Abstract 310: Aerobic Exercise Training Improves Blood Pressure Variability in Obese Female Mice.

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Michelle Sartori ◽  
Leandro E de Souza ◽  
Pamella R de Souza ◽  
Fernando dos Santos ◽  
Christiane Malfitano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Exercise Training ◽  
Arterial Pressure ◽  
Aerobic Exercise ◽  
Blood Pressure Variability ◽  
Low Frequency ◽  
Aerobic Exercise Training ◽  
Obese Mice ◽  
Obesity And Diabetes

Background: Clinical issues related with obesity and diabetes are focused not only on metabolic dysfunctons, but also on cardiovascular pathologies which are the likely cause of morbidity and mortality in these patients. In this sense, blood pressure variability (BPV) has been reported to be associated with an adverse cardiovascular prognosis. Ob/ob mice have been used as a model of type 2 diabetes and obesity. However, the effects of aerobic exercise training on cardiovascular parameters in this model are unknown. Objective: The aim of this study was to evaluate the blood pressure variability in trained youth obese mice. METHODS: Female ob/ob mice (4 weeks) were randomized into sedentary (OS, n=11) or trained (OT, n=8) (treadmill,5 days/w, 60 min/d, during 8 wks) groups. Blood glucose was measured by reagent strips. Arterial pressure signals were recorded using a data acquisition system. Results: The OT group had higher exercise capacity compared to the OS group. OT group had reduced body weight and blood glucose (45±2g, 133±3 mg/dL) compared to OS group (50±2g e 169±8 mg/dL). Mean arterial pressure and heart rate were similar between groups (OS: 106 ± 4mmHg and 513± 18bpm vs. OT: 104 ± 6 mmHg and 514±28bpm). The BPV and the low frequency band of BPV were higher in the OS (23 ± 3mmHg2 and 7 ± 1 mmHg2) compared to the OT group (15 ± 2 mmHg2 and 5 ± 1 mmHg2). Moreover, the spontaneous baroreflex sensitivity, represented by alpha index, was lower in the sedentary group (1.2 ± 0.3 ms/mmHg) compared to the trained group (1.9 ± 0.2 ms/mmHg). Conclusion: Our results suggest that early physical training in obese mice can be effective in attenuating the increase in weight and blood glucose in addition to improving blood pressure variability in these animals. Sources of funding: FAPESP,CNPq

Effects of 12 weeks of aerobic versus combined aerobic plus resistance exercise training on short-term blood pressure variability in patients with hypertension

2021 ◽  
Vol 130 (4) ◽  
pp. 1085-1092
Author(s):  
Giuseppe Caminiti ◽  
Ferdinando Iellamo ◽  
Annalisa Mancuso ◽  
Anna Cerrito ◽  
Matteo Montano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Blood Pressure Variability ◽  
Short Term ◽  
Resistance Exercise Training ◽  
Hypertensive Patients ◽  
Combined Exercise ◽  
Resistance Exercises

Combined exercise training (CT) including aerobic plus resistance exercises could be more effective in comparison with aerobic exercise (AT) alone in reducing blood pressure variability (BPV) in hypertensive patients. We report that CT was indeed more effective than AT in reducing short-term BPV, and both exercise modalities reduced BP levels to the same extent. CT appears to be a more appropriate exercise modality if the objective is to reduce BPV in addition to BP levels.

scholarly journals Aerobic Exercise Training Enhances The Blood Pressure-lowering Effect Of Antihypertensive Medication.

2020 ◽  
Vol 52 (7S) ◽  
pp. 856-856
Author(s):  
MIGUEL RAMIREZ-JIMENEZ ◽  
FELIX MORALES-PALOMO ◽  
ALFONSO MORENO-CABAÑAS ◽  
JUAN FERNANDO ORTEGA ◽  
LAURA ALVAREZ-JIMENEZ ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Antihypertensive Medication ◽  
Aerobic Exercise Training ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Pressure Lowering

scholarly journals The sex Differences in Blood Pressure and Cardiac Autonomic Modulation during the Menopause Transition at Rest and after Aerobic Exercise Training

2019 ◽  
Author(s):  
Maycon Jr Ferreira ◽  
Rodrigo D. Esposti ◽  
Aline O. Jarrete ◽  
Carlos H. G. Sponton ◽  
Angelina Zanesco
Keyword(s):  
Blood Pressure ◽  
Sex Differences ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Menopausal Transition ◽  
Autonomic Modulation ◽  
Sod Activity ◽  
Cardiac Autonomic Modulation ◽  
Menopause Transition

Background: Sex differences in blood pressure (BP) exist during all reproductive life between women and men whereas a sharper increase in BP occurs after menopause which is associated with increased prevalence of cardiovascular diseases. This study examined cardiovascular and biochemical parameters in perimenopausal women (PW) aiming to investigate the influence of sex on a) office BP and for 24 hours; b) cardiac autonomic modulation; c) redox state by measuring MDA, SOD, and catalase; d) NOx- concentration. In addition, aerobic exercise training (AET) was applied for detecting changes in cardiovascular responsiveness during the menopausal transition. Methods: Thirty-one participants were enrolled, healthy PW and age-matched men. Cardiovascular and biochemical biomarkers were evaluated at baseline and after AET (8 weeks of exercise on a treadmill, three sessions/week, duration of 30-40 minutes). Results: At rest, PW presented: a) a lower diastolic BP during daytime; b) a lower absolute and normalized LF component as well as a higher HF normalized component; d) no sex differences for redox biomarkers and NOx- concentration. After AET, only PW was responsive in lowering systolic BP that was accompanied by an increase in NOx- concentration and SOD activity. Regarding HRV, both groups were responsive to the AET. Conclusions: During the menopausal transition, systolic BP was similar to men whereas cardiac autonomic modulation remained unaltered showing the influence of sex steroids on BP. In Addition, AET was fundamental during the menopause transition by preventing an elevation in BP, minimizing the effects of aging associated with estrogen deficiency on women's cardiovascular health.

scholarly journals Effects of Aerobic Exercise on Energy Metabolism in the Hypertensive Rat Heart

2001 ◽  
Vol 81 (4) ◽  
pp. 1006-1017 ◽  
Author(s):  
Tanya L Kinney LaPier ◽  
Kenneth J Rodnick
Keyword(s):  
Blood Pressure ◽  
Energy Metabolism ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Spontaneously Hypertensive Rats ◽  
Aerobic Exercise Training ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Cardiac Energy Metabolism ◽  
Cardiac Energy

AbstractBackground and Purpose. In order to explore the possible effects of physical therapy interventions on patients with hypertension, we evaluated the effects of aerobic exercise training on myocardial energy metabolism in an animal model of hypertension. Subjects. We used 36 female spontaneously hypertensive rats (rats with genetically induced hypertension) and 12 normotensive Wistar-Kyoto rats. Methods. The normotensive rats were sedentary and formed the CONsed group. The spontaneously hypertensive rats were randomly divided into 3 experimental groups (12 rats per group). Hypertensive rats that were sedentary formed the HTNsed group, those that received 8 weeks of exercise training formed the HTN×8 group, and those that received 16 weeks of exercise training formed the HTN×16 group. We measured systolic blood pressure, heart wet weight, maximal activities of cardiac energy metabolism enzymes, glucose transporter content, and total concentrations of protein, glycogen, and triglyceride. Results. Systolic blood pressure was greater than 200 mm Hg in the CONsed group at the time of testing. Exercise training modestly (∼11–18 mm Hg) lowered blood pressure in the HTN×8 and HTN×16 groups. Fatty acid enzyme activity was greater in the CONsed group than in the HTNsed and HTN×8 groups, but activity was roughly equivalent between the CONsed group and the HTN×16 group. Glucose enzyme activity was greater in the HTN×16 group than in the CONsed group and the HTNsed group. Intracellular glycogen concentration was greater in the HTN×8 group than in the HTNsed group. Discussion and Conclusion. Results of this study suggest that aerobic exercise training may help to normalize cardiac energy metabolism in mammals with hypertension.

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