scholarly journals On Cellular Darwinism: Mitochondria

2016 ◽  
Vol 22 (1) ◽  
pp. 112-118 ◽  
Author(s):  
Larry Bull

The significant role of mitochondria within cells is becoming increasingly clear. This letter uses the NKCS model of coupled fitness landscapes to explore aspects of organelle-nucleus coevolution. The phenomenon of mitochondrial diversity is allowed to emerge under a simple intracellular evolutionary process, including varying the relative rate of evolution by the organelle. It is shown how the conditions for the maintenance of more than one genetic variant of mitochondria are similar to those previously suggested as needed for the original symbiotic origins of the relationship using the NKCS model.

Author(s):  
Arwanto Arwanto ◽  
Wike Anggraini

ABSTRACT Understanding policy process involves many distinctive approaches. The most common are institutional, groups or networks, exogenous factors, rational actors, and idea-based approach. This paper discussed the idea-based approach to explain policy process, in this case policy change. It aims to analyse how ideas could assist people to understand policy change. What role do they play and why are they considered as fundamental element? It considers that ideas are belong to every policy actor, whether it is individual or institution. In order to answer these questions, this paper adopts Kingdon’s multi streams approach to analyse academic literatures. Through this approach, the relationship between ideas and policy change can be seen clearer. Ideas only can affect in policy change if it is agreed and accepted by policy makers. Therefore the receptivity of ideas plays significant role and it emerges policy entrepreneurs. They promote ideas (through problem framing, timing, and narrative construction) and manipulate in order to ensure the receptivity of ideas. Although policy entrepreneurs play significant role, political aspects remains the most important element in the policy process. Keywords: policy change, ideas, idea-based approach, Kingdon’s multiple streams, policy entrepreneurs.


2017 ◽  
Vol 14 (1) ◽  
pp. 67-81
Author(s):  
Mohd A’Tarahim Mohd Razali Bin Mohd Razali ◽  
Mohd Yakub @ Zulkifli Mohd Yusoff Bin Mohd Yusoff ◽  
Nor Hafizi Yusof Bin Yusof ◽  
Siti Fatimah Salleh Binti Salleh ◽  
Mohd Faiz Hakimi Mat Deris Bin Mat Deris ◽  
...  

The aim of this study is to explore the importance of Qira’at Mutawatirah as a discipline particularly in the field of fiqh (jurisprudence). As a field of study, Qiraat (Quranic reading) plays a significant role in Islamic Fiqh by way of shaping the opinions and views of the fuqaha’ (jurists). Nevertheless, some fuqaha’ are less familiar with Qiraat as a study which has thus led to some confusion and ambiguity on the matter. It was even suggested that the differences of fiqh found within the madzhabs (sects) are based on the fuqaha’s own Qiraat. Thus this paper is a discussion on the differences of wajh Qiraat within the farsh letters as found among the Qiraat scholars. This paper also analyses the relationship and influence of the Qiraat readings among the fuqaha when it comes to deriving a hukm (principle), particularly on fiqh ibadah (the laws of worship). As such, this significant study sheds light into the approach used by the fuqaha’ when it comes to extracting and deriving laws and principles based on the different Qiraat readings. The objectives of this study are to investigate the extent and role of Qiraat, to analyse and observe the relationship between Qiraat readings of the fuqaha and its relationship to the hukm. This study is based entirely on library research. Overall, the findings show that Qiraat is undoubtedly important; the differences in Qiraat have a major impact in the way that the various Islamic Fiqh were derived from the Qur’anic verses. Nevertheless, the chosen Qiraat readings by Fuqaha, on the other hand, do not play a major role in determining the fiqh within the various sects; instead the wajh Qiraat plays a major role within their respective sects. However, in some circumstances, the chosen Qiraat readings do sometimes become a source which a hukm is decided within their sects, and vice versa. It is hoped that this study becomes a pioneer for other researchers to conduct a more in-depth study on the sciences of Qiraat by exploring it critically within the various perspectives of the Islamic discipline. It is hoped that it can be analysed, studied, understood and implemented in the field of teaching and learning, in line with its importance within the other branches of Islamic discipline. It is hoped that as a study, it can be further expanded and remain significant to the Islamic scholars and the community at large. Keyword: Qiraat Mutawatirah, Fiqh, Qiraat, fuqaha‘   Penulisan ini bertujuan merungkai hubungan rapat Qiraat dalam disiplin ilmu Islam terutamanya ilmu Fiqh. Qiraat menjadi salah satu faktor yang dominan terutamanya dalam mencorakkan perbezaan hukum Fiqh Islami dalam kalangan Fuqaha’. Namun masih terdapat kalangan yang kurang mengetahui dan memahami hakikat kewujudan ilmu Qiraat sehingga menimbulkan kekeliruan dan kesamaran mengenainya bahkan wujudnya pendapat menyatakan bahawa hukum fiqh yang diinstibatkan dalam mazhab adalah berdasarkan daripada Qiraat yang dibaca oleh kalangan fuqaha itu sendiri. Justeru kajian ini akan menyentuh dan membincangkan perbezaan wajh qiraat yang terdapat pada farsh huruf dalam kalangan ulama Qiraat. Dalam masa yang sama, kajian ini juga akan menyingkap dan menganalisis perkaitan dan pengaruhnya terhadap pengeluaran hukum oleh kalangan Fuqaha’ terutama ayat-ayat al-Quran yang melibatkan fiqh ibadat. Kajian ini penting demi memahami keadaan sebenar bagaimana kalangan Fuqaha mengeluarkan hukum fiqh berdasarkan perbezaan Qiraat. Objektif kajian ialah mengkaji sejauhmana perkaitan dan peranan Qiraat pada hukum fiqh, menganalisis dan menilai sejauh mana pertalian bacaan Qiraat yang dibaca Fuqaha’ dengan hukum yang diinstibatkan oleh Fuqaha.’ Secara keseluruhannya, kajian ini dijalankan berdasarkan kajian ke perpustakaan sepenuhnya. Ternyata dapatan hasil kajian ini merumuskan bahawa perbezaan Qiraat pula memberi impak yang besar dalam mencorakkan hukum fiqh dalam ayat al-Quran. Bacaan ‘Qiraat PilihanFuqaha‘ pula tidaklah menjadi faktor utama mempengaruhi hukum fiqh mazhab yang diasaskan oleh mereka bahkan fuqaha hanya menjadikan wajh Qiraat itu sebagai platform utama dalam menentukan hukum fiqh dalam mazhab yang diasaskan mereka. Namun tidak dinafikan juga, bacaan ‘Qiraat Pilihan Fuqaha‘ itu kekadang menjadi sebab penentuan hukum bagi mazhab mereka dan kekadangnya sebaliknya. Kajian ini diharap menjadi perintis kepada pengkaji yang lain untuk lebih prolifik mengenai ilmu Qiraat dalam membahaskannya dari pelbagai sudut disiplin ilmu Islam secara lebih kritis supaya ia dapat ditelaah, dikaji, difahami, diperkasai dan diimplimentasikan dalam aspek pengajaran dan pembelajaran sejajar dengan kepentingannya terhadap cabangan ilmu-ilmu Islam yang lain agar terus berkembang dan bertapak pada kaca mata Ilmuan Islam secara khusus dan masyarakat sejagat secara umumnya.   Kata Kunci: Qiraat Mutawatirah, Fiqh, Qiraat, fuqaha‘.


Author(s):  
N.D. Kobzeva ◽  
◽  
R.S. Durov ◽  
E.V Varnakova ◽  
K.O Kobzev ◽  
...  

The article discusses in detail the relationship between insurance and medical law. On the basis of the analysis of normative-legal acts, as well as law enforcement practice, the conclusion is made about the significant role of territorial funds of medical insurance and insurance medical organizations in the protection of the citizen's right to its provision in the system of compulsory medical insurance.


2007 ◽  
Vol 28 (1) ◽  
pp. 55-84
Author(s):  
Ruth Lusterio Rico

This article analyzes the important role of civil society groups in the enactment of a significant legislation — the Indigenous Peoples’ Rights Act (IPRA) which was passed by the Philippine Congress in 1997. It examines the legislative process, the significant role of non-government organizations (NGOs) and people’s organizations (POs) in the process, the relationship between state and non-state actors, and how this relationship affected the enactment of the law. This paper shows that in spite of the limitations faced by civil society groups, they are able to play a significant role in the making of a significant legislation. The active role of civil society groups specifically in policy formulation, the collaboration between state and civil society actors and the strong support of the administration are three important factors in the making of IPRA.


2021 ◽  
Vol 30 (1) ◽  
pp. 69-81
Author(s):  
Antonio Williams ◽  
Sungwook Son ◽  
Patrick Walsh ◽  
Jin Park

Despite sport rebranding becoming an emerging topic for both academia and industry, there has been a limited number of investigations on how sport rebranding influences sport fans. The aim of this study is to investigate how sport rebranding in the form of logo redesign influences fan loyalty. Through an experimental approach, the results indicate that attitude toward rebranding plays a significant role in fan response when sport rebranding occurs. Additional findings suggest that logo evaluation partially mediates the relationship between logo change and brand loyalty. This study makes significant contributions to the body of knowledge on sport rebranding by revealing how fans’ attitudes toward rebranding affects brand loyalty. The proposed model suggests directions for future sport rebranding research, and the paper provides implications for how sport marketers can use various rebranding strategies to improve rebranding outcomes and diminish negative responses from sport fans.


2008 ◽  
Vol 36 (6) ◽  
pp. 1149-1160 ◽  
Author(s):  
K Huang ◽  
LD Wu

Aggrecanase-mediated aggrecan degradation is a significant event in early-stage osteoarthritis (OA). Aggrecanases belonging to the ‘A Disintegrin And Metalloproteinase with ThromboSpondin motifs’ (ADAMTS) family of proteinases play a significant role in aggrecan depletion in osteoarthritic cartilage. There has been considerable interest in the possible role of these aggrecanases, especially ADAMTS-4 and ADAMTS-5, as therapeutic targets in OA. This article discusses recent data regarding ADAMTS-4 and ADAMTS-5 in OA, with emphasis on the relationship between aggrecanase and aggrecan degradation as well as the role of aggrecanase in OA.


2013 ◽  
Vol 834-836 ◽  
pp. 1862-1868
Author(s):  
Xiao Qin Zhu ◽  
Zhao Hui Du

This paper analyzes the relationship between the resources restriction, the entrepreneurs' cognition and the dynamic capability, and using the market research and the structural equation model to test them, it is found that entrepreneurs' cognition of three aspects: namely, environmental alertness, enterprise internal cognition and metacognitive ,which have significant positive influence on dynamic capability, the influence of the environmental alertness on the dynamic capability is the largest among them. At the same time, the resources restriction plays a significant role of regulation for the relationship between entrepreneurs' cognition and dynamic capability.


2012 ◽  
Vol 6 (3) ◽  
pp. 292-305 ◽  
Author(s):  
Willem Fourie

Abstract This article reflects on the relationship between public theology and the state. It suggests that a state-centric paradigm plays a significant role in the self-understanding and practice of public theology, and that transnationalism can serve as correction to state-centrism. It argues that these concepts complement the existing discourse on glocalization in public theology. The article investigates the role of churches in the struggle against apartheid as an early example of transnationalism in public theology. The concluding section shows that transnationalism may aid the practitioners of public theology to reflect critically on its relation to the state.


2018 ◽  
Author(s):  
Inès Fragata ◽  
Sebastian Matuszewski ◽  
Mark A. Schmitz ◽  
Thomas Bataillon ◽  
Jeffrey D. Jensen ◽  
...  

AbstractFitness landscapes map the relationship between genotypes and fitness. However, most fitness landscape studies ignore the genetic architecture imposed by the codon table and thereby neglect the potential role of synonymous mutations. To quantify the fitness effects of synonymous mutations and their potential impact on adaptation on a fitness landscape, we use a new software based on Bayesian Monte Carlo Markov Chain methods and reestimate selection coefficients of all possible codon mutations across 9 amino-acid positions in Saccharomyces cerevisiae Hsp90 across 6 environments. We quantify the distribution of fitness effects of synonymous mutations and show that it is dominated by many mutations of small or no effect and few mutations of larger effect. We then compare the shape of the codon fitness landscape across amino-acid positions and environments, and quantify how the consideration of synonymous fitness effects changes the evolutionary dynamics on these fitness landscapes. Together these results highlight a possible role of synonymous mutations in adaptation and indicate the potential mis-inference when they are neglected in fitness landscape studies.


2021 ◽  
Vol 30 (1) ◽  
pp. 69-81
Author(s):  
Antonio Williams ◽  
Sungwook Son ◽  
Patrick Walsh ◽  
Jin Park

Despite sport rebranding becoming an emerging topic for both academia and industry, there has been a limited number of investigations on how sport rebranding influences sport fans. The aim of this study is to investigate how sport rebranding in the form of logo redesign influences fan loyalty. Through an experimental approach, the results indicate that attitude toward rebranding plays a significant role in fan response when sport rebranding occurs. Additional findings suggest that logo evaluation partially mediates the relationship between logo change and brand loyalty. This study makes significant contributions to the body of knowledge on sport rebranding by revealing how fans’ attitudes toward rebranding affects brand loyalty. The proposed model suggests directions for future sport rebranding research, and the paper provides implications for how sport marketers can use various rebranding strategies to improve rebranding outcomes and diminish negative responses from sport fans.


Sign in / Sign up

Export Citation Format

Share Document