Activation of STAT Signaling Pathways and Induction of Suppressors of Cytokine Signaling (SOCS) Proteins in Mammalian Lens by Growth Factors

2004 ◽  
Vol 45 (3) ◽  
pp. 872 ◽  
Author(s):  
Samuel Ebong ◽  
Cheng-Rong Yu ◽  
Deborah A. Carper ◽  
Ana B. Chepelinsky ◽  
Charles E. Egwuagu
Keyword(s):  
Growth Factors ◽  
Signaling Pathways ◽  
Cytokine Signaling ◽  
Stat Signaling ◽  
Socs Proteins ◽  
Suppressors Of Cytokine Signaling

Atomistic insight into the inhibition mechanisms of suppressors of cytokine signaling on Janus kinase

2019 ◽  
Vol 21 (24) ◽  
pp. 12905-12915 ◽  
Author(s):  
Yaru Wei ◽  
Zhiyang Zhang ◽  
Nai She ◽  
Xin Chen ◽  
Yuan Zhao ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Negative Feedback ◽  
Janus Kinase ◽  
Cytokine Signaling ◽  
Signal Transducer ◽  
Jak Kinase ◽  
Stat Signaling ◽  
Suppressors Of Cytokine Signaling ◽  
Insight Into

Suppressors of cytokine signaling (SOCS) act as negative feedback regulators of the Janus kinase/signal transducer (JAK–STAT) signaling pathway by inhibiting the activity of JAK kinase.

scholarly journals Suppressors of Cytokine Signaling 3 Expression in Eosinophils: Regulation by PGE2and Th2 Cytokines

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Esther López ◽  
María Paz Zafra ◽  
Beatriz Sastre ◽  
Cristina Gámez ◽  
Mar Fernández-Nieto ◽  
...  
Keyword(s):  
Human Peripheral Blood ◽  
Th2 Cells ◽  
Cytokine Signaling ◽  
Prostaglandin E ◽  
Th2 Cytokines ◽  
Eosinophilic Bronchitis ◽  
Socs Proteins ◽  
Suppressors Of Cytokine Signaling ◽  
Blood Eosinophils ◽  
Socs3 Protein

Asthma and nonasthmatic eosinophilic bronchitis (NAEB) are respiratory disorders characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins play an important role in Th2-mediated allergic responses through control of the balance between Th1 and Th2 cells, particularly, SOCS3 and SOCS5. The aim of this study was to analyze SOCS expression in human peripheral blood eosinophils from patients with asthma, NAEB and healthy controls. SOCS expression in eosinophils from subjects was demonstrated by different techniques. Results showed that expression of SOCS3 in eosinophils and CD4 T cells from patients was higher than in healthy subjects. In addition, we demonstrated that prostaglandin E2(PGE2) and Th2 cytokines are able to upregulate SOCS3 production in eosinophils and attenuate its degranulation. In conclusion, eosinophils are able to transcribe and translate SOCS3 protein and can contribute to the regulation of the Th1/Th2 balance through SOCS3 production.

Suppressors of cytokine signaling (SOCS) proteins in inflammatory bone disorders

Bone ◽  
2020 ◽  
Vol 140 ◽  
pp. 115538
Author(s):  
Mariana Rates Gonzaga Santos ◽  
Celso M. Queiroz-Junior ◽  
Mila Fernandes Moreira Madeira ◽  
Fabiana Simão Machado
Keyword(s):  
Cytokine Signaling ◽  
Bone Disorders ◽  
Socs Proteins ◽  
Suppressors Of Cytokine Signaling

scholarly journals Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways

2011 ◽  
Vol 31 (5) ◽  
pp. 980-985 ◽  
Author(s):  
Taiga Tamiya ◽  
Ikko Kashiwagi ◽  
Reiko Takahashi ◽  
Hideo Yasukawa ◽  
Akihiko Yoshimura
Keyword(s):  
Cytokine Signaling ◽  
Socs Proteins ◽  
Suppressors Of Cytokine Signaling

scholarly journals Comprehensive analysis of suppressor of cytokine signaling proteins in human breast Cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mingyu Sun ◽  
Chuangang Tang ◽  
Jun Liu ◽  
Wenli Jiang ◽  
Haifeng Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Prognostic Factor ◽  
Cytokine Signaling ◽  
Suppressor Of Cytokine Signaling ◽  
Expression Levels ◽  
Pathway Enrichment ◽  
Stat Signaling ◽  
Socs Proteins ◽  
Mrna Expression Levels

Abstract Background Abnormal expression of suppressor of cytokine signaling (SOCS) proteins regulates tumor angiogenesis and development in cancers. In this study, we aimed to perform a comprehensive bioinformatic analysis of SOCS proteins in breast invasive carcinoma (BRCA). Methods The gene expression, methylation level, copy number, protein expression and patient survival data related to SOCS family members in BRCA patients were obtained from the following databases: Oncomine, The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Human Protein Atlas (HPA), Gene Expression Profiling Interactive Analysis (GEPIA), PCViz, cBioPortal and Kaplan-Meier plotter. Correlation analyses, identification of interacting genes and construction of regulatory networks were performed by functional and pathway enrichment analyses, weighted gene coexpression network analysis (WGCNA) and gene set enrichment analysis (GSEA). Results Data related to 1109 BRCA tissues and 113 normal breast tissue samples were extracted from the TCGA database. SOCS2 and SOCS3 exhibited significantly lower mRNA expression levels in BRCA tissues than in normal tissues. BRCA patients with high mRNA levels of SOCS3 (p < 0.01) and SOCS4 (p < 0.05) were predicted to have significantly longer overall survival (OS) times. Multivariate analysis showed that SOCS3 was an independent prognostic factor for OS. High mRNA expression levels of SOCS2 (p < 0.001), SOCS3 (p < 0.001), and SOCS4 (p < 0.01), and a low expression level of SOCS5 (p < 0.001) were predicted to be significantly associated with better recurrence-free survival (RFS). Multivariate analysis showed that SOCS2 was an independent prognostic factor for RFS. Lower expression levels of SOCS2 and SOCS3 were observed in patients with tumors of more advanced clinical stage (p < 0.05). Functional and pathway enrichment analyses, together with WGCNA and GSEA, showed that SOCS3 and its interacting genes were significantly involved in the JAK-STAT signaling pathway, suggesting that JAK-STAT signaling might play a critical role in BRCA angiogenesis and development. Western blot results showed that overexpression of SOCS3 inhibited the activity of the JAK-STAT signaling pathway in vitro. Conclusions SOCS family proteins play a very important role in BRCA. SOCS3 may be a prognostic factor and SOCS2 may be a potential therapeutic target in breast cancer.

scholarly journals Cross Talk between Notch and Growth Factor/Cytokine Signaling Pathways in Neural Stem Cells

2007 ◽  
Vol 27 (11) ◽  
pp. 3982-3994 ◽  
Author(s):  
Motoshi Nagao ◽  
Michiya Sugimori ◽  
Masato Nakafuku
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Growth Factor ◽  
Neural Stem Cells ◽  
Signaling Pathways ◽  
Intracellular Signaling ◽  
The Self ◽  
Cell Surface Receptor ◽  
Cytokine Signaling ◽  
Self Renewal

ABSTRACT Precise control of proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for proper development of the nervous system. Although signaling through the cell surface receptor Notch has been implicated in many aspects of neural development, its role in NSCs remains elusive. Here we examined how the Notch pathway cross talks with signaling for growth factors and cytokines in controlling the self-renewal and differentiation of NSCs. Both Notch and growth factors were required for active proliferation of NSCs, but each of these signals was sufficient and independent of the other to inhibit differentiation of neurons and glia. Moreover, Notch signals could support the clonal self-renewing growth of NSCs in the absence of growth factors. This growth factor-independent action of Notch involved the regulation of the cell cycle and cell-cell interactions. During differentiation of NSCs, Notch signals promoted the generation of astrocytes in collaboration with ciliary neurotrophic factor and growth factors. Their cooperative actions were likely through synergistic phosphorylation of signal transducer and activator of transcription 3 on tyrosine at position 705 and serine at position 727. Our data suggest that distinct intracellular signaling pathways operate downstream of Notch for the self-renewal of NSCs and stimulation of astrogenesis.

scholarly journals Leishmania donovaniPrevents Oxidative Burst-mediated Apoptosis of Host Macrophages through Selective Induction of Suppressors of Cytokine Signaling (SOCS) Proteins

2013 ◽  
Vol 289 (2) ◽  
pp. 1092-1105 ◽  
Author(s):  
Supriya Srivastav ◽  
Writoban Basu Ball ◽  
Purnima Gupta ◽  
Jayeeta Giri ◽  
Anindita Ukil ◽  
...  
Keyword(s):  
Oxidative Burst ◽  
Cytokine Signaling ◽  
Socs Proteins ◽  
Suppressors Of Cytokine Signaling

scholarly journals Suppressors of cytokine signaling proteins in human preterm placental tissues

2005 ◽  
Vol 35 (1) ◽  
pp. 165-175 ◽  
Author(s):  
M Blumenstein ◽  
J A Keelan ◽  
J M Bowen-Shauver ◽  
M D Mitchell
Keyword(s):  
Intrauterine Infection ◽  
Cell Types ◽  
Cytokine Signaling ◽  
Immunoperoxidase Staining ◽  
Signaling Proteins ◽  
Hofbauer Cells ◽  
Inflammatory Processes ◽  
Socs Proteins ◽  
Suppressors Of Cytokine Signaling ◽  
Gestational Tissues

Decreased suppressors of cytokine signaling (SOCS) activity in human gestational tissues may play a part in the onset/progression of term labor. Since SOCS proteins negatively regulate cytokine-mediated inflammatory processes, we hypothesized that SOCS proteins are elevated in gestational tissues from spontaneous preterm deliveries with intrauterine infection. SOCS1, −2 and −3 mRNAs and proteins were detectable by RT-PCR and immunoblotting respectively, in preterm amnion, choriodecidua and placenta, irrespective of infection status. Immunoperoxidase staining localized SOCS1, −2 and −3 to all cell types of the gestational membranes, with infiltrating leukocytes reacting strongly in infected tissues. In villous placenta, SOCS was immunolocalized to the syncytiotrophoblast with marked staining of round mesenchymal cells, possibly Hofbauer cells. Nuclear SOCS staining was seen in amnion, chorion and placental syncytiotrophoblasts. SOCS proteins were, in general, significantly more abundant in placenta compared with amnion or choriodecidua. Placental SOCS1 and interleukin-1β concentrations were positively correlated (r2=0.47; P<0.05). However, no changes in SOCS levels in any tissues were observed with intrauterine infection. The relatively large amounts of SOCS proteins in the placenta may reflect a placenta-specific immunoprotective response to minimize the elaboration and effects of cytokines with potential to harm the placenta and fetus. Lack of labor-associated changes in SOCS levels suggests that the regulation of SOCS expression in preterm gestational tissues differs from those at term, perhaps reflecting roles in regulating placental somatotropic responses.

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