Abstract 3311: Relationships Among Renal Function Loss Within the Normal to Mildly Impaired Range, Arterial Stiffness, Inflammation and Oxidative Stress

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
masanobu yoshida ◽  
Hirofumi Tomiyama ◽  
Chisa Matsumoto ◽  
Jiko Yamada ◽  
Kazuki Shiina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Function ◽  
Cardiovascular Risk ◽  
Arterial Stiffness ◽  
Impaired Renal Function ◽  
Linear Regression Analysis ◽  
Lipid Peroxides ◽  
Multiple Linear Regression Analysis ◽  
Reactive Protein ◽  
And Oxidative Stress

Objective: This study was conducted to clarify whether subjects with mildly impaired renal function {glomerular filtration rate (GFR) = 60 – 89 mL/min per 1.73 m 2 body surface area} show increased arterial stiffness, microinflammation and oxidative stress as compared to those with normal renal function, and also to examine the association of these parameters with GFR loss in middle-aged Japanese men with a low cardiovascular risk. Methods and Results: The brachial-ankle pulse wave velocity (baPWV) and plasma levels of C-reactive protein (CRP) and lipid peroxides (LipOX) were measured in 1873 male subjects (42±9 years old). The baPWV, but not the CRP or LipOX, was increased in subjects with mildly impaired renal function (Figure ). Multiple linear regression analysis demonstrated a significant relationship between the GFR and the baPWV independent of the conventional atherosclerotic risk factors (beta = −0.08, t-value = −2.19, p<0.05). This relationship was significant even in subjects with renal function within the normal range. Conclusions : Increased arterial stiffness, rather than microinflammation and/ or oxidative stress, may underlie the elevated cardiovascular risk in subjects with mildly impaired renal function. The association between GFR loss and arterial stiffness seems to precede the occurrence of microinflammation and/or oxidative stress associated with GFR loss.

High Hemoglobin glycation index is associated with telomere attrition independent of HbA1c, mediating by TNFα

2021 ◽  
Author(s):  
Lu Lyu ◽  
Jie Yu ◽  
Yiwen Liu ◽  
Shuli He ◽  
Yuan Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Diseases ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional ◽  
Telomere Attrition ◽  
Mitochondrial Dna Copy Number ◽  
The Relationship ◽  
And Oxidative Stress ◽  
Hemoglobin Glycation

Abstract Context The hemoglobin glycation index(HGI) is correlated with metabolic diseases and inflammations. Whether the HGI is associated with the ageing process and how inflammation and oxidative stress affect the relationship remain unclear. Objective We aim to analyze links between HGI and ageing biomarkers, and to explore a potential role of inflammation and oxidative stress in the correlations. Methods A cross-sectional study of 434 subjects with different glucose intolerances in a rural community was enrolled. The HGI was calculated as the difference between the measured and predicted hemoglobin A1c(HbA1c). The population was categorized into tertiles of HGI. Telomere length(LTL) and mitochondrial DNA copy number(mtDNAcn) determined by PCR assay. Tumor necrosis factor α(TNFα) and interleukin 6(IL-6), 8-oxo-2′-deoxyguanosine(8-oxo-dG), superoxide dismutase(SOD) activities and glutathione reductase(GR) were measured. Result Participants in the high HGI group were older and reported a shorter LTL, higher levels of TNFα, SOD activities and HbA1c. Correlation analyses demonstrated that HGI was correlated with LTL(r=-0.25,p&lt;0.001) and TNFα(r=0.19,p&lt;0.001) regardless of HbA1c levels. No relationship was found between HGI and mtDNAcn. HGI(β=-0.238,95%CI(-0.430,-0.046),p=0.015) and TNFα(β=-0.02,95%CI(-0.030,-0.014),p&lt;0.001) were proved to be correlated with LTL independently using multiple linear regression analysis. Ordinal logistic regression models showed that compared with subjects in High-HGI, the possibilities of a higher-level LTL was 5.29-fold in Low-HGI(OR5.29,95%CI(2.45,11.41),p&lt;0.001), 2.41-fold in Moderate-HGI (OR2.41,95%CI(1.35,4.30),p=0.003) after controlling for confounding variables. Mediation analyses indicated that TNFα accounted for 30.39% effects of HGI on LTL. Conclusion HGI was negatively related to telomere attrition, independent of HbA1c. TNFα acted as a mediator of the relationship between HGI and LTL.

scholarly journals Relationships among Renal Function Loss within the Normal to Mildly Impaired Range, Arterial Stiffness, Inflammation, and Oxidative Stress

2007 ◽  
Vol 2 (6) ◽  
pp. 1118-1124 ◽  
Author(s):  
Masanobu Yoshida ◽  
Hirofumi Tomiyama ◽  
Jiko Yamada ◽  
Yutaka Koji ◽  
Kazuki Shiina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Function ◽  
Arterial Stiffness ◽  
Function Loss ◽  
And Oxidative Stress

scholarly journals Polyphenol-rich extract of Ocimum gratissimum leaves Prevented Toxic Effects of Cyclophosphamide on the kidney Function of Wistar rats

2021 ◽  
Author(s):  
Quadri K. Alabi ◽  
Rufus O. Akomolafe ◽  
Joseph G. Akomolafe ◽  
Ayodeji Aturamu ◽  
Mokolade S. Ige ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Function ◽  
Low Cost ◽  
Plasma Concentrations ◽  
Kidney Injury ◽  
Ocimum Gratissimum ◽  
Reactive Protein ◽  
Aldosterone Production ◽  
Food And Water Intake ◽  
And Oxidative Stress

Abstract Background Cyclophosphamide (CP) is one of the potent and low cost chemotherapy used in clinical setting against a variety of tumors. However, its association with nephrotoxicity limits its therapeutic use. Ocimum gratissimum leaf is a natural plant with numerous pharmacological and therapeutic efficacies, such as antioxidant, anti-inflammation, and anti-apoptotic properties.Methods The present study was designed to evaluate the protective effect of Ocimum gratissimum (OG) against CP-induced kidney dysfunction in rats. Rats were pre-treated with 400 mg/kg b.w. of polyphenol-rich Ocimum gratissimum leaves (PREOG) for 4 days and then 50 mg/kg b.w. of CP was co-administered from day 5 to day 7 along with PREOG. Markers of renal function and oxidative stress, food and water intake, electrolytes, aldosterone, leukocytes infiltration, inflammation and histopathological alteration were evaluated.Results Obvious renal inflammation and kidney injuries were observed in CP treated groups. PREOG administration prevented oxidative stress, kidney injuries, attenuated inflammation, increased aldosterone production and reduced sodium and water loss in rats. PREOG also decreased the plasma concentrations of Interleukin-(IL)-6, C-reactive protein and activity of myeloperoxidase and malondialdehyde in CP treated rats.Conclusion OG prevented kidney injury and enhanced renal function via inhibiting inflammation and oxidant-induced CP toxicity. The efficacy of OG is related to the presence of various phytochemicals in the plant.

scholarly journals The Association of Dietary Intake with Arterial Stiffness and Vascular Ageing in a Population with Intermediate Cardiovascular Risk—A MARK Study

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 244
Author(s):  
Leticia Gómez-Sánchez ◽  
Emiliano Rodríguez-Sánchez ◽  
Rafel Ramos ◽  
Ruth Marti-Lluch ◽  
Marta Gómez-Sánchez ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Cardiovascular Risk ◽  
Arterial Stiffness ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Arterial Disease ◽  
Lower Probability ◽  
Vascular Ageing ◽  
Peripheral Arterial ◽  
Additional Point

The aim of this study was to analyse the association of diet with arterial stiffness and vascular ageing in a Caucasian population with intermediate cardiovascular risk. We recruited 2475 individuals aged 35–75 years with intermediate cardiovascular risk. Brachial-ankle pulse wave velocity (baPWV) was measured using a VaSera VS-1500® device. Vascular ageing was defined in two steps. Step 1: The 20 individuals who presented kidney disease, peripheral arterial disease, or heart failure were classified as early vascular ageing (EVA). Step 2: The individuals with percentiles by age and sex above the 90th percentile of baPWV among the participants of this study were classified as EVA, and the rest of the individuals were classified as non-EVA. The diet of the participants was analysed with two questionnaires: (1) the diet quality index (DQI) questionnaire and (2) the Mediterranean diet (MD) adherence questionnaire. The mean age of the sample was 61.34 ± 7.70 years, and 61.60% were men. Adherence to the MD was 53.30%. The DQI was 54.90%. Of the entire sample, 10.70% (11.15% of the men and 9.95% of the women) were EVA. In the multiple linear regression analysis, for each additional point in the DQI questionnaire, there was a decrease of −0.081 (95%CI (confidence intervals) −0.105–−0.028) in baPWV; in the MD adherence questionnaire, there was a decrease of −0.052 (95%CI −0141–−0.008). When performing the analysis, separated by sex, the association remained significant in men but not in women. In the logistic regression analysis, there was an increase in MD adherence and a decrease in the probability of presenting EVA, both with the DQI questionnaire (OR (odds ratio) = 0.65; 95%CI 0.50–0.84) and with the MD adherence questionnaire (OR = 0.75; 95%CI 0.58–0.97). In the analysis by sex, the association was only maintained in men (with DQI, OR = 0.54; 95%CI 0.37–0.56) (with MD, OR = 0.72; 95%CI 0.52–0.99). The results of this study suggest that a greater score in the DQI and MD adherence questionnaires is associated with lower arterial stiffness and a lower probability of presenting EVA. In the analysis by sex, this association is only observed in men.

scholarly journals Serum C-Reactive Protein and Interleukin-6 Levels as Biomarkers for Disease Severity and Clinical Outcomes in Patients with Idiopathic Granulomatous Mastitis

2021 ◽  
Vol 10 (10) ◽  
pp. 2077
Author(s):  
Yi-Min Huang ◽  
Chiao Lo ◽  
Chiao-Feng Cheng ◽  
Cheng-Hsun Lu ◽  
Song-Chou Hsieh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Severe Disease ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Serum Biomarkers ◽  
Healthy Controls ◽  
Granulomatous Mastitis ◽  
C Reactive Protein ◽  
Idiopathic Granulomatous Mastitis ◽  
Reactive Protein

Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease mimicking breast cancer. Limited research has been conducted on the application of serum biomarkers. This study aims to investigate the association of serum biomarkers with disease severity in patients with IGM. From November 2011 to March 2020, medical records of patients with IGM were reviewed. Serum cytokine levels were measured in patients and healthy controls between July 2018 and March 2020. A total of 41 patients with histologically proven IGM were found. Serum interleukin (IL)-6 level was significantly higher in patients with IGM (n = 11) than healthy controls (n = 7). Serum IL-6 and C-reactive protein (CRP) levels were significantly higher in patients with severe disease than mild and moderate disease. Serum IL-6 (Spearman’s ρ = 0.855; p < 0.001) and CRP (Spearman’s ρ = 0.838; p = 0.001) levels were associated with time to resolution. A higher serum CRP level was associated with a longer time to resolution (B = 0.322; p < 0.001) in multiple linear regression analysis. Serum IL-6 and CRP levels can be used as biomarkers for the evaluation of disease severity in IGM. IL-6 may play a crucial role in the immunopathology of IGM.

scholarly journals Donor Smoking Negatively Affects Donor and Recipient Renal Function following Living Donor Nephrectomy

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Jonathan Heldt ◽  
Robert Torrey ◽  
Daniel Han ◽  
Pedro Baron ◽  
Christopher Tenggardjaja ◽  
...  
Keyword(s):  
Renal Function ◽  
Patient Survival ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Tobacco Exposure ◽  
Kidney Donor ◽  
Chi Square ◽  
Living Donor Nephrectomy ◽  
Percent Increase ◽  
Percent Decrease

Background.While tobacco use by a renal transplant recipient has been shown to negatively affect graft and patient survival, the effect of smoking on the part of the kidney donor remains unknown.Methods.29 smoking donors (SD) and their recipients (SD-R) as well as 71 non-smoking donors (ND) and their recipients (ND-R) were retrospectively reviewed. Preoperative demographics and perioperative variables including serum creatinine (Cr) and glomerular filtration rate (GFR) were calculated and stratified by amount of tobacco exposure in pack-years. Clinical outcomes were analyzed with a Student'st-test, chi-square, and multiple linear regression analysis ().Results.At most recent followup, SD-R's had a significantly smaller percent decrease in postoperative Cr than ND-R's (−57% versus −81%; ) and lower calculated GFR's (37.0 versus 53.0 mL/min per 1.73 m2; . SD's had a larger percent increase in Cr than ND's at most recent followup (57% versus 40%; ), with active smokers having a larger increase than those who quit, although this difference was not statistically significant (68% versus 52%; ).Conclusions.Use of tobacco by kidney donors is associated with decreased posttransplant renal function, although smoking cessation can improve outcomes. Kidneys from donors who smoke should be used with caution.

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