scholarly journals A 24-Week Physical Activity Intervention Increases Bone Mineral Content without Changes in Bone Markers in Youth with PWS

Genes ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 984
Author(s):  
Daniela A. Rubin ◽  
Kathleen S. Wilson ◽  
Camila E. Orsso ◽  
Erik R. Gertz ◽  
Andrea M. Haqq ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Bone Markers ◽  
Physical Activity Intervention ◽  
Type I ◽  
Mineral Density ◽  
Group I ◽  
Bone Remodeling Markers

Bone mineral density (BMD) is of concern in Prader-Willi syndrome (PWS). This study compared responses to a physical activity intervention in bone parameters and remodeling markers in youth with PWS (n = 45) and youth with non-syndromic obesity (NSO; n = 66). Measurements occurred at baseline (PRE) and after 24 weeks (POST) of a home-based active games intervention with strengthening and jumping exercises (intervention group = I) or after a no-intervention period (control group = C). Dual x-ray absorptiometry scans of the hip and lumbar spine (L1-L4) determined BMD and bone mineral content (BMC). Bone markers included fasting bone-specific alkaline phosphatase (BAP) and C-terminal telopeptide of type I collagen (CTx). Both I and C groups increased their hip BMD and BMC (p < 0.001). Youth with PWS-I increased their spine BMC from PRE to POST (p < 0.001) but not youth with PWS-C (p = 1.000). Youth with NSO (I and C) increased their spine BMC between PRE and POST (all p < 0.001). Youth with PWS showed lower BAP (108.28 ± 9.19 vs. 139.07 ± 6.41 U/L; p = 0.006) and similar CTx (2.07 ± 0.11 vs.1.84 ± 0.14 ng/dL; p = 0.193) than those with NSO regardless of time. Likely, the novelty of the intervention exercises for those with PWS contributed to gains in spine BMC beyond growth. Bone remodeling markers were unaltered by the intervention.

Abstract 422: Relationship Between N-Telopeptide-Mediated Bone Mineral Resorption and Peripheral Arterial Disease

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
Danlin Mao ◽  
Lea Moukarzel ◽  
Scott Lilly ◽  
Paul DiMuzio ◽  
Luis Eraso
Keyword(s):  
Peripheral Arterial Disease ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Type I Collagen ◽  
Arterial Disease ◽  
Type I ◽  
Mineral Density ◽  
Peripheral Arterial ◽  
Mineral Resorption

Background: Patients with peripheral arterial disease (PAD) have a higher incidence of hip bone loss and non-spinal fractures independent of their cardiovascular risk or degree of claudication. The mechanisms explaining this excess risk of osteoporosis are poorly understood. N-telopeptide (NTX) is an amino-terminal cross-linked type I collagen peptide that is released during fibrillogenesis, reflecting both the derivative products of bone collagen and bone resorption. When elevated, it serves as an early marker for osteoporosis and predictor of therapeutic response. We hypothesized that patients with PAD have reduced bone mineral content and that PAD is associated with biomarkers of accelerated bone mineral resorption. Methods: We analyzed data from 4354 participants ages 40 years or older with measured ankle-brachial indexes (ABI) from the National Health and Nutrition Examination Survey from 1999 to 2002, defining PAD as an ABI < 0.9 in either leg. N-telopeptides were measured in the urine. Total bone mineral content and bone mineral density were measured using dual energy X-ray absorptiometry. Results: The overall prevalence of PAD was 4.4 % (S.E, 0.3). The geometric mean of NTX was 248.3 nmol (S.E, 7.0). NTX decreased with age. Women, non-Hispanic blacks and obese individuals had significantly higher NTX levels, whereas diabetics had reduced NTX levels. Current smokers, chronic kidney disease and PAD patients tended to have higher levels as well. In an age, gender, and race adjusted multivariate analysis, one standard deviation increase in NTX level was associated with a three-fold increase in the odds of having reduced total bone mineral density (OR 3.22, p <0.0001). Additionally, patients with PAD had significantly increased odds of having NTX levels in the higher tertile (O.R 1.57, p=0.035). This association persisted even after further adjustment for obesity, smoking, and C-reactive protein. Conclusion: Peripheral arterial disease is associated with reduced levels of bone mineral content and density. PAD is independently associated with N-telopeptides, suggesting abnormal type I collagen metabolism abnormalities. Further prospective studies will determine the role of NTX as a marker of osteoporosis found in PAD and their relationship with walking activity.

scholarly journals Impact of Dehydroepiandrosterone (DHEA) on Bone Mineral Density and Bone Mineral Content in a Rat Model of Male Hypogonadism

2020 ◽  
Vol 7 (4) ◽  
pp. 185
Author(s):  
Hussein F. Sakr ◽  
Abdelaziz M. Hussein ◽  
Elsayed A. Eid ◽  
Ammar Boudaka ◽  
Lashin S. Lashin
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Serum Levels ◽  
Male Rats ◽  
Type I ◽  
Male Hypogonadism ◽  
Mineral Density ◽  
Trap 5B

Objectives: The present study examined the effect DHEA (dehydroepiandrosterone) on bone mineral content (BMC) and bone mineral density (BMD) and biomarkers of bone remodeling in orchidectomized male rats. Material and Methods: A total of 32 male rats were divided equally into four groups (n = 8): (i) control group (C), (ii) control treated with DHEA (Control + DHEA), (iii) orchidectomized (ORCH) group that underwent bilateral orchidectomy and (iv) orchidectomized (ORCH) rats treated with DHEA (ORCH+DHEA). DHEA treatment started 4 weeks after orchidectomy and continued for 12 weeks. After 12 weeks the bone mineral density (BMD) and bone mineral content (BMC) were assayed in the tibia and femur of the right hind limb of each rat. We also measured the serum levels of the bone turnover markers deoxypyridinoline (Dpd), N-telopeptide of type I collagen (NTx), alkaline phosphatase (ALP), tartrate-resistant acid phosphatase 5b (TRAP-5b) and osteocalcin (OC) as well as receptor activator of nuclear factor kappa B (RANK) and osteoprotegerin (OPG). Results: Orchidectomy in rats caused significant reduction in BMD, BMC, serum levels of testosterone, PTH (parathyroid hormone), OPG, OC and ALP with significant rise in serum levels of TRAP-5B, RANK, Dpd and NTx1 (p < 0.05). On the other hand, DHEA therapy for 12 weeks caused significant improvement in all studied parameters except NTx1 (p < 0.05). Conclusions: DHEA corrected hypogonadism-induced osteoporosis in male rats probably via inhibiting osteoclastogenesis, stimulating the activity of osteoblasts and stimulating the secretion of PTH and testosterone.

scholarly journals Biochemical Bone Markers, Bone Mineral Content, and Bone Mineral Density in Rats with Experimental Nephrotic Syndrome

Renal Failure ◽  
1997 ◽  
Vol 19 (3) ◽  
pp. 409-424 ◽  
Author(s):  
Rosa I. Sierra ◽  
Bonny L. Specker ◽  
Felipe JimÉNez ◽  
Cristino Cruz ◽  
José Pedraza-ChaverrÍ
Keyword(s):  
Bone Mineral Density ◽  
Nephrotic Syndrome ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Bone Markers ◽  
Mineral Density ◽  
Biochemical Bone Markers

scholarly journals The Impact of Diet and Physical Activity on Bone Health in Children and Adolescents

2021 ◽  
Vol 12 ◽  
Author(s):  
Patrizia Proia ◽  
Alessandra Amato ◽  
Patrik Drid ◽  
Darinka Korovljev ◽  
Sonya Vasto ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Content ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Bone Health ◽  
Mineral Content ◽  
Mineral Density ◽  
Diet And Physical Activity ◽  
The Impact

There is growing recognition of the role of diet and physical activity in modulating bone mineral density, bone mineral content, and remodeling, which in turn can impact bone health later in life. Adequate nutrient composition could influence bone health and help to maximize peak bone mass. Therefore, children’s nutrition may have lifelong consequences. Also, physical activity, adequate in volume or intensity, may have positive consequences on bone mineral content and density and may preserve bone loss in adulthood. Most of the literature that exists for children, about diet and physical activity on bone health, has been translated from studies conducted in adults. Thus, there are still many unanswered questions about what type of diet and physical activity may positively influence skeletal development. This review focuses on bone requirements in terms of nutrients and physical activity in childhood and adolescence to promote bone health. It explores the contemporary scientific literature that analyzes the impact of diet together with the typology and timing of physical activity that could be more appropriate depending on whether they are children and adolescents to assure an optimal skeleton formation. A description of the role of parathyroid hormone (PTH) and gut hormones (gastric inhibitory peptide (GIP), glucagon-like peptide (GLP)-1, and GLP-2) as potential candidates in this interaction to promote bone health is also presented.

Estrogen Receptor α Polymorphism Modifies the Association between Childhood Exercise and Bone Mass: Follow-Up Study

2007 ◽  
Vol 19 (4) ◽  
pp. 444-458 ◽  
Author(s):  
Miia Suuriniemi ◽  
Harri Suominen ◽  
Anitta Mahonen ◽  
Markku Alén ◽  
Sulin Cheng
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Areal Bone Mineral Density ◽  
Mineral Density ◽  
Follow Up Study

This follow-up study confirms our previous findings that the ER-α PvuII polymorphism (Pp) modulates the association between exercise and bone mass. The differences in bone properties of girls with consistently low physical activity (LLPA) and consistently high physical activity (HHPA) were evident only in those bearing the heterozygote ER-α genotype (Pp). In particular, areal bone mineral density of the total femur, bone mineral content and areal bone mineral density of the femoral neck, and bone mineral content and cortical thickness of the tibia shaft were significantly (p < .05) lower in the Pp girls with LLPA than in their HHPA counterparts. These findings might partly explain the genetic basis of human variation associated with exercise training.

Influence of anthropometric parameters on assessment of paediatric bone mineral density and bone mineral content

2013 ◽  
Author(s):  
N Hangartner Thomas ◽  
F Short David ◽  
Gilsanz Vicente ◽  
J Kalkwarf Heidi ◽  
M Lappe Joan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Mineral Density ◽  
Anthropometric Parameters

scholarly journals Intra-Bone Marrow Administration of Mesenchymal Stem/Stromal Cells Is a Promising Approach for Treating Osteoporosis

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Hideki Agata ◽  
Yoshinori Sumita ◽  
Tatsuro Hidaka ◽  
Mayumi Iwatake ◽  
Hideaki Kagami ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Intravenous Administration ◽  
Stromal Cells ◽  
Mineral Content ◽  
Bone Diseases ◽  
Research Progress ◽  
Bone Thickness ◽  
Mineral Density

Mesenchymal stem/stromal cells (MSCs) are known to be useful for treating local bone diseases. However, it is not known if MSCs are effective for treating systemic bone diseases, as the risk for mortality following intravenous MSC administration has hindered research progress. In this study, we compared the safety and efficacy of intra-bone marrow and intravenous administration of MSCs for the treatment of ovariectomy- (OVX-) induced osteoporosis. Cells capable of forming bone were isolated from the murine compact bones and expanded in culture. Relatively pure MSCs possessing increased potential for cell proliferation, osteogenic differentiation, and inhibition of osteoclastogenesis were obtained by magnetic-activated cell sorting with the anti-Sca-1 antibody. Sca-1-sorted MSCs were administered to OVX mice, which were sacrificed 1 month later. We observed that 22% of the mice died after intravenous administration, whereas none of the mice died after intra-bone marrow administration. With respect to efficacy, intravenous administration improved bone mineral density (BMD) by increasing bone mineral content without affecting bone thickness, whereas intra-bone marrow administration improved BMD by increasing both bone mineral content and bone thickness. These results indicate that intra-bone marrow administration of pure MSCs is a safer and more effective approach for treating osteoporosis.

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