THE INFLUENCE OF COMPLEX LIPOSOMAL ANTIOXIDANT PREPARATIONS ON BIOLOGICAL OXIDATIVE STRESS MARKERS IN ISCHEMIC HEART DISEASE

Objective: The objective of the current study is to compare the levels of oxidative stress markers malondialdehyde (MDA), zinc, and antioxidant Vitamins (A, E, and C) in ischemic heart disease (IHD) and non-IHD patients with diabetes mellitus.Method: This is cross-sectional study group, conducted in the advanced diagnostic center (Khartoum- Sudan) from the period May 2013 to August 2015. Comprised 100 healthy subjects were, control group with mean (fasting blood sugar) 5.61=m mol/L, the age ranged from 22 to 78 years old, the average of the age was 50.1 years. 300 patients (78 IHD and 222 without) as cases groups, the ages ranged from 30 to 80 years. The age average was 51.2 years, all samples were in a state of fasting for 12 h, and the data were collected using a structured questionnaire and direct interview to collect information. Blood specimens were collected from both groups, and plasma levels of MDA, zinc, and antioxidant Vitamins (A, E, and C) were determined.Results: There was a significant difference between the level of serum Vitamin A, E, and MDA in diabetic patients with IHD and those diabetic without IHD (p<0.05). No significant differences in serum Vitamin C level between both groups (p>0.05).Conclusion: Due to the significant differences in serum Vitamin A, E, Zinc, and MDA between diabetics with IHD and diabetics without IHD, these parameters can be used as prognostic markers for prediction of oxidative stress and antioxidant stress of diabetic patients with IHD complications.

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Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease

Atherosclerosis ◽

10.1016/j.atherosclerosis.2004.08.007 ◽

2005 ◽

Vol 178 (1) ◽

pp. 115-121 ◽

Cited By ~ 85

Author(s):

Jerome L. Abramson ◽

W. Craig Hooper ◽

Dean P. Jones ◽

Salman Ashfaq ◽

Steven D. Rhodes ◽

...

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Reactive Protein ◽

Stress Markers

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Association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons

Medicina ◽

10.3390/medicina44050051 ◽

2008 ◽

Vol 44 (5) ◽

pp. 392 ◽

Cited By ~ 2

Author(s):

Liucija Černiauskienė ◽

Dalia Lukšienė ◽

Abdonas Tamošiūnas ◽

Regina Rėklaitienė ◽

Lilija Margevičienė

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Heart Disease ◽

Vitamin E ◽

Ischemic Heart Disease ◽

Odds Ratio ◽

Ischemic Heart ◽

Middle Aged ◽

Men And Women ◽

And Oxidative Stress

The aim of this study was to evaluate the association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons (men and women aged 45–64 years). Material and methods. In this study, we have used data of 533 persons (247 men and 286 women) aged 45– 64 years from Kaunas population cohort investigated according to WHO MONICA study protocol during 2001–2002 in whom concentrations of malondialdehyde, a marker of lipid peroxidation, and antioxidant vitamin E in blood serum were determined. Metabolic syndrome was defined by the criteria of Adult Treatment Panel III. Oxidative stress was determined in the presence of increased level of malondialdehyde (≥5 mmol/L) and decreased level of lipid-standardized vitamin E (<20 mmol/L). The levels of malondialdehyde and vitamin E were measured by fluorimetric methods. Results. Ischemic heart disease was diagnosed in 19.8% of men and 21.3% of women. The frequency of ischemic heart disease among persons (men and women) with metabolic syndrome was significantly higher than among persons without metabolic syndrome (27.4% vs. 17.8%, respectively; odds ratio, 1.63; P=0.032). The frequency of ischemic heart disease among persons with oxidative stress was significantly higher than among persons without oxidative stress (29.1% vs. 17.6%, respectively; odds ratio, 1.88; P=0.029). The highest prevalence of ischemic heart disease (30.0%) was among persons with metabolic syndrome and oxidative stress, and the lowest prevalence of this disease (13.8%) was among persons without metabolic syndrome and without oxidative stress (odds ratio, 2.54; P=0.017). These data were adjusted by sex and age. Conclusion. Metabolic syndrome and oxidative stress are significantly associated with ischemic heart disease among 45–64-year-old persons.

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Inhibition of the Cardiomyocyte-Specific Troponin I–Interacting Kinase Limits Oxidative Stress, Injury, and Adverse Remodeling due to Ischemic Heart Disease

Circulation Research ◽

10.1161/circresaha.113.303238 ◽

2014 ◽

Vol 114 (6) ◽

pp. 938-940 ◽

Cited By ~ 8

Author(s):

Dennis M. Abraham ◽

Douglas A. Marchuk

Keyword(s):

Oxidative Stress ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Troponin I ◽

Ischemic Heart ◽

Stress Injury ◽

Oxidative Stress Injury ◽

Adverse Remodeling

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Dynamics of parameters of oxidative stress in blood of ischemic heart disease patients before and after coronary bypass surgery

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2012-4-13-17 ◽

2012 ◽

Vol 11 (4) ◽

pp. 13-17

Author(s):

N. L. Vorontsova ◽

M. V. Bogdanov ◽

А. S. Golovkin ◽

R. A. Mukhamadiyarov ◽

Ye. V. Grigoriyev ◽

...

Keyword(s):

Oxidative Stress ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Bypass Surgery ◽

Coronary Bypass ◽

Ischemic Heart ◽

Coronary Bypass Surgery ◽

Before And After

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Role of Oxidative Stress in Subcellular Defects in Ischemic Heart Disease

Biochemistry of Oxidative Stress ◽

10.1007/978-3-319-45865-6_9 ◽

2016 ◽

pp. 129-146 ◽

Cited By ~ 1

Author(s):

Monika Bartekova ◽

Miroslav Barancik ◽

Naranjan S. Dhalla

Keyword(s):

Oxidative Stress ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Ischemic Heart

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Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke

Oxidative Medicine and Cellular Longevity ◽

10.1155/2017/8526438 ◽

2017 ◽

Vol 2017 ◽

pp. 1-16 ◽

Cited By ~ 51

Author(s):

Yu-Chen Cheng ◽

Jer-Ming Sheen ◽

Wen Long Hu ◽

Yu-Chiang Hung

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Heart Disease ◽

Platelet Aggregation ◽

Ischemic Heart Disease ◽

Radical Scavenging ◽

Ischemic Heart ◽

Vsmc Proliferation

Good nutrition could maintain health and life. Polyphenols are common nutrient mainly derived from fruits, vegetables, tea, coffee, cocoa, mushrooms, beverages, and traditional medicinal herbs. They are potential substances against oxidative-related diseases, for example, cardiovascular disease, specifically, atherosclerosis-related ischemic heart disease and stroke, which are health and economic problems recognized worldwide. In this study, we reviewed the risk factors for atherosclerosis, including hypertension, diabetes mellitus, hyperlipidemia, obesity, and cigarette smoking as well as the antioxidative activity of polyphenols, which could prevent the pathology of atherosclerosis, including endothelial dysfunction, low-density lipoprotein oxidation, vascular smooth muscle cell proliferation, inflammatory process by monocytes, macrophages or T lymphocytes, and platelet aggregation. The strong radical-scavenging properties of polyphenols would exhibit antioxidative and anti-inflammation effects. Polyphenols reduce ROS production by inhibiting oxidases, reducing the production of superoxide, inhibiting OxLDL formation, suppressing VSMC proliferation and migration, reducing platelet aggregation, and improving mitochondrial oxidative stress. Polyphenol consumption also inhibits the development of hypertension, diabetes mellitus, hyperlipidemia, and obesity. Despite the numerousin vivoandin vitrostudies, more advanced clinical trials are necessary to confirm the efficacy of polyphenols in the treatment of atherosclerosis-related vascular diseases.

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