Abstract 562: Association Of The Heteroplasmic Level Of The Mitochondrial Gene Nd2 5178c>A Variant With Essential Hypertension

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Tong Yin ◽  
Yusong Zhang ◽  
Xi Chen ◽  
Jie Yang ◽  
Yuxiao Zhang ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Protective Effect ◽  
Total Cholesterol ◽  
Mitochondrial Gene ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Health Examination ◽  
Coding Region ◽  
Chinese Han ◽  
Blood Leukocytes

BACKGROUND: The mitochondrial genetic variant of nicotinamide adenine dinucleotide dehydrogenase subunit-2 (ND2) 5178C>A (Leu237Met) was previously found to have a protective effect against essential hypertension (EH) in Chinese and Japanese populations. AIM: The present study aimed to determine whether the protective effect of ND2 5178C>A against EH is associated with the mitochondrial heteroplasmy level of the variant. METHODS: This case-control study involved 109 unrelated Chinese-Han matched pairs of essential hypertension and healthy normotensive controls. All consented subjects were recruited consecutively from Institute of Geriatric Cardiology and Health Examination Center in General Hospital of Chinese People’s Liberation Army from February 2013 to January 2014. Demographic and clinical characteristics were recorded. Mitochondrial DNA was isolated from the blood leukocytes for each subject. The level of heteroplasmy for 5178C>A variant occurring in the coding region of ND2 was quantified using real-time polymerase chain reaction (PCR) method. RESULTS: The ND2 5178C>A heteroplasmy level ranged between 27% and 77%, with a median level of 44%. Between the upper and lower quartiles of 5178C>A heteroplasmy distribution, significant differences were observed for systolic blood pressure (116±17 vs. 129±25 mmHg, P=0.004) , body mass index (BMI) (24.6±3.3 vs.26.5±3.6, P=0.008) , total cholesterol (4.0±0.8 vs. 3.4±0.9 mmol/L, P<0.001) , low density lipoprotein (2.5±0.7 vs. 1.5±0.7 mmol/L, P<0.001) and triglyceride levels (1.8±1.6 vs. 4.0±1.6 mmol/L, P<0.001). ND2 5178C>A heteroplasmic level was negatively correlated with the presence of hypertension (r = -0.38, P < 0.001), BMI (r = -0.19, P = 0.007), and the level of total cholesterol (r = -0.18, P = 0.01). Logistic regression analysis showed that participants with higher ND2 5178C>A heteroplasmy level (≥44%) were found to have significantly lower prevalence of essential hypertension (29%, 32 in 109), as compared to those with lower (< 44%) ND2 5178C>A heteroplasmy level (71%, 77 in 109) (OR: 0.18, 95% CI: 0.10-0.31, P<0.001). CONCLUSION: The protective effect of mitochondrial ND2 5178C>A against EH is associated with the heteroplasmy level of the variant.

scholarly journals Association of Metabolic Syndrome and Blood Pressure in Patients with Essential Hypertension

2021 ◽  
Vol 8 (7) ◽  
pp. 453-457
Author(s):  
Abhishek Kumar Chandra ◽  
Anurag Kumar ◽  
Ansuman Dalbehera
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Essential Hypertension ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Male And Female ◽  
Hypertensive Patients

Objective: In Indian hypertensive patients, to investigate the prevalence and characteristics of the MS was the main objective of the present study. Material and Method: Current study was conducted in a tertiary care OPD among 130 patients who were diagnosed with essential hypertension. Any patients who were more that 18 years of age and diagnosed with essential hypertension and willing to participate in the study were included. By routine laboratory techniques which is generally used at NABL accredited private or government testing laboratories for analysis of lipid profile total cholesterol, total triglycerides, low-density lipoprotein cholesterol and high density lipoprotein cholesterol were assayed. Result: Average MS score were high in both the male and female group. Both male and female groups patients receives adequate blood pressure lowering treatment. In both the groups maximum patients were in ARB therapy. All parameters which are related to occurrence of metabolic syndrome like, abdominal obesity, Total Cholesterol (TC), Triglycerides (TG), Low Density Lipoprotein (LDL), fasting blood glucose (FBG) and uric acids were significantly higher in both male and female patients than the control one. Conclusion: Current study conclude that, in Indian hypertensive patients, especially in females, metabolic syndrome was highly prevalent. Keywords: Metabolic syndrome, metabolic risk factors, hhypertension,

Risk predictors of arterial hypertension development in population of Mountain Shoriya of various ethnical origins

2019 ◽  
Vol 1 (3) ◽  
pp. 39-42
Author(s):  
T. A. Mulerova ◽  
M. Yu. Ogarkov ◽  
O. L. Barbarash
Keyword(s):  
Cardiovascular Diseases ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density Lipoprotein Cholesterol ◽  
Type Settlement ◽  
The Family ◽  
Genotype C ◽  
Hypertension Development ◽  
Risk Predictors

1409 people (901 Shors, 508 non-indigenous people) from remote villages of Mountain Shoriya (Orton and Ust-Kabyrsa) and urban-type settlement Sheregesh took part in the survey. In Shors, the risk of developing hypertension was determined by elevated levels of total cholesterol and low density lipoprotein cholesterol, violation of carbohydrate metabolism, obesity, including its abdominal type, the family anamnesis of early cardiovascular diseases, and a carriage of prognostically unfavorable genotypes D/D and C/C of the corresponding genes ACE and AGTR 1 candidates; in the cohort of non-indigenous ethnos-elevated levels of total cholesterol and triglycerides, obesity, abdominal obesity, the family anamnesis of early cardiovascular diseases, a carrier of the minor genotype C/C of the AGTR 1 gene

scholarly journals Observational Study of Lipid Profile and C-Reactive Protein after a Seven-Day Fast

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 255
Author(s):  
Valeria Galetti ◽  
Marica Brnic ◽  
Benjamin Lotin ◽  
Mauro Frigeri
Keyword(s):  
Total Cholesterol ◽  
Medical Center ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Parameters ◽  
Swiss Alps ◽  
Risk Level ◽  
Metabolic Risk ◽  
C Reactive Protein ◽  
Reactive Protein

Fasting is becoming an increasingly popular practice. Nevertheless, its clinical benefits and possible inconveniences remain limitedly evaluated. We observed the effects of a seven-day fast conducted in a non-medical center located in the Swiss Alps. Clinical parameters were measured on the first and last day of fasting (D1 and D7), and two months later (D60). Among the 40 participants, blood analyses were done on 25 persons with an increased metabolic risk, with the primary goal of assessing the lasting effect on low-density lipoprotein (LDL) cholesterol. By comparing D60 with D1, high-density lipoprotein cholesterol (HDL) (+0.15 mmol/L) and insulin-like growth factor-1 (IGF-1) (+2.05 mmol/L) increased (both p < 0.009), all other blood parameters (LDL, glucose, total cholesterol, triglycerides, C-reactive protein (CRP)) did not change; weight (−0.97 kg) and hearth rate (−7.31 min−1) decreased (both p < 0.006). By comparing D7 with D1, total cholesterol (+0.44 mmol/L), triglycerides (+0.37 mmol/L) and CRP (+3.37 mg/L) increased (all p < 0.02). The lack of LDL variation at D60 may be due to the low metabolic risk level of the participants. The increase of total cholesterol, triglycerides and CRP at D7 warrants studies to understand whether such fluctuations represent a stress reaction to the fasting state, which may vary in different fasting types.

scholarly journals High serum cholesterol levels in persons with 'high-normal' TSH levels: should one extend the definition of subclinical hypothyroidism?

1998 ◽  
pp. 141-145 ◽  
Author(s):  
G Michalopoulou ◽  
M Alevizaki ◽  
G Piperingos ◽  
D Mitsibounas ◽  
E Mantzos ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Subclinical Hypothyroidism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Serum ◽  
High Serum Cholesterol ◽  
Cholesterol Levels ◽  
Group D ◽  
Tsh Levels

OBJECTIVE: The association between established hypothyroidism and high cholesterol levels is well known. The aim of the present study was to investigate the effect of thyroxine (T4) administration on cholesterol levels in hypercholesterolemic subjects with TSH levels within the normal range ('high-normal' TSH compared with 'low-normal' TSH). DESIGN AND METHODS: We determined TSH levels in 110 consecutive patients referred for hypercholesterolemia (serum cholesterol >7.5 mmol/l). Those with 'high-normal' TSH (2.0-4.0 microU/ml) as well as those with 'low-normal' TSH (0.40-1.99 microU/ml) were randomly assigned to receive either 25 or 50 microg T4 daily for two months. Thus, groups A and B (low-normal TSH) received 25 and 50 microg T4 respectively and groups C and D (high-normal TSH) received 25 and 50 microg T4 respectively. Serum T4, tri-iodothyronine (T3), TSH, free thyroxine index, resin T3 uptake and thyroid autoantibodies (ThAab) as well as total cholesterol, high and low density lipoprotein cholesterol (HDL, LDL), and triglycerides were determined before and at the end of the two-month treatment period. RESULTS: TSH levels were reduced in all groups. The most striking effect was observed in group D (TSH levels before: 2.77+/-0.55, after: 1.41+/-0.85 microU/ml, P < 0.01). Subjects in groups C and D had a higher probability of having positive ThAabs. A significant reduction in total cholesterol (P < 0.01) and LDL (P < 0.01) was observed after treatment only in group D. In those subjects in group D who were ThAab negative, there was no significant effect of thyroxine on cholesterol levels. CONCLUSIONS: Subjects with high-normal TSH levels combined with ThAabs may, in fact, have subclinical hypothyroidism presenting with elevated cholesterol levels. It is possible that these patients might benefit from thyroxine administration.

Low-density lipoprotein oxidation in essential hypertension

1993 ◽  
Vol 11 (10) ◽  
pp. 1103-1111 ◽  
Author(s):  
Elena Maggi ◽  
Eugenia Marchesi ◽  
Valentina Ravetta ◽  
Francesco Falaschi ◽  
Giorgio Finardi ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation

scholarly journals Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

2014 ◽  
Vol 20 (3) ◽  
pp. 332-338
Author(s):  
Maria Fátima Glaner ◽  
Thales Boaventura Rachid Nascimento ◽  
Otávio de Tôledo Nóbrega
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Aerobic Fitness ◽  
Low Density Lipoprotein ◽  
Apoe Genotype ◽  
Density Lipoprotein ◽  
European Ancestry ◽  
Low Density ◽  
Genotype Group ◽  
Apoe Genotypes

The purpose of this study was to analyze the association between APOE alleles and serum lipemia in adolescents with low and adequate aerobic fitness. The sample was comprised of 105 boys and 151 girls (49% and 46% from rural area) of European ancestry, aged 11 to 17 years, and classified according to: 1) APOE genotype: group ε2 (ε2/3+ε2/2), ε3 (ε3/3), and ε4 (ε3/4+ε4/4); 2) aerobic fitness: adequate or low; 3) serum lipemia: elevated total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides, and low high-density lipoprotein (HDL). The results showed that aerobic fitness modulates the association between APOE alleles and serum lipemia in adolescents, suggesting that adequate aerobic fitness levels exert a greater effect of reducing TC and LDL in ε2 carriers, as well as of increasing HDL and reducing triglycerides in ε3 and ε4 carriers.

scholarly journals Short-Term Feeding of Fibre-Enriched Biscuits: Protective Effect against Hepatotoxicity in Diabetic Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Ochuko L. Erukainure ◽  
Osaretin A. T. Ebuehi ◽  
Folasade O. Adeboyejo ◽  
Olufunmilola O. Oladunmoye ◽  
Muhammad Aliyu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hepatic Function ◽  
Treated Group ◽  
Albumin Level ◽  
Diabetic Rats ◽  
Protein Levels ◽  
Significant Difference ◽  
Alloxan Monohydrate

The effects of fibre-enriched biscuit on biomarkers associated with hepatotoxicity in diabetic rats were investigated. Diabetes was induced by single intraperitoneal injection of alloxan monohydrate. Treatment lasted for 14 days after which the rats were sacrificed by cervical dislocation. Blood serum was analyzed to determine hepatic function enzymes. The liver was also analyzed to determine hepatic lipid profile and antioxidant enzymes. Induction of diabetes led to elevated levels of ALP, AST, and ALT. These were, however, significantly (p<0.05) reduced in the fibre-enriched biscuit fed (treated) group. There was no significant difference in the serum bilirubin and total protein levels of the studied groups. Reduced albumin level was observed in the diabetic group; this was further lowered on feeding with fibre-enriched biscuits. Induction of diabetes led to increased hepatic level of cholesterol, triglyceride (TG), low density lipoprotein (LDL), and lipid peroxidation and decreased activities of glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) and HDL level. These were significantly (p<0.05) reversed on feeding with fibre-enriched biscuit. This study portrays the protective effect of fibre-enriched biscuit on increased oxidative stress and hyperlipidemia in hepatic tissues of alloxan-induced diabetic rats.

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