scholarly journals RISK FACTORS FOR FEMALE INFERTILITY AT A TERTIARY HEALTH FACILITY IN AKURE, SOUTH-WEST NIGERIA

2020 ◽  
Vol 5 (2) ◽  
pp. 61-68
Author(s):  
T. A. Irinyenikan
Keyword(s):  
Risk Factors ◽  
Polycystic Ovary ◽  
Family Relationship ◽  
Significant Risk ◽  
Female Infertility ◽  
Control Group ◽  
Secondary Infertility ◽  
Transmitted Infection ◽  
Multiple Sexual Partners ◽  
The Mean

Background. The inability of couples to achieve pregnancy is a major cause of psycho-social problems in family relationship that could lead to marital disharmony. Objective. The aim of this study was to find out the possible risk factors for female infertility. Methods. A case-control design and a sample size of 400 (200 cases of infertility and 200 controls) were used in the study. Cases and controls were selected at random at the infertility and family planning clinic of the University of Medical Sciences Teaching Hospital Complex, Akure and were subjected to a predesigned interviewer administered questionnaire to collect the data. The cases were classified into primary and secondary infertility; binary and stepwise logistic regressions were used to generate the Odds ratio and 95% confidence interval of the possible risk factors and the level of significance was set at P<0.05. Results. The mean age of the women with infertility was 28.5±5.43 years and the mean age of those in the control group was 29.1±5.62 years. Among the cases, 155 (77.5%) had secondary infertility, while 45 (22.5%) had primary infertility. Significant risk factors for female infertility included presence of fibroids, having had fibroid operation, multiple sexual partners, previous abortion, polycystic ovary syndrome (PCOS), sexually transmitted infection (STI) and post abortion sepsis. Conclusion. The study showed that secondary infertility is still the most prevalent and the risk factors were multi factorial. Efforts should be intensified to reduce infertility due to preventable causes.

scholarly journals Assessment of risk factors for the development of simple and complex non-atypical endometrial hyperplasia

2020 ◽  
Vol 24 (4) ◽  
pp. 584-588
Author(s):  
N. A. Bykova
Keyword(s):  
Risk Factors ◽  
Endometrial Hyperplasia ◽  
Polycystic Ovary ◽  
Statistical Significance ◽  
Significant Risk ◽  
Risk Groups ◽  
Control Group ◽  
Case Histories ◽  
Atypical Endometrial Hyperplasia ◽  
The Hierarchical Structure

Annotation. Goal – to identify and assess the most significant risk factors for the development of simple non-atypical endometrial hyperplasia (SNAEH) and complex non-atypical endometrial hyperplasia (CNAEH) in women. Retrospective analysis of anamnestic data of 58 case histories of patients with SNAEH, 35 case histories of patients with CNAEH and data of 30 women of the control group, which allowed to identify risk factors for hyperproliferative processes of the endometrium (HPE) for research, the statistical significance of which was further assessed by calculating odds ratio (OR). The main feature associated with the risk of SNAEH is heredity – OR = 49.73 (95% CI 2.90–852.32). Significantly increases the risk of developing SNAEH in the presence of thyroid gland lesion (TGL) – OR = 34.97 (95% CI 2.03–601.20). The third in the hierarchical sequence is the polycystic ovary syndrome factor; OR = 25.72 (95% CI 1.488–444.59). Heredity occupies the top of the hierarchical structure in the group of patients with CNAEH. OR is 80.67 (95% CI 4.56–1424.76). A high probability of developing CNAEH is also observed for women over the age of 50 (OR = 32.44 (95% CI 1.82–576.56). In third place – the presence of TGL, which significantly increases the risk of developing CNAEH; OR = 28.63 (95% CI 1.60–510.56) Identification of statistically significant risk factors for the development of HPE will help to identify risk groups among the population, to carry out preventive measures among them (lifestyle adjustments, treatment of concomitant diseases) and decrease the incidence of the HPE.

The State of Pregnancy Alters the Mean Number of Platelet Dense Granules

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4672-4672
Author(s):  
Hermann T Simo ◽  
Eleonora Cekova ◽  
Joseph Karnitis ◽  
William T. Gunning
Keyword(s):  
Risk Factors ◽  
Blood Loss ◽  
Postpartum Hemorrhage ◽  
Significant Risk ◽  
The State ◽  
Control Group ◽  
Bleeding Tendency ◽  
Bleeding Disorders ◽  
Storage Pool ◽  
The Mean

Abstract Abstract 4672 Postpartum hemorrhage (PPH) is one of the leading causes of maternal mortality and is estimated to occur in 1–10% of all childbirths. Postpartum hemorrhage is defined as a blood loss of >500 ml for vaginal delivery or >1000 ml for cesarean delivery. The etiology of PPH is attributed most often to uterine atony (80%); the etiology of atony is unknown. Studies of rat and human myometrial tissues suggest that an increase of 5-HT2 receptors late in pregnancy might trigger parturition by increasing uterine contractility when presented with 5-HT released by mast cells and platelets. Furthermore, the up-regulated receptors may serve to maintain uterine tone postpartum. The most common cited risk factors for PPH include PPH in a previous pregnancy, chorioamnionitis, use of magnesium sulfate, labor induction and augmentation, increased birth weight, and retention of the placenta. The obstetrics literature discounts bleeding disorders as significant risk factors for PPH for the immediate postpartum period although acknowledging that if diagnosed, such disorders should be considered during management of pregnancy. In essence, bleeding disorders are thought to be rare causes of PPH. A few case reports in the literature suggest that platelet storage pool deficiency (SPD) may be a contributing factor for development of PPH. We report the first investigation of the platelet dense granule storage pool during pregnancy. Our hypotheses include that platelet (PLT) delta (δ) granule storage pool deficiency (δSPD) may be a risk factor for the development of PPH. As the PLT dense (δ) granules (DG) store the majority of 5HT excluding the central nervous system, δSPD would intuitively present less 5-HT at parturition potentially resulting in atony. Our IRB approved study is recruiting women during prenatal check-ups. To assess for potential bleeding tendencies, we are utilizing a modified Vincenza bleeding checklist (Tosetto, et al., 2007), a pictorial blood loss assessment (Jannsen, et al, 1995), and a blood sample for PLT whole mounts and biochemical assays. To date, a total of 32 women have been enrolled in the study having an average age of 24.2 ± 4. Bleeding scores average 0.24 ± 0.21 (normal <5) and the pictorial menorrhagia scores average 170.44 ± 30.94 (normal <185). Four women have scores ranging from 267–522 consistent with a clinical diagnosis of menorrhagia and suggesting that they may have a bleeding tendency although their bleeding scores are all within the normal range. The mean number of DG/PLT is 5.34 ± 0.58 which is significantly different than a vetted control group of women (n=26) who have an average of 4.16 ± 0.08 DG/PLT. These data suggest that the state of pregnancy includes an increase in the average number of DG/PLT. It is known that pregnancy results in a variety of hematologic deviations from normal CBC ranges in non-pregnant women including Hgb and Hct that decrease, related to a dilution effect of increased blood volume. Pregnancy is also related to an increased state of coagulability. The increased number of DG/PLT might suggest a potential for increased coagulability in preparation of parturition as all women studied have significantly increased DG numbers in comparison to control subjects. These results are in direct contradiction to our original hypothesis that δSPD might contribute to PPH. We have yet to analyze 5HT extracts from PLTs however these results will be presented with significantly more data as we continue with our recruitment of test subjects. Disclosures: No relevant conflicts of interest to declare.

Characterizing the Magnitude of and Risk Factors for Functional Limb Lengthening in Patients Undergoing Primary Total Knee Arthroplasty

2021 ◽  
pp. 155633162110091
Author(s):  
Brian P. Chalmers ◽  
Mark LaGreca ◽  
Jacqueline Addona ◽  
Peter K. Sculco ◽  
Steve B. Haas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Total Knee Arthroplasty ◽  
Significant Risk ◽  
Primary Total Knee Arthroplasty ◽  
Limb Lengthening ◽  
Leg Lengthening ◽  
Total Knee ◽  
Plane Deformity ◽  
The Mean ◽  
Primary Total Knee

Background: There is little data on the magnitude and factors for functional leg lengthening after primary total knee arthroplasty (TKA). Questions/Purpose: We sought to determine the incidence of and risk factors for functional leg lengthening after primary TKA. Methods: We retrospectively reviewed consecutive unilateral primary TKAs at a single institution from 2015 to 2018. Of the 782 TKAs included, 430 (55%) were performed in women; the mean age was 66 years, and the mean body mass index was 29 kg/m2. Preoperatively, 541 (69%) knees were varus deformities and 223 (29%) were valgus deformities. Hip to ankle biplanar radiographs were obtained preoperatively and 6 weeks postoperatively for all patients. Two independent researchers measured leg length, coronal plane deformity, lateral knee flexion angle, and overall mechanical alignment on all preoperative and postoperative radiographs. Results: The mean overall ipsilateral functional leg lengthening was 7.0 mm. Seven hundred knees (90%) were overall functionally lengthened, including 462 (59%) knees lengthened >5 mm and 250 (31%) knees lengthened 10 mm or more. A valgus deformity and coronal plane deformity of 10° or more were significant risk factors for increased functional lengthening. Patients with severe valgus deformities (>10°) had the largest amount of functional lengthening, at a mean of 13.5 mm. Conclusion: After primary TKA, 90% of limbs are functionally lengthened, including roughly one-third over a centimeter. Valgus knee deformities and severe deformities (>10°) were significant risk factors for increased limb lengthening.

scholarly journals Risk factors for the failure to achieve normal albumin serum levels after albumin transfusion in neonates

2016 ◽  
Vol 56 (3) ◽  
pp. 129
Author(s):  
Nadya Arafuri ◽  
Pudjo Hagung Widjajanto ◽  
Ekawaty L. Haksari
Keyword(s):  
Risk Factors ◽  
Critical Illness ◽  
Very Low Birth Weight ◽  
Significant Risk ◽  
Albumin Level ◽  
Control Group ◽  
Case Group ◽  
Severe Bleeding ◽  
Normal Albumin ◽  
Neonatal Ward

Background Albumin transfusion for the treatment of neonatal hypoalbuminemia may reduce morbidity. In conditions with disrupted endothelial integrity (e.g., sepsis and critical illness), the administered albumin may leak into the interstitial space, hence, serum albumin levels may fall below expected levels after transfusion. To date, few studies have been done to evaluate the risk factors for failure to achieve normal neonatal albumin levels after transfusion.Objectives To determine the risk factors for failure to achieve normal neonatal albumin levels after transfusion.Methods We performed a case-control study in the Neonatal Ward of Dr. Sardjito Hospital from 2007 to 2012. Normal albumin level was defined as above 3 g/dL. The case group included neonates with post-transfusion albumin levels <3 g/dL and the control group included those with post-transfusion albumin ≥3 g/dL. Subjects received intravenous transfusions of 25% or 20% albumin according to the clinical standard of the Neonatal Ward of Dr. Sardjito Hospital. Neonates with very low birth weight, severe birth trauma, burn injuries, severe bleeding, or incomplete medical records were excluded. The data were analyzed with logistic regression test.Results From January 2007 to December 2012, 124 neonates were enrolled in the study. Multivariate analysis showed that low albumin levels before transfusion (OR 12.27; 95%CI 2.17 to 69.30), presence of critical illness (OR 4.01; 95%CI 1.49 to 10.79), diagnosis of sepsis (OR 3.56; 95%CI 1.36 to 9.32), and the >24-hour interval between albumin examination and transfusion (OR 0.06; 95%CI 0.01 to 0.37) were significant risk factors affecting the failure to achieve normal albumin levels.Conclusions Failure to achieve normal albumin levels after transfusion in neonates was significantly associated with low albumin level prior to transfusion, critical illness, sepsis, and >24-hour interval between transfusion and post-transfusion albumin examination.[Paediatr Indones. 2016;56:129-33.].

Serum Vitamin D Binding Protein Level Associated with Metabolic Cardiovascular Risk Factors in Women with the Polycystic Ovary Syndrome

2018 ◽  
Vol 51 (01) ◽  
pp. 54-61 ◽  
Author(s):  
Justyna Kuliczkowska-Plaksej ◽  
Renato Pasquali ◽  
Andrzej Milewicz ◽  
Felicja Lwow ◽  
Diana Jedrzejuk ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Polycystic Ovary ◽  
Serum Insulin ◽  
Normal Weight ◽  
Control Group ◽  
Vitamin D Binding Protein ◽  
Ovary Syndrome

AbstractThe objective of the study was to measure the levels of 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) and assess their relationships with cardiovascular risk factors in women with the polycystic ovary syndrome (PCOS). A group of 267 women, aged 20–35 years (24.7 ± 4.9): 167 with PCOS and 100 healthy women were divided according to body mass index. Biochemical and hormonal parameters were measured. Free and bioavailable 25(OH)D were calculated using the mathematical equations. The percentage of body fat and visceral fat deposit were assessed by DXA. In the normal weight control group total, free, bioavailable 25(OH)D (p<0.001 for all) were significantly higher than in its overweight/obese counterpart, while VDBP levels were comparable. In PCOS women total 25(OH)D (p<0.001), and VDBP (p –0.006) were lower in the overweight/obese subgroups than in the normal weight ones. In both groups serum VDBP levels correlated negatively with serum insulin and positively with sex hormone binding globulin. In PCOS group, in contrast to control group, VDPB was negatively correlated with abdominal fat deposit, BMI, fasting glucose and positively with HDL. Despite lower total 25(OH)D in obese PCOS women, all women with PCOS (lean and obese) had comparable free and bioavailable 25(OH)D, which might be a result of concomitantly lowered serum VDBP levels in obese PCOS women. VDBP might play important role in the regulation of availability of active fractions of 25(OH)D in PCOS women. VDBP seems to be associated with cardiovascular risk factors such as BMI, waist circumference, visceral fat, and fasting serum insulin in women with PCOS.

scholarly journals Association of Hypertriglycerideamia with Ischaemic Stroke

2016 ◽  
Vol 32 (1) ◽  
pp. 34-38
Author(s):  
Biplob Kumar Das ◽  
Kanak Jyoti Mondal
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Ischaemic Stroke ◽  
Significant Risk ◽  
Serum Triglyceride ◽  
Control Group ◽  
Case Group ◽  
Stepwise Logistic Regression ◽  
Serum Triglyceride Level ◽  
Analysis Model

Stroke is one of the foremost causes of morbidity, mortality and is a socioeconomic challenge. This is particularly true for developing countries like Bangladesh, where health support system including the rehabilitation system is not within the reach of common people. Hypertriglycerademia has an effective influence in the pathogenesis of Ischaemic Stroke (IS). So, the focus of this study was to evaluate and assess the association of serum triglyceride level in patients of IS. This case control study was carried out in the Department of Neurology in collaboration with Department of Biochemistry, BSMMU, Dhaka from July 2011 to June 2013. In this study, 60 diagnosed cases of ischaemic stroke patients and 60 age and sex matched healthy controls were enrolled. Risk factors of Ischemic Stroke (IS) patients were assessed ( adjusted Odds Ratio) in comparison with healthy adults. In this study, being married [OR. 1.95, 95% CI (0.40-9.42), p=0.409] , smoker [OR.1.65, 95% CI (0.57 - 4.82),p= 0.357], DM [OR. 1.48, 95% CI (0.36-6.06), p=0.582 ], IHD [OR. 1.51, 95% CI (0.29 – 7.89), p=0.624] , HTN [OR. 3.66, 95% CI (1.11–12.12), p=0.033] , overweight [OR.2.31, 95% CI (0.77 – 6.91), 0.135] and obesity [OR. 16.19, 95% CI (1.31–200.6), p=0.030] , increased level of serum TC [OR.8.24, 95% CI (2.07 – 32.83), p=0.003], TG [OR. 9.40, 95% CI (1.17 -75.86), p=0.035], LDL [OR. 0.45, 95% CI (0.10–2.05), p=0.308],and decreased level of HDL [OR. 3.37, 95% CI (1.03 - 12.25), p=0.045] were found as risk factors in developing IS. Independent t-test was done to find out the statistically significant differences of continuous variables like serum lipid profile between case and control group. The mean (SD) value of TG which is focus of this study, was found 237.67 (61.74) in case group, and 169.97 (26.95) in control group which was highly statistically significant (p < 0.0001). All of the significant variables were entered into stepwise logistic regression analysis model. From the logistic regression model, it can be finally concluded that hypertension, obesity, increased level of TC, increased level of TG and decreased level of HDL were statistically significant risk factors for development of IS. Bangladesh Journal of Neuroscience 2016; Vol. 32 (1): 34-38

scholarly journals Splenectomy and its relation to non-transfusion-transmitted infection in thalassemic patients

2016 ◽  
Vol 46 (3) ◽  
pp. 134
Author(s):  
Mururul Aisyi ◽  
Alan Roland Tumbelaka ◽  
Bulan Ginting Munthe ◽  
Bambang Madiyono
Keyword(s):  
Risk Factors ◽  
Common Cold ◽  
Severe Infection ◽  
Cross Sectional Study ◽  
Control Group ◽  
Transmitted Infection ◽  
Cross Sectional ◽  
Transfusion Transmitted Infection ◽  
Common Group ◽  
Level Of Significance

Background Splenectomy has been associated with an increasedsusceptibility to infection. Overwhelming postspelenectomy infec-tion (OPSI) can lead to high mortality. Decreased IgM and tuftsinconcentration on splenectomized patients seems to play a role ininfection’s susceptibility. Many studies have been performed todetermine the risk factors of infection in thalassemic patients.Objective To find out morbidity patterns and risk factors for pre-dicting the likelihood of infection in splenectomized thalassemicpatients.Methods A retrospective cross sectional study was conducted onconfirmed thalassemic children who came to Department of ChildHealth, Cipto Mangunkusumo Hospital within the period of 1973-2003. Splenectomized patients were categorized as cases groupand non-splenectomized patients as control group. Risk factors fordevelopment of common cold and diarrhea were analyzed usingchi-square test with level of significance <0.05.Results A total of 300 thalassemic patients, 100 of them were sple-nectomized, were enrolled in this study. The 15-year-age group orabove is the most common group underwent splenectomy (35%).Common cold is the most common mild infection in both splenec-tomized group (75%) and non-splenectomized (71%). A significantassociation was found between the risk of infection and splenec-tomy in thalassemic patients (OR=3.8;CI=2.2;6.62; P=0.000). As-sociation between time after splenectomy and frequency of com-mon cold in thalassemia was significant (OR=2.85;CI=1.16;7.14;P=0.011). Severe infection and acute diarrhea were considerednot significantly different between the two groups.Conclusion Splenectomy in thalassemia can increase the sus-ceptibility of non-transfusion-transmitted mild infection. Furtherstudy is needed to elaborate this finding

scholarly journals Differences in Risk Factors for Retinopathy of Prematurity Development in Paired Twins: A Chinese Population Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Gordon S. K. Yau ◽  
Jacky W. Y. Lee ◽  
Victor T. Y. Tam ◽  
Stan Yip ◽  
Edith Cheng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Retinopathy Of Prematurity ◽  
Very Low Birth Weight ◽  
Significant Risk ◽  
The Mean ◽  
Record Review ◽  
Chinese Twins ◽  
Retrospective Medical Record Review

Purpose.To determine the differences in risk factors for retinopathy of prematurity (ROP) in paired twins.Methods.A retrospective medical record review was performed for all paired twins screened for ROP between 2007 and 2012. Screening was offered to very low birth weight (≤1500 grams) and preterm (≤32 weeks) neonates. Twins 1 and 2 were categorized based on the order of delivery. Maternal and neonatal covariates were analyzed using univariate and multivariate regression analyses for both ROP and Type 1 ROP.Results.In 34 pairs of Chinese twins, the mean gestational age (GA) was 30.2 ± 2.0 weeks. In Twin 1, smaller GA (OR = 0.44,P=0.02), higher mean oxygen concentration (OR = 1.34,P=0.03), presence of thrombocytopenia (OR = 1429.60,P<0.0001), and intraventricular hemorrhage (OR = 18.67,P=0.03) were significant risk factors for ROP. For Twin 2, a smaller GA (OR = 0.45,P=0.03) was the only risk factor. There were no significant risk factors for ROP in Twin 1 or Twin 2 on multivariate analysis.Conclusion.In Chinese twin pairs, smaller GA was the only common risk factor for ROP while Twin 1 was more susceptible to the postnatal risks for ROP.

Abstract 2877: Ultra-early Endovascular Embolization Of Ruptured Cerebral Aneurysms Increases The Risk Of Hematoma Growth Unrelated To Aneurysmal Rebleeding

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Yusuke Egashira ◽  
Shinichi Yoshimura ◽  
Yukiko Enomoto ◽  
Kiyofumi Yamada ◽  
Takahiko Asano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Significant Risk ◽  
Cerebral Aneurysms ◽  
Female Gender ◽  
Endovascular Embolization ◽  
Anterior Circulation ◽  
Hematoma Growth ◽  
Group 3 ◽  
The Mean ◽  
Systemic Anticoagulation

Background and purpose: Hematoma growth unrelated to aneurysmal rebleeding has been poorly studied, but is not a rare complication following endovascular embolization of ruptured cerebral aneurysms. The aim of this study is to elucidate the possible risk factors for this phenomenon. Methods: We included 101 consecutive patients with subarachnoid hemorrhage (SAH) who underwent endosaccular embolization at our institution within 72 hours of symptom onset in this study. All endovascular procedures were conducted under intraprocedural systemic anticoagulation. Age, gender, hypertension, diabetes, preoperative antiplatelet or anticoagulation use, neurological grade, Fisher computed tomography group, location and size of the aneurysm, the grade of aneurysm occlusion, and timing of endovascular procedure were retrospectively analyzed to find the risk factors for hematoma growth. Results: This series included 32 men (31.7%) and 69 women (68.3%), and the mean age ± SD was 65.5 ± 14.0 years. The mean time ± SD from onset to endovascular procedure was 12.1 ± 14.0 hours. Following the procedure, hematoma growth unrelated to aneurysmal rebleeding occurred in 14 patients (13.9%), and 10 of the 14 patients required surgical removal of hematoma and/or ventriculostomy to control intracranial pressure. All 14 patients had an anterior circulation aneurysm and had Fisher group 3 or 4 SAH. Ultra-early embolization (conducted within 6 hours after onset), female gender, history of hypertension, and poor neurological grade (WFNS grades 4 and 5) were significant risk factors of hematoma growth (p < 0.05 for all) by the univariate logistic analysis. In multivariate analysis, ultra-early embolization (OR, 18.0; 95% CI, 3.26-338; p = 0.0002), and female gender (OR, 9.83; 95% CI, 1.73-187; p = 0.0067) were independent risk factors for this phenomenon. Anterior circulation aneurysm and Fisher group 3 or 4 SAH did not suit for the logistic regression model, but were found to be significant risk factors by chi-square test (p = 0.018 and 0.022, respectively). Conclusions: Ultra-early endovascular embolization for ruptured cerebral aneurysm under systemic anticoagulation increases the risk of growth of hematomas unrelated to aneurysmal rebleeding. In addition, women with anterior circulation aneurysm presenting with dense focal SAH or intracerebral hematoma are at higher risk for this phenomenon.

scholarly journals 2272. Evaluation of Clinical Features, Carbapenem Resistance and Risk Factors of Klebsiella Species: A 4-Year Retrospective Study in Turkey

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S777-S778
Author(s):  
Zuhal Umit ◽  
Zumrut Sahbudak Bal ◽  
Gizem Guner ◽  
Gulhadiye Avcu ◽  
Duygu Bozkurt ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hospital Stay ◽  
Significant Risk ◽  
Carbapenem Resistance ◽  
Steroid Use ◽  
Carbapenem Resistant ◽  
Vitek 2 ◽  
The Mean ◽  
Klebsiella Spp ◽  
Klebsiella Infections

Abstract Background Gram-negative-resistant bacterial infections are increasing due to widespread use of antibiotics. Infections caused by Klebsiella spp. are an important part of healthcare-associated infections and cause morbidity and mortality. The aim of this study was to determine the epidemiological, clinical features, carbapenem resistance rates and risk factors of bloodstream infections of children with Klebsiella spp. Methods In this retropective study, medical records of 85 episodes of 75 patients caused by with Klebsiella spp. bacteriaemia who admitted to Ege University Faculty of Medicine, Pediatric Hospital in Turkey between 2014 and 2017 were evaluated. Conventional biochemical methods were performed using the automated systems of MALDİ-TOFF MS / VITEK 2 (Biomerieux, France). According to EUCAST recommendations, VITEK 2 (Biomerieux, France) automated microdilution method was used in sensitivity tests. Results The mean age of 85 episodes included in the study was 3.49 (±5.4) years. 58% of the patients were male and 42% were female. 18.8% of the patients were premature. The most common service was newborn service (30.6%). Neutropenia was 26% and thrombocytopenia was 55% at the time of diagnosis. Klebsiella pneumonia was 93% and Klebsiella oxytoca was 7%. Carbapenem resistance rate was found to be 30.6% in Klebsiella spp. Carbapenem resistance was found 18% in 2014, 38% in 2015, 42% in 2016 and 25% in 2017. In patients who developed carbapenem-resistant Klebsiella infection, the duration of pre-hospitalization ≥14 days (P = 0.034), the absolute neutrophil count < 100 (P = 0.048) and steroid use (P = 0.025) were statistically significant risk factors. The mean length of hospital stay was 107 (±103) days. Klebsiella spp. attributable mortality due to infection was 14% and crude mortality was 15%. No statistically significant difference was found in patients who developed resistant and susceptible infections. Conclusion Carbapenem resistance in Klebsiella infections was increased. Prolonged hospital stay, neutropenia and steroid use in the last 3 months were identified as significant risk factors for carbapenem-resistant Klebsiella infections. Disclosures All authors: No reported disclosures.

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