Sirt1 Activator SRT1720 Promotes Tumor Cell Migration And Lung Metastasis In Mouse Models Of Breast Cancer

2010 ◽  
Author(s):  
Kensuke Suzuki ◽  
Ryuji Hayashi ◽  
Tomomi Ichikawa ◽  
Shingo Imanishi ◽  
Toru Yamada ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Tumor Cell ◽  
Mouse Models ◽  
Lung Metastasis ◽  
Tumor Cell Migration ◽  
Sirt1 Activator

scholarly journals HERC1 regulates breast cancer cells migration and invasion

2020 ◽  
Author(s):  
Fabiana Alejandra Rossi ◽  
Ezequiel Hernán Calvo Roitberg ◽  
Juliana Haydeé Enriqué Steinberg ◽  
Molishree Joshi ◽  
Joaquín Maximiliano Espinosa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Tumor Cell ◽  
Inverse Correlation ◽  
Migration And Invasion ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Loss Of Function ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration

Tumor cell migration and invasion into adjacent tissues is one of the hallmarks of cancer and the first step towards secondary tumors formation, which represents the leading cause of cancer-related deaths. This process is considered an unmet clinical need in the treatment of this disease, particularly in breast cancers characterized by high aggressiveness and metastatic potential. In order to identify and characterize genes with novel functions as regulators of tumor cell migration and invasion, we performed a genetic loss-of-function screen using a shRNA library directed against the Ubiquitin Proteasome System (UPS) in a highly invasive breast cancer derived cell line. Among the candidates, we validated HERC1 as a gene regulating cell migration and invasion. Furthermore, using animal models, our results indicated that HERC1 silencing affects primary tumor growth and lung colonization. Finally, we conducted an in-silico analysis using publicly available protein expression data and observed an inverse correlation between HERC1 expression levels and breast cancer patients overall survival. Altogether, our findings demonstrate that HERC1 might represent a novel therapeutic target for the development or improvement of breast cancer treatment.

scholarly journals Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

2015 ◽  
Vol 125 (4) ◽  
pp. 1648-1664 ◽  
Author(s):  
Wies van Roosmalen ◽  
Sylvia E. Le Dévédec ◽  
Ofra Golani ◽  
Marcel Smid ◽  
Irina Pulyakhina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Tumor Cell ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Tumor Cell Migration

Abstract C05: Pulmonary laminin 332 in tumor cell migration and breast cancer survival

2016 ◽  
Author(s):  
Philip M. Carpenter ◽  
Priyanka Sivadas ◽  
Argyrios Ziogas ◽  
Hoda Anton-Culver
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Tumor Cell ◽  
Cancer Survival ◽  
Breast Cancer Survival ◽  
Tumor Cell Migration ◽  
Laminin 332

scholarly journals HERC1 Regulates Breast Cancer Cells Migration and Invasion

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1309
Author(s):  
Fabiana Alejandra Rossi ◽  
Ezequiel Hernán Calvo Roitberg ◽  
Juliana Haydeé Enriqué Steinberg ◽  
Molishree Umesh Joshi ◽  
Joaquín Maximiliano Espinosa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Tumor Cell ◽  
Inverse Correlation ◽  
Migration And Invasion ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Loss Of Function ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration

Tumor cell migration and invasion into adjacent tissues is one of the hallmarks of cancer and the first step towards secondary tumors formation, which represents the leading cause of cancer-related deaths. This process is considered an unmet clinical need in the treatment of this disease, particularly in breast cancers characterized by high aggressiveness and metastatic potential. To identify and characterize genes with novel functions as regulators of tumor cell migration and invasion, we performed a genetic loss-of-function screen using a shRNA library directed against the Ubiquitin Proteasome System (UPS) in a highly invasive breast cancer derived cell line. Among the candidates, we validated HERC1 as a gene regulating cell migration and invasion. Furthermore, using animal models, our results indicate that HERC1 silencing affects primary tumor growth and lung colonization. Finally, we conducted an in silico analysis using publicly available protein expression data and observed an inverse correlation between HERC1 expression levels and breast cancer patients’ overall survival. Altogether, our findings demonstrate that HERC1 might represent a novel therapeutic target for the development or improvement of breast cancer treatment.

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