scholarly journals Metastasis of Testicular Choriocarcinoma in the Stomach, Complicated by the Development of Choriocarcinoma Syndrome

2021 ◽  
pp. 954-959
Author(s):  
Valery I. Podzolkov ◽  
Anna E. Pokrovskaya ◽  
Aida I. Tarzimanova ◽  
Maria V. Vetluzhskaya
Keyword(s):  
Characteristic Feature ◽  
Gastrointestinal Bleeding ◽  
High Mortality ◽  
Poor Prognosis ◽  
Advanced Disease ◽  
Clinical Signs ◽  
Hematogenous Spread ◽  
Gastrointestinal Metastases ◽  
Gastric Metastases

Choriocarcinoma (CC) is a very rare and aggressive neoplasm. The characteristic feature of this disease is a rapid hematogenous spread, mainly to the lungs and brain, which largely defines clinical signs of the disease and complicates the diagnosis. Gastrointestinal metastases are rare, and of those, only few cases with gastric location have been reported. There are publications describing choriocarcinoma syndrome (CCS). As a rule, it presents in patients with an advanced disease and is characterized by hemorrhage from metastatic foci, leading to hemoptysis and gastrointestinal bleeding. CCS development is associated with poor prognosis and high mortality. This article describes a case of testicular CC with rare few gastric metastases, complicated by CCS.

Comparison of immunohistochemical profiles of ovarian germ cells in dysgerminomas of a captive maned wolf and domestic dogs

2021 ◽  
pp. 104063872110199
Author(s):  
Rafael B. Rosa ◽  
Matheus V. Bianchi ◽  
Paula R. Ribeiro ◽  
Fernando F. Argenta ◽  
Andréia Vielmo ◽  
...  
Keyword(s):  
Germ Cells ◽  
Poor Prognosis ◽  
Expression Profiles ◽  
Clinical Signs ◽  
Domestic Dogs ◽  
Domestic Dog ◽  
Placental Alkaline Phosphatase ◽  
Immunohistochemical Expression ◽  
Cytoplasmic Expression ◽  
Maned Wolf

We characterized the immunohistochemical expression profiles of dysgerminomas from a 16-y-old maned wolf and 13 domestic dogs using the following biomarkers: Sal-like protein 4 (SALL4), octamer-binding transcription factor 3/4 (OCT3/4), placental alkaline phosphatase (PLAP), c-kit, and vimentin. The maned wolf had nonspecific and long-standing clinical signs of lethargy, anorexia, and weight loss, and was euthanized because of poor prognosis. At autopsy, the left ovary was effaced by a 12 × 8 × 6 cm mass, comprised of anaplastic cells with a mitotic count of 20 mitoses in 10 high power fields. Dysgerminomas from 7 of 13 domestic dogs had nuclear expression of SALL4. Dysgerminomas from the maned wolf and 2 domestic dogs had both nuclear and cytoplasmic expression of SALL4. Cytoplasmic expression of PLAP and OCT3/4 was present in dysgerminomas from the maned wolf and 3 (PLAP) or 4 (OCT3/4) domestic dogs. All dysgerminomas expressed vimentin. Membranous c-kit expression was rare in the dysgerminoma from the maned wolf, and variable in dysgerminomas from 4 domestic dogs. A dysgerminoma from a domestic dog had cytoplasmic expression of c-kit. SALL4 is a useful marker to confirm germ cell origin of dysgerminoma in canids.

scholarly journals Osteoarthritis in pet guinea pigs: an update on diagnosis, treatment and management

2021 ◽  
Vol 26 (6) ◽  
pp. 100-106
Author(s):  
Emma Keeble
Keyword(s):  
Quality Of Life ◽  
Early Diagnosis ◽  
Guinea Pigs ◽  
Advanced Disease ◽  
Early Stage ◽  
Clinical Signs ◽  
Nutritional Supplements ◽  
Lifestyle Changes ◽  
Early Age

This article reviews the current literature on osteoarthritis in pet and laboratory guinea pigs. The associated clinical signs, diagnosis and treatment of osteoarthritis in pet guinea pigs will be discussed, with options for analgesia detailed. This condition is thought to be common in pet guinea pigs, even from an early age in some genetic lines, although osteoarthritis often goes undiagnosed in this species until advanced disease is present, posing a major welfare concern. Increasing awareness of this condition in veterinary practitioners should aid early diagnosis in pets and help improve their quality of life. Prevention may be possible using oral protective nutritional supplements to slow down the progression of this disease at an early stage. Lifestyle changes are also discussed for the management of this condition in pet guinea pigs.

scholarly journals Key-Gaskell syndrome in Brazil: first case report

2014 ◽  
Vol 66 (4) ◽  
pp. 1046-1050
Author(s):  
B.B.J. Torres ◽  
G.C. Martins ◽  
P.E. Ferian ◽  
B.C. Martins ◽  
M.A. Rachid ◽  
...  
Keyword(s):  
Case Report ◽  
Poor Prognosis ◽  
Neuronal Degeneration ◽  
Clinical Signs ◽  
Definitive Treatment ◽  
Autonomic Ganglia ◽  
Nervous Systems ◽  
First Case ◽  
The World

Feline dysautonomia is a devastating disease characterized by neuronal degeneration in autonomic ganglia that results in clinical signs related to dysfunction of the sympathetic and parasympathetic nervous systems. The cause is unknown and this disease has a poor prognosis and no definitive treatment. Most reports have been described in few countries around the world, but the prevalence may be underestimated in countries like Brazil. This study describes the progression and clinicopathological changes of dysautonomia in a 17-month-old female Brazilian shorthair cat.

Gastric metastases of cervical carcinoma, rare cause of gastrointestinal bleeding

2019 ◽  
Vol 42 (4) ◽  
pp. 249-250
Author(s):  
Carolina Simões ◽  
Luís Carrilho-Ribeiro ◽  
José Velosa
Keyword(s):  
Gastrointestinal Bleeding ◽  
Cervical Carcinoma ◽  
Gastric Metastases

Nanotherapeutic macrophage-based immunotherapy for peritoneal carcinomatosis of lung cancer

Nanoscale ◽  
2022 ◽  
Author(s):  
Yonghui Wang ◽  
Binfan Chen ◽  
Zhidi He ◽  
Bin Tu ◽  
Pengfei Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Peritoneal Carcinomatosis ◽  
High Mortality ◽  
Distant Metastasis ◽  
Cancer Mortality ◽  
Poor Prognosis ◽  
Abdominal Metastasis ◽  
The World

Lung cancer is the top cause of cancer mortality in the world. Distant metastasis leads to high mortality. Abdominal metastasis of lung cancer is characterized by a very poor prognosis...

Small Cell Carcinocythemia

1999 ◽  
Vol 123 (5) ◽  
pp. 426-428
Author(s):  
Cynthia C. Sile ◽  
David J. Perry ◽  
Lucy Nam
Keyword(s):  
Lung Cancer ◽  
Poor Prognosis ◽  
Advanced Disease ◽  
Small Cell ◽  
Small Cell Lung ◽  
Peripheral Smear ◽  
Stage Disease ◽  
Splenic Metastases ◽  
Generalized Lymphadenopathy ◽  
End Stage

Abstract Tumor cells circulate in the blood, but it is unusual to find cancer cells on a routine peripheral smear. The term carcinocythemia is used to describe this phenomenon. Four patients have been reported previously with small cell lung cancer and carcinocythemia. A fifth case is described in this article. These patients presented with advanced disease and had generalized lymphadenopathy and liver involvement; 3 had splenic metastases. All of these patients experienced rapid clinical deterioration. Death occurred 3 days to 2 weeks from the time carcinocythemia was detected. The presence of small cell carcinocythemia can be one of the manifestations of end-stage disease and is associated with an extremely poor prognosis.

scholarly journals Peritonitis from perforated sigmoid mass as the first manifestation of metastatic squamous cell lung cancer: a case report and review of literature

2020 ◽  
Vol 2020 (9) ◽  
Author(s):  
Raghav Chandra ◽  
Epameinondas Dogeas ◽  
Nicole Nevarez ◽  
Mathew Augustine ◽  
Sergio Huerta
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Poor Prognosis ◽  
Metastatic Spread ◽  
Squamous Cell Lung Cancer ◽  
Review Of Literature ◽  
Gastrointestinal Metastases

Abstract Lung cancer (LC) is an aggressive malignancy with early metastatic spread and poor prognosis. Gastrointestinal metastases from primary LC are extremely rare with highly variable presentations. In this report, we review the case of a patient who presented with peritonitis secondary to perforated sigmoid mass as the first manifestation of metastatic squamous cell LC.

scholarly journals Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

Children ◽  
2020 ◽  
Vol 7 (12) ◽  
pp. 309
Author(s):  
Maura-Adelina Hincu ◽  
Gabriela-Ildiko Zonda ◽  
Gabriela Dumitrita Stanciu ◽  
Dragos Nemescu ◽  
Luminita Paduraru
Keyword(s):  
High Mortality ◽  
Early Onset ◽  
Clinical Signs ◽  
Developed Countries ◽  
Extremely Low Birth Weight ◽  
Invasive Infection ◽  
Acute Phase Reactants ◽  
Hematological Indices ◽  
Live Births ◽  
Early Onset Sepsis

Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first 72 h of life. The incidence of EOS varies from 0.5–2% live births in developed countries, up to 9.8% live births in low resource settings, generating a high mortality rate, especially in extremely low birth weight neonates. Clinical signs are nonspecific, leading to a late diagnosis and high mortality. Currently, there are several markers used for sepsis evaluation, such as hematological indices, acute phase reactants, cytokines, which by themselves do not show acceptable sensitivity and specificity for the diagnosis of EOS in neonates. Newer and more selective markers have surfaced recently, such as presepsin and endocan, but they are currently only in the experimental research stages. This comprehensive review article is based on the role of biomarkers currently in use or in the research phase from a basic, translational, and clinical viewpoint that helps us to improve the quality of neonatal early-onset sepsis diagnosis and management.

scholarly journals KCNT1 epilepsy with migrating focal seizures shows a temporal sequence with poor outcome, high mortality and SUDEP

Brain ◽  
2019 ◽  
Vol 142 (10) ◽  
pp. 2996-3008 ◽  
Author(s):  
Mathieu Kuchenbuch ◽  
Giulia Barcia ◽  
Nicole Chemaly ◽  
Emilie Carme ◽  
Agathe Roubertie ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
High Mortality ◽  
Poor Prognosis ◽  
Early Mortality ◽  
Temporal Sequence ◽  
Clinical Spectrum ◽  
Neurological Manifestations ◽  
Focal Seizures ◽  
Poor Outcome ◽  
High Prevalence

Data on KCNT1 epilepsy of infancy with migrating focal seizures are heterogeneous and incomplete. Kuchenbuch et al. refine the syndrome phenotype, showing a three-step temporal sequence, poor prognosis with acquired microcephaly, high prevalence of extra-neurological manifestations and early mortality, particularly due to SUDEP. Refining the electro-clinical spectrum should facilitate early diagnosis.

scholarly journals Prediction modelling of inpatient neonatal mortality in high-mortality settings

2020 ◽  
pp. archdischild-2020-319217
Author(s):  
Jalemba Aluvaala ◽  
Gary Collins ◽  
Beth Maina ◽  
Catherine Mutinda ◽  
Mary Waiyego ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
High Mortality ◽  
Clinical Decision Making ◽  
Clinical Signs ◽  
Prognostic Models ◽  
Routine Practice ◽  
Low Resource ◽  
C Statistic ◽  
Temporal Validation ◽  
Time Of Admission

ObjectivePrognostic models aid clinical decision making and evaluation of hospital performance. Existing neonatal prognostic models typically use physiological measures that are often not available, such as pulse oximetry values, in routine practice in low-resource settings. We aimed to develop and validate two novel models to predict all cause in-hospital mortality following neonatal unit admission in a low-resource, high-mortality setting.Study design and settingWe used basic, routine clinical data recorded by duty clinicians at the time of admission to derive (n=5427) and validate (n=1627) two novel models to predict in-hospital mortality. The Neonatal Essential Treatment Score (NETS) included treatments prescribed at the time of admission while the Score for Essential Neonatal Symptoms and Signs (SENSS) used basic clinical signs. Logistic regression was used, and performance was evaluated using discrimination and calibration.ResultsAt derivation, c-statistic (discrimination) for NETS was 0.92 (95% CI 0.90 to 0.93) and that for SENSS was 0.91 (95% CI 0.89 to 0.93). At external (temporal) validation, NETS had a c-statistic of 0.89 (95% CI 0.86 to 0.92) and SENSS 0.89 (95% CI 0.84 to 0.93). The calibration intercept for NETS was −0.72 (95% CI −0.96 to −0.49) and that for SENSS was −0.33 (95% CI −0.56 to −0.11).ConclusionUsing routine neonatal data in a low-resource setting, we found that it is possible to predict in-hospital mortality using either treatments or signs and symptoms. Further validation of these models may support their use in treatment decisions and for case-mix adjustment to help understand performance variation across hospitals.

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