Infertility, Miscarriage, Stillbirth, and the Risk of Stroke Among Women: A Systematic Review and Meta-Analysis

Background and Purpose: Stroke is one of the leading causes of mortality, and women are impacted more from stroke than men in terms of their absolute number and in having worse outcomes. A growing number of studies have explored the association between pregnancy complications, pregnancy outcomes, and stroke. Limited studies, however, have investigated links involving infertility, miscarriage, and stillbirth, which could plausibly be associated via a background of endocrine conditions, endothelial dysfunction, and chronic systematic inflammation. This review aims to summarize current evidence and provide up-to-date information on the associations of infertility, miscarriage, and stillbirth, with stroke incidence. Methods: A comprehensive literature search was conducted for cohort and case-control studies on associations between infertility, miscarriage, stillbirth, and stroke up to September 26, 2020. Seven databases were searched: PubMed, Embase, Cochrane, CINIHL, PsyclNFO, Wanfang, and CNKI. Random-effects models were used to estimate the pooled hazard ratios (HRs) and 95% CIs. Results: Sixteen cohort studies and 2 case-control studies enrolling 7 808 521 women were included in this meta-analysis. Women who had experienced miscarriage or stillbirth were at higher risk of stroke (miscarriage: HR, 1.07 [95% CI, 1.00–1.14]; stillbirth: HR, 1.38 [95% CI, 1.11–1.71]) than other women. The HRs of stroke for each additional miscarriage and stillbirth were 1.13 (95% CI, 0.96–1.33) and 1.25 (95% CI, 1.06–1.49), respectively. In subgroup analysis, increased risk of stroke was associated with repeated miscarriages and stillbirths (miscarriage ≥3: HR, 1.42 [95% CI, 1.05–1.90]; stillbirth ≥2: HR, 1.14 [95% CI, 1.04–1.26]). Associations between infertility and stroke were inconsistent and inconclusive (HR, 1.07 [95% CI, 0.87–1.32]). Conclusions: Miscarriage and stillbirth are associated with increased risk of stroke among women, which could be used as a contributing risk factor to help identify women at higher risk of stroke.

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Association of PIN3 16-bp Duplication Polymorphism of TP53 gene with Breast Cancer Risk in Mali and A Meta-analysis.

10.21203/rs.2.19205/v2 ◽

2020 ◽

Author(s):

Brehima Diakite ◽

Yaya Kassogue ◽

Guimogo Dolo ◽

Oumar Kassogue ◽

Mamadou Lassine Keita ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Meta Analysis ◽

Tp53 Gene ◽

Case Control ◽

Recessive Model ◽

Case Control Studies ◽

Random Effects Models ◽

Increased Risk

Abstract Background. Breast cancer, the most common tumor in women in Mali and worldwide has been linked to several risk factors, including genetic factors, such as the PIN3 16-bp duplication polymorphism of TP53 gene. The aim of our study was to evaluate the role of the PIN3 16-bp duplication polymorphism in the susceptibility to breast cancer in the Malian population and to perform a meta-analysis to better understand the correlation with data from other populations.Methods. We analyzed the PIN3 16-bp duplication polymorphism in blood samples of 60 Malian women with breast cancer and 60 healthy appearing Malian women using PCR. In addition, we performed a meta-analysis of data from case-control studies published in articles retrieved from international databases (Pubmed, Harvard University Library, Genetics Medical Literature Database, Genesis Library and Web of Science). Overall, odds ratio (OR) with 95% CI from fixed and random effects models were determined. Inconsistency was used to assess heterogeneity between studies and publication bias was estimated using the funnel plot.Results. In the studied Malian patients, a significant association of PIN3 16-bp duplication polymorphism with breast cancer risk was observed in dominant (A1A2+A2A2 vs. A1A1: OR = 2.26, CI 95% = 1.08-4.73; P = 0.02) and additive (A2 vs. A1: OR =1.87, CI 95% = 1.05-3.33; P = 0.03) models, but not the recessive model (P = 0.38). In the meta-analysis, nineteen (19) articles were included with a total of 6,018 disease cases and 4,456 controls. Except for the dominant model (P = 0.15), an increased risk of breast cancer was detected with the recessive (OR=1.46, 95% CI = 1.15-1.85; P = 0.002) and additive (OR = 1.11, 95% CI = 1.02-1.19; P = 0.01) models.Conclusion. The Malian case-control study suggests that PIN3 16-bp polymorphism duplication of TP53 gene is an important risk factor for breast cancer in Malian women. These findings are supported by the meta-analysis of studies from different ethnicities.

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Association of PIN3 16-bp Duplication Polymorphism of TP53 gene with Breast Cancer Risk in Mali and A Meta-analysis.

10.21203/rs.2.19205/v1 ◽

2019 ◽

Author(s):

Brehima Diakite ◽

Yaya Kassogue ◽

Guimogo Dolo ◽

Oumar Kassogue ◽

Mamadou Lassine Keita ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Meta Analysis ◽

Tp53 Gene ◽

Case Control ◽

Recessive Model ◽

Case Control Studies ◽

Random Effects Models ◽

Increased Risk

Abstract Background Breast cancer, the most common tumor in women in Mali and worldwide has been linked to several risk factors including genetic factors, such as the PIN3 16-bp duplication polymorphism of TP53 gene. The aim of our study was to evaluate the role of the PIN3 16-bp duplication polymorphism in the susceptibility to breast cancer in the Malian population and to perform a meta-analysis to better understand the correlation with data from other populations.Methods We analyzed the PIN3 16-bp duplication polymorphism in blood samples of 60 Malian women with breast cancer and 60 healthy appearing Malian women using PCR. In addition, we performed a meta-analysis of data from case-control studies published in articles retrieved from international databases (Pubmed, Harvard University Library, Genetics Medical Literature Database, Genesis Library and Web of Science). Overall, odds ratio (OR) with 95% CI from fixed and random effects models were determined. Inconsistency was used to assess heterogeneity between studies and publication bias was estimated using the funnel plot.ResultsIn the Malian patients studied here, a significant association of PIN3 16-bp duplication polymorphism with breast cancer risk was observed in dominant (A1A2+A2A2 vs. A1A1: OR = 2.26, CI 95% = 1.08-4.73; P = 0.02) and additive (A2 vs. A1: OR =1.87, CI 95% = 1.05-3.33; P = 0.03) models, but not the recessive model ( P = 0.38). In the meta-analysis, nineteen (19) articles were included with a total of 6,018 disease cases and 4,456 controls. Except for the dominant model ( P = 0.15), an increased risk of breast cancer was detected with the recessive (OR=1.46, 95% CI = 1.15-1.85; P = 0.002) and additive (OR = 1.11, 95% CI = 1.02-1.19; P = 0.01) models.Conclusion The Malian case-control study suggests that PIN3 16-bp polymorphism duplication of TP53 gene is an important risk factor for breast cancer in Malian women. These data are supported by the meta-analysis of broader ethnic and population groups.

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Non-Hodgkin Lymphoma and Smoking: A Meta-Analysis of Case-Control Studies

Blood ◽

10.1182/blood.v112.11.5292.5292 ◽

2008 ◽

Vol 112 (11) ◽

pp. 5292-5292 ◽

Cited By ~ 1

Author(s):

Cannon Milani ◽

Sheila Pascual ◽

Joanna Mitri ◽

Jorge Castillo

Keyword(s):

Viral Infections ◽

Case Reports ◽

English Literature ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Random Effects Models ◽

Non Hodgkin Lymphoma ◽

Increased Risk ◽

The Relationship

Abstract Background: The incidence of non-Hodgkins lymphoma (NHL) has followed a sustained increasing pattern for the last few decades. Potential factors implicated in developing an increased risk for NHL include immunosuppression, bacterial, and viral infections. The pathological heterogeneity of NHL suggests multifactorial etiologies. Several reports around the world have linked lifestyle habits to the development of NHL, but thus far, the relationship between smoking and NHL has been largely inconclusive. Objective: To perform a meta-analysis of published case-control studies to clarify the potential relationship between smoking and the development of NHL. Methods: An English literature search was conducted using Pubmed of case-control studies investigating the relationship between smoking and development of NHL. Prospective studies, case reports, editorials and letters were not included. Data were gathered including the following variables: country of origin, source of cases and controls, number of female/male cases and controls, adjusted odds ratio (OR) with 95% confidence intervals (CI) for former and current smokers, divided by male/female when available, and adjustments. Effect measures were obtained trough fixed and random-effects models to assess for heterogeneity. Results: Eighteen case-control studies were included in the meta-analysis. A total of 22,226 cases and 30,792 controls were finally analyzed. Based on our meta-analysis, former smokers had an OR of 1.02 (95% CI, 0.92 – 1.12) when compared to never smokers; heterogeneity between studies was evident (p < 0.001; I2 = 75.3%). Current smokers, on the other hand, had an OR of 1.06 (95% CI, 1.00 – 1.14); some degree of heterogeneity was observed (p = 0.04; I2 = 41.1%). Conclusions: Despite the limitations of this meta-analysis, current smokers seem to have small but statistically significant increase in the risk of developing NHL. Clinically speaking, smoking may be a non-negligible risk factor for developing NHL. Although a causal relationship will be hard to prove, further research is needed to clarify the potential role of smoking in lymphomagenesis.

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Relevance of hMLH1 -93G>A, 655A>G and 1151T>A polymorphisms with colorectal cancer susceptibility: a meta-analysis based on 38 case-control studies

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.64.10.942 ◽

2018 ◽

Vol 64 (10) ◽

pp. 942-951 ◽

Cited By ~ 1

Author(s):

Mohammad Zare ◽

Jamal Jafari-Nedooshan ◽

Mohammadali Jafari ◽

Hossein Neamatzadeh ◽

Seyed Mojtaba Abolbaghaei ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Asian Population ◽

Case Control ◽

Biomedical Literature ◽

Case Control Studies ◽

Increased Risk ◽

Comprehensive Search ◽

Meta Analyses

SUMMARY OBJECTIVE: There has been increasing interest in the study of the association between human mutL homolog 1 (hMLH1) gene polymorphisms and risk of colorectal cancer (CRC). However, results from previous studies are inconclusive. Thus, a meta-analysis was conducted to derive a more precise estimation of the effects of this gene. METHODS: A comprehensive search was conducted in the PubMed, EMBASE, Chinese Biomedical Literature databases until January 1, 2018. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. RESULTS: Finally, 38 case-control studies in 32 publications were identified met our inclusion criteria. There were 14 studies with 20668 cases and 19533 controls on hMLH1 −93G>A, 11 studies with 5,786 cases and 8,867 controls on 655A>G and 5 studies with 1409 cases and 1637 controls on 1151T>A polymorphism. The combined results showed that 655A>G and 1151T>A polymorphisms were significantly associated with CRC risk, whereas −93G>A polymorphism was not significantly associated with CRC risk. As for ethnicity, −93G>A and 655A>G polymorphisms were associated with increased risk of CRC among Asians, but not among Caucasians. More interestingly, subgroup analysis indicated that 655A>G might raise CRC risk in PCR-RFLP and HB subgroups. CONCLUSION: Inconsistent with previous meta-analyses, this meta-analysis shows that the hMLH1 655A>G and 1151T>A polymorphisms might be risk factors for CRC. Moreover, the −93G>A polymorphism is associated with the susceptibility of CRC in Asian population.

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Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020

Cancers ◽

10.3390/cancers13225654 ◽

2021 ◽

Vol 13 (22) ◽

pp. 5654

Author(s):

Agnieszka Barańska ◽

Agata Błaszczuk ◽

Wiesław Kanadys ◽

Maria Malm ◽

Katarzyna Drop ◽

...

Keyword(s):

Breast Cancer ◽

Oral Contraceptive ◽

Cancer Risk ◽

Meta Analysis ◽

Case Control ◽

Cochrane Library ◽

Control Group ◽

Case Control Studies ◽

Increased Risk ◽

Breast Cancer Risk Assessment

To perform a meta-analysis of case-control studies that addressed the association between oral contraceptive pills (OC) use and breast cancer (BrCa), PubMED (MEDLINE), Embase, and the Cochrane Library were searched to identify case-control studies of OC and BrCa published between 2009 and 2020. We used the DerSimonian–Laird method to compute pooled odds ratios (ORs) and confidence intervals (CIs), and the Mantel–Haenszel test to assess the association between OC use and cancer. Forty-two studies were identified that met the inclusion criteria and we included a total of 110,580 women (30,778 into the BrCa group and 79,802 into the control group, of which 15,722 and 38,334 were using OC, respectively). The conducted meta-analysis showed that the use of OC was associated with a significantly increased risk of BrCa in general, OR = 1.15, 95% CI: 1.01 to 1.31, p = 0.0358. Regarding other risk factors for BrCa, we found that increased risk was associated significantly with early menarche, nulliparous, non-breastfeeding, older age at first parity, postmenopause, obesity, smoking, and family history of BrCa. Despite our conclusion that birth control pills increase the cancer risk being supported by extensive previous studies and meta-analyzes, further confirmation is required.

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ASSOCIATION OF IL-8 -251T>A (RS4073) POLYMORPHISM WITH SUSCEPTIBILITY TO GASTRIC CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS BASED ON 33 CASE-CONTROL STUDIES

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.202000000-16 ◽

2020 ◽

Vol 57 (1) ◽

pp. 91-99

Author(s):

Mansour MOGHIMI ◽

Seyed Alireza DASTGHEIB ◽

Naeimeh HEIRANIZADEH ◽

Mohammad ZARE ◽

Elnaz SHEIKHPOUR ◽

...

Keyword(s):

Gastric Cancer ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Case Control ◽

Case Control Studies ◽

Effect Model ◽

Increased Risk ◽

Mixed Populations ◽

Stratified Analysis

ABSTRACT BACKGROUND: The role of -251A>T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene in gastric cancer was intensively evaluated, but the results of these studies were inconsistent. OBJECTIVE: Therefore, we performed a meta-analysis to provide a comprehensive data on the association of IL-8 -251T>A polymorphism with gastric cancer. METHODS: All eligible studies were identified in PubMed, Web of Science, EMBASE, Wanfang and CNKI databases before September 01, 2019. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were derived from a fixed effect or random effect model. RESULTS: A total of 33 case-control studies with 6,192 cases and 9,567 controls were selected. Overall, pooled data showed that IL-8 -251T>A polymorphism was significantly associated with an increased risk of gastric cancer under all five genetic models, i.e., allele (A vs T: OR=1.189, 95% CI 1.027-1.378, P=0.021), homozygote (AA vs TT: OR=1.307, 95% CI 1.111-1.536, P=0.001), heterozygote (AT vs TT: OR=1.188, 95% CI 1.061-1.330, P=0.003), dominant (AA+AT vs TT: OR=1.337, 95% CI 1.115-1.602, P=0.002) and recessive (AA vs AT+TT: OR=1.241, 95% CI 1.045-1.474, P=0.014). The stratified analysis by ethnicity revealed an increased risk of gastric cancer in Asians and mixed populations, but not in Caucasians. Moreover, stratified by country found a significant association in Chinese, Korean and Brazilian, but not among Japanese. CONCLUSION: This meta-analysis suggests that the IL-8 -251T>A polymorphism is associated with an increased risk of gastric cancer, especially by ethnicity (Asian and mixed populations) and country (Chinese, Korean and Brazilian).

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Hypertension and the risk of endometrial cancer: a systematic review and meta-analysis of case-control and cohort studies

Scientific Reports ◽

10.1038/srep44808 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 24

Author(s):

Dagfinn Aune ◽

Abhijit Sen ◽

Lars J. Vatten

Keyword(s):

Systematic Review ◽

Endometrial Cancer ◽

Cohort Studies ◽

Contraceptive Use ◽

Meta Analysis ◽

Case Control ◽

Adjusted Relative Risk ◽

Case Control Studies ◽

Relative Risks ◽

Increased Risk

Abstract A history of hypertension has been associated with increased risk of endometrial cancer in several studies, but the results have not been consistent. We conducted a systematic review and meta-analysis of case-control and cohort studies to clarify the association between hypertension and endometrial cancer risk. PubMed and Embase databases were searched up to 27th of February 2016. Prospective and case-control studies which reported adjusted relative risk estimates and 95% confidence intervals of endometrial cancer associated with a hypertension diagnosis were included. Summary relative risks were estimated using a random effects model. Nineteen case-control studies and 6 cohort studies were included. The summary RR was 1.61 (95% CI: 1.41–1.85, I2 = 86%) for all studies, 1.73 (95% CI: 1.45–2.06, I2 = 89%) for case-control studies and 1.32 (95% CI: 1.12–1.56, I2 = 47%) for cohort studies. The association between hypertension and endometrial cancer was weaker, but still significant, among studies with adjustment for smoking, BMI, oral contraceptive use, and parity, compared to studies without such adjustment. This meta-analysis suggest an increased risk of endometrial cancer among patients with hypertension, however, further studies with more comprehensive adjustments for confounders are warranted to clarify the association.

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PF284 OCCUPATIONAL PESTICIDES EXPOSURE IS ASSOCIATED WITH AN INCREASED RISK OF ACUTE MYELOID LEUKEMIA: A META-ANALYSIS OF CASE-CONTROL STUDIES INCLUDING 2981 PATIENTS AND 248705 CONTROLS

HemaSphere ◽

10.1097/01.hs9.0000559348.09806.86 ◽

2019 ◽

Vol 3 (S1) ◽

pp. 93-94

Author(s):

A. Foucault ◽

N. Vallet ◽

E. Gyan ◽

O. Herault

Keyword(s):

Acute Myeloid Leukemia ◽

Myeloid Leukemia ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Increased Risk ◽

Pesticides Exposure ◽

Acute Myeloid

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Association between IL-13 +1923C/T polymorphism and asthma risk: a meta-analysis based on 26 case-control studies

Bioscience Reports ◽

10.1042/bsr20160505 ◽

2017 ◽

Vol 37 (1) ◽

Cited By ~ 7

Author(s):

Yueli Xu ◽

Junjuan Li ◽

Zhaolei Ding ◽

Juan Li ◽

Bin Li ◽

...

Keyword(s):

Genetic Model ◽

Meta Analysis ◽

Age Groups ◽

Allergic Inflammation ◽

Case Control ◽

Respiratory Disorder ◽

Case Control Studies ◽

Increased Risk ◽

Asthma Patients ◽

Highly Correlated

Asthma is a serious and hereditary respiratory disorder affecting all age groups. Interleukin-13 (IL-13) is a central regulator of allergic inflammation. The purpose of the present study was to estimate the relationship between IL-13 +1923C/T polymorphism and asthma susceptibility. Relevant case-control studies published between January 2000 and July 2016 were searched in the online databases. Review Manage (RevMan) 5.3 was used to conduct the statistical analysis. The pooled odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the strength of association. A total of 26 articles were retrieved, including 17642 asthma patients and 42402 controls. Overall, our results found that IL-13 +1923C/T polymorphism was significantly associated with increased risk of asthma under each genetic model (P<0.00001). Subgroup analysis by ethnicity showed that alleles and genotypes of this variant correlated with asthma among Asians and Caucasians, but only TT genotype under the homozygote model in Africans. When stratified by age group, this variant highly correlated with asthma in children and moderately in adults. Furthermore, the TT, CT and CC genotypes in asthma group were all significantly associated with increased IgE levels in sera of asthma patients when compared with controls. Our results suggested that IL-13 +1923C/T polymorphism contributed to the development of asthma. Further case-control studies with more ethnicities are still needed.

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