Abstract P132: Time Since Smoking Cessation and Pulse Wave Velocity: The Atherosclerosis Risk in Communities (ARIC) Study

Cigarette smoking is a preventable cause of cardiovascular disease and is associated with arterial stiffening among young adults. While smoking cessation lowers the risk of cardiovascular morbidity and mortality, evidence for a relationship between time since smoking cessation and arterial stiffness is limited in older adults. We assessed the association of smoking status and time since smoking cessation with arterial stiffness, measured by carotid-femoral (cfPWV) and brachial-ankle (baPWV) pulse wave velocity, conditional on intensity and duration of exposure to smoking (pack-years). Analyses included 1,996 men and 2,767 women aged 67 to 90 years examined in the ARIC study in 2011-2013. Smoking status was ascertained at all five ARIC examinations and during annual telephone interviews. Information on age at initiation of smoking, smoking intensity and duration were also collected. Pack-years were calculated as the product of the average number of cigarettes smoked per day and years smoked divided by 20. Two measures of baPWV and cfPWV were obtained then averaged. Multivariable linear regression was used to estimate the association between smoking status and time since smoking cessation with PWV by gender, adjusted for age, hypertension, body mass index (BMI), and heart rate. Estimates of the association between smoking cessation and PWV were further adjusted for pack-years. Among women, former smokers and current smokers had a lower baPWV when compared to never smokers [β = -40.9 (95% confidence interval (CI): -64.2, -17.6) and β = -119.7 (95%CI: -168.7, -70.7), respectively]. Similar patterns were observed for cfPWV; however, the relationship was only significant among former smokers [β = -25.3 (95%CI: -48.0, -2.5)]. Association of smoking status and PWV was not significant in men. Among men who were former smokers there was a negative and significant association between smoking cessation and cfPWV [β = -1.4 (-2.7, -0.4)]; however, this same relationship was not observed for baPWV. BMI modified the association between smoking cessation and PWV in women. Time since smoking cessation was positively associated with PWV in women with a BMI <25 kg/m 2 [baPWV: β = 3.8 (95%CI: 1.2, 6.5); cfPWV: β = 2.5 (0.3, 4.7)], but not in women with a BMI ≥25 kg/m 2 . In these cross-sectional analyses, ever smokers had lower PWV compared to never smokers among older women, but not among older men. Greater time since smoking cessation was positively associated with arterial stiffness among normal or underweight women, but not among women who were overweight or obese, or among men. Accounting for cumulative exposure to smoking over the life course, gender-specific and arterial segment-specific patterns were observed in the association between time since smoking cessation and arterial stiffness measured in community-dwelling older adults, as well as a modification of these associations by excess weight among women.

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Abstract P336: Diabetes and Impaired Fasting Glucose are Associated with Pulse Wave Velocity in Older Adults: the ARIC Study

Circulation ◽

10.1161/circ.129.suppl_1.p336 ◽

2014 ◽

Vol 129 (suppl_1) ◽

Author(s):

Laura R Loehr ◽

Michelle Snyder ◽

Elizabeth Selvin ◽

Priya Palta ◽

James Pankow ◽

...

Keyword(s):

Older Adults ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Impaired Fasting Glucose ◽

Path Length ◽

Pulse Wave ◽

Fasting Glucose ◽

Cross Sectional ◽

Aric Study

Introduction: Arterial stiffness measured by pulse wave velocity (PWV) predicts cardiovascular disease and mortality. Diabetes and impaired fasting glucose (IFG) have been related to arterial stiffness in smaller studies. We assessed whether diabetes and impaired fasting glucose are associated with greater arterial stiffness measured by PWV in older adults, and to evaluate gender as a modifier. Methods: PWV data on 5,147 men and women with mean age of 75.5 years (range 66-90) examined in 2011-2013 by the Atherosclerosis Risk in Communities (ARIC) study were analyzed. Diabetes was defined as fasting glucose >126 mg/dl or on hypoglycemic agents and IFG as non-diabetics with fasting glucose 100-125 mg/dl. Technicians measured carotid-femoral (cfPWV) and brachial-ankle (baPWV) velocities at least twice using the Omron VP-1000 plus system (Colin Co., Ltd., Komaki, Japan). The mean of the last two available measurements was used. The path length for cfPWV was calculated by: path length (cm) = carotid to femoral distance (cm) - (suprasternal notch - carotid distance (cm)). Path length for baPWV was automatically calculated using height-based formulas. Multivariable linear regression was used to model the cross-sectional association between diabetes status and PWV. The multivariable association of age categories with PWV was evaluated for comparison to the effect size of diabetes. Results: Participants were 57% female, 20% African-American, and 73% hypertensive. Among them 1,354 had diabetes (26%) and 2,295 (45%) had impaired fasting glucose. After adjustment for age, race-center, gender, heart rate, hypertension, BMI, and smoking status (current, former and never), cfPWV was 87 cm/s higher on average for those with diabetes, and 21 cm/s higher for those with IFG, as compared to those free of diabetes or IFG. In comparison, a 4 year increase in age (after multivariable adjustment) was associated with 64 cm/s higher cfPWV among non-smokers without diabetes. Estimates for baPWV were smaller than those for cfPWV but showed a similar pattern. There was no significant interaction by gender (P >0.1). Conclusion: Diabetes and impaired fasting glucose are both associated with arterial stiffness in older adults. We estimate that the magnitude of the cross-sectional effect of diabetes on arterial stiffness is equivalent to 4 years of arterial aging.

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Smoking Behaviors and Arterial Stiffness Measured by Pulse Wave Velocity in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study

American Journal of Hypertension ◽

10.1093/ajh/hpv189 ◽

2015 ◽

Vol 29 (11) ◽

pp. 1268-1275 ◽

Cited By ~ 13

Author(s):

Ricky Camplain ◽

Michelle L. Meyer ◽

Hirofumi Tanaka ◽

Priya Palta ◽

Sunil K. Agarwal ◽

...

Keyword(s):

Older Adults ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Atherosclerosis Risk In Communities ◽

Atherosclerosis Risk ◽

Smoking Behaviors ◽

Aric Study

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Short-Term Effect of Acute Aerobic Exercise On Arterial Stiffness in People with Different Smoking Statuses

10.21203/rs.3.rs-798856/v1 ◽

2021 ◽

Author(s):

Xianxuan Wang ◽

Guanzhi Chen ◽

Zegui Huang ◽

Yiran Zang ◽

Zefeng Cai ◽

...

Keyword(s):

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Aerobic Exercise ◽

Wave Velocity ◽

Pulse Wave ◽

Load Test ◽

Short Term ◽

Before And After ◽

Former Smokers ◽

Never Smokers

Abstract Background Smoking is strongly associated with arterial stiffness. Long-term regular aerobic exercise is an effective lifestyle intervention that improve arterial stiffness in healthy young people, however, the results of research on the immediate effect of short-term aerobic exercise on arterial stiffness in individuals with different smoking statuses have been inconsistent. The purpose of this study was to investigate the immediate effects of acute aerobic exercise on arterial stiffness in people with different smoking statuses. Method: People who participated in the sixth follow-up visit of the Kailuan Study (trial registration number: ChiCTR-TNRC-11001489) and participated in the fifth National Physical Fitness Monitoring were selected as subjects. All participants completed measurements of brachial–ankle pulse wave velocity, blood pressure, and heart rate before and after a two-stage load test on a power bicycle. The generalized linear model was established to analyze between-group differences in the change in brachial–ankle pulse wave velocity before and after aerobic exercise in people with different smoking statuses. Results There was a total of 940 male participants (36.82 ± 7.76 years old). On the basis of the smoking status, the subjects were divided into the following four groups: never smokers (n = 231), former smokers (n = 165), low-intensity smokers (n = 254), and high-intensity smokers (n = 290). After the two-stage load test, brachial–ankle pulse wave velocity was immediately decreased overall (1375.08 ± 209.09 vs. 1341.53 ± 208.04 cm/s, P < 0.05). The generalized linear model showed that after adjusting for confounding factors, the β-values and 95% confidence intervals of former smokers, low-intensity smokers, and high-intensity smokers were − 12.17 (− 30.08, 5.75), − 18.43 (− 34.69, − 2.16), and − 22.46 (− 38.39, − 6.54) cm/s compared with never smokers, respectively. Conclusion Our results suggest that a single short-term aerobic exercise can immediately improve arterial stiffness in people with different smoking statuses. and clinicians must prescribe individualized exercises for different groups of people to improve arterial stiffness, and reduce the damage to blood vessels caused by smoking.

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Abstract P048: Segment-Specific Pulse Wave Velocity and Subclinical Cardiac Overload and Damage in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽

10.1161/circ.137.suppl_1.p048 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Shuiqing Liu ◽

Esther Kim ◽

Aozhou Wu ◽

Michelle L Meyer ◽

Susan Cheng ◽

...

Keyword(s):

Older Adults ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Cardiac Disease ◽

Pulse Wave ◽

Troponin T ◽

High Sensitivity ◽

Clinical History ◽

Cardiac Biomarkers

Background: Pulse wave velocity (PWV) independently predicts cardiovascular disease. However, few studies simultaneously explored the associations of segment-specific PWV measures with markers of both cardiac overload (natriuretic peptide [NT-proBNP]) and damage (high-sensitivity cardiac troponin T [hs-cTnT]) among adults without cardiac disease. Methods: We examined 2,845 whites and blacks (67-90 years) without clinical history of cardiac disease during ARIC visit 5 (2011-13). The association of PWV quartiles (cf [carotid-femoral], hc [heart-carotid], hf [heart-femoral], ha [heart-ankle], ba [brachial-ankle], and fa [femoral-ankle]) with log-transformed NT-proBNP and hs-cTnT was evaluated using linear and logistic regression models to adjust for potential confounders. Results: Most PWV measures demonstrated J- or U-shaped associations with NTpro-BNP and hs-cTnT [Figure]. The highest vs. the second lowest quartile of central PWV measures (cfPWV, hfPWV, and hcPWV) was associated with higher levels of NT-proBNP independently of demographic characteristics. The associations were weaker for hs-cTnT. These associations were attenuated after further adjustment, but hcPWV and NT-proBNP remained borderline significant (p=0.069). haPWV, baPWV, and faPWV including peripheral elements had less evident positive associations after adjusting for traditional risk. Conclusion: The positive associations between PWV and cardiac biomarkers were stronger for central vs. peripheral arterial stiffness and for NT-proBNP vs. hs-cTnT among older adults without prevalent cardiac disease. Our findings indicate the relative importance of central arterial stiffness behind subclinical cardiac overload.

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Abstract P024: Associations Between Carotid-femoral And Estimated Pulse Wave Velocity In Older Adults: The Atherosclerosis Risk In Communities (ARIC) Study

Circulation ◽

10.1161/circ.143.suppl_1.p024 ◽

2021 ◽

Vol 143 (Suppl_1) ◽

Author(s):

Patricia Pagan Lassalle ◽

Michelle L Meyer ◽

Kevin S Heffernan ◽

Adam W Kiefer ◽

Lauren C Bates ◽

...

Keyword(s):

Older Adults ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Atherosclerosis Risk In Communities ◽

Black And White ◽

Simple Alternative ◽

Atherosclerosis Risk ◽

Screening Device ◽

Aric Study

Background: Carotid to femoral pulse wave velocity (cfPWV), the gold-standard measure of aortic stiffness, is associated with the incidence of cardiovascular disease (CVD) events. Most cfPWV measurements depend on technical proficiency, which limit broader implementation in clinical settings. Recently, an estimated pulse wave velocity (ePWV) measure derived from age and mean arterial pressure (MAP) has been shown to be associated with the risk of CVD events and all-cause mortality and may be a simple alternative to cfPWV. However, ePWV is poorly predictive in non-White individuals, possibly because it was originally developed from European Cohorts. Consequently, our purpose was to: estimate the strength of association between cfPWV and ePWV, and determine whether agreement is consistent across race. Hypothesis: cfPWV and ePWV are in good agreement and association would be consistent across race. Methods: We included Black and White older adults (n= 4,478; 75.2 [5.0] years) from visit 5 (2011-13) of the community-based Atherosclerosis Risk in Communities Study (ARIC). cfPWV was measured using an automated cardiovascular screening device. ePWV was calculated as presented in Fig 1. Association between cfPWV and ePWV was determined using Pearson’s correlation coefficient (r) and Bland-Altman plots. Results: As reported in Fig 1, there was a weak (r=0.35) correlation between cfPWV and ePWV for the total population, with similar correlations when stratified by Blacks (r=0.31) and Whites (r=0.36). Bland-Altman plots indicated significant systematic differences between cfPWV and ePWV (-0.17 m/s, 95% confidence interval: -0.25 to -0.09 m/s, P <.001), which was consistent by race. Conclusion: In older adults, there was weak correlation between cfPWV and ePWV and systematic differences in agreement. Our results do not support ePWV as a surrogate measure of cfPWV in a sample of older White and Black adults.

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Short-Term Prognostic Impact of Arterial Stiffness in Older Adults Without Prevalent Cardiovascular Disease

Hypertension ◽

10.1161/hypertensionaha.119.13496 ◽

2019 ◽

Vol 74 (6) ◽

pp. 1373-1382 ◽

Cited By ~ 6

Author(s):

Esther D. Kim ◽

Shoshana H. Ballew ◽

Hirofumi Tanaka ◽

Gerardo Heiss ◽

Josef Coresh ◽

...

Keyword(s):

Heart Failure ◽

Cardiovascular Disease ◽

Older Adults ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Prognostic Impact ◽

Bottom Quartile ◽

All Cause Mortality

Arterial stiffness, represented as carotid-femoral pulse wave velocity (cfPWV), predicts cardiovascular disease (CVD). In older populations, however, this association seems attenuated. Moreover, the prognostic values of pulse wave velocity at different arterial segments and newer parameters like cardio-ankle vascular index (CAVI) remain unclear, especially in US older adults. In 3034 Atherosclerosis Risk in Communities (ARIC) study participants (66–90 years) without CVD, we examined the associations of 4 pulse wave velocity measures (cfPWV, heart-femoral, brachial-ankle, heart-ankle) and 2 new measures of arterial stiffness (CAVI and cardio-femoral vascular index derived from heart-ankle and heart-femoral, respectively) with incident CVD (coronary disease, stroke, and heart failure) and all-cause mortality. Over a median follow-up of 4.4 years, there were 168 incident CVD events and 244 deaths. Overall, stiffness measures did not show strong associations with CVD, except cfPWV, which demonstrated a J-shaped association even after adjusting for potential confounders (hazard ratio, 1.83 [95% CI, 1.08–3.09] in top quartile and 1.97 [1.14–3.39] in bottom quartile versus second bottom quartile). When each CVD was examined separately, heart failure was most robustly associated with higher cfPWV, and stroke was strongly associated with lower cfPWV. There were no significant associations with all-cause mortality. Among different measures of pulse wave velocity, cfPWV showed the strongest associations with CVD, especially heart failure, in older adults without CVD. Other pulse wave velocity measures had no strong associations. Our findings further support cfPWV as the index measure of arterial stiffness and the link of arterial stiffness to heart failure development but also suggest somewhat limited prognostic value of arterial stiffness in older adults overall.

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Arterial Stiffness in Nonhypertensive Type 2 Diabetes Patients in Ghana

International Journal of Endocrinology ◽

10.1155/2016/6107572 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Kwame Yeboah ◽

Daniel A. Antwi ◽

Ben Gyan

Keyword(s):

Type 2 Diabetes ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Smoking Status ◽

Entire Study ◽

Diabetes Status ◽

Diabetes Patients

Background. Increased arterial stiffness is an independent cardiovascular risk factor in diabetes patients and general population. However, the contribution of diabetes to arterial stiffness is often masked by coexistent obesity and hypertension. In this study, we assessed arterial stiffness in nonhypertensive, nonobese type 2 diabetes (T2DM) patients in Ghana.Methods. In case-control design, 166 nonhypertensive, nonobese participants, comprising 96 T2DM patients and 70 nondiabetes controls, were recruited. Peripheral and central blood pressure (BP) indices were measured, and arterial stiffness was assessed as aortic pulse wave velocity (PWVao), augmentation index (AIx), cardioankle vascular index (CAVI), and heart-ankle pulse wave velocity (haPWV).Results. With similar peripheral and central BP indices, T2DM patients had higher PWVao (8.3 ± 1versus7.8 ± 1.3,p=0.044) and CAVI (7.9 ± 1.2versus6.9 ± 0.7,p=0.021) than nondiabetic control. AIx and haPWV were similar between T2DM and nondiabetic controls. Multiple regression models showed that, in the entire study participants, the major determinants of PWVao were diabetes status, age, gender, systolic BP, and previous smoking status (β= 0.22, 0.36, 0.48, 0.21, and 0.25, resp.; allp<0.05); the determinants of CAVI were diabetes status, age, BMI, heart rate, HbA1c, total cholesterol, HDL cholesterol, and previous smoking status (β= 0.21, 0.38, 0.2, 0.18, 0.24. 0.2, −0.19, and 0.2, resp.; allp<0.05).Conclusion. Our findings suggest that nonhypertensive, nonobese T2DM patients have increased arterial stiffness without appreciable increase in peripheral and central pressure indices.

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Elevated Aortic Pulse Wave Velocity, a Marker of Arterial Stiffness, Predicts Cardiovascular Events in Well-Functioning Older Adults

Circulation ◽

10.1161/circulationaha.104.483628 ◽

2005 ◽

Vol 111 (25) ◽

pp. 3384-3390 ◽

Cited By ~ 747

Author(s):

Kim Sutton-Tyrrell ◽

Samer S. Najjar ◽

Robert M. Boudreau ◽

Lakshmi Venkitachalam ◽

Varant Kupelian ◽

...

Keyword(s):

Older Adults ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Cardiovascular Events ◽

Pulse Wave ◽

Aortic Pulse Wave Velocity

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Arterial stiffness and age moderate the association between physical activity and global cognition in the older adults

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.203 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

A Noriega De La Colina ◽

A Badji ◽

M Lamarre-Cliche ◽

L Bherer ◽

H Girouard ◽

...

Keyword(s):

Physical Activity ◽

Older Adults ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Structural Damage ◽

Pulse Wave ◽

Conditional Effects ◽

Global Cognition ◽

The Impact

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Merck Sharp & Dohme Corp Program of the Faculty of Medicine of the Université de Montréal The Canadian Institutes of Health Research (CIHR) Background The growing concern on the impact of higher arterial stiffness on cognitive decline in older adults, leads to the question of whether non-pharmacological interventions like physical activity should be introduced to correct or diminish the progression of arterial stiffness. Purpose The goal of this study is to elaborate a model for arterial stiffness as a moderator for the physical activity and global cognition relationship in function of age. Methods One hundred ten healthy older adults aged 60 to 75 years old (46 men and 64 women) were examined for arterial stiffness (carotid-femoral Pulse Wave Velocity (cf-PWV)), global cognition (Montreal Cognitive Assessment and Mini Mental State Examination) and self-reported physical activity (PACED diary). The double moderation analysis used PROCESS macro for SPSS, where physical activity was included as the independent variable (X), global cognition as the dependent variable (Y), arterial stiffness as moderator 1 (W), and age moderator 2 (Z). This study used a cf-PWV cutoff of 8.5 m/s to identify micro-structural damage in the brain related to arterial stiffness. Results Results found that the arterial stiffness x age interaction moderated the effect of physical activity on global cognition (β = -.89, SE = .42, p = .037) (Model: R2 = .15, p = .018). Physical activity had a positive effect on cognition in younger-older adults (aged 60 to 68.5 years) with high arterial stiffness i.e. cf-PWV > 8.5 m/s (β = .57, SE = .222, p = .011, 95% CI .133 to 1.014), and in older-older adults (aged 68.6 to 75 years) with low arterial stiffness i.e. cf-PWV < 8.5 m/s (β = .49, SE = .190, p = .010, 95% CI = .116 to .869). Conclusions These results support targeted physical activity interventions based on age and degree of arterial stiffness, furthering the notion that even daily life physical activity could play an important role in older adults’ cognitive performances. Physical activity on global cognition Conditional effects of physical activity on global cognition Moderators cf-PWV Age Effect SE p CI < 8.5 m/s < 68.5 years .171 .245 .487 -.315 to .657 < 8.5 m/s > = 68.5 years .574 .222 .011* .133 to 1.014 > = 8.5 m/s < 68.5 years .492 .190 .010* .116 to .868 > = 8.5 m/s > = 68.5 years .002 .180 .990 -.355 to .359 Physical activity conditional effects on global cognition at determined values of arterial stiffness and age. SE: Standard Error, CI: Confidence Interval, cf-PWV: carotid-femoral Pulse Wave Velocity, *p-value<.05.

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