽  
Mesenchymal Stem Cell ◽  
Hair Follicle ◽  
Hair Loss ◽  
Hair Growth ◽  
Follicle Development ◽  
Hair Regrowth ◽  
Hair Follicle Development

The use of stem cells has been reported to improve hair regrowth in several therapeutic strategies, including reversing the pathological mechanisms, that contribute to hair loss, regeneration of hair follicles, or creating hair using the tissue-engineering approach. Although various promising stem cell approaches are progressing via pre-clinical models to clinical trials, intraoperative stem cell treatments with a one-step procedure offer a quicker result by incorporating an autologous cell source without manipulation, which may be injected by surgeons through a well-established clinical practice. Many authors have concentrated on adipose-derived stromal vascular cells due to their ability to separate into numerous cell genealogies, platelet-rich plasma for its ability to enhance cell multiplication and neo-angiogenesis, as well as human follicle mesenchymal stem cells. In this paper, the significant improvements in intraoperative stem cell approaches, from in vivo models to clinical investigations, are reviewed. The potential regenerative instruments and functions of various cell populaces in the hair regrowth process are discussed. The addition of Wnt signaling in dermal papilla cells is considered a key factor in stimulating hair growth. Mesenchymal stem cell-derived signaling and growth factors obtained by platelets influence hair growth through cellular proliferation to prolong the anagen phase (FGF-7), induce cell growth (ERK activation), stimulate hair follicle development (β-catenin), and suppress apoptotic cues (Bcl-2 release and Akt activation).

scholarly journals Treatment of alopecia areata affecting both eyebrows: case study

2019 ◽  
Vol 5 (3) ◽  
pp. 87
Author(s):  
Shafia Mushtaq ◽  
Salisa Shafi ◽  
Shahnaz Hafeez Kawoosa
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Outpatient Department ◽  
Local Application ◽  
Unani Medicine ◽  
Males And Females

<p><em>Safa</em> (alopecia areata) means loss of hairs where ordinarily hair would be found. <em>Safa</em> (AA) is a type of non scaring alopecia that affects males and females equally and occurs in both children and adults. About 2% of the patients are affected and come to outpatient department for care. It is characterized by reversible hair loss most commonly involving the scalp although other parts of head, including eyelashes and beard may also be affected. A patient 16 years old was given Unani medicine for 45 days as local application on lateral aspects of eyebrows twice daily for thirty days and once for later 15 days. New hairs were seen on affected areas after one month, after 45 days normal hairs were seen on affected sites. It can be concluded that Unani medicine is effective in treating alopecia.</p>

scholarly journals Efficacy of plum blossom acupuncture on alopecia areata – A case report

2021 ◽  
pp. 395-397
Author(s):  
Sujithra Sreekumari Thanudhas
Keyword(s):  
Case Report ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Pharmacological Treatment ◽  
Hair Growth ◽  
Genetic Factors ◽  
The Past ◽  
Autoimmune Condition

Alopecia areata (AA) is a complex autoimmune condition that causes non-scarring hair loss and may present at any age. It typically presents with sharply demarcated round patches of hair loss. AA presents heterogeneously and is influenced by both environmental and genetic factors. There is no effective pharmacological treatment currently available for this disorder so far. We had an opportunity to treat a patient with AA using acupuncture. The patient was a 23-year-old male who presented to us with a complaint of sudden hair loss in patches in two demarcated round areas in a diameter of 2–3 cm on the back of the head for the past year. He was diagnosed as AA by AA progression index. After a long treatment course of about 3 months with acupuncture, this patient showed significant hair growth.

Canities Subita after Extreme Trauma Showing Positive Staining for Anti-PD-L1 Antibodies: A New Clue into Etiopathogenesis?

2021 ◽  
Vol 8 (1) ◽  
pp. 65-69
Author(s):  
Francisco J. Navarro-Triviño ◽  
Ricardo Ruiz-Villaverde ◽  
Francisco Manuel Ramos-Pleguezuelos ◽  
Sergio Vañó-Galván
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Inflammatory Infiltrate ◽  
Hair Color ◽  
Histopathological Study ◽  
Positive Staining ◽  
Immune Mediated ◽  
History Of ◽  
Salt And Pepper

Canities subita has been considered by some authors an acute episode of diffuse alopecia areata in which the sudden whitening is caused by the preferential loss of pigmented hair in this immune-mediated disorder. Clinically, the “salt and pepper” pattern of hair color is the most frequent manifestation of canities subita. However, the exact physiopathology of canities subita is not completely understood. A 69-year-old Caucasian man was referred for the sudden and asymptomatic whitening of the hair on the scalp and eyebrows, without an associated hair loss. The trigger was the death of his brother. Hair whitening appeared 24 h after the event. He reported a history of alopecia areata in plaques on the scalp, with spontaneous complete resolution in 2006. The physical examination showed full whitening hair on the scalp and eyebrows. Eyelashes were not affected. The pull test was negative, and the patient denied a significant hair loss in the last days. The histopathological study showed several follicle-sebaceous structures in the anagen, and one of them (inset) with a transforming hair bulb. The anterior bulb was surrounded by a lymphocytic inflammatory infiltrate in an advanced stage of transformation to the catagen and incipient scar changes. Immunohistochemistry staining showed a positive anti-PD-L1 antibody expressed in the inflammatory infiltrate. Based on the clinical and histological findings, a diagnosis of canities subita was made. The histopathological study showed a positive staining for anti-PD-L1 antibodies, supporting the role of the immune system in the development of this phenomenon. The interaction between melanogenesis and the lymphocytes warrants further research.

A Case Study on Indralupta

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Seema J. MB ◽  
U. Sreelekshmi ◽  
Radhika Ranjan Geethesh P
Keyword(s):  
Clinical Application ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Personal Beliefs ◽  
External Application ◽  
Ancient Science ◽  
Different Cultures ◽  
Historical Periods ◽  
Strict Rule

Attitudes towards different hair, such as hairstyles and hair removal, vary widely across different cultures and historical periods, but it is often used to indicate a person's personal beliefs or social position, such as their age, sex, or religion. As hair is considered as barometer of beauty each one is over conscious about it and is in search for a better remedy for the maintenance and management of their crowning glory. Alopecia areata is characterized by acquired skin aliment that can affect all the hair bearing skin including scalp, beard, which is characterized by localized areas of non-scarring hair loss which can be compared with Indralupta. Hence all these are pointing towards a better and affordable remedy which can be provided much effectively by our ancient science Ayurveda. Hence considering all these the treatment was planned for a week with internal administration of Vidangarishta along with Krimikutararasa and Shatavari Guda as Rasayana. Also an external application of milky exudates of papaya over the scalp region where head bath was not allowed as per the strict rule of our Acharya for more precise result. The results shown were profound, quick and permanent and are an outstanding evidence of clinical application of principles of Ayurveda.

Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study

Dermatology ◽  
2018 ◽  
Vol 235 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Nawaf Almutairi ◽  
Tarek M. Nour ◽  
Nasser Haji  Hussain
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Kinase Inhibitors ◽  
Autoimmune Disorder ◽  
Janus Kinase ◽  
Open Label ◽  
Janus Kinase Inhibitors ◽  
Hair Regrowth ◽  
Significant Difference

Background: Alopecia areata (AA) is a common autoimmune disorder characterized by patchy hair loss. There are many treatments available for AA. However, treatments of severe forms of AA are not satisfactory. Recently, oral Janus kinase (JAK) inhibitors were found to be effective for the treatment of severe AA variants. Objective: The aim of this work was to evaluate and compare the efficacy, side effects, and durability of two oral JAK inhibitor medications (ruxolitinib and tofacitinib) in the treatment of severe AA. Methods: This study included 75 patients with AA with more than 30% scalp hair loss, alopecia totalis, and alopecia universalis randomized into 2 groups. The first group (n = 38) received ruxolitinib 20 mg twice daily, and the second group (n = 37) received oral tofacitinib 5 mg twice daily. The treatment continued for 6 months followed by 3 months of follow-up off therapy. Efficacy of treatment was assessed by monitoring the change in the Severity of Alopecia Tool (SALT) score. Results: Both tofacitinib and ruxolitinib induced remarkable hair regrowth, with a mean change in SALT score of 93.8 ± 3.25 in the ruxolitinib group and 95.2 ± 2.69 in the tofacitinib group. However, the ruxolitinib group showed a shorter duration for initial hair regrowth. There was no statistically significant difference between the groups regarding hair regrowth at the end of the 6-month treatment and relapse rate at the end of the 3-month follow-up. Around two thirds of cases experienced relapse. Both drugs were well tolerated, with no reported serious adverse effects. Conclusion: Both ruxolitinib and tofacitinib could be considered effective and well-tolerated treatments for extensive AA.

Indralupta (alopecia areata) Kshudraroga management in Sushruta Samhita and Alopathy

2018 ◽  
Vol 6 (5th) ◽  
Author(s):  
Pratibha Gayakwad ◽  
Seema Giri ◽  
Gauri P. Patange
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Hair Follicle ◽  
Hair Loss ◽  
Alopecia Areata ◽  
The Body ◽  
Stress And Strain ◽  
Metabolic Defect ◽  
The World ◽  
History Of

 The history of cosmetics extents at least 6000 years and is present in almost every society all over the world. In today’s era people are suffering from stress and strain due to the hustle and bustle of urban lifestyle. This has succumbed them to various lifestyle disorder.. Due to which it’s effects are seen on the body and out of which hair is affected the most. Sushruta has mentioned about Khalitya. It is caused by vitiation of  vata and  pitta doshas. In Indralupta there will be vitiation of rakta with kapha which obstruct the hair follicle.  sushruta had said that the drushti and the lomkupaa never grow throughtout lifetime but hairs  and nail do. In chikitsasthana the treatment for Indralupta. The bald paer or seat should be anointed and fomented, and then bleeding (by venesection) should be resorted to, after which a plaster composed of Manahsila, Kasisa, Tuttha and Maricha, or of Kutannata and Devadaru pasted tighter, should be applied to it. Alopecia areata also known as spot baldness,  is a state in which hair is lost from some or all areas of the body. Typical symptoms of alopecia areata are small bald patches, underlying skin is unscarred and looks superficially normal. Patients also tend to have a slightly higher incidence of condition related to the immune system, such as asthama, allergies atopic dermatitis, and hypothyroidism. It occurs at any age. Hair loss area may tingle or painful. Due to autoimmunity, colic disease, endogenous retinoids metabolic defect alopecia areata occur..

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