Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice

2020 ◽  
Vol 16 (2) ◽  
pp. 179-192 ◽  
Author(s):  
Willie O. Pinheiro ◽  
Maria L. Fascineli ◽  
Khellida L. V. Ramos ◽  
Laise R. de Andrade ◽  
Gabriel R. Farias ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Incidence ◽  
Breast Adenocarcinoma ◽  
Breast Cancer Patients ◽  
Ehrlich Tumor ◽  
Cancer Treatments ◽  
Conventional Drug ◽  
Tnf Α ◽  
Traditional Therapies ◽  
Potential Use

Nanobiotechnology strategies for cancer treatments are currently being tested with increasing interest, except in elderly groups. It is well established that breast cancer incidence increases with age and that traditional therapies usually generate severe adverse effects, especially for elderly groups. To investigate if the benefits of nanotechnology could be extended to treating cancer in this group, citrate-coated maghemite nanoparticles (NpCit) were used for magnetohyperthermia (MHT) in combination with the administration of PLGA-Selol nanocapsule (NcSel), a formulation with antioxidant and antitumor activity. The combined therapies significantly inhibited breast Ehrlich tumor growth and prevented metastases to the lymph nodes, liver and lungs until 45 days after tumor induction, a better result than the group undergoing conventional drug treatment. The levels of TNF-α, associated with poor prognosis in Ehrlich tumor, were also normalized. Therefore, the results evidenced the potential use of these therapies for future clinical trials in elderly breast cancer patients.

scholarly journals Antioxidants for the Treatment of Breast Cancer: Are We There Yet?

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 205
Author(s):  
Carmen Griñan-Lison ◽  
Jose L. Blaya-Cánovas ◽  
Araceli López-Tejada ◽  
Marta Ávalos-Moreno ◽  
Alba Navarro-Ocón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Cancer Progression ◽  
Redox Homeostasis ◽  
Breast Carcinogenesis ◽  
Breast Cancer Patients ◽  
Chemopreventive Agents ◽  
Low Degree ◽  
Potential Use

Breast cancer is the most frequent cancer and the leading cause of cancer death in women. Oxidative stress and the generation of reactive oxygen species (ROS) have been related to cancer progression. Compared to their normal counterparts, tumor cells show higher ROS levels and tight regulation of REDOX homeostasis to maintain a low degree of oxidative stress. Traditionally antioxidants have been extensively investigated to counteract breast carcinogenesis and tumor progression as chemopreventive agents; however, there is growing evidence indicating their potential as adjuvants for the treatment of breast cancer. Aimed to elucidate whether antioxidants could be a reality in the management of breast cancer patients, this review focuses on the latest investigations regarding the ambivalent role of antioxidants in the development of breast cancer, with special attention to the results derived from clinical trials, as well as their potential use as plausible agents in combination therapy and their power to ameliorate the side effects attributed to standard therapeutics. Data retrieved herein suggest that antioxidants play an important role in breast cancer prevention and the improvement of therapeutic efficacy; nevertheless, appropriate patient stratification based on “redoxidomics” or tumor subtype is mandatory in order to define the dosage for future standardized and personalized treatments of patients.

scholarly journals IL-6, IL-8 and TNF-α levels correlate with disease stage in breast cancer patients

2017 ◽  
Vol 26 (3) ◽  
pp. 421-426 ◽  
Author(s):  
Yunfeng Ma ◽  
Yi Ren ◽  
Zhi-Jun Dai ◽  
Cai-Jun Wu ◽  
Yan-Hong Ji ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Disease Stage ◽  
Breast Cancer Patients ◽  
Tnf Α

scholarly journals Lifestyle breast cancer patients among Indonesian women: A nationwide survey

2021 ◽  
Vol 10 (4) ◽  
pp. 730
Author(s):  
Solikhah Solikhah ◽  
Khairunnisaa Nuur Aliifah Setyawati ◽  
Monthida Sangruangake
Keyword(s):  
Breast Cancer ◽  
High School ◽  
Cancer Patients ◽  
Breast Cancer Incidence ◽  
Education Level ◽  
Lifestyle Changes ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Significance Level

Recently, cancer is a major health problem in the world. Lifestyle changes and growing urbanization likely led to increasing breast cancer incidence in such in Indonesia. Therefore, this study aimed to explore lifestyle breast cancer patients among Indonesian women. The investigation was a cross-sectional study distributed among 3,392 females drawn from 13 out of 27 provinces in Indonesia. Multiple binary logistic regressions were conducted to investigate breast cancer risk among Indonesian. A significance level of 0.05 was employed in all analysis. Of the 3,392 respondents included in the analysis, more than half (52.71%; n=1,788) was aged 40–49 years old. The most common marital status of the participants was married (98.20%; n=3,331), followed by no smoking (94.69%; n=3,212) and active exercise (62.12%; n=2,107). Education level was significantly associated with breast cancer (AdjOR_Junior high school=0.21; 95%CI=0.06 to 0.70; p<0.01 and AdjOR_senior high school=0.60; 95%CI=0.15 to 2.26; p<0.05). Education level was significantly related to breast cancer. Lifestyle such as smoking and physical activity was suspected to affect breast cancer indirectly.

Bilateral breast cancer: a case study

2019 ◽  
Vol 19 (3) ◽  
pp. 305-308
Author(s):  
Rajanigandha Tudu ◽  
Anup Kumar ◽  
Rashmi Singh ◽  
Payal Raina
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Breast Cancer Incidence ◽  
Bilateral Breast Cancer ◽  
Late Presentation ◽  
Incidence Rates ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Screening Guidelines ◽  
Cancer Management

AbstractBackground:Breast cancer is the most common cancer among females worldwide. Increasing breast cancer incidence rates, improved diagnosis and management modalities and growing life expectancy have resulted in increasing numbers of women at risk of developing contralateral primary breast cancer. Bilateral breast cancer can occur synchronously or metachronously.Material and methods:This study reports three cases of bilateral breast cancer patients treated at our oncology department between March 2018 and March 2019. The features of presentation, investigation, diagnosis and follow-up care are the highlights of this study.Results:Bilateral breast cancer was noted in three patients among the study population in the age group of 35 –55 years. Two of these patients had metachronous bilateral breast cancer, and one patient developed cancer in the second breast during the course of management. The second breast cancers differed histologically from primary breast cancer.Conclusion:Poor awareness on breast cancer care and the lack of national screening guidelines and programmes, and poor infrastructure, all contribute to late presentation and difficult breast cancer management. Proper history, clinical examination and imaging of opposite breast should be done to ensure adequate and timely management of bilateral breast cancer.

The analysis of NBS-1 gene mutation [657del(5)] in exon 6 in the population of 472 sporadic breast cancer patients in the Czech Republic

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 20087-20087
Author(s):  
J. Melter ◽  
G. Pazdrova ◽  
F. Janku ◽  
Z. Kleibl ◽  
J. Novotny ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Internal Control ◽  
Sporadic Breast Cancer ◽  
Breast Cancer Incidence ◽  
Published Data ◽  
Agarose Gel ◽  
Breast Cancer Patients ◽  
Blood Monocytes ◽  
Specific Band

20087 Background: Nijmegen breakage syndrome (NBS) caused by mutation [657del(5)] in exon 6 of NBS-1 is an autosomal recessive disorder with microcephaly, immunodeficiency, radiosensitivity, and predisposition to lymphoid malignancies. Recently, high frequency of NBS-1 mutation was found in some Slavic populations. Because NBS-1 heterozygotes may have high incidence of neoplastic changes, there is an urgent need to clarify the role of NBS-1 mutation in breast cancer carcinogenesis. Methods: We analyzed the NBS-1 status in 472 sporadic breast cancer patients treated in the Department of Oncology, Charles University Prague. DNA was extracted from peripheral blood monocytes. Subsequently two PCRs for each sample were carried out. Reaction was visualized using electrophoresis on agarose gel. Agarose gel wells with both the NBS-1 gene-specific band and internal control band were interpreted as positive. Wells with internal control only were interpreted as negative. PCR from samples giving neither an internal control band nor specific band were repeated. DNA samples obtained from a previously typed NBS family were used as a positive control. Results: Based on previously published data we expect to find at least 5 mutation carriers. Surprisingly, in our population of 472 subjects there was no mutation identified. Conclusions: Based on results of this study there is no relationship between NBS-1 mutation and breast cancer incidence. Acknowledgment: The study was supported in part by the RASO grant from Czech Society of Oncology, and MSM0021620808. No significant financial relationships to disclose.

Breast cancer patients' rights: How can they be respected in Iran?

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 81-81
Author(s):  
Azadeh Joulaee ◽  
Soodabeh Joolaee ◽  
Naser Bahrani ◽  
Maryam Kadivar ◽  
Mojgan Kalantari
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Care Delivery ◽  
Frozen Section ◽  
Breast Cancer Incidence ◽  
Conservative Surgery ◽  
Published Data ◽  
Breast Cancer Patients ◽  
Patients Rights ◽  
Trucut Biopsy

81 Background: The revolutionary concept in breast cancer diagnosis and treatment has significantly changed many aspects of cancer treatment in favor of patients' rights. The best useful targeted treatment is offered to them with the least harm and invasion. As the most common cancer, breast cancer incidence is 24/100, 000 or one-fourth of all new cancers. The aim of this study is to compare the international rights for breast cancer patients with actual situation in Iran. Methods: All published data in Iran are reviewed since 2001 to 2012 to see the actual care in Iran. Codification of new radiology, surgical and pathologic procedure and insurance coverage are searched through available national references. These data are compared with international references. Results: Diagnosis is done by excisional/incisional biopsy or frozen section. Trucut biopsy is done in a low minority of cases. Insurance system does not cover vacuum assisted biopsy. Only mastectomy and axillary dissection are accepted by insurance. No codification exists for conservative surgery, oncoplastic surgery and sentinel node biopsy and the rate for these surgeries are low. Breast reconstruction, conservative surgery as bilateral mammoreduction, and symmetrization of controlateral breast are considered as cosmetic surgery with no coverage. The majority of cases are treated in general surgical wards. There are very few breast nurses and few centers for rehabilitation, lymphedema treatment, and psychological support of survivor. Conclusions: The ministry of health insists on full respection of the patient’s rights in medical practice. The new rights of breast cancer patients based on new treatment strategy are not highlighted in Iran. Valid evidence must be provided for policy makers about the rights of these vulnerable patients to consider them in Iranian health care delivery system. Specialized breast unit can improve significantly the quality of breast cancer care toward the patients' right. Pre-operative confirmation of cancer by trucut biopsy seems to be the key point. This gives the patient the opportunity to know more about the disease and to search for the best therapeutic plan according to international guideline.

scholarly journals 125P Cognitive impairment in breast cancer patients up to 18 months after cancer treatments: The French multicentric longitudinal CANTO-Cog cohort substudy

2021 ◽  
Vol 32 ◽  
pp. S412-S413
Author(s):  
F. Joly Lobbedez ◽  
I. Hardy-Léger ◽  
S. Lefevre Arbogast ◽  
O. Rigal ◽  
J. Le Fel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cognitive Impairment ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Cancer Treatments ◽  
After Cancer

scholarly journals Pengkajian dan Symptom Mangement Pada Pasien Dengan Fungating Breast Cancer di Pelayanan Perawatan Paliatif: Literature Review

2021 ◽  
Vol 8 (1) ◽  
pp. 61-74
Author(s):  
Yodang Yodang ◽  
Nuridah Nuridah
Keyword(s):  
Breast Cancer ◽  
Palliative Care ◽  
Literature Review ◽  
Cancer Patients ◽  
Breast Cancer Incidence ◽  
Assessment Tools ◽  
Advanced Stage ◽  
Breast Cancer Patients ◽  
Palliative Care Setting ◽  
Palliative Care Services

Currently, cancer includes breast cancer is a predominant disease treated in palliative care services. Breast cancer incidence increased significantly during the last decade and can progress to a late or advanced stage. At this advanced stage, the incidence of the fungating wound occurs in 5-10% of breast cancer patients. The study aims to identify assessment and symptoms management of fungating breast cancer in the palliative care setting. This study applied a literature review method. Searching for articles using 4 journal databases including DOAJ, Google Scholar, Proquest, and Science Direct. 17 articles that met the inclusion criteria of the study. The literature review identifies that the assessment tools are holistic assessment methods, wound assessment charts, and time framework assessments. The major symptoms are mal-odor, pain, exudation, peri-wound maceration and bleeding, psychological and spiritual issues. The studies, which focus on assessment and symptoms management of fungating breast cancer was limited. This affects the comprehensiveness of the review study. Investigation on quality of life among fungating breast cancer patients shortly is needed.   

scholarly journals Racial Disparities in the Incidence, Breast Conserving Rate and Survival of Breast Cancer Patients Who Underwent Breast Conserving Surgery

2021 ◽  
Author(s):  
Shu Han ◽  
Jianjun Liu ◽  
Weifang Tang ◽  
Shengying Wang ◽  
Shikai Hong
Keyword(s):  
Breast Cancer ◽  
Racial Disparities ◽  
Cancer Incidence ◽  
White Women ◽  
Breast Cancer Incidence ◽  
Relative Survival ◽  
Breast Conserving Surgery ◽  
Incidence Rates ◽  
Breast Cancer Patients ◽  
Cancer Specific Survival

Abstract Objective: In the current study, we aimed to provide a clear insight on the racial disparity of breast conserving rate (BCR) and survival in breast cancer after breast conserving surgery (BCS). Materials and Methods: Using data from the Surveillance, Epidemiology, and End Results program (SEER), we estimated breast cancer incidence rates and the rate of BCS by race in two periods (2000-2004 and 2013-2017). Relative survival analysis was based on patient-level data from 1998 to 2017. To be adjusted for baseline differences for different races, inverse probability weighting (IPW) models were stepwise performed.Results: From 2000-2004 to 2013-2017, both the breast cancer incidence (from 4.18 to 5.05 per 1000 white women) and the proportion of patients after BCS (from 55.5% to 59.9) were highest in whites than that of other races. Black individuals’ incidence (1.20 per 1000 black women or relatives 43.6% increased) and the BCR were increased most rapidly (6%) than other races. Asian or Pacific Islanders (APIs) were less likely to be diagnosed at a later stage and had the best prognosis than those of other races. After baselines fully adjusted, whites had the better Breast Cancer Specific Survival (BCSS) and Overall Survival (OS) than that of minorities (all p< 0.001).Conclusions: We identified the racial disparities of breast cancer incidence, BCR, and survival differences. We found increase trends of breast cancer incidence and BCR in minorities; however, we also identified the worse survival of minorities than that of whites, regardless of age, tumor stage, grade, and Luminal subtype.

scholarly journals Correlation Between Family Support and Emotional Regulation with The Resilience of Breast Cancer Patients in The City of Surabaya: A Literature Review

2020 ◽  
Vol 6 (1) ◽  
pp. 57
Author(s):  
Mauna Qurrotul Ain ◽  
Mira Triharini ◽  
Tiyas Kusumaningrum
Keyword(s):  
Breast Cancer ◽  
Family Support ◽  
Cancer Patients ◽  
Emotional Regulation ◽  
Breast Cancer Incidence ◽  
Psychological Impact ◽  
Emotional Reactions ◽  
Review Literature ◽  
Breast Cancer Patients ◽  
The Individual

Introduction: Breast cancer incidence has increased recently. Breast cancer patients usually feel inconvenience, psychological impact, and unstable emotions. The purpose of this study is to review the literature on the relationship between family support and emotional regulation with the resilience of breast cancer patients.Methods: The review literature search uses a database "Google Scholar, Sinta, Jurnal Ners dan Scopus with keywords "Family Support, Emotion Regulation, Resilience, Breast Cancer, Patient" in the last ten years 2009-2019.Results: 4,434 journals then identified for titles obtained as much as 2,142 and filtered according to abstract obtained 98 remaining journals, then review the complete full-text publication of a fully detailed 46 journal The final article that was in accordance with the inclusion criteria was 19 journals (articles).There is a significant relationship between family support and emotional regulation to the resilience of breast cancer patients.Conclusion: Family support can affect the health conditions felt by breast cancer patients; good emotional regulation is needed so that the patient can survive. On the articles that have been reviewed, Family support and hope given to people suffering from chronic diseases can be mediators of the emergence of resilient characters With good emotional regulation Individuals can control emotions by monitoring, evaluating and modifying emotional reactions, thus acquired adaptive emotions and organized behavior, then forming good self-acceptance and the individual feeling confident in him, able to live a life of positive, optimistic, and confident 

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