Abstract T P161: Asymmetric Dimethylarginine, C-reactive Protein, and the Risk of Developing Metabolic Syndrome in Middle-Aged Men

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Yasuhiro Nishiyama ◽  
Toshiaki Otsuka ◽  
Masayuki Ueda ◽  
Kazumi Kimura
Keyword(s):  
Metabolic Syndrome ◽  
Asymmetric Dimethylarginine ◽  
Serum Levels ◽  
Cox Proportional Hazards Model ◽  
New Combination ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein ◽  
The Metabolic Syndrome ◽  
Hs Crp

BACKGROUND: The metabolic syndrome has known as an independent risk factor of stroke. We have recently shown that the measurement of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, may be useful for identifying individuals with a high risk of stroke among Japanese population. We aimed to examine whether serum levels of ADMA and a high-sensitivity C-reactive protein (hs-CRP) are associated with the risk of developing metabolic syndrome in middle-aged men. METHODS: In this longitudinal study, serum ADMA and hs-CRP levels were measured in Japanese men without metabolic syndrome, which was diagnosed according to the currently accepted unified criteria. The subjects were followed-up for a maximum of four years to determine new-onset metabolic syndrome. A Cox proportional hazards model with adjusting for potential confounders was applied to determine the hazard ratio (HR) for developing metabolic syndrome according to serum levels of ADMA and hs-CRP, considered either alone or in combination. RESULTS: Of the 848 subjects (mean age, 43 ± 6 years), 100 subjects developed metabolic syndrome. High ADMA levels (≥ 0.45μmol/L) alone did not show a significant HR for developing metabolic syndrome, while high hs-CRP levels (≥ 0.3 mg/L) did (HR 1.82, 95% CI 1.17-2.83). The combination of high levels of both hs-CRP and ADMA had a high HR (2.32, 95% CI 1.30-4.14) as compared to low levels of both markers. In contrast, the HR was not significant in the combination of high hs-CRP and low ADMA levels, as well as low hs-CRP and high ADMA levels. CONCLUSIONS: Serum hs-CRP, but not ADMA, levels were associated with the risk of metabolic syndrome. Furthermore, the combination of high ADMA and high CRP levels increased the risk of metabolic syndrome. Hence, further studies are needed, but measuring the new combination of two markers may potentiate the predictive value for developing cardiovascular diseases including stroke.

scholarly journals C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men

Diabetologia ◽  
2004 ◽  
Vol 47 (8) ◽  
Author(s):  
D.E. Laaksonen ◽  
L. Niskanen ◽  
K. Nyyss�nen ◽  
K. Punnonen ◽  
T.-P. Tuomainen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein ◽  
The Metabolic Syndrome

scholarly journals Association of Testosterone, Insulin-Like Growth Factor-I, and C-Reactive Protein with Metabolic Syndrome in Chinese Middle-Aged Men with a Family History of Type 2 Diabetes

2005 ◽  
Vol 90 (12) ◽  
pp. 6418-6423 ◽  
Author(s):  
Peter C. Y. Tong ◽  
Chung-Shun Ho ◽  
Vincent T. F. Yeung ◽  
Maggie C. Y. Ng ◽  
Wing-Yee So ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Family History ◽  
Total Testosterone ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein ◽  
Igf I ◽  
History Of ◽  
Hs Crp

Context: Age-related declines in testosterone and IGF-I are associated with deposition of visceral fat, a component of the metabolic syndrome (MES). Objective: Testosterone and IGF-I may interact with familial disposition to diabetes mellitus to increase the association with MES. Design: We conducted a cross-sectional cohort study. Setting: The study was conducted in a university teaching hospital. Subjects: Study subjects included 179 middle-aged men with a family history of diabetes (FH) (aged 39.1 ± 8.1 yr) and 128 men without FH (aged 43.8 ± 8.5 yr). Main Outcome Measures: Clinical characteristics, frequency of MES using the World Health Organization criteria with Asian definitions of obesity (body mass index ≥ 25 kg/m2), and serum levels of total testosterone, IGF-I, and high-sensitive C-reactive protein (hs-CRP) were measured. Results: Men with FH had higher frequency of MES than those without FH [39.1 vs. 23.4% (P = 0.004)]. On multivariate analysis, smoking (former and current smokers), low total testosterone, and IGF-I but elevated hs-CRP levels explained 35% of the MES variance in men with FH. The frequency of MES increased with declining tertiles of total testosterone and IGF-I but increasing tertiles of hs-CRP. After adjustment for age and smoking history, subjects with all three risk factors had a 13-fold increase in risk association with MES compared with those without hormonal and inflammatory risk factors. These risk associations were not found in men without FH in whom only smoking (ex and current) and low total testosterone level were independent predictors for MES, which explained 14% of the variance. Conclusions: Clustering of FH, hormonal abnormalities, and high hs-CRP is associated with MES in Chinese middle-aged men.

Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents

2016 ◽  
Vol 0 (0) ◽  
Author(s):  
Ummugulsum Can ◽  
Muammer Buyukinan ◽  
Asuman Guzelant ◽  
Ayse Ugur ◽  
Adnan Karaibrahimoglu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Serum Levels ◽  
Inflammatory Biomarkers ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Age And Sex

AbstractBackground:Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), αMethods:This study was performed in 43 (18 males, 25 females) MetS adolescents between the ages of 13 and 17 years (14.70±1.15) and 43 lean controls were matched for age and sex. The serum levels of Hp, αResults:Serum Hp, fetuin-A (p<0.01) and PF-4, hs-CRP, SAP, AGP (p<0.001) values of the MetS subjects were significantly higher than those of the controls. No difference was found in serum αConclusions:This finding suggests the possibility of using these markers in diagnosis of MetS in adolescents to prevent future complications.

scholarly journals Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome

2007 ◽  
Vol 2007 ◽  
pp. 1-8 ◽  
Author(s):  
Juha Saltevo ◽  
Mauno Vanhala ◽  
Hannu Kautiainen ◽  
Esko Kumpusalo ◽  
Markku Laakso
Keyword(s):  
Metabolic Syndrome ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
High Sensitivity ◽  
Population Based ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Interleukin 1 Receptor Antagonist ◽  
The Metabolic Syndrome ◽  
Hs Crp

This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to subjects with MetS. If MetS was present according to both IDF and NCEP criteria, BMI, waist, triglycerides, hs-CRP, and IL-1Ra were significantly higher compared to subjects who had MetS according to either only IDF or only NCEP criteria. The hs-CRP, IL-1Ra, and adiponectin linearly correlated with the number of the components of MetS according to both definitions. Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of MetS. Individuals who had MetS according to both criteria had the most adverse changes in cardiovascular risk factors.

scholarly journals Predictive value of asymmetric dimethylarginine and C-reactive protein for the risk of developing metabolic syndrome in middle-aged men

2014 ◽  
Vol 5 ◽  
pp. 42-47 ◽  
Author(s):  
Toshiaki Otsuka ◽  
Yasuhiro Nishiyama ◽  
Yuko Kachi ◽  
Katsuhito Kato ◽  
Hirofumi Inagaki ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Predictive Value ◽  
Asymmetric Dimethylarginine ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein

scholarly journals Association of high sensitivity C-reactive protein and metabolic syndrome components in middle-aged subjects without overt cardiovascular disease in LitHiR primary prevention programme

2020 ◽  
Vol 26 (1) ◽  
pp. 14-19
Author(s):  
Ieva Marija Saulė ◽  
Jurgita Mikolaitytė ◽  
Jolita Badarienė ◽  
Jūratė Zupkauskienė ◽  
Roma Puronaitė ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein ◽  
Hs Crp ◽  
Aged Subjects

Summary Objectives: Circulating levels of inflammatory markers such as high sensitivity C-reactive protein (hs-CRP) have been reported to be associated with increased risk of cardiovascular disease (CVD), as well as with metabolic syndrome (MetS). Therefore, our objectives were to investigate the associations between hs-CRP levels and individual MetS components as well as to analyse if hs-CRP levels are linked with the number of MetS components present in middle-aged subjects. Design and methods: A cross-sectional study included 4628 middle-aged MetS subjects from the Lithuanian High Cardiovascular Risk primary prevention programme (LitHiR) from 2011 to 2020. MetS was diagnosed according to the National Cholesterol Education Program ATP III modified criteria. CRP was measured by a validated high-sensitivity assay. A hs-CRP cutpoint of 5 mg/l was used to differentiate high and low hs-CRP groups. Results: The mean value of hs-CRP was 3.23 ± 4.04 mg/l, and significantly increased as the number of components of MetS increased (p < 0.001). The concentration of serum hs-CRP was significantly associated with waist circumference, systolic and diastolic blood pressure, and fasting blood glucose (all p < 0.001). However, no statistically significant associations were found between hs-CRP and serum triglycerides (p = 0.340) or serum high-density lipoprotein cholesterol (p = 0.148). Conclusions: Serum hs-CRP increased progressively with increased waist circumference, blood pressure, fasting blood glucose in middle-aged subjects with MetS. The higher values of hs-CRP were more often present in obese subjects and women. The incremental rise in mean serum hs-CRP level was found with an increasing number of MetS components.

HIGH SENSITIVITY- C REACTIVE PROTEIN AS CARDIOVASCULAR RISK MARKER IN METABOLIC SYNDROME PATIENTS.

2021 ◽  
pp. 26-28
Author(s):  
Sangeeta M Gawali ◽  
Mahesh S Karandikar
Keyword(s):  
Metabolic Syndrome ◽  
High Sensitivity ◽  
Abdominal Circumference ◽  
Healthy Population ◽  
Care Hospital ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Hs Crp

Background & Objectives: 20-25% of the world's adult population have metabolic syndrome (MetS); mortality of these people is double, and the morbidity of heart attack or stroke is three times higher than in the healthy population. Recent research has focused on the use of high-sensitivity C-reactive protein (hs-CRP), a marker of inammation, in the detection of patients at increased risk for cardiovascular disease. The study was conducted to evaluate for the evidence of the association between baseline hs-CRP levels and the metabolic syndrome. Methods: It was a cross-sectional study of 200 adults, 18–50 years of age, both the sexes randomly selected from diabetes & obesity OPD at tertiary care hospital & compared with 200 age & sex-matched controls. Diagnosis of Metabolic syndrome was done according to Modied National Cholesterol Education Program ATP III criteria (2004). High Sensitivity -C Reactive Proteins -hs-CRP was done by ELISA method (CAL BIOTECH). Statistical Analysis was done by Pearson correlation coefcient to study the correlation between hs-CRP & various components of metabolic syndrome. Results: We found signicantly increased hs-CRP levels (P<0.001) in metabolic syndrome, 60% of patients with metabolic syndrome belonged to the high-risk group with a mean hs-CRP value >3 mg/L & a positive correlation of hs-CRP with abdominal circumference & triglyceride & HDL levels Conclusion: increased hs- CRP levels in metabolic syndrome may increase the risk of having cardiovascular mortality. These prospective data suggest that measurement of hs-CRP adds clinically important prognostic information to the metabolic syndrome.

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