TPI ASM8, An Inhaled Antisense Oligonucleotide Drug Candidate Targeting CCR3 And The Common Beta Chain Of IL-3, IL-5 And GM-CSF Receptors, Potentiates The Anti-inflammatory Activity Of An Inhaled Corticosteroid In A Rat Model Of Asthma

2010 ◽  
Author(s):  
Marylène Fortin ◽  
Kamel Moktefi ◽  
Mary Jane Court ◽  
Serge Séguin ◽  
Nicolay Ferrari
Keyword(s):  
Rat Model ◽  
Antisense Oligonucleotide ◽  
Inflammatory Activity ◽  
Drug Candidate ◽  
Beta Chain ◽  
Inhaled Corticosteroid ◽  
Gm Csf ◽  
The Common ◽  
Anti Inflammatory

Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis

Cytokine ◽  
2010 ◽  
Vol 52 (3) ◽  
pp. 194-202 ◽  
Author(s):  
Marylène Fortin ◽  
James G. Wagner ◽  
Julie Brault ◽  
Jack R. Harkema ◽  
Paolo M. Renzi ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Rat Model ◽  
Nasal Epithelium ◽  
Lymphoid Tissues ◽  
Beta Chain ◽  
Temporal Expression ◽  
Gm Csf ◽  
The Common

VSL#3 probiotics exerts the anti-inflammatory activity via PI3k/Akt and NF-κB pathway in rat model of DSS-induced colitis

2012 ◽  
Vol 374 (1-2) ◽  
pp. 1-11 ◽  
Author(s):  
Cong Dai ◽  
Chang-Qing Zheng ◽  
Fan-ji Meng ◽  
Zheng Zhou ◽  
Li-xuan Sang ◽  
...  
Keyword(s):  
Rat Model ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Pharmacological Effects of ASM8, an Antisense Oligonucleotide to CCR3 and the Common Beta Chain Receptor in Mild Asthmatics

2007 ◽  
Vol 119 (1) ◽  
pp. S46 ◽  
Author(s):  
G.M. Gauvreau ◽  
L.P. Boulet ◽  
D.W. Cockcroft ◽  
M. Duong ◽  
H. D' Anjou ◽  
...  
Keyword(s):  
Antisense Oligonucleotide ◽  
Pharmacological Effects ◽  
Beta Chain ◽  
The Common

scholarly journals Antibacterial, Anti-inflammatory and Antioxidant Potential of Ethanol Extract of Ipomoea staphylina Roem. & Schult

2021 ◽  
pp. 97-106
Author(s):  
G. Kokila ◽  
P. Jeevan
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Medicinal Plant ◽  
Ethanol Extract ◽  
Inflammatory Activity ◽  
Diffusion Method ◽  
Drug Candidate ◽  
Dependent Manner ◽  
Human Beings ◽  
Anti Inflammatory

In the present study we evaluate the antibacterial, anti-inflammatory and antioxidant activity of medicinal plant Ipomoea staphylina Roem & Schult. Many bacteria are harmful to human beings and animals. Theses bacteria make diseases the host organisms. Many antibiotics are available in the marker for the treatment of bacterial diseases. However, antibiotics cause unwanted side effect. Thus, the study focused to evaluate ethanol extract of Ipomoea staphylina against bacterial pathogens. Antibacterial activity was evaluated by the method of well diffusion method. Antiinflamatory and antioxidant activity was evaluated by in vitro study method. Ethanol extract of Ipomoea staphylina showed antibacterial activity against different bacteria isolated from chicken at dose depended manner ie., higher dose of plant extract possessed maximum inhibition zone (21.67 ± 1.45 mm) (P<0.05) against selected bacteria. Moreover, plant ethanol extract possessed anti-inflammatory activity and antioxidant activity at dose dependent manner (P<0.05). Higher dose (100 μg/ml) of ethanol extract of Ipomoea staphylina showed maximum anti-inflammatory activity (68.38 %) and antioxidant activity (72%). From this result it is concluded that the medicinal plant Ipomoea staphylina Roem. & Schult. possessed antibacterial, anti-inflammatory and antioxidant activity. Further detailed study will be conducted for the new drug candidate discovery.

Simvastatin and Indomethacin Have Similar Anti-Inflammatory Activity in a Rat Model of Acute Local Inflammation

2009 ◽  
Vol 104 (3) ◽  
pp. 185-191 ◽  
Author(s):  
Lana Nežić ◽  
Ranko Škrbić ◽  
Silva Dobrić ◽  
Miloš P. Stojiljković ◽  
Vesna Jaćević ◽  
...  
Keyword(s):  
Rat Model ◽  
Inflammatory Activity ◽  
Local Inflammation ◽  
Anti Inflammatory

scholarly journals Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Li Wang ◽  
Linjie Feng ◽  
Jingyu Zhang
Keyword(s):  
Rat Model ◽  
Inflammatory Activity ◽  
Control Group ◽  
Anti Inflammatory ◽  
The Sacrifice ◽  
Creb Pathway

Abstract Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups were sacrificed, they were in different weeks of age. If the rats in the control group were compared to the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups respectively, the results may be biased due to differences in the week age of the rats. We believe that addressing this issue could further increase the value of their study.

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