Abstract 422: Relationship Between N-Telopeptide-Mediated Bone Mineral Resorption and Peripheral Arterial Disease

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
Danlin Mao ◽  
Lea Moukarzel ◽  
Scott Lilly ◽  
Paul DiMuzio ◽  
Luis Eraso
Keyword(s):  
Peripheral Arterial Disease ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Type I Collagen ◽  
Arterial Disease ◽  
Type I ◽  
Mineral Density ◽  
Peripheral Arterial ◽  
Mineral Resorption

Background: Patients with peripheral arterial disease (PAD) have a higher incidence of hip bone loss and non-spinal fractures independent of their cardiovascular risk or degree of claudication. The mechanisms explaining this excess risk of osteoporosis are poorly understood. N-telopeptide (NTX) is an amino-terminal cross-linked type I collagen peptide that is released during fibrillogenesis, reflecting both the derivative products of bone collagen and bone resorption. When elevated, it serves as an early marker for osteoporosis and predictor of therapeutic response. We hypothesized that patients with PAD have reduced bone mineral content and that PAD is associated with biomarkers of accelerated bone mineral resorption. Methods: We analyzed data from 4354 participants ages 40 years or older with measured ankle-brachial indexes (ABI) from the National Health and Nutrition Examination Survey from 1999 to 2002, defining PAD as an ABI < 0.9 in either leg. N-telopeptides were measured in the urine. Total bone mineral content and bone mineral density were measured using dual energy X-ray absorptiometry. Results: The overall prevalence of PAD was 4.4 % (S.E, 0.3). The geometric mean of NTX was 248.3 nmol (S.E, 7.0). NTX decreased with age. Women, non-Hispanic blacks and obese individuals had significantly higher NTX levels, whereas diabetics had reduced NTX levels. Current smokers, chronic kidney disease and PAD patients tended to have higher levels as well. In an age, gender, and race adjusted multivariate analysis, one standard deviation increase in NTX level was associated with a three-fold increase in the odds of having reduced total bone mineral density (OR 3.22, p <0.0001). Additionally, patients with PAD had significantly increased odds of having NTX levels in the higher tertile (O.R 1.57, p=0.035). This association persisted even after further adjustment for obesity, smoking, and C-reactive protein. Conclusion: Peripheral arterial disease is associated with reduced levels of bone mineral content and density. PAD is independently associated with N-telopeptides, suggesting abnormal type I collagen metabolism abnormalities. Further prospective studies will determine the role of NTX as a marker of osteoporosis found in PAD and their relationship with walking activity.

scholarly journals A 24-Week Physical Activity Intervention Increases Bone Mineral Content without Changes in Bone Markers in Youth with PWS

Genes ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 984
Author(s):  
Daniela A. Rubin ◽  
Kathleen S. Wilson ◽  
Camila E. Orsso ◽  
Erik R. Gertz ◽  
Andrea M. Haqq ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Bone Markers ◽  
Physical Activity Intervention ◽  
Type I ◽  
Mineral Density ◽  
Group I ◽  
Bone Remodeling Markers

Bone mineral density (BMD) is of concern in Prader-Willi syndrome (PWS). This study compared responses to a physical activity intervention in bone parameters and remodeling markers in youth with PWS (n = 45) and youth with non-syndromic obesity (NSO; n = 66). Measurements occurred at baseline (PRE) and after 24 weeks (POST) of a home-based active games intervention with strengthening and jumping exercises (intervention group = I) or after a no-intervention period (control group = C). Dual x-ray absorptiometry scans of the hip and lumbar spine (L1-L4) determined BMD and bone mineral content (BMC). Bone markers included fasting bone-specific alkaline phosphatase (BAP) and C-terminal telopeptide of type I collagen (CTx). Both I and C groups increased their hip BMD and BMC (p < 0.001). Youth with PWS-I increased their spine BMC from PRE to POST (p < 0.001) but not youth with PWS-C (p = 1.000). Youth with NSO (I and C) increased their spine BMC between PRE and POST (all p < 0.001). Youth with PWS showed lower BAP (108.28 ± 9.19 vs. 139.07 ± 6.41 U/L; p = 0.006) and similar CTx (2.07 ± 0.11 vs.1.84 ± 0.14 ng/dL; p = 0.193) than those with NSO regardless of time. Likely, the novelty of the intervention exercises for those with PWS contributed to gains in spine BMC beyond growth. Bone remodeling markers were unaltered by the intervention.

Bone Turnover Markers and Lean Mass in Pubescent Boys: Comparison Between Elite Soccer Players and Controls

2017 ◽  
Vol 29 (4) ◽  
pp. 513-519 ◽  
Author(s):  
Ammar Nebigh ◽  
Mohamed Elfethi Abed ◽  
Rihab Borji ◽  
Sonia Sahli ◽  
Slaheddine Sellami ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Mineral Content ◽  
Type I Collagen ◽  
Soccer Players ◽  
Whole Body ◽  
Type I ◽  
Mineral Density ◽  
Turnover Markers

The aim of this study was to examine the relationship between bone mass and bone turnover markers with lean mass (LM) in pubescent soccer players. Two groups participated in this study, which included 65 elite young soccer players who trained for 6–8 hours per week and 60 controls. Bone mineral density; bone mineral content in the whole body, lower limbs, lumbar spine, and femoral neck; biochemical markers of osteocalcin; bone-specific alkaline phosphatase; C-telopeptide type I collagen; and total LM were assessed. Young soccer players showed higher bone mineral density and bone mineral content in the whole body and weight-bearing sites (P < .001). Indeed, the total LM correlated with whole-body bone mineral density and bone mineral content (P < .001). There were significant differences within the bone formation markers and osteocalcin (formation)/C-telopeptide type I collagen (resorption) ratio between young soccer players compared with the control group, but no significant difference in C-telopeptide type I collagen was observed between the 2 groups. This study showed a significant positive correlation among bone-specific alkaline phosphatase, osteocalcin, and total LM (r = .29; r = .31; P < .05) only for the young soccer players. Findings of this study highlight the importance of soccer practice for bone mineral parameters and bone turnover markers during the puberty stage.

Bone Mineral Density and the Risk of Peripheral Arterial Disease: The Rotterdam Study

2002 ◽  
Vol 70 (6) ◽  
pp. 443-449 ◽  
Author(s):  
M. van der Klift ◽  
H.A.P. Pols ◽  
A.E. Hak ◽  
J.C.M. Witteman ◽  
A. Hofman ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Peripheral Arterial Disease ◽  
Bone Mineral ◽  
Arterial Disease ◽  
Rotterdam Study ◽  
Mineral Density ◽  
Peripheral Arterial

scholarly journals Novel Strong Association Between Bone Mineral Density Scores and the Prevalence of Peripheral Arterial Disease in Both Sexes

2015 ◽  
Vol 62 (3) ◽  
pp. 807-808
Author(s):  
Caron B. Rockman ◽  
Thomas Maldonado ◽  
Jade Hiramoto ◽  
Stephen Honig ◽  
Michael Conte ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Peripheral Arterial Disease ◽  
Bone Mineral ◽  
Strong Association ◽  
Arterial Disease ◽  
Mineral Density ◽  
Peripheral Arterial

scholarly journals Impact of Dehydroepiandrosterone (DHEA) on Bone Mineral Density and Bone Mineral Content in a Rat Model of Male Hypogonadism

2020 ◽  
Vol 7 (4) ◽  
pp. 185
Author(s):  
Hussein F. Sakr ◽  
Abdelaziz M. Hussein ◽  
Elsayed A. Eid ◽  
Ammar Boudaka ◽  
Lashin S. Lashin
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Serum Levels ◽  
Male Rats ◽  
Type I ◽  
Male Hypogonadism ◽  
Mineral Density ◽  
Trap 5B

Objectives: The present study examined the effect DHEA (dehydroepiandrosterone) on bone mineral content (BMC) and bone mineral density (BMD) and biomarkers of bone remodeling in orchidectomized male rats. Material and Methods: A total of 32 male rats were divided equally into four groups (n = 8): (i) control group (C), (ii) control treated with DHEA (Control + DHEA), (iii) orchidectomized (ORCH) group that underwent bilateral orchidectomy and (iv) orchidectomized (ORCH) rats treated with DHEA (ORCH+DHEA). DHEA treatment started 4 weeks after orchidectomy and continued for 12 weeks. After 12 weeks the bone mineral density (BMD) and bone mineral content (BMC) were assayed in the tibia and femur of the right hind limb of each rat. We also measured the serum levels of the bone turnover markers deoxypyridinoline (Dpd), N-telopeptide of type I collagen (NTx), alkaline phosphatase (ALP), tartrate-resistant acid phosphatase 5b (TRAP-5b) and osteocalcin (OC) as well as receptor activator of nuclear factor kappa B (RANK) and osteoprotegerin (OPG). Results: Orchidectomy in rats caused significant reduction in BMD, BMC, serum levels of testosterone, PTH (parathyroid hormone), OPG, OC and ALP with significant rise in serum levels of TRAP-5B, RANK, Dpd and NTx1 (p < 0.05). On the other hand, DHEA therapy for 12 weeks caused significant improvement in all studied parameters except NTx1 (p < 0.05). Conclusions: DHEA corrected hypogonadism-induced osteoporosis in male rats probably via inhibiting osteoclastogenesis, stimulating the activity of osteoblasts and stimulating the secretion of PTH and testosterone.

Influence of anthropometric parameters on assessment of paediatric bone mineral density and bone mineral content

2013 ◽  
Author(s):  
N Hangartner Thomas ◽  
F Short David ◽  
Gilsanz Vicente ◽  
J Kalkwarf Heidi ◽  
M Lappe Joan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Mineral Density ◽  
Anthropometric Parameters

scholarly journals Intra-Bone Marrow Administration of Mesenchymal Stem/Stromal Cells Is a Promising Approach for Treating Osteoporosis

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Hideki Agata ◽  
Yoshinori Sumita ◽  
Tatsuro Hidaka ◽  
Mayumi Iwatake ◽  
Hideaki Kagami ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Intravenous Administration ◽  
Stromal Cells ◽  
Mineral Content ◽  
Bone Diseases ◽  
Research Progress ◽  
Bone Thickness ◽  
Mineral Density

Mesenchymal stem/stromal cells (MSCs) are known to be useful for treating local bone diseases. However, it is not known if MSCs are effective for treating systemic bone diseases, as the risk for mortality following intravenous MSC administration has hindered research progress. In this study, we compared the safety and efficacy of intra-bone marrow and intravenous administration of MSCs for the treatment of ovariectomy- (OVX-) induced osteoporosis. Cells capable of forming bone were isolated from the murine compact bones and expanded in culture. Relatively pure MSCs possessing increased potential for cell proliferation, osteogenic differentiation, and inhibition of osteoclastogenesis were obtained by magnetic-activated cell sorting with the anti-Sca-1 antibody. Sca-1-sorted MSCs were administered to OVX mice, which were sacrificed 1 month later. We observed that 22% of the mice died after intravenous administration, whereas none of the mice died after intra-bone marrow administration. With respect to efficacy, intravenous administration improved bone mineral density (BMD) by increasing bone mineral content without affecting bone thickness, whereas intra-bone marrow administration improved BMD by increasing both bone mineral content and bone thickness. These results indicate that intra-bone marrow administration of pure MSCs is a safer and more effective approach for treating osteoporosis.

Effects of One-Year Adjuvant Treatment with Tamoxifen on Bone Mineral Density in Postmenopausal Breast Cancer Women

1996 ◽  
Vol 82 (1) ◽  
pp. 65-67 ◽  
Author(s):  
Sandro Barni ◽  
Paolo Lissoni ◽  
Gabriele Tancini ◽  
Antonio Ardizzoia ◽  
Marina Cazzaniga
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Adjuvant Treatment ◽  
Mineral Content ◽  
Postmenopausal Breast Cancer ◽  
Mineral Density ◽  
One Year

In this study, the authors have analyzed the possible effects of one-year adjuvant treatment with tamoxifen on bone mineral density in postmenopausal breast cancer women. Bone mineral content was studied by photon absorptiometry (I-125), whereas bone balance was analyzed indirectly by serum PTH, osteocalcin, calcitonin, calcium and alkaline phosphatase levels. Bone mineral content and serum bone-related substances were measured before starting treatment and after one year. Results were analyzed using Student's t test for paired data. No difference was found between the two measurements for bone mineral content, PTH, calcitonin, calcium and alkaline phosphatase levels. Measurements at entry and after one year of treatment showed a statistically significant difference ( P < 0.001) only for osteocalcin. In accordance with other authors, we can conclude that treatment with tamoxifen does not cause an increase in menopausal bone resorption. The finding that osteocalcin levels decreased after one year of therapy with tamoxifen is interesting, but further studies are necessary to clarify the role of such levels in predicting a turnover of bone balance towards osteoblastic activity.

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