Association of Chinese Visceral Adiposity Index and Its Dynamic Change With Risk of Carotid Plaque in a Large Cohort in China

Background We aimed to evaluate the association between the Chinese visceral adiposity index (CVAI) and its dynamic change and risk of carotid plaque based on a large Chinese cohort. Methods and Results This cohort included 23 522 participants aged 20 to 80 years without elevated carotid intima‐media thickness and carotid plaque at baseline and who received at least 2 health checkups. CVAI was calculated at baseline and at every checkup. The dynamic change in CVAI was calculated by subtracting CVAI at baseline from that at the last follow‐up. Cox proportional hazard regression model was used to estimate hazard ratios (HRs) and 95% CIs. The restricted cubic spline was applied to model the dose‐response association between CVAI and carotid plaque risk. During the 82 621 person‐years of follow‐up, 5987 cases of carotid plaque developed (7.25/100 person‐years). We observed a significant positive correlation between CVAI and carotid plaque risk (HR, 1.53; 95% CI, 1.48–1.59 [ P <0.001]) in a nonlinear dose‐response pattern ( P nonlinearity <0.001). The sensitivity analyses further confirmed the robustness of the results. The association was significant in all subgroup analyses stratified by sex, hypertension, and fatty liver disease except for the diabetes subgroup. The association between CVAI and carotid plaque risk was much higher in men than in women. No significant association was identified between change in CVAI and carotid plaque risk. Conclusions CVAI was positively associated with carotid plaque risk in a nonlinear dose‐response pattern in this study. Individuals should keep their CVAI within a normal level to prevent the development of carotid plaque.

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Chinese visceral adiposity index, a novel indicator of visceral obesity for assessing the risk of incident hypertension in a prospective cohort study

British Journal Of Nutrition ◽

10.1017/s0007114520004298 ◽

2020 ◽

pp. 1-9

Author(s):

Minghui Han ◽

Ranran Qie ◽

Quanman Li ◽

Leilei Liu ◽

Shengbing Huang ◽

...

Keyword(s):

Cohort Study ◽

Characteristic Curve ◽

Visceral Obesity ◽

Visceral Adiposity ◽

Sensitivity Analyses ◽

Cluster Sampling ◽

Visceral Adiposity Index ◽

Adiposity Index ◽

Hypertension Risk ◽

Obesity Indices

Abstract The present study aimed to investigate the association of the Chinese visceral adiposity index (CVAI) and its 6-year change with hypertension risk and compare the ability of CVAI and other obesity indices to predict hypertension based on the Rural Chinese Cohort Study. Study participants were randomly recruited by a cluster sampling procedure, and 10 304 participants ≥18 years were included. Modified Poisson regression was used to derive adjusted relative risks (RR) and 95 % CI. We identified 2072 hypertension cases during a median of 6·03 years of follow-up. The RR for the highest v. lowest CVAI quartile were 1·29 (95 % CI 1·05, 1·59) for men and 1·53 (95 % CI 1·22, 1·91) for women. Per-sd increase in CVAI was associated with hypertension for both men (RR 1·09, 95 % CI 1·02, 1·16) and women (RR 1·14, 95 % CI 1·06, 1·22). Also, the area under the receiver operating characteristic curve value for hypertension was higher for CVAI than the four other obesity indices for both sexes (all P < 0·05). Finally, per-sd increase in CVAI change was associated with hypertension for both men (RR 1·26, 95 % CI 1·16, 1·36) and women (RR 1·23, 95 % CI 1·15, 1·30). Similar results were observed in sensitivity analyses. CVAI and its 6-year change are positively associated with hypertension risk. CVAI has better performance in predicting hypertension than other visceral obesity indices for both sexes. The current findings suggest CVAI as a reliable and applicable predictor of hypertension in rural Chinese adults.

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Visceral adiposity index as a predictor of NAFLD: A prospective study with 4-year follow-up

Liver International ◽

10.1111/liv.13941 ◽

2018 ◽

Vol 38 (12) ◽

pp. 2294-2300 ◽

Cited By ~ 5

Author(s):

Chaonan Xu ◽

Zhimin Ma ◽

Yunfeng Wang ◽

Xiangtong Liu ◽

Lixin Tao ◽

...

Keyword(s):

Prospective Study ◽

Visceral Adiposity ◽

Visceral Adiposity Index ◽

Adiposity Index ◽

A Prospective Study

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Predictive performance of lipid accumulation product and visceral adiposity index for renal function decline in non-diabetic adults, an 8.6-year follow-up

Clinical and Experimental Nephrology ◽

10.1007/s10157-019-01813-7 ◽

2019 ◽

Vol 24 (3) ◽

pp. 225-234

Author(s):

Pouria Mousapour ◽

Maryam Barzin ◽

Majid Valizadeh ◽

Maryam Mahdavi ◽

Fereidoun Azizi ◽

...

Keyword(s):

Renal Function ◽

Lipid Accumulation ◽

Predictive Performance ◽

Visceral Adiposity ◽

Visceral Adiposity Index ◽

Lipid Accumulation Product ◽

Renal Function Decline ◽

Adiposity Index

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The Visceral Adiposity Index Is a Predictor of Incident Chronic Kidney Disease: A Population-Based Longitudinal Study

Kidney & Blood Pressure Research ◽

10.1159/000506461 ◽

2020 ◽

Vol 45 (3) ◽

pp. 407-418 ◽

Cited By ~ 1

Author(s):

Ryo Bamba ◽

Takuro Okamura ◽

Yoshitaka Hashimoto ◽

Masahide Hamaguchi ◽

Akihiro Obora ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Visceral Adiposity ◽

Visceral Adiposity Index ◽

Historical Cohort ◽

Men And Women ◽

Adiposity Index ◽

Incident Chronic Kidney Disease ◽

The Impact

Background and Aims: Visceral adiposity index (VAI), calculated with body mass index, high density lipoprotein-cholesterol, triglycerides and waist circumference, has been proposed as a marker of visceral fat accumulation and dysfunction in adipose tissue. Methods: The impact of VAI on incident chronic kidney disease (CKD) in a historical cohort study of 15,159 (8,260 men and 6,899 women) participants was investigated. CKD was defined when estimated glomerular filtration rate was <60 mL/min/1.73 m2 or proteinuria (positive: ≥1+). We divided the participants into 2 groups according to sex and into quartiles according to VAI (Q1–4). We performed Cox proportional hazard models, adjusting for age, smoking status, exercise, alcohol consumption, systolic blood pressure, hemoglobin A1c, uric acid, and creatinine. Results: During the median 3.3-year follow-up for men and 3.2-year follow-up for women, 1,078 participants (629 men and 449 women) developed CKD. The 4,000 days cumulative incidence rate of CKD for men and women were 3.7 and 3.9% in Q1, 5.2 and 5.9% in Q2, 6.5 and 7.0% in Q3, and 8.4 and 9.3% in Q4 respectively. Compared to Q1, the hazard ratios of incident CKD in Q2, Q3 and Q4 for men and women were 1.23 (95% CI 0.91–1.66, p = 0.184) and 1.30 (0.87–1.96, p = 0.203), 1.42 (1.06–1.90, p = 0.018) and 1.38 (0.94–2.05, p = 0.105), and 1.51 (1.12–2.02, p = 0.006) and 1.65 (1.12–2.46, p = 0.013) respectively. Additionally, the area under the curve of VAI for incidence of CKD was superior to that of VAI in men (0.595 vs. 0.552, p < 0.001) and equal to in women (0.597 vs. 0.591, p = 0.708). Conclusions: The VAI can be a predictor of incident CKD.

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