Peptide Multifunctionalized Gold Nanorods with Dual pH/NIR Responsive Release of Doxorubicin for High-Efficiency Cancer Treatment

2019 ◽  
Vol 15 (11) ◽  
pp. 2164-2178 ◽  
Author(s):  
Jing Wang ◽  
Kang Ma ◽  
Hui Wang ◽  
Zhiqiang Hu ◽  
Yan Fu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Gold Nanorods ◽  
Therapeutic Efficacy ◽  
Near Infrared ◽  
High Efficiency ◽  
Infrared Light ◽  
Cancer Tissue ◽  
Cell Ablation ◽  
Poly Ethylene ◽  
Targeting Ability

In this study, gold nanorods (GNRs), uniformly coated with polydopamine (PDA), were developed as a multifunctional nanocarrier for targeted, pH, and near infrared (NIR) irradiation dual-stimuli triggered drug delivery. Doxorubicin (DOX), a hydrophobic chemotherapeutic drug, was conveniently and heavily loaded into the nanocarrier through π–π stacking and hydrogen bonding interactions. It was further passivated by thiolated poly(ethylene glycol)-tumor homing peptides (NGR and TAT) to improve its cancer tissue penetrating, and accurate targeting ability. The developed NGR/TAT-DOX-PDA@GNRs could not only specifically and effectively deliver therapeutic agents to the tumor sites, but also facilitated controlled release of DOX, triggered via pH and near infrared light dual-stimuli. The studies of tumor cell ablation confirmed that this chemo-photothermal synergistic therapy offered superior therapeutic efficacy, improved chemosensitivity, and enhanced chemotherapeutic efficacy. Therefore, this combination of photothermal therapy and chemotherapy, based on NGR/TAT-DOX-PDA@GNRs, can maximize the therapeutic efficacy, and minimize the dosage-related adverse effects in cancer treatment.

Plasmon-activated nanozymes with enhanced catalytic activity by near-infrared light irradiation

2020 ◽  
Vol 56 (12) ◽  
pp. 1784-1787 ◽  
Author(s):  
Xu Liu ◽  
Yilin Wan ◽  
Tao Jiang ◽  
Yifang Zhang ◽  
Peng Huang ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Cancer Treatment ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Light Irradiation ◽  
Infrared Light ◽  
Near Infrared Light ◽  
In Cells

The platinum-decorated gold nanorods exhibited notably enhanced enzyme-like catalytic activity under the near-infrared light irradiation and showed the potential in cancer treatment by evaluation of the catalytic activity and cytotoxicity in cells.

scholarly journals Photothermal Therapy Using Gold Nanorods and Near-Infrared Light in a Murine Melanoma Model Increases Survival and Decreases Tumor Volume

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Mary K. Popp ◽  
Imane Oubou ◽  
Colin Shepherd ◽  
Zachary Nager ◽  
Courtney Anderson ◽  
...  
Keyword(s):  
Light Source ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Volume ◽  
Infrared Light ◽  
Led Light ◽  
Murine Melanoma ◽  
Nir Light ◽  
Melanoma Model

Photothermal therapy (PTT) treatments have shown strong potential in treating tumors through their ability to target destructive heat preferentially to tumor regions. In this paper we demonstrate that PTT in a murine melanoma model using gold nanorods (GNRs) and near-infrared (NIR) light decreases tumor volume and increases animal survival to an extent that is comparable to the current generation of melanoma drugs. GNRs, in particular, have shown a strong ability to reach ablative temperatures quickly in tumors when exposed to NIR light. The current research tests the efficacy of GNRs PTT in a difficult and fast growing murine melanoma model using a NIR light-emitting diode (LED) light source. LED light sources in the NIR spectrum could provide a safer and more practical approach to photothermal therapy than lasers. We also show that the LED light source can effectively and quickly heatin vitroandin vivomodels to ablative temperatures when combined with GNRs. We anticipate that this approach could have significant implications for human cancer therapy.

In Vivo Monitoring of Intravenously Injected Gold Nanorods Using Near‐Infrared Light

Small ◽  
2008 ◽  
Vol 4 (7) ◽  
pp. 1001-1007 ◽  
Author(s):  
Takuro Niidome ◽  
Yasuyuki Akiyama ◽  
Kohei Shimoda ◽  
Takahito Kawano ◽  
Takeshi Mori ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
In Vivo Monitoring

A near-infrared light-controlled system for reversible presentation of bioactive ligands using polypeptide-engineered functionalized gold nanorods

2015 ◽  
Vol 51 (13) ◽  
pp. 2569-2572 ◽  
Author(s):  
Jie Yang ◽  
Ming-Hao Yao ◽  
Ming-Shuo Du ◽  
Rui-Mei Jin ◽  
Dong-Hui Zhao ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Near Infrared ◽  
Infrared Light ◽  
Controlled System ◽  
Near Infrared Light ◽  
Bioactive Ligands ◽  
Hybrid Platform

A hybrid platform with polypeptide-engineered functionalized gold nanorods has been designed for reversible presentation of immobilized bioactive ligands by near-infrared light.

Dendrimer-modified gold nanorods as efficient controlled gene delivery system under near-infrared light irradiation

2011 ◽  
Vol 152 ◽  
pp. e137-e139 ◽  
Author(s):  
Daxiang Cui ◽  
Peng Huang ◽  
Chunlei Zhang ◽  
Cengiz S. Ozkan ◽  
Bifeng Pan ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Light Irradiation ◽  
Infrared Light ◽  
Gene Delivery System ◽  
Near Infrared Light

scholarly journals An in vitro of radiation dose enhancement using gold nanorods and plasmonic photothermal therapy

2021 ◽  
Author(s):  
Daniel DiCenzo DiCenzo
Keyword(s):  
Radiation Dose ◽  
Ionizing Radiation ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Infrared Light ◽  
Nuclear Localization Sequence ◽  
X Rays ◽  
Dose Enhancement ◽  
Near Infrared Light ◽  
Pc3 Cells

Gold nanoparticles (GNP) have been shown to highly absorb ionizing radiation compared to tissue. GNPs have also been shown to be high absorbers of non-ionizing radiation with a peak absorbance at a wavelength dependent on their shape and size. This study investigated radiation dose enhancement in PC3 cells when in the presence of gold nanorods (NR) and near infrared light (IR). The PC3 cells were incubated with either PEGylated NRs (PNR) or anti prostate stem cell antigen antibody with nuclear localization sequence peptide conjugated NRs (AbNR). They were exposed to near infrared light at a wavelength of 810 nm to achieve a temperature of 42 ºC to 43 ºC for 60 minutes. They were also exposed to 160 kVp x-rays. It was found that both targeted and non-targeted GNPs when exposed to radiation and near infrared light synergistically enhanced radiation dose. It was also found that AbNRs provide greater dose enhancement than PNRs.

Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging

2021 ◽  
Author(s):  
Yue Yan ◽  
Binlong Chen ◽  
Qingqing Yin ◽  
Zenghui Wang ◽  
Ye Yang ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Therapeutic Efficacy ◽  
Near Infrared ◽  
Therapeutic Response ◽  
Intracellular Distribution ◽  
Infrared Light ◽  
Dual Responsive ◽  
Efficient Delivery ◽  
Ratiometric Imaging ◽  
Intracellular Targets

Abstract Efficient delivery of payload to intracellular targets has been identified as the central principle for nanomedicine development, while the extracellular targets are equally important for cancer treatment. Notably, the contribution of extracellularly distributed nanoparticles to therapeutic outcome is far from being understood. Herein, we develop a pH/light dual-responsive monochromatic ratiometric imaging nanoparticle (MRIN), which functions through sequentially lighting up the intracellular and extracellular fluorescence signals by acidic endocytic pH and near-infrared light. Enabled by MRIN nanotechnology, we accurately quantify the extracellular and intracellular distribution of nanoparticles in several tumor models, which account for 65-80% and 20-35% of total tumor exposure, respectively. Given that the majority of nanoparticles are trapped in extracellular regions, we successfully dissect the contribution of extracellularly distributed nanophotosensitizer to therapeutic efficacy, thereby maximize the treatment outcome. Our study provides key strategies to precisely quantify nanocarrier microdistribtion and engineer multifunctional nanomedicines for efficient theranostics.

scholarly journals Potential of Polymeric Films Loaded with Gold Nanorods for Local Hyperthermia Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 582 ◽  
Author(s):  
Álvaro Cárcamo-Martínez ◽  
Juan Domínguez-Robles ◽  
Brónach Mallon ◽  
Md. Taifur Raman ◽  
Ana Sara Cordeiro ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Near Infrared ◽  
Infrared Light ◽  
Skin Model ◽  
Porcine Skin ◽  
Swelling Properties ◽  
Adhesion Properties ◽  
Local Hyperthermia ◽  
Burning Pain

Current strategies for the treatment of superficial non-melanoma skin cancer (NMSC) lesions include topical imoquimod, 5-fluorouracil, and photodynamic therapy. Although these treatments are effective, burning pain, blistering, and dermatitis have been reported as frequent side effects, making these therapies far from ideal. Plasmonic materials have been investigated for the induction of hyperthermia and use in cancer treatment. In this sense, the effectiveness of intratumorally and systemically injected gold nanorods (GnRs) in inducing cancer cell death upon near-infrared light irradiation has been confirmed. However, the in vivo long-term toxicity of these particles has not yet been fully documented. In the present manuscript, GnRs were included in a crosslinked polymeric film, evaluating their mechanical, swelling, and adhesion properties; moreover, their ability to heat up neonatal porcine skin (such as a skin model) upon irradiation was tested. Inclusion of GnRs into the films did not affect mechanical or swelling properties. GnRs were not released after film swelling, as they remained entrapped in the polymeric network; moreover, films did not adhere to porcine skin, altogether showing the enhanced biocompatibility of the material. GnR-loaded films were able to heat up the skin model over 40 °C, confirming the potential of this system for non-invasive local hyperthermia applications.

Sign in / Sign up

Export Citation Format

Share Document