scholarly journals Preeclamptic Women Have Decreased Circulating IL-10 (Interleukin-10) Values at the Time of Preeclampsia Diagnosis

Hypertension ◽  
2020 ◽  
Vol 76 (6) ◽  
pp. 1817-1827
Author(s):  
Meryl C. Nath ◽  
Hajrunisa Cubro ◽  
Daniel J. McCormick ◽  
Natasa M. Milic ◽  
Vesna D. Garovic
Keyword(s):  
Therapeutic Potential ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Hypertensive Disorder ◽  
Sample Type ◽  
Measurement Methodology ◽  
Mean Differences ◽  
Active Disease ◽  
Multiplex Bead

A key immunomodulatory cytokine, IL-10 (interleukin-10), has been shown to be dysregulated in preeclampsia, a pregnancy-specific hypertensive disorder, further characterized by multi-system involvement. However, studies have reported inconsistent findings about circulating IL-10 levels in preeclamptic versus normotensive pregnancies. The aim of the present systematic review and meta-analysis was to assess circulating IL-10 levels in preeclamptic and normotensive pregnancies at 2 time points: before, and at the time of preeclampsia diagnosis. PubMED, EMBASE, and Web of Science databases were searched to include all published studies examining circulating IL-10 levels in preeclamptic and normotensive pregnancies. Differences in IL-10 levels were evaluated by standardized mean differences. Of 876 abstracts screened, 56 studies were included in the meta-analysis. Circulating IL-10 levels were not different before the time of active disease (standardized mean differences, −0.01 [95% CI, −0.11 to 0.08]; P =0.76). At the time of active disease, women with preeclampsia (n=1599) had significantly lower IL-10 levels compared with normotensive controls (n=1998; standardized mean differences, −0.79 [95% CI, −1.22 to −0.35]; P =0.0004). IL-10 levels were lower in both early/severe and late/mild forms of preeclampsia. Subgroup analysis revealed that IL-10 measurement methodology (ELISA or multiplex bead array) and the sample type (plasma or serum) significantly influenced the observed differences, with the use of sera paired with ELISA technology providing the best distinction in IL-10 levels between preeclamptic and normotensive pregnancies. These findings support the role of decreased IL-10 levels in the pathophysiology of preeclampsia. Future studies should address the therapeutic potential of IL-10 in preeclampsia.

scholarly journals Effects of physical activity on the progression of diabetic nephropathy: a meta-analysis

2021 ◽  
Vol 41 (1) ◽  
Author(s):  
Zixin Cai ◽  
Yan Yang ◽  
Jingjing Zhang
Keyword(s):  
Physical Activity ◽  
Diabetic Nephropathy ◽  
Healthy Lifestyle ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Cochrane Library ◽  
Diabetic Patients ◽  
Mean Differences

Abstract Background: Diabetic nephropathy (DN) is an important microvascular complication of diabetes. Physical activity (PA) is part of a healthy lifestyle for diabetic patients; however, the role of PA in DN has not been clarified. Our aim was to conduct a meta-analysis to explore the association between PA and DN risk. Methods: PubMed, Embase, Cochrane Library and Web of Science were systematically searched for articles examining PA in diabetic patients and its effect on renal function. Standardized mean differences (SMDs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. The study protocol is registered with PROSPERO (CRD42020191379). Results: A total of 38991 participants were identified from 18 studies. The results indicated that PA was associated with increases in the glomerular filtration rate (SMD = 0.01, 95% CI = [0.02–0.17]) and decreases in the urinary albumin creatinine ratio (SMD = −0.53, 95% CI: −0.72 to −0.34), rate of microalbuminuria (OR = 0.61, 95% CI = [0.46–0.81]), rate of acute kidney injury (OR = 0.02, 95% CI = [0.01–0.04]), rate of renal failure (OR = 0.71, 95% CI = [0.52–0.97]) and risk of DN in patients with Type 1 diabetes (OR = 0.67, 95% CI = [0.51–0.89]). Conclusions: This meta-analysis indicated that PA is effective for improving DN and slowing its progression; however, more high-quality randomized controlled trials are required on this topic.

scholarly journals A meta-analysis of client-therapist perspectives on the therapeutic alliance: Examining the moderating role of type of measurement and diagnosis

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Libby Igra ◽  
Michal Lavidor ◽  
Dana Atzil-Slonim ◽  
Nitzan Arnon-Ribenfeld ◽  
Steven de Jong ◽  
...  
Keyword(s):  
Therapeutic Alliance ◽  
Meta Analysis ◽  
Schizophrenia Spectrum Disorders ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
Mean Differences ◽  
Therapist Perspectives ◽  
Therapist Perspective ◽  
Moderating Role

Abstract Background: Clients and therapists often have different perspectives on their therapeutic alliance (TA), affecting the process and outcome of therapy. The aim of the present meta-analysis was to assess the mean differences between clients’ and therapists’ estimations of TA among clients with severe disturbances, while focusing on two potential moderators: client diagnosis and alliance instrument. Method: We conducted a systematic literature search of studies examining both client perspective and therapist perspective on TA in psychotherapy among people with schizophrenia spectrum disorders, personality disorders, and substance misuse disorders. We then analyzed the data using a random-effects meta-analytic model with Cohen’s d standardized mean effect size. Results: Heterogeneity analyses (k = 22, Cohen’s d = −.46, 95% confidence interval = .31–1.1) produced a significant Q-statistic (Q = 94.96) and indicated high heterogeneity, suggesting that moderator analyses were appropriate. Conclusions: Our findings show that the type of TA instrument moderates the agreement on TA between client and therapist, but there was no indication of the client’s diagnosis moderating the effect. The agreement between client and therapist estimations seems to be dependent on the instrument that is used to assess TA. Specific setting-related instruments seem to result in higher agreement between clients’ and therapists’ estimations than do more general instruments that are applied to assess TA.

scholarly journals Association between serum iron levels and the risk of cervical cancer in Chinese: a meta-analysis

2019 ◽  
Vol 48 (3) ◽  
pp. 030006051988280
Author(s):  
Shu Chen ◽  
Liyuan Shen ◽  
Shujuan Luo ◽  
Xia Lan ◽  
Lan Wang
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Serum Iron ◽  
Meta Analysis ◽  
R Software ◽  
Chinese Populations ◽  
Cervical Cancer Risk ◽  
Mean Differences

Objectives To evaluate the association between serum iron levels and cervical cancer risk in Chinese populations. Methods A literature search was conducted using the PubMed, WanFang, and SinoMed databases up to April 30, 2019. Pooled standard mean differences (SMD) and 95% confidence intervals (CI) were analyzed using R software with a random-effects model. Results Data from nine studies comprising 454 cervical cancer patients and 880 controls were used in the analysis. Our results demonstrated that serum iron levels in cervical cancer patients were significantly lower than those in controls in Chinese populations (summary SMD = −1.24, 95%CI = −1.37 to −1.10; I2 = 93.4%). No publications bias was detected. Sensitivity analysis indicated that no single study had a significant effect on the overall SMD. Conclusions Our findings show that serum iron levels are lower in patients with cervical cancer than in control individuals. However, further high-quality studies are necessary to clarify the role of serum iron levels in cervical cancer risk.

scholarly journals Circulating Resistin Levels and Risk of Colorectal Cancer: A Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Gui Yang ◽  
Wei Fan ◽  
Baohong Luo ◽  
Zhigao Xu ◽  
Ping Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Sensitivity Analyses ◽  
Published Data ◽  
Significant Heterogeneity ◽  
Sample Type ◽  
Effect Model ◽  
Mean Differences

Objectives. Published data on resistin levels in patients with colorectal cancer (CRC) were conflicting and heterogeneous. We conducted a meta-analysis of observational studies to examine the association of circulating resistin levels with carcinogenesis of the CRC.Methods. Potentially eligible studies published up to November 2015 were searched through MEDLINE, EMBASE, Science Citation Index Expanded database, CNKI, and WanFang database. The pooled weighted mean differences (WMDs) with 95% confidence intervals (CIs) calculated by fixed- or random-effect model were used to estimate the effects.Results. A total of 11 studies involving 965 patients were admitted in our meta-analysis. The pooled effects indicated that resistin levels were higher in CRC patients compared to healthy controls (WMD: 1.47 ng/mL; 95% CI: 0.78 to 2.16), with significant heterogeneity across the studies (I2=72%,p<0.0001). Subgroup analyses and sensitivity analyses revealed that study quality, design, sample type, and resistin assays may account for this heterogeneity. No publication bias was observed.Conclusions. Our meta-analysis suggests that increased circulating resistin levels are associated with greater risk of colorectal cancer. Given the limited number of available studies and significant heterogeneity, larger well-designed randomized studies are warranted.

scholarly journals The Role of Anterior Cervical Discectomy and Fusion on Relieving Axial Neck Pain in Patients With Single-Level Disease: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 10 (3) ◽  
pp. 312-323
Author(s):  
Colby Oitment ◽  
Tracy Watson ◽  
Victor Lam ◽  
Mohammed Aref ◽  
Alex Koziarz ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neck Pain ◽  
Meta Analysis ◽  
Neck Disability Index ◽  
Clinically Significant ◽  
Mean Differences ◽  
Neck Disability ◽  
Axial Neck Pain

Study Design: Systematic review and meta-analysis. Objectives: This study aims to evaluate the effects of anterior cervical decompression and fusion (ACDF) on axial neck pain in adult patients receiving surgery for myelopathy, radiculopathy, or a combination of both. Methods: Two independent reviewers completed a librarian-assisted search of 4 databases. Visual Analogue Scale (VAS) and Neck Disability Index (NDI) scores were extracted preoperatively and at 3, 6, 12, 24, 36, 48, and 48+ months postoperatively for ACDF groups and pooled using a random-effects model. Results: Of 17 850 eligible studies, 37 were included for analysis, totaling 2138 patients analyzed with VAS and 2477 with NDI score. Individual VAS mean differences were reduced at 6 weeks (−2.5 [95% confidence interval (CI): −3.5 to −1.6]), 3 months (−2.9 [−3.7 to −2.2]), 6 months (−3.2 [−3.9 to −2.6]), 12 months (−3.7 [−4.3 to −3.1]), 24 months (−4.0 [−4.4 to −3.5]), 48 months (−4.6 [−5.5 to −3.8]), and >48 months (−4.7 [−5.8 to −3.6]) follow-up ( P < .0001 for all endpoints). Individual NDI mean differences were reduced at 6 weeks (−26.7 [−30.9 to −22.6]), 3 months (−29.8 [−32.7 to −26.8]), 6 months (−31.2 [−35.5 to −26.8)], 12 months (−29.3 [−33.2 to −25.4]), 24 months (−28.9 [−32.6 to −25.2]), 48 months (−33.1 [−37.4 to −28.7]), and >48 months (−37.6 [−45.9 to −29.3]) follow-up ( P < .0001 for all endpoints). Conclusions: ACDF is associated with a significant reduction in axial neck pain compared with preoperative values in patients being treated specifically for myelopathy or radiculopathy. This influences the preoperative discussions surgeons may have with patients regarding their expectations for surgery. The effects seen are stable over time and represent a clinically significant reduction in axial neck pain.

scholarly journals Role of Galectins in the Liver Diseases: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Yang An ◽  
Shixue Xu ◽  
Yiting Liu ◽  
Xiangbo Xu ◽  
Cyriac Abby Philips ◽  
...  
Keyword(s):  
Overall Survival ◽  
Liver Diseases ◽  
Vascular Invasion ◽  
Meta Analysis ◽  
High Expression ◽  
Cochrane Library ◽  
Hazard Ratios ◽  
Galectin 3 ◽  
Mean Differences

Background: Galectins, a family of β-galactoside-binding proteins, are related to the development and progression of various human diseases such as cancer, heart failure, and chronic kidney disease. However, its role in liver diseases is unclear.Methods: The PubMed, Embase, and Cochrane Library databases were searched. Hazard ratios (HRs), odds ratios (ORs), and mean differences (MDs) with 95% CIs were pooled to evaluate the association of the galectins with the outcomes and risk of liver diseases by a random effects model.Results: Thirty three studies involving 43 cohorts and 4,168 patients with liver diseases were included. In the patients with hepatocellular carcinoma (HCC), high expression of galectin-1 and -3 in the tissues was significantly associated with worse overall survival (galectin-1: HR = 1.94, 95% CI = 1.61–2.34, p &lt; 0.001; galectin-3: HR = 3.29, 95% CI = 1.62–6.68, p &lt; 0.001) and positive vascular invasion (galectin-1: OR = 1.74, 95% CI = 1.18–2.58, p = 0.005; galectin-3: OR = 2.98, 95% CI = 1.58–5.60, p = 0.001); but, high expression of galectin-4 and −9 in the tissues was significantly associated with better overall survival (galectin-4: HR = 0.53, 95% CI = 0.36–0.79, p = 0.002; galectin-9: HR = 0.56, 95% CI = 0.44–0.71, p &lt; 0.001) and negative vascular invasion (galectin-4: OR = 0.36, 95% CI = 0.19–0.72, p = 0.003; galectin-9: OR = 0.60, 95% CI = 0.37–0.97, p = 0.037). Serum galectin-3 level was significantly higher in HCC (MD = 3.06, 95% CI = 1.79–4.32, p &lt; 0.001), liver failure (MD = 0.44, 95% CI = 0.23–0.66, p &lt; 0.001), liver cirrhosis (MD = 1.83, 95% CI = 1.15–2.51, p &lt; 0.001), and chronic active hepatitis B (MD = 18.95, 95% CI = 10.91–27.00, p &lt; 0.001); serum galectin-9 level was significantly higher in HCC (MD = 3.74, 95% CI = 2.57–4.91, p &lt; 0.001) and autoimmune hepatitis (MD = 8.80, 95% CI = 7.61–9.99, p &lt; 0.001).Conclusion: High galectin-1 and -3 and low galectin-4 and -9 expression indicate worse outcomes of patients with HCC. Serum galectin-3 and -9 levels are positively associated with the risk of chronic liver diseases.

scholarly journals Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 1-30
Author(s):  
Mahmoud Yousefifard ◽  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Primary Therapy ◽  
Severity Of Injury ◽  
Cord Injury ◽  
Moderate Effect ◽  
Mean Differences ◽  
Rats And Mice

Objective: The present systematic review and meta-analysis intends to conduct a comprehensive and complete search in electronic resources to investigate the role of administrating ChABC in improving complications following SCI. Methods: Medline, Embase, Scopus and Web of sciences were searched until the end of 2019. Two independent reviewers assessed the studies conducted on rats and mice and summarized the data. Using STATA 14.0 program, the findings were reported as pooled standardized mean differences (SMD) with 95% confidence intervals (CI). Results: 34 pre-clinical studies were included. ChABC administration generally improves locomotion recovery after SCI (SMD = 0.90; 95% CI: 0.61 to 1.20; p <0.001). Subgroup analysis showed that differences in SCI model (p = 0.732), severity of injury (p = 0.821), number of ChABC administration (p = 0.092), blinding status (p = 0.294), use of different locomotor score (p = 0.567) and follow up duration (p = 0.750) have no effect on the efficacy of ChABC treatment. Conclusion: The findings of the present study showed that prescribing ChABC has a moderate effect in the improvement of locomotion after SCI in mice and rats. However, this moderate effect introduces ChABC as an adjuvant therapy and not as a primary therapy.

scholarly journals THE ROLE OF CANNABIDIOL IN THE INFLAMMATORY PROCESS AND ITS PROPERTIES AS AN ALTERNATIVE THERAPY – A REVIEW (META-ANALYSIS)

2020 ◽  
pp. 18-24
Author(s):  
FERRO M ◽  
ESCALANTE P ◽  
GRAUBARD A
Keyword(s):  
Therapeutic Potential ◽  
Meta Analysis ◽  
Alternative Therapy ◽  
Therapy Option ◽  
Relationship Of ◽  
Anxiety Depression ◽  
The Relationship ◽  
Positive Results ◽  
Time Of Administration

Abstract Cannabis has been used as a medicinal plant for thousands of years in Asia. Numerous physical, psychological, and emotional benefits have been attributed to cannabis since its first reported use in 2,600 BC in a Chinese pharmacopoeia. Recent years have seen a resurgence in interest in the therapeutic potential of compounds derived from these plants, mainly the non-psychoactive compound cannabidiol (CBD). In this way, we seek to evaluate, through this present study, what has been published about CBD in the Pubmed / Medline database in the last two years (2019/2020) in relation to anxiety, depression, panic attack and dementia, as well as therapeutic dosages, results with significant values, side effects and others reported in the studies found.  The results were distributed in 4 tables. In the first, the types of publication were reported; in the second, the proposal for evaluation; in the third, the results with significance evaluated; and in the fourth the doses used. Although the majority of studies found are in the form of a review (55.3%), several studies in humans have shown promising results with the use of CBD in therapies. The treatments for anxiety and stress with CBD were the most evident accounting for 37.8% of the total studies found in table 2. The relationship of CBD in metabolic processes as inflammatory markers, activator of specific nuclear receptors and protein modulations was the second most evident item na tabela 2 with 11,1%. Cognitive processes and depression appear comes in sequence with 8.9% both. The results of significance values found in this study demonstrated a good acceptance in the treatment with CBD regarding anxiety and stress. With 70.6% of positive results in table 3, CBD appears as a promising option in the treatment of anxiety, stress and similar behaviors. Regarding depression, the results were slightly lower. With 66.6% positive results, depression can also be treated with CBD as an alternative therapy option. In dose used CBD administration are extremely diverse. The doses ranged from 25mg to 800mg depending on the time of administration and also the purpose of the therapy. Although the results presented in this study are promising, we need more information to be able to position ourselves on the efficiency of CBD in proposed treatments.

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