Inhibition of the Cardiomyocyte-Specific Troponin I–Interacting Kinase Limits Oxidative Stress, Injury, and Adverse Remodeling due to Ischemic Heart Disease

Background: The aim of the present study was to investigate the cardioprotective effects of the perioperative use of N(2)-L-alanyl-L-glutamine (GLN) in patients with ischemic heart disease (IHD) who undergo their operations under cardiopulmonary bypass (CPB).Methods: This double-blind, placebo-controlled, randomized study included 50 patients who underwent cardiac surgery with CPB. Exclusion criteria were a left ventricular ejection fraction <50%, diabetes mellitus, <3 months since the onset of myocardial infarction, and emergency surgery. Patients in the study group (n = 25) received 0.4 g/kg GLN (Dipeptiven, 20% solution) per day. Patients in the control group (n = 25) were administered a placebo (0.9% NaCl). The primary end point was the dynamics of troponin I at the following stages: (1) prior to anesthesia, (2) 30 minutes after CPB, (3) 6 hours after CPB, (4) 24 hours after surgery, and (5) 48 hours after surgery. Secondary end points included measurements of hemodynamics with a Swan-Ganz catheter.Results: On the first postoperative day after the surgery, the median troponin I level was significantly lower in the study group than in the placebo group: 1.280 ng/mL (interquartile range [IQR], 0.840-2.230 ng/mL) versus 2.410 ng/mL (IQR, 1.060-6.600 ng/mL) (P = .035). At 4 hours after cardiopulmonary bypass (CPB), the median cardiac index was higher in the patients in the study group: 2.58 L/min per m2 (IQR, 2.34-2.91 L/min per m2) versus 2.03 L/min per m2 (IQR, 1.76-2.32 L/min per m2) (P = .002). The median stroke index also was higher in the patients who received GLN: 32.8 mL/m2 (IQR, 27.8-36.0 mL/m2) versus 26.1 mL/m2 (IQR, 22.6-31.8 mL/m2) (P = .023). The median systemic vascular resistance index was significantly lower in the study group than in the placebo group: 1942 dyn�s/cm5 per m2 (IQR, 1828-2209 dyn�s/cm5 per m2) versus 2456 dyn�s/cm5 per m2 (IQR, 2400-3265 dyn�s/cm5 per m2) (P = .001).Conclusion: Perioperative administration of GLN during the first 24 hours has cardioprotective effects in IHD patients following CPB. This technique enhances the troponin concentration at 24 hours after surgery and is associated with improved myocardial function.

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Association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons

Medicina ◽

10.3390/medicina44050051 ◽

2008 ◽

Vol 44 (5) ◽

pp. 392 ◽

Cited By ~ 2

Author(s):

Liucija Černiauskienė ◽

Dalia Lukšienė ◽

Abdonas Tamošiūnas ◽

Regina Rėklaitienė ◽

Lilija Margevičienė

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Heart Disease ◽

Vitamin E ◽

Ischemic Heart Disease ◽

Odds Ratio ◽

Ischemic Heart ◽

Middle Aged ◽

Men And Women ◽

And Oxidative Stress

The aim of this study was to evaluate the association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons (men and women aged 45–64 years). Material and methods. In this study, we have used data of 533 persons (247 men and 286 women) aged 45– 64 years from Kaunas population cohort investigated according to WHO MONICA study protocol during 2001–2002 in whom concentrations of malondialdehyde, a marker of lipid peroxidation, and antioxidant vitamin E in blood serum were determined. Metabolic syndrome was defined by the criteria of Adult Treatment Panel III. Oxidative stress was determined in the presence of increased level of malondialdehyde (≥5 mmol/L) and decreased level of lipid-standardized vitamin E (<20 mmol/L). The levels of malondialdehyde and vitamin E were measured by fluorimetric methods. Results. Ischemic heart disease was diagnosed in 19.8% of men and 21.3% of women. The frequency of ischemic heart disease among persons (men and women) with metabolic syndrome was significantly higher than among persons without metabolic syndrome (27.4% vs. 17.8%, respectively; odds ratio, 1.63; P=0.032). The frequency of ischemic heart disease among persons with oxidative stress was significantly higher than among persons without oxidative stress (29.1% vs. 17.6%, respectively; odds ratio, 1.88; P=0.029). The highest prevalence of ischemic heart disease (30.0%) was among persons with metabolic syndrome and oxidative stress, and the lowest prevalence of this disease (13.8%) was among persons without metabolic syndrome and without oxidative stress (odds ratio, 2.54; P=0.017). These data were adjusted by sex and age. Conclusion. Metabolic syndrome and oxidative stress are significantly associated with ischemic heart disease among 45–64-year-old persons.

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COMPARATIVE STUDY OF LEVELS OF SELECTIVE OXIDATIVE STRESS MARKERS (MALONDIALDEHYDE, ZINC, AND ANTIOXIDANT VITAMINS A, E, AND C) IN ISCHEMIC AND NON-ISCHEMIC HEART DISEASE PATIENTS SUFFERING FROM TYPE- 2 DIABETES

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i8.27772 ◽

2018 ◽

Vol 11 (8) ◽

pp. 508

Author(s):

Abd Elgadir A Altoum ◽

Ahmed L Osman ◽

Asaad Ma Babker

Keyword(s):

Oxidative Stress ◽

Heart Disease ◽

Vitamin A ◽

Ischemic Heart Disease ◽

Serum Vitamin ◽

Antioxidant Vitamins ◽

Ischemic Heart ◽

Diabetic Patients ◽

Oxidative Stress Markers ◽

Stress Markers

Objective: The objective of the current study is to compare the levels of oxidative stress markers malondialdehyde (MDA), zinc, and antioxidant Vitamins (A, E, and C) in ischemic heart disease (IHD) and non-IHD patients with diabetes mellitus.Method: This is cross-sectional study group, conducted in the advanced diagnostic center (Khartoum- Sudan) from the period May 2013 to August 2015. Comprised 100 healthy subjects were, control group with mean (fasting blood sugar) 5.61=m mol/L, the age ranged from 22 to 78 years old, the average of the age was 50.1 years. 300 patients (78 IHD and 222 without) as cases groups, the ages ranged from 30 to 80 years. The age average was 51.2 years, all samples were in a state of fasting for 12 h, and the data were collected using a structured questionnaire and direct interview to collect information. Blood specimens were collected from both groups, and plasma levels of MDA, zinc, and antioxidant Vitamins (A, E, and C) were determined.Results: There was a significant difference between the level of serum Vitamin A, E, and MDA in diabetic patients with IHD and those diabetic without IHD (p<0.05). No significant differences in serum Vitamin C level between both groups (p>0.05).Conclusion: Due to the significant differences in serum Vitamin A, E, Zinc, and MDA between diabetics with IHD and diabetics without IHD, these parameters can be used as prognostic markers for prediction of oxidative stress and antioxidant stress of diabetic patients with IHD complications.

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