Study on the Relationship Between the Imaging Characteristics of Inflammatory Infection and the Expression of Serum Cytokines in Patients with Blood Tumor

2021 ◽  
Vol 11 (2) ◽  
pp. 648-653
Author(s):  
Feibo Zhu ◽  
Chenglong Sun ◽  
Yongwei Hong ◽  
Jinhu Li ◽  
Yuhong Zhou
Keyword(s):  
Ct Imaging ◽  
Control Group ◽  
Imaging Features ◽  
Ct Image ◽  
Spearman Correlation ◽  
Ct Diagnosis ◽  
Tumor Patients ◽  
Serum Cytokines ◽  
Imaging Characteristics ◽  
The Relationship

To study the relationship between the CT image characteristics of inflammatory infection in patients with blood tumor and expression of serum cytokines in patients, and provide a theoretical basis for the application of CT imaging in the diagnosis of inflammation in clinical hematologic tumor patients in the future, 110 patients with inflammatory infection of blood tumor admitted to the hospital from October 30, 2017 to December 30, 2019 were selected as experimental group (EG), and 80 patients without infection in the general blood tumor department were selected as control group (CG). CT imaging was performed on both groups of patients, and two senior doctors read the imaging features and recorded the infection. At the same time, with flow cytometry, levels of IL2, IL-4, IL-6, IL-10, IFN-γ, and TNF-α in serum were detected. Cytokines levels and CT diagnosis results were analyzed by the working characteristic curve of the subjects. Kappa was used to test the consistency of the two physicians, and Spearman correlation was used to analyze the correlation between cytokines and CT diagnosis results. The results demonstrated that IL-6 level, IL-10 level, and TNF-α level in EG were obviously higher than those in CG (P < 0.05), and there was no obvious difference in levels of IL-2, IL-4, and IFN-γ (P > 0.05). The consistency coefficient of kappa test was 0.82. In the EG, sensitivity (Se) and specificity (Spe) of IL-6, IL-10, TNF-α, and CT diagnosis were 53.5% and 76.8%, 53.5% and 80.8%, 53.5% and 72.0%, 86.7% and 72.8%, respectively. Area under curve (AUC) was 0.686, 0.747, 0.657 and 0.859. Spearman correlation analysis (SCA) indicated obvious positive correlation between CT diagnosis results and levels of serum cytokines IL-6, IL-10, and TNF-α in both groups (P < 0.05). The results showed that the levels of IL-6, IL-10 and TNF-α in patients with inflammatory infection were obviously higher than those in patients with common blood tumor. Se and AUC area of CT image diagnosis are the highest, which has a better diagnostic value in inflammatory infection of blood tumor patients. Moreover, it is obviously correlated with cytokines levels, including IL-6, IL-10, and TNF-α, in serum.

CT Image Analysis of Gastrointestinal Tumors Based on Simple Linear Iterative Cluster Algorithm

2019 ◽  
Vol 9 (8) ◽  
pp. 1770-1775
Author(s):  
Wentao Huang ◽  
Danhua Zhou ◽  
Dawei Liu ◽  
Baolong Li
Keyword(s):  
Gastrointestinal Cancer ◽  
Malignant Tumors ◽  
Ct Scanning ◽  
Ct Imaging ◽  
Gastrointestinal Tumors ◽  
Common Disease ◽  
Imaging Features ◽  
Ct Image ◽  
Texture Information ◽  
Imaging Characteristics

Objective: Gastrointestinal cancer is a very common disease at present. The purpose of this experiment is to use CT scanning technology and Simple Linear Iterative Cluster (SLIC) algorithm to analyze and fuse the scanning results, to explore the imaging characteristics of gastrointestinal neuroendocrine tumors by CT scanning and its application value in gastrointestinal tumors. Methods: The medical records of 25 patients with gastrointestinal tumors were selected as samples and analyzed retrospectively. Texture information fusion of CT image based on SLIC algorithm. This algorithm can fuse the texture information in the image, and then propose more targeted treatment for gastrointestinal tumors in different periods. Results: It was found that the diameter of malignant gastrointestinal tumors was more than 5 cm, and most of them occurred in the intestinal tract and the edge. The specific manifestations are blurred or lobulated, uneven density, invasion of surrounding structures and combined transfer rate. Therefore, it can be concluded that there are significant differences in CT features between benign and malignant gastrointestinal tumors. CT examination is helpful to differentiate benign and malignant tumors. Conclusion: Based on CT imaging, it can be found that the main cause of gastric neurosecretory tumors is blood-rich lesions. Gastrointestinal cancer cells of different pathological grades have different CT imaging features. CT imaging has certain value for preliminary judgment of pathological grading of patients.

scholarly journals Early MRI imaging and follow-up study in cerebral amyloid angiopathy

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 257-263
Author(s):  
Shan-chun Zhang ◽  
Jian-jun Jia ◽  
Heng-li Zhao ◽  
Bo Zhou ◽  
Wei Wang ◽  
...  
Keyword(s):  
Recurrence Rate ◽  
Cerebral Amyloid Angiopathy ◽  
Superficial Siderosis ◽  
Control Group ◽  
Amyloid Angiopathy ◽  
Imaging Features ◽  
Follow Up Study ◽  
Imaging Characteristics ◽  
Cerebral Amyloid

Abstract Aim To study the imaging features of leukoaraiosis (LA) and hemorrhage in cerebral amyloid angiopathy (CAA) patients. Methods The earliest MRI images of probable CAA patients and non-CAA patients were collected. The characteristics of LA in the two groups were analyzed. Cerebral micro bleeding (CMB), superficial siderosis (SS), and intracranial hemorrhage (ICH) were recorded in the follow-up study. The space relationship between CMB or SS and ICH was assessed. Results We found that 10/21 (47.6%) patients had occipital prominent LA and 14/21 (66.7%) patients had subcortical punctate LA before the ICH, which was higher than that of the ones in the control group (p = 0.015 and 0.038, respectively). The recurrence rate of ICH was 100% (3/3) in patients with diffuse SS and 36.4% (4/11) in patients without. The recurrence rate of ICH was 60% (3/5) in patients with multiple-lobe CMBs and 44.4% (4/9) in those without. The location of the ICH and CMB was inconsistent. ICH occurred in the ipsilateral cerebral hemisphere of SS in three patients with diffuse SS. Conclusion LA, diffuse SS, and multiple-lobe CMBs are important imaging characteristics of CAA, which may help make early diagnosis and predict the recurrence of ICH.

scholarly journals CT Imaging Features During Disease Progression of 2019 Novel Coronavirus (COVID-19) Pneumonia

2020 ◽  
Vol 17 (4) ◽  
Author(s):  
Nan Yu ◽  
Yong Yu ◽  
Shubo Cai ◽  
Cong Shen ◽  
Youmin Guo
Keyword(s):  
Disease Progression ◽  
Symptom Onset ◽  
Early Stage ◽  
Ground Glass Opacity ◽  
Ct Imaging ◽  
Imaging Features ◽  
Imaging Characteristics ◽  
Novel Coronavirus ◽  
Stage 1

Objectives: To describe the characteristics of computed tomography (CT) in patients with 2019 novel coronavirus (COVID-19) pneumonia and their changes during disease progression. Patients and Methods: A total of 96 chest CT scans of 61 pneumonia patients associated with COVID-19 were reviewed to identify CT features associated with the time of symptom onset and the evolution of disease. Results: The initial CTs of 61 patients were obtained during 1 to 11 days after the onset. The main CT pattern of initial CT obtained during 1 - 3 days after the symptom onset was single (7/23, 35%) or multiple ground-glass opacity (GGO, 8/23, 35%). At 4 - 7 days after the symptom onset, the main imaging features were crazy paving GGO mixed with partial consolidation pattern (15/32, 47%). At 8 - 11 days after the symptom onset, the CT images showed consolidation pattern (3/6, 50%). A total of 35 follow up CTs were collected. The mean interval time between each follow up CT was 3 ± 2 days. The CT patterns also changed with the evolution of the disease: the features of GGO manifested at the early stage (1 - 3d). The crazy paving GGO pattern, consolidation pattern and mixed with partial consolidation pattern were found 4 to 14 days after the onset. In the absorption stage (15 - 24d), both density and extent of lesions were reduced. Conclusion: The CT imaging features are associated with the time of symptom onset and evolution of disease. Understanding the imaging characteristics of each stage is very helpful for understanding the development of disease.

Treatment of Lung Cancer Complicated with Infection of Talaromyces Marneffei Based on Chest Imaging Characteristics Monitoring (Preprint)

2020 ◽  
Author(s):  
Yiling Feng ◽  
Xiaoping Li ◽  
Yanqin Wang ◽  
Shar Lenepe
Keyword(s):  
Lung Cancer ◽  
Control Group ◽  
Imaging Features ◽  
Observation Group ◽  
Chest Imaging ◽  
Lung Cancer Patients ◽  
Talaromyces Marneffei ◽  
Imaging Characteristics ◽  
Strip Shape ◽  
Male Patients

BACKGROUND Background: At present, although the infection of Talaromyces Marneffei has been known at home and abroad, there are few reports of Talaromyces Marneffei in lung cancer. OBJECTIVE Objective: The objective is to explore the diagnosis and treatment process of lung cancer patients with infection of Talaromyces Marneffei and its chest imaging characteristics, so as to improve the clinicians' realization of the disease. METHODS Method: The patients with lung cancer and infection of Talaromyces Marneffei (observation group) and the patients with infection of Talaromyces Marneffei (control group) are taken as the study objects, and the clinical characteristics and chest CT (computed tomography) imaging characteristics of the two groups are compared and summarized. RESULTS Results: The number of male patients infected with Talaromyces Marneffei is significantly higher than that of female patients (P < 0.05). The symptoms of cough and expectoration in the observation group are more than those in the control group (P < 0.05). The main imaging features of the observation group are obvious enhancement of focus enhancement scanning, strip shape and nodule, and the situation of obvious enhancement of focus enhancement scanning in the observation group is significantly higher than that in the control group (P < 0.05). CONCLUSIONS Conclusion: The clinical and imaging features of lung cancer and Talaromyces Marneffei infection overlap. When the lung lesions of patients with Talaromyces Marneffei have significant malignant signs, the possibility of lung cancer should be considered.

Effect of MiR-21 on Regulating the Proliferation of Synovial Fibroblasts in Rheumatoid Arthritis

2020 ◽  
Vol 10 (7) ◽  
pp. 1052-1058
Author(s):  
Zhichao Li ◽  
Jin Wang ◽  
Jing Yang
Keyword(s):  
Rheumatoid Arthritis ◽  
Cell Proliferation ◽  
Cell Apoptosis ◽  
Mrna Level ◽  
Synovial Fibroblasts ◽  
Control Group ◽  
Spearman Correlation ◽  
Qrt Pcr ◽  
Relationship Of ◽  
The Relationship

Background: This study investigated whether miR-21 regulates the expression of STAT3 and affects FLS cells. Methods: MiR-21 and STAT3 mRNA level was assessed by qRT-PCR and STAT3 and p-STAT3 level was evaluated by Western blot. Spearman correlation was used to analyze the relationship between miR-21 and STAT3 mRNA expression in synovial tissue of RA patients. FLS cells were treated with IL-17A, and the cells without treatment was included as the control group. Under IL-17A treatment, FLS cells were divided into 2 groups: miR-NC group and miR-21 mimic group. MiR-21, STAT3, p-STAT3 expression were detected and compared. EdU staining was used to detect cell proliferation and flow cytometry was used to measure cell apoptosis. Results: There was a target relationship of miR-21 with STAT3 mRNA. IL-17A treatment significantly downregulated miR-21 in FLS cells, upregulated STAT3 and p-STAT3 and enhanced cell proliferation. Transfection of miR21 mimic significantly downregulated STAT3 and p-STAT3 in FLS cells, reduced cell proliferation and increased cell apoptosis. Conclusion: MiR-21 overexpression down-regulates STAT3, inhibits FLS cell proliferation and promotes apoptosis, indicating that it might be a therapeutic target for treating RA.

scholarly journals Optimized Backprojection Filtration Algorithm for Postoperative Reduction and Analysis of Respiratory Infection-Related Factors of Pelvic Fractures by CT Imaging

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Aihua Pu ◽  
Hua Wang ◽  
Jichong Ying
Keyword(s):  
Pelvic Fracture ◽  
Ct Images ◽  
Ct Imaging ◽  
Pelvic Fractures ◽  
Conventional Group ◽  
Ct Image ◽  
Diagnosis Group ◽  
Imaging Characteristics ◽  
Conventional Ct ◽  
Projection Filtering

To explore the computed tomography (CT) imaging characteristics and BPF algorithm fine lung CT image efficiency for the diagnosis of pelvic fracture patients and assist clinicians to carry out the disease care and treatment, CT images based on optimized back-projection filtering (BPF) algorithm were utilized to diagnose postoperative reduction of pelvic fractures and penetrating lung infection caused by long-term bed rest. A total of 100 patients with pelvic fracture were selected and all of them underwent pelvic fracture surgery and were rolled into conventional CT diagnosis group (conventional group) and BPF algorithm optimized CT image diagnosis group (BPF group). One group used conventional CT images to guide pelvic reduction and detect lung infections, and the other used BPF algorithm to optimize the images. The results showed that the BPF group was superior to the conventional CT group in both image clarity and shadow area, and the peak signal-to-noise ratio (PSNR) was significantly better than that of the conventional group ( P < 0.05 ). Nine more cases were detected in the algorithm group than in the conventional group, and the incidence of complications was 48% in the conventional group and 28% in the BPF group, with a statistical difference of 20% between the two groups ( P < 0.05 ). In addition, the satisfaction of returning patients was 96% in the BPF group and 77% in the conventional group ( P < 0.05 ). The diagnosis of pulmonary infection was more obvious in the BPF group, indicating that BPF optimization of the CT image was suitable for clinical diagnosis and had a practical application value.

Abstract W MP67: Etiology-Specific Clinical and Imaging Features in Ischemic Stroke

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Ethem Murat Arsava ◽  
Robert D Brown ◽  
Steven J Kittner ◽  
James F Meschia ◽  
Braxton D Mitchell ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Large Artery ◽  
Imaging Features ◽  
Imaging Characteristics ◽  
Cardiac Assessment ◽  
History Of ◽  
The Relationship ◽  
Ischemic Events ◽  
Watershed Infarcts

Background: Identification of clinical and imaging characteristics of ischemic stroke that can predict the underlying etiology is critical for accurate stroke subtyping. We sought to investigate the relationship between stroke characteristics and stroke etiology in 7,591 patients in the NINDS Stroke Genetics Network Study. Methods: We determined the probability of having a major etiology in the presence of certain stroke characteristics that were previously linked to specific stroke mechanisms. We excluded patients with multiple competing major etiologies. All patients had brain imaging, intra- and extra-cranial vascular imaging, and complete cardiac assessment. We defined major etiologies according to the Causative Classification of Stroke System Criteria without reference to the stroke characteristics under study. Results: History of 1 ipsilateral ischemic events within the last month, the presence of internal watershed infarcts or multiple, ipsilateral, unilateral, and temporally separate infarcts were associated with large artery atherosclerosis (Table). Multiple acute infarcts in different cerebral circulations were more common in patients with major cardiac source of embolism as well as in those with uncommon/cryptogenic causes. Stereotypic lacunar TIAs within the last week and lacunar syndrome were associated with lacunar infarction Discussion: Clinical and imaging stroke characteristics appear to predict stroke etiologies. This information may find utility in developing algorithms for a guided stroke evaluation as well as help identify the most likely causative etiology in the presence of multiple competing etiologies.

scholarly journals Correlation between Imaging Features and Pathological Stages of Primary Lung Tumors Based on Nanocontrast Agents

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Jin Li ◽  
Qian Xu ◽  
Cunhua Mao ◽  
Yuliang Liu
Keyword(s):  
Lung Cancer ◽  
Contrast Agents ◽  
Adverse Reactions ◽  
Lung Tumors ◽  
Ct Imaging ◽  
Ct Scans ◽  
Imaging Features ◽  
Display Time ◽  
Imaging Characteristics ◽  
Primary Lung Tumors

As one of the conventional methods of lung cancer detection, computed tomography (CT) usually requires the use of contrast agents to enhance the imaging effect. Conventional iodine contrast agents have poor signal-to-noise ratio and are prone to adverse reactions. It is necessary to find more effective and safe contrast agents for CT scans. The gold nanoparticles with secondary electron effect and photoelectric absorption effect can prolong the display time of the patient’s blood circulation after being injected into the patient’s body, which makes the nanocontrast agent a research hotspot in the field of CT imaging. In this study, ultrasmall gold nanoclusters with a diameter of about 5 nm were used as the contrast agent in CT scans. It was found that CT scans based on nanocontrast agents can obtain high-quality lung cancer imaging images, and the patient has no obvious adverse reactions. When observing the CT image, it was found that the stage of lung cancer patients can be clearly distinguished through the CT scan image. When analyzing the consistency of CT imaging and pathological classification, the Kappa value was 0.810, indicating that the two have a high degree of consistency. Therefore, this study believes that the imaging characteristics of primary lung tumors based on nanocontrast agents are highly correlated with their pathological types.

The Relationship Between the Imaging Characteristics of Tumor Angiogenesis and the Expression of Serum Cytokines in Lung Cancer

2020 ◽  
Vol 10 (9) ◽  
pp. 2228-2235
Author(s):  
Xihu Yao ◽  
Jianying Zhou ◽  
Zhicheng Zhang ◽  
Qingyun Zhou ◽  
Bernice Brown
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Blood Supply ◽  
Matrix Metalloproteinase 2 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Lung Cancer Patients ◽  
Imaging Characteristics ◽  
The Difference ◽  
The Relationship

Objective: As for the lung cancer patients, their imaging characteristics of CT and DSA are evaluated, so as to analyze the relationship between the degree of angiogenesis and the expression of cytokines. Method: Firstly, the CT and DSA data of 40 lung cancer patients who are confirmed by pathology and received intravascular interventional therapy are collected. 5 mL venous blood of patients is extracted and serum samples are extracted. The levels of matrix metalloproteinase-2 (MMP-2) as well as basic fibroblast growth factor (bFGF) in 40 patients with lung cancer are detected by enzyme-linked immunosorbent assay (ELISA). Meanwhile, the contents of MMP-2 and bFGF in serum of 40 healthy people are collected as normal control group. Normal distribution, t-test and F-test are used to verify the correlation between the image features of lung cancer and the expression levels of MMP-2 and bFGF in serum. Results: Firstly, the levels of MMP-2 and bFGF in lung cancer group are obviously higher than those in the control group, and the difference was statistically significant. P values were 0.002 and 0, respectively (P < 0.01). In addition, a positive correlation exists between MMP-2 and bFGF in the group of lung cancer as well as control, and the correlation coefficients are 0.602 as well as 0.712, respectively. Secondly, DSA of lung cancer shows that MMP-2 and bFGF of different types of blood supply lung cancer are different. The P value of intra group and inter group comparison was 0, and the difference is statistically significant. Thirdly, on the image, the lung cancer has necrotic cavity. The P value of MMP-2 and bFGF are 0.046 and 0.005 respectively. The P value of MMP-2 and bFGF are 0.001 and 0.001 respectively with the burr sign on the image. The P value of serum MMP-2 and bFGF are 0 and 0.001 with the deep lobulated sign on the image, both of which are statistically significant. There is no correlation between the size and location of lung cancer focus, whether there is peripheral obstructive pneumonia and the level of MMP-2 and bFGF. Conclusion: The DSA blood supply of lung cancer is related to the expression of MMP-2 as well as bFGF in serum, which can reflect the angiogenic state of tumor and be used as the basis of anti-angiogenic therapy. Whether the CT image of lung cancer shows necrotic cavity, burr sign and deep lobulated sign has a correlation with the expression of MMP-2 as well as bFGF in the serum. The combination of the two is helpful for the accurate assessment of the disease.

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